Atopic Dermatitis-like Pre-Sézary Syndrome: Role of Immunosuppression
Małgorzata Sokołowska-Wojdyło, Wioletta Barańska-Rybak, Agnieszka Cegielska, Magdalena Trzeciak, Hanna Ługowska-Umer, Robert Gniadecki
We describe here 4 patients with Sézary syndrome masquerading as adult-onset atopic dermatitis. The patients presented with a clinical picture compatible with widespread atopic dermatitis and did not fulfil the criteria for Sézary syndrome (lack of lymphoadenopathy and blood involvement, skin histology without presence of atypical cells). In our patients, overt Sézary syndrome developed after immunosuppressive treatment (including cyclosporine). These cases support the validity of the concept of pre-Sézary syndrome, which is a long-lasting, pre-malignant condition, and which may develop to true malignancy in a state of immunosuppression.