Dermatitis herpetiformis: effect of gluten-restricted and gluten-free diet on dapsone requirement and on IgA and C3 deposits in uninvolved skin
Ljunghall K, Tjernlund U.
DOI: 10.2340/0001555563129136
Abstract
Of 58 patients wi1h classical dermatitis herpetiformis (DH), I 7 were rreatcd with a gluten-frec diet (GFD) for periods varying from 6 to 47 months and 11 with a gluten-reduced diet (GRD) for 7 to 29 months. The patients were able to reduce their requirement of dapsone significantly compared with 30 patients on a normal diet, of whom only an 86-year-old man was able to discontinue his JO mg dapsonc dose. In 7 of the 17 patients on GFD. dapsone could be completely withdrawn after diet periods of 4 10 38 month?. None of the patients on GRO could stop dapsone treatment. The occurrence and amount of immunoglobulin A (IgA) and of the third component of complement (C3) in non-lesional skin were studied in the three diet groups during treatment. At the start of the study all patients had lgA deposits of the granular pattem. This pattern remained unchanged
Significance
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