Content - Volume 63, Issue

All articles

The influence of limonene on induced delayed hypersensitivity to citral in guinea pigs. II. Label distribution in the skin of 14C-labelled citral
Barbier P, Benezra C.
14C-labelled citral was applied on four groups of guinea pigs: (a) one sensitized to citral alone; (b) one sensitized to a citral-d-limonene 1 : 1 molar mixture; (c) FCA-treated controls; (d) controls. The most important results concern the amount of labelled material in soluble compared with insoluble skin protein extracts (SPE). In citral-sensitized animals, more label was found in the soluble S ...
Pages: 93-96
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Urinary 5-S-cysteinyldopa in Parkinsonism after DOPA and carbidopa
Stewart RM, Miller S, Gunder M.
The effect of anti-Parkinson therapy on the urinary excretion of 5-S-cysteinyldopa (5SCD), a catechol metabolite of dihydroxyphenylalanine (DOPA) and marker for the melanocyte, was studied by means of high performance liquid chromatography. 5SCD was normal in Parkinson patients treated with anticholinergics. DOPA administration increased 5SCD excretion. Carbidopa and DOPA together elevated 5SCD ma ...
Pages: 97-101
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Demonstration of Ia-like antigens on T lymphocytes in lesions of psoriasis, lichen planus and discoid lupus erythematosus
Bjerke JR, Matre R.
A combined indirect immunofluorescence technique with a murine monoclonal antibody against human Ia-like antigens (OKIal) and an IgG F(ab´)2 preparation of a rabbit anti-T lymphocyte serum was used to study Ia-like antigens on T lymphocytes in skin lesions of psoriasis, lichen planus and discoid lupus erythematosus. The majority of the T lymphocytes in the various skin lesions expressed Ia-like a ...
Pages: 103-107
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T cell subsets and soluble immune response suppressor (SIRS) factor in skin squamous cell carcinoma
Angelini G, Vena GA, D´Ovidio R, Lospalluti M, Meneghini CL.
T cell subsets (theophylline-sensitive T lymphocytes and T gamma lymphocytes), and the activity of soluble immune response suppressor (SIRS) factor have been investigated in a total of 53 patients with squamous cell carcinoma (SCC) of the skin. Eight of these had metastatic regional lymph nodes. The results showed decreased values for theophylline-sensitive T lymphocytes and elevated values for T ...
Pages: 109-114
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Pemphigus serum-induced loss of microvilli from human epidermal cells
Hietanen J, Salo OP, Kariniemi AL.
Scanning electron microscopic examination of human epidermal cells prepared from suction blister roofs by treatment with trypsin and dithioerythritol and incubated (37 degrees C, 18 hours) with pemphigus sera revealed a smooth or wrinkled surface texture in 83 to 96% and surface microvilli in only 17 to 4%. The disappearance of microvilli was not affected by the presence of complement. In the cont ...
Pages: 115-121
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Linear IgA dermatosis: a study of ten adult patients
Mobacken H, Kastrup W, Ljunghall K, Löfberg H, Nilsson LA, Svensson A, Tjernlund U.
Ten adult patients with homogeneous-linear deposition of IgA along the basement membrane zone have been studied. The direct immunofluorescence IgA pattern was stable, and there was no deposition of IgG or IgM. The clinical presentations were heterogeneous and resembled dermatitis herpetiformis (DH) (3 cases) or bullous pemphigoid (5 cases). Two patients had widespread gyrate blistering lesions of ...
Pages: 123-128
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Dermatitis herpetiformis: effect of gluten-restricted and gluten-free diet on dapsone requirement and on IgA and C3 deposits in uninvolved skin
Ljunghall K, Tjernlund U.
Of 58 patients wi1h classical dermatitis her­petiformis (DH), I 7 were rreatcd with a gluten-frec diet (GFD) for periods varying from 6 to 47 months and 11 with a gluten-reduced diet (GRD) for 7 to 29 months. The patients were able to reduce their requirement of dapsone significantly compared with 30 patients on a normal diet, of whom only an 86-year-old man was able to discontinue his JO mg daps ...
Pages: 129-136
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Skin photosensitizing and Langerhans´ cell depleting activity of topical (bath) PUVA therapy: comparison of trimethylpsoralen and 8-methoxypsoralen
Koulu L, Jansén CT.
The skin photosensitizing and Langerhans´ cell (LC) depleting effects of a single bath PUVA exposure were studied in 22 healthy young volunteers. The photosensitizing effect of bathing for 15 min in a 0.2 mg/1 trioxsalen-water solution was about 30 times as great as a similar treatment in an equipotent methoxsalen solution. The skin erythema induced by methoxsalen bath PUVA peaked on day 2 and di ...
Pages: 137-141
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Bullous acrodermatitis due to zinc deficiency during total parenteral nutrition: an ultrastructural study of the epidermal changes
Welsmann K, Kvist N, Kobayasi T.
A 5 1/2-year-old girl with idiopathic intestinal pseudo-obstruction became severely depleted of zinc during total parenteral nutrition and developed a vesico-bullous rash on face, hands and feet such as is seen in acrodermatitis enteropathica. Light and electron microscopy of a bullous lesion on one foot revealed a pronounced extracellular edema with cyst and cleft formation in the deep part of th ...
Pages: 143-146
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The effect of UVB light on serum concentrations of 5-S-cysteinyldopa
Tegner E, Agrup G, Rosengren E.
No abstract available.
Pages: 149-152
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Methaemoglobin-catalysed formation of dopa and 6-OH-dopa from tyrosine
Agrup G, Hansson C, Rorsman H, Rosengren E, Tegner E.
An extract of bovine retina and choroid with tyrosine hydroxylating and dopa-oxidizing capacity also showed marked formation of 6-OH-dopa on incubation with tyrosine and ascorbic acid. The extract contained appreciable amounts of methaemoglobin as determined spectrophotometrically, and boiled extracts also showed catalytic activity. The effect of methaemoglobin on the oxidation of tyrosine and dop ...
Pages: 152-155
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Skin surface and open comedone pH in acne patients
Holland DB, Cunliffe WJ.
To assess the variability of surface and comedone pH in one and the same individual and between individuals, pH measurements were made on extracted single comedone material and on the adjacent skin surface, at face and back sites on 56 acne patients. The pH values were normally distributed. The mean values were: comedone pH 5.52 and surface pH, 5.26. The pH ranges were similar: comedones 4.01 to 6 ...
Pages: 155-158
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Bacteria and fungi in severe foot infection
Noble WC, Clayton YM, Davies H, Blatchford NR.
In a study of severe foot infection in 21 miners, an attempt was made to match nine clinical parameters with both bacteriological and mycological findings. Erythema was significantly more pronounced in the presence of dermatophytes but less pronounced in the presence of Gram-negative bacilli. No other clinical parameter differed in relation to the presence of particular microorganisms.
Pages: 158-160
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Effect of betamethasone valerate on the normal human facial skin flora
Daltrey DC, Cunliffe WJ.
Eighteen volunteers were randomly divided into two groups and allocated either an active corticosteroid preparation (Betamethasone valerate) or the basal formulation only (placebo). The cream was applied to the face twice daily for one month. The treated area was sampled by the scrub-wash method immediately before treatment began and after 2 and 4 weeks, and microorganisms were enumerated and iden ...
Pages: 160-162
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Passive transfer of idiopathic cold urticaria to monkeys
Misch K, Black AK, Greaves MW, Almosawi T, Stanworth DR.
No abstract available.
Pages: 163-164
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Methotrexate in psoriatic arthritis: a retrospective study
Kragballe K, Zachariae E, Zachariae H.
The response of psoriatic arthritis to methotrexate was evaluated retrospectively in 59 consecutive patients. Initially almost all received 15 mg weekly. When clinical improvement occurred, the dose was gradually reduced. In 7 patients methotrexate had to be discontinued within a year due to adverse reactions. The remaining 52 patients were treated from 1 to 11 years, median 3 years. Among these a ...
Pages: 165-167
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Segmental pigmentation disorder
Metzker A, Morag C, Weitz R.
Pigmentary changes with a dermatomal distribution are described in 30 children. The disorder, up to now unrecognized as an entity, is apparently caused by an embryological determination. It is more obvious in children with darker skin, and seems to fade very slowly over the years. In our experience the incidence is 0.35%. No relation to other anomalies could be established.
Pages: 167-169
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Purpura with a linear epidermo-dermal deposition of IgA
Väätäinen N, Fräki JE, Hyvönen M, Neittaanmäki H.
A patient suffering from purpura is reported, having persistent linear deposition of IgA along the basement membrane zone in both lesional and healthy skin. The ordinary histopathology showed the picture of purpura pigmentosa with perivascular lymphocytes, polymorphonuclear cells and extravasated erythrocytes. No blisters have been observed.
Pages: 169-170
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Nail bed immunofluorescence in pemphigus vulgaris
Fulton RA, Campbell I, Carlyle D, Simpson NB.
No abstract available.
Pages: 170-172
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Primary macroglobulinemia presenting as multiple ulcers of the legs
Nishijima S, Hosokawa H, Yanase K, Asada Y, Fujinami S
Multiple ulcers developed on the lower legs of a 67-year-old man suffering from macroglobulinemia. Histological and direct immunofluorescence studies on biopsy specimens taken from the lesions revealed dilation of capillaries, deposition of large quantities of IgM in the vessels, and deposition of C3 in the vessel walls. A marked increase in blood Clq binding immune complexes was also noted. These ...
Pages: 173-175
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Multicentric reticulohistiocytosis: a case report
Hansen E, Nilsen R, Milde EJ.
With the present case report we call attention to the clinical entity of multicentric reticulohistiocytosis (MR). Referring to earlier case reports on this rare condition we present the history, clinical and histopathological findings. We stress the importance of revealing possible underlying internal diseases, including malignancies, and also the importance of histological examination of synovium ...
Pages: 175-176
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Atopic dermatitis and Hodgkin´s disease
Winkelmann RK, Rajka G.
No abstract available.
Pages: 176-177
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Nevus oligemicus with sensory changes
Dupre A, Viraben R.
No abstract available.
Pages: 177-180
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Herpes zoster in a 6-month-old infant
Helander I, Arstila P, Terho P.
No abstract available.
Pages: 180-181
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Ear ache during etretinate treatment
Juhlin L.
No abstract available.
Pages: 181-182
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Demodex folliculorum in human skin
Westermark P.
No abstract available.
Pages: 183-184
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