Content » Vol 95, Issue 7

Clinical Report

Sentinel Node Status and Immunosuppression: Recurrence Factors in Localized Merkel Cell Carcinoma

Thomas Jouary, Emeline Kubica, Stéphane Dalle, Cecile Pages, Anne-Benedicte Duval-Modeste, Bernard Guillot, Sandrine Mansard, Philippe Saiag, François Aubin, Christophe Bedane, Sophie Dalac, Anne Dompmartin, Florence Granel-Brocard, Catherine Lok, Pierre-Emmanuel Stoebner, Jean-Philippe Lacour, Marie-Therese Leccia, Abou Diallo, Khaled Ezzedine, Christina Mateus
DOI: 10.2340/00015555-2099


The prognostic value of the sentinel lymph node in Merkel cell carcinoma (MCC) has been examined previously in heterogeneous retrospective studies. The current retrospective study included a homogeneous population of patients with a localized MCC, all staged with sentinel lymph node biopsy. Factors associated with 3-year progression-free survival were analysed using logistic regression. The sentinel lymph node was positive in 32% of patients. The recurrence rate was 26.9%. In first analyses (n=108), gender (p=0.0115) and the presence of immunosuppression (p=0.0494) were the only significant independent factors. In further analyses (n=80), excluding patients treated with regional radiotherapy, sentinel lymph node status was the only significant prognostic factor (p=0.0281). Immunosuppression and positive sentinel lymph node are associated with a worse prognosis in patients with MCC. Nodal irradiation impacts on the prognostic value of the sentinel lymph node status.


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