Content » Vol 68, Issue 5

The pharmacokinetics of selenium in psoriasis and atopic dermatitis

Fairris GM, Perkins PJ, Lawson AD, Blake GM.
DOI: 10.2340/0001555568434436


The pharmacokinetics of [75Se-L]-selenomethionine was studied in 10 patients with psoriasis, 10 with atopic dermatitis and 10 healthy subjects. Values for the gut absorption and the rate of endogenous excretion of [75Se-L]-selenomethionine, the exchangeable total-body selenium and plasma selenium concentration showed no significant differences between either patient group and the controls. The results suggest that there is no gross abnormality of selenium pharmacokinetics in either disease, and fail to explain why previous studies have found reduced selenium concentrations and selenium-dependent glutathione peroxidase activity in psoriasis and atopic dermatitis.


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