Content

Content - Volume 95, Issue 7

Editor's choice in this issue

REVIEW
Human Surrogate Models of Histaminergic and Non-histaminergic Itch
Hjalte H. Andersen, Jesper Elberling, Lars Arendt-Nielsen
Within the last decade understanding of the mechanistic basis of itch has improved significantly, resulting in the development of several human surrogate models of itch and related dysesthetic states. Well-characterized somatosensory models are useful in basic studies in healthy volunteers, in clinical studies for diagnostic and segmentation purposes, and in pharmacological studies to evaluate the ...
Pages: 771-777
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INVESTIGATIVE REPORT
A Case of Subepidermal Blistering Disease with Autoantibodies to Multiple Laminin Subunits who Developed Later Autoantibodies to Alpha-5 Chain of Type IV Collagen Associated with Membranous Glomerulonephropathy
Hirohiko Sueki, Yoshinori Sato, Shinpei Ohtoshi, Tokio Nakada, Ashio Yoshimura, Chiharu Tateishi, Dorin-Bogdan Borza, William Fader, Reza F. Ghohestani, Yoshiaki Hirako, Hiroshi Koga, Norito Ishii, Atsunari Tsuchisaka, Hua Qian, Xiaoguang Li, Takashi Hashimoto
We report a 68-year-old Japanese female patient with subepidermal blistering disease with autoantibodies to multiple laminins, who subsequently developed membranous glomerulonephropathy. At skin disease stage, immunofluorescence demonstrated IgG anti-basement membrane zone antibodies reactive with dermal side of NaCl-split skin. Immunoblotting of human dermal extract, purified laminin-332, hemides ...
Pages: 826-829
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INVESTIGATIVE REPORT
A Human Surrogate Model of Itch Utilizing the TRPA1 Agonist Trans-cinnamaldehyde
Chris R. Højland, Hjalte H. Andersen, Jeppe N. Poulsen, Lars Arendt-Nielsen, Parisa Gazerani
The thermoreceptive transient receptor potential ankyrin 1 (TRPA1) is important in the transmission of itch, and its agonist trans-cinnamaldehyde has occasionally been reported to be a pruritogen in humans. However, no studies have accurately quantified the capabilities of trans-cinnamaldehyde to induce itch and related dysesthetic sensations. The present study examined alterations in somatosenso ...
Pages: 798-803
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All articles

REVIEW
Human Surrogate Models of Histaminergic and Non-histaminergic Itch
Hjalte H. Andersen, Jesper Elberling, Lars Arendt-Nielsen
Within the last decade understanding of the mechanistic basis of itch has improved significantly, resulting in the development of several human surrogate models of itch and related dysesthetic states. Well-characterized somatosensory models are useful in basic studies in healthy volunteers, in clinical studies for diagnostic and segmentation purposes, and in pharmacological studies to evaluate the ...
Pages: 771-777
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SPECIAL REPORT
Intralesional 5-Fluorouracil in Keloid Treatment: A Systematic Review
Eveline Bijlard, Sanne Steltenpool, Frank B. Niessen
In the 1990s, 5-flourouracil (5-FU) was introduced as a treatment for keloids; however, there is still no consensus on its use. In order to guide clinical practice, a systematic review of the clinical evidence on the effectiveness of 5-FU in keloid treatment was carried out. Eight databases were searched on 10 September 2014 using the terms “keloid” and “5-FU”, together with all synonyms o ...
Pages: 778-782
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INVESTIGATIVE REPORT
Reduced Expression of Dermcidin, a Peptide Active Against Propionibacterium acnes, in Sweat of Patients with Acne Vulgaris
Toshiaki Nakano, Takashi Yoshino, Takao Fujimura, Satoru Arai, Akira Mukuno, Naoya Sato, Kensei Katsuoka
Dermcidin (DCD), an antimicrobial peptide with a broad spectrum of activity against bacteria such as Propionibacterum acnes, is expressed constitutively in sweat in the absence of stimulation due to injury or inflammation. The aim of this study was to determine the relationship between DCD expression and acne vulgaris associated with P. acnes. The antimicrobial activity of recombinant full-length ...
Pages: 783-786
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INVESTIGATIVE REPORT
Ultra-pure Soft Water Ameliorates Atopic Skin Disease by Preventing Metallic Soap Deposition in NC/Tnd Mice and Reduces Skin Dryness in Humans
Akane Tanaka, Akira Matsuda, Kyungsook Jung, Hyosun Jang, Ginnae Ahn, Saori Ishizaka, Yosuke Amagai, Kumiko Oida, Peter D. Arkwright, Hiroshi Matsuda
Mineral ions in tap water react with fatty acids in soap, leading to the formation of insoluble precipitate (metallic soap) on skin during washing. We hypothesised that metallic soap might negatively alter skin conditions. Application of metallic soap onto the skin of NC/Tnd mice with allergic dermatitis further induced inflammation with elevation of plasma immunoglobulin E and proinflammatory cyt ...
Pages: 787-791
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INVESTIGATIVE REPORT
Melanoma Growth and Progression After Ultraviolet A Irradiation: Impact of Lysosomal Exocytosis and Cathepsin Proteases
Cecilia Bivik Eding, Jakob Domert, Petra Wäster, Fredrik Jerhammar, Inger Rosdahl, Karin Öllinger
Ultraviolet (UV) irradiation is a risk factor for development of malignant melanoma. UVA-induced lysosomal exocytosis and subsequent cell growth enhancement was studied in malignant melanoma cell lines and human skin melanocytes. UVA irradiation caused plasma membrane damage that was rapidly repaired by calcium-dependent lysosomal exocytosis. Lysosomal content was released into the culture medium ...
Pages: 792-797
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INVESTIGATIVE REPORT
A Human Surrogate Model of Itch Utilizing the TRPA1 Agonist Trans-cinnamaldehyde
Chris R. Højland, Hjalte H. Andersen, Jeppe N. Poulsen, Lars Arendt-Nielsen, Parisa Gazerani
The thermoreceptive transient receptor potential ankyrin 1 (TRPA1) is important in the transmission of itch, and its agonist trans-cinnamaldehyde has occasionally been reported to be a pruritogen in humans. However, no studies have accurately quantified the capabilities of trans-cinnamaldehyde to induce itch and related dysesthetic sensations. The present study examined alterations in somatosenso ...
Pages: 798-803
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INVESTIGATIVE REPORT
Changes in Body-site Distribution of Common Melanocytic Naevi Among 7-year-old Swedish Children Between 2002 and 2007
Maria A. Karlsson, Bernt Lindelöf, Carl-Fredrik Wahlgren, Ylva Rodvall, Kerstin Wiklund
An observational population-based study conducted among 2 sets of 7-year-old children in Sweden in 2002 and 2007 revealed evidence of improved sun protection, also reflected in a significant reduction in the total number of melanocytic naevi. Based on these data-sets, the aim of the current study was to determine whether the overall reduction in naevi had impacted differently on body sites based o ...
Pages: 804-808
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INVESTIGATIVE REPORT
Increased Cause-specific Mortality in Patients with Mild and Severe Psoriasis: A Population-based Swedish Register Study
Axel Svedbom, Johan Dalén, Carla Mamolo, Joseph C. Cappelleri, Lotus Mallbris, Ingemar F. Petersson, Mona Ståhle
Several studies have shown excess risk for a number of comorbidities in patients with psoriasis compared with the general population, but data on cause-specific mortality in this patient population are limited. The aim of this study was to estimate the associations of psoriasis and 12 specific causes of death and all-cause mortality in patients with mild and severe psoriasis. The study was based o ...
Pages: 809-815
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CLINICAL REPORT
Prevalence of Chronic Itch and Associated Factors in Haemodialysis Patients: A Representative Cross-sectional Study
Melanie Weiss, Thomas Mettang, Ulrich Tschulena, Jutta Passlick-Deetjen, Elke Weisshaar
Chronic itch is a common symptom in haemodialysis (HD) patients, which is often underestimated. The aim of this cross-sectional study was to investigate the prevalence and factors associated with chronic itch in HD patients. A total of 860 HD patients from a randomly selected cluster-sample of patients attending dialysis units in Germany were included. The patients’ mean?±?SD age was 67.2?±?13 ...
Pages: 816-821
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CLINICAL REPORT
Retrospective Evaluation of Conservative Treatment for 140 Ingrown Toenails with a Novel Taping Procedure
Akiko Watabe, Kenshi Yamasaki, Akira Hashimoto, Setsuya Aiba
The aim of this study is retrospectively to review the efficacy of a taping procedure for treating ingrown toe­nails or for supporting other conservative treatments of ingrown toenails. A total of 140 ingrown toenails treated at the Dermatology Clinic in Tohoku University Hospital were retrospectively reviewed for demographic characteristics, association with granulation tissue or infection, trea ...
Pages: 822-825
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INVESTIGATIVE REPORT
A Case of Subepidermal Blistering Disease with Autoantibodies to Multiple Laminin Subunits who Developed Later Autoantibodies to Alpha-5 Chain of Type IV Collagen Associated with Membranous Glomerulonephropathy
Hirohiko Sueki, Yoshinori Sato, Shinpei Ohtoshi, Tokio Nakada, Ashio Yoshimura, Chiharu Tateishi, Dorin-Bogdan Borza, William Fader, Reza F. Ghohestani, Yoshiaki Hirako, Hiroshi Koga, Norito Ishii, Atsunari Tsuchisaka, Hua Qian, Xiaoguang Li, Takashi Hashimoto
We report a 68-year-old Japanese female patient with subepidermal blistering disease with autoantibodies to multiple laminins, who subsequently developed membranous glomerulonephropathy. At skin disease stage, immunofluorescence demonstrated IgG anti-basement membrane zone antibodies reactive with dermal side of NaCl-split skin. Immunoblotting of human dermal extract, purified laminin-332, hemides ...
Pages: 826-829
Abstract  HTML  PDF
CLINICAL REPORT
Actinic Keratoses, Actinic Field Change and Associations with Squamous Cell Carcinoma in Renal Transplant Recipients in Manchester, UK
Sarah C. Wallingford, Sheila A. Russell, Andy Vail, Charlotte M. Proby, John T. Lear, Adèle C. Green
While actinic keratoses (AKs) have a known association with cutaneous squamous cell carcinoma (SCC), the relation of actinic field change to SCC has not been quantified. This study investigated the presence of field change and AKs in renal transplant recipients (RTRs) and estimated SCC risk. In May 2010 to October 2011, a dermatologist examined 452 white RTRs (mean age 53 years) at two hospitals i ...
Pages: 830-834
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CLINICAL REPORT
Sentinel Node Status and Immunosuppression: Recurrence Factors in Localized Merkel Cell Carcinoma
Thomas Jouary, Emeline Kubica, Stéphane Dalle, Cecile Pages, Anne-Benedicte Duval-Modeste, Bernard Guillot, Sandrine Mansard, Philippe Saiag, François Aubin, Christophe Bedane, Sophie Dalac, Anne Dompmartin, Florence Granel-Brocard, Catherine Lok, Pierre-Emmanuel Stoebner, Jean-Philippe Lacour, Marie-Therese Leccia, Abou Diallo, Khaled Ezzedine, Christina Mateus
The prognostic value of the sentinel lymph node in Merkel cell carcinoma (MCC) has been examined previously in heterogeneous retrospective studies. The current retrospective study included a homogeneous population of patients with a localized MCC, all staged with sentinel lymph node biopsy. Factors associated with 3-year progression-free survival were analysed using logistic regression. The sentin ...
Pages: 835-840
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SHORT COMMUNICATION
Treponema pallidum Haemagglutination Assay Serum Titres as a Predictor of Cerebrospinal Fluid Abnormalities in Patients with Syphilis
Nadezhda Levchik, Marina Ponomareva, Vera Surganova, Natalia Zilberberg
Abstract is missing (Short communication)
Pages: 841-842
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SHORT COMMUNICATION
Elevated Serum Levels of BP180 Antibodies in the First Trimester of Pregnancy Precede Gestational Pemphigoid and Remain Elevated for a Long Time After Remission of the Disease
Laura Huilaja, Heljä-Marja Surcel, Aini Bloigu, Kaisa Tasanen
Abstract is missing (Short communication)
Pages: 843-844
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SHORT COMMUNICATION
Preoperative Management of Antithrombotic Medication in Mohs Micrographic Surgery
Xiaomeng Liu, Luca Lammers, Patty J. Nelemans, Klara Mosterd, Nicole W.J. Kelleners-Smeets
Abstract is missing (Short communication)
Pages: 845-847
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SHORT COMMUNICATION
Safety and Efficacy of Human Fibroblast Lysate Cream for Vulvar Lichen Sclerosus: A Randomized Placebo-controlled Trial
Andrew T. Goldstein, Lara J. Burrows, Zoe R. Belkin, Richard Pfau, Matthew Bremmer, Corrie Goldfinger, Frank Dreher
Abstract is missing (Short communication)
Pages: 847-849
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SHORT COMMUNICATION
Junctional Epidermolysis Bullosa with LAMB3 Splice-site Mutations
Dimitra Kiritsi, Laura Huilaja, Claus-Werner Franzke, Nina Kokkonen, Chiara Pazzagli, Agnes Schwieger-Briel, Markku Larmas, Leena Bruckner-Tuderman, Cristina Has, Kaisa Tasanen
Abstract is missing (Short communication)
Pages: 849-851
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SHORT COMMUNICATION
Absence of Full-length Neurokinin-1 Receptor Protein Expression by Cutaneous T Cells: Implications for Substance P-mediated Signaling in Mycosis Fungoides
Marina Tuzova, Tara Conniff, Clara Curiel-Lewandrowski, Keri Chaney, William Cruikshank, Deon Wolpowitz
Abstract is missing (Short communication)
Pages: 852-854
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SHORT COMMUNICATION
Drug Eruption Following High-calorie Infusion: A Possible Systemic Type IV Allergic Reaction to Sulphites
Tetsuya Honda, Akihiko Kitoh, Yoshiki Miyachi, Kenji Kabashima
Abstract is missing (Short communication)
Pages: 854-855
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SHORT COMMUNICATION
Deep Cutaneous Infection with Microsphaeropsis arundinis: Report of two Japanese Cases
Akihiko Asahina, Miwa Kobayashi, Kazuaki Nakano, Ikuo Saito, Kyoko Yarita, Katsuhiko Kamei, Yoshiki Tokura
Abstract is missing (Short communication)
Pages: 855-857
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SHORT COMMUNICATION
Lamellar Ichthyosis Caused by a Previously Unreported Homozygous ALOXE3 Mutation in East Asia
Kazumitsu Sugiura, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 858-859
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SHORT COMMUNICATION
Congenital and Disseminated Pyogenic Granuloma-like Vascular Lesions
Stéphanie Mallet, Charlotte Rebelle, Isabelle Ligi, Didier Scavarda, Corinne Bouvier, Philippe Petit, Sylvie Fraitag, Michel Wassef, Caroline Gaudy-Marqueste, Sylvie Hesse, Marie-Aleth Richard, Jean-Jacques Grob, Nicolas André
Abstract is missing (Short communication)
Pages: 860-861
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SHORT COMMUNICATION
Social Anxiety Disorder and Agoraphobia in Dermatology Patients; Two Cases and a Review of the Literature
Claire Marshall, Anthony Bewley
Abstract is missing (Short communication)
Pages: 862-863
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SHORT COMMUNICATION
Successful Treatment of Refractory Neuropathic Pruritus with Capsaicin 8% Patch: A Bicentric Retrospective Study with Long-term Follow-up
Laurent Misery, Nouran Erfan, Emeline Castela, Emilie Brenaut, Michel Lantéri-Minet, Jean-Philippe Lacour, Thierry Passeron
Abstract is missing (Short communication)
Pages: 864-865
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SHORT COMMUNICATION
Oral Tacrolimus Treatment of Pruritus in Prurigo Nodularis
Jon Anders Halvorsen, Willy Aasebø
Abstract is missing (Short communication)
Pages: 866-867
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SHORT COMMUNICATION
Successful Methotrexate Treatment of Oesophageal Pemphigus Vulgaris in an Immunosuppressed Patient with Crohn’s Disease
Orsolya N. Horváth, Alena Borovaya, Elisabeth Roider, Joachim Klose, Eva Hartlieb, Jens Waschke, Thomas Ruzicka, Miklós Sárdy
Abstract is missing (Short communication)
Pages: 868-869
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LETTER TO THE EDITOR
Smartphone Teledermoscopy Referrals: Comment on the paper by Börve et al.
Claire Leitch, Ruth Jones, Stephen A. Holme
Abstract is missing (Letter)
Pages: 869-871
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LETTER TO THE EDITOR
What are the “True” Pathogenic Anti-desmoglein Antibodies?
Yoshinao Muro, Kazumitsu Sugiura, Masashi Akiyama
Abstract is missing (Letter)
Pages: 872-874
Abstract  HTML  PDF
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