Identification of a Single Nucleotide Polymorphism in NFKBIA with Different Effects on Psoriatic Arthritis and Cutaneous Psoriasis in China
Qing Zhao, Yonghu Sun, Xi’an Fu, Zhenzhen Wang, Gongqi Yu, Zhenhua Yue, Yaru Wang, Huimin Zhang, Chuan Wang, Hong Liu, Qing Yang, Furen Zhang
Genome-wide association studies have recently identified a number of non-major histocompatibility complex regions associated with psoriatic arthritis. However, data on Chinese patients with psoriatic arthritis and the differences between psoriatic arthritis and cutaneous psoriasis are limited. This study genotyped 12 single nucleotide polymorphisms in 379 patients with psoriatic arthritis, 376 with cutaneous psoriasis, and 760 healthy controls using Sequenom’s Mass ARRAY system. The aim of the study was to expand the database for psoriatic arthritis and cutaneous psoriasis, and develop a genetic prediction system for the early diagnosis of psoriatic arthritis in the Chinese population. One variant in NFKBIA, rs12883343, had a significantly different association with psoriatic arthritis than with cutaneous psoriasis (p = 4.93×10–10, odds ratio 2.371). This suggests that there are differences in the pathogenesis of psoriatic arthritis and cutaneous psoriasis.
A number of novel psoriatic arthritis genetic susceptibility loci have been identified recently, but data on their association with Chinese psoriatic arthritis patients are limited. In addition, the data of differences between psoriatic arthritis and cutaneous psoriasis are lacking. We performed a genetic study in a Chinese population to expand the database for psoriatic arthritis and cutaneous psoriasis and to develop a genetic prediction model for early diagnosis of psoriatic arthritis.