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Clinical Report

Economic Burden of Adult Patients with Moderate to Severe Atopic Dermatitis Indicated for Systemic Treatment

Lieneke F.M. Ariëns, Kirsten J.M. van Nimwegen, Marjan Shams, Digna T. de Bruin, Jorien van der Schaft, Harmieke van Os-Medendorp, Marjolein De Bruin-Weller
DOI: 10.2340/00015555-3212

Preview of fully accepted paper, still not published in any volume

Abstract

Given the introduction of new therapies targeting specific immune pathways for atopic dermatitis (AD), information on the economic burden of AD patients is needed. Direct costs (medication use and healthcare resource utilization) and costs of productivity loss were studied in 90 adult patients with AD indicated for systemic treatment. Costs were calculated for patients with controlled (Investigator Global Assessment (IGA) 0–2) and uncontrolled (IGA 3–5) disease at inclusion. Mean (95% confidence interval (95% CI)) total direct costs were €5,191 (€4,382–6,019) per patient per year (PPY), €4,401 (€3,695–5,215) for patients with controlled AD vs. €6,993 (€5,552–8,406), mean difference €2,593 (€820–4,282) (p=0.014) for patients with uncontrolled AD. Costs of productivity loss were €10,040 (€6,260–14,012) PPY for the total group, €6,886 (€4,188–10,129) PPY for patients with controlled AD vs. €13,702 (€6,124–22,996) for patients with uncontrolled AD, mean difference €6,816 (–€1,638–16,677; p=0.148). Total costs (direct costs+costs of productivity loss) were €15,231 (€11,487–19,455) PPY for the total group, €11,287 (€7,974–15,436) for patients with controlled AD vs. €20,695 (€14,068–34,564), mean difference €9,408 (–€119–19,964) (p=0.077) for patients with uncontrolled AD. Patients with AD using systemic immunosuppressive treatment incur considerable direct costs and costs of productivity loss.

Significance

Given the introduction of new therapies targeting specific immune pathways for atopic dermatitis, information on the economic burden of patients with atopic dermatitis is needed. In 90 adult patients with atopic dermatitis indicated for systemic treatment, direct costs (including medication use and healthcare resource utilization) and costs due to reduced work productivity were calculated. Total costs (including directs and costs of productivity loss) were €15,231 per patient per year for the total group and €20,695 for patients with uncontrolled disease vs. €11,287 for patients with controlled disease. Costs of productivity loss had the larger impact on total costs. These data indicate that patients with atopic dermatitis using systemic immunosuppressive treatment incur considerable direct costs and costs of productivity loss.

Supplementary content

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