Content » Vol 68, Issue 3

The expression of the Hodgkin´s disease-associated antigen Ki-1 in cutaneous infiltrates

van der Putte SC, Toonstra J, van Wichen DF, van Unnik JA, van Vloten WA.
DOI: 10.2340/0001555568202208


Reactivity for Ki-1 antibody was studied in 145 patients with a large variety of cutaneous disorders. The antigen was consistently expressed and by a high proportion of tumour cells in infiltrates in which atypical cells revealed a ´histiocytic´ appearance, i.e. lymphomatoid papulosis (LP), T-immunoblastic lymphoma with the characteristic of true histiocytic lymphoma, Hodgkin´s disease, T-blast cell proliferation with giant multivesicular bodies, concurrent LP and mycosis fungoides (MF), and two cases of MF. Ki-1+ cells with the usual morphology of atypical T-cells formed a major component in 2 other cases of MF, and a minor component in 7 other cases of MF. A possible non-neoplastic counterpart was found in small to medium-sized Ki-1+ cells, including blast cells, which occurred occasionally in the T-cell infiltrates of eczema, actinic reticuloid, lichen planus and pityriasis lichenoides. Small Ki-1+ cells which were observed in the reactive B/T cell component of lymphocytoma cutis but also in similar components occurring occasionally in non-epidermotropic cutaneous T-cell lymphoma, and malignant B-cell lymphomas, might be analogous to the Ki-1+ cells in normal lymphoid tissue.


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