Content - Volume 68, Issue 5

All articles

Sequence of changes in psoriatic epidermis. Immunocompetent cell redistribution precedes altered expression of keratinocyte differentiation markers
Placek W, Haftek M, Thivolet J.
Recent studies suggest that the immune system is involved in the pathogenesis of psoriasis. We studied the expression and distribution of immunocompetent cells and of some chosen differentiation antigens of keratinocytes at various stages of lesion development, using indirect and amplified immunofluorescence, and avidin-biotin-peroxidase method. Serial cryostat sections were collected so as to all ...
Pages: 369-377
Abstract  PDF
Biochemical characterization of scleroderma-inducing glycosaminoglycan
Ishikawa H, Kitabatake M, Akiyama F.
The scleroderma-inducing N-sulfated glycosaminoglycan previously isolated by us from the urine of patients with systemic scleroderma was further purified: it was biochemically characterized by low O-sulfation and relative high N-sulfation. Consistent with this finding, desulfated and N-resulfated heparin, which had a similar composition to the urine-derived scleroderma-inducing glycosaminoglycan, ...
Pages: 378-384
Abstract  PDF
Melanin-related metabolites in urine of B16 melanoma-bearing mice
Wakamatsu K, Ito S, Fujita K.
5-S-Cysteinyldopa (5-S-CD), a pheomelanin precursor, has been used as a biochemical marker of melanoma metastasis. Recently, 5-hydroxy-6-methoxyindole-2-carboxylic acid (5H6MI2C), a eumelanin-related metabolite, was shown to reflect well the degree of skin pigmentation. We measured the urinary excretion of 5H6MI2C and 5-S-CD in mice bearing B16 melanoma to determine which of the two markers better ...
Pages: 385-389
Abstract  PDF
Cutaneous melanoma--season and invasion? A preliminary report
Akslen LA, Hartveit F.
Histological diagnosis of superficial spreading melanoma (SSM) of invasive type was found to vary significantly with season, such cases being most numerous in April-September. Cases of in situ type were evenly distributed throughout the year. This distinction has not been made previously. It suggests that different mechanisms may be involved in the development of these two lesions. The results as ...
Pages: 390-394
Abstract  PDF
HLA class II restriction specificity for nickel-reactive T lymphocytes
Emtestam L, Marcusson JA, Möller E.
Nickel-specific T cells were primed in vitro and restimulated with nickel in combination with autologous or allogeneic antigen-presenting cells. We have previously shown that not only DR, but also DQ molecules may take part in this process. To investigate this phenomenon further we applied recently available knowledge based on studies using specific cDNA probes and Restriction Fragment Length Poly ...
Pages: 395-401
Abstract  PDF
Palmar eczema: a pathogenetic role for acetylsalicylic acid, contraceptives and smoking?
Edman B.
A statistical study of the relationship between vesicular palmar eczema and various clinical variables was carried out. Vesicular palmar eczema was found in 153 cases (38%), thereof 113 females (76%). Ninety-two percent of all found cases could be regarded as pompholyx. Three new pathogenetic factors were suggested in the vesicular palmar eczema: use of acetylsalicylic acid (Aspirin), contraceptiv ...
Pages: 402-407
Abstract  PDF
Experimental photoallergic contact dermatitis to bisphenol A
Maguire HC Jr.
A single clinical report describes photoallergic contact dermatitis to bisphenol A, with subsequent persistent light reactivity, in a group of eight outdoor workers. In a mouse model we have induced photoallergic contact dermatitis to bisphenol A; sites of photochallenge reactions flared when later tested with UVA alone. Attempts to induce photoallergy to bisphenol A in guinea pigs failed.
Pages: 408-412
Abstract  PDF
Mucous membrane manifestations of pemphigus vulgaris. A 25-year survey of 185 patients treated with corticosteroids or with combination of corticosteroids with methotrexate or heparin
Mashkilleyson N, Mashkilleyson AL.
One hundred and eighty-five patients with pemphigus vulgaris were treated and followed up over a period of 25 years, from 1962 to 1987, at the Department of Dermatology of Moscow Medical Stomatological Institute. In all these patients the diagnosis was confirmed clinically, histologically and cytologically, and in 152 patients by means of direct and indirect immunofluorescence. The patients were t ...
Pages: 413-421
Abstract  PDF
Studies on the lipophilic yeast Pityrosporum ovale in HIV-seropositive and HIV-seronegative homosexual men
Håkansson C, Faergemann J, Löwhagen GB.
Pityrosporum ovale has been implicated in the pathogenesis of seborrheic dermatitis, a dermatosis occurring with high prevalence in symptomatic HIV-infected individuals. Quantitative cultures for P. ovale were taken in 12 HIV-seropositive patients and in 12 HIV-seronegative controls. Sera were analysed for antibodies to P. ovale. In HIV-seropositive patients, lymphocyte subsets were analysed. The ...
Pages: 422-426
Abstract  PDF
Transfollicular percutaneous absorption. Skin model for quantitative studies
Illel B, Schaefer H.
Theoretically percutaneous absorption comprises two components: the transepidermal route and the transappendageal route, so-called ´shunt´ diffusion. The relative importance of ´shunt´ diffusion was investigated with a model of appendage-free skin. After treatment with 60 degrees C water for exactly 1 min, hairless dorsal rat skin regrows as a continuous epidermis. We present preliminary resul ...
Pages: 427-430
Abstract  PDF
A prospective study of the Koebner reaction and T lymphocytes in uninvolved psoriatic skin
Baker BS, Powles AV, Lambert S, Valdimarsson H, Fry L.
T lymphocyte and dendritic cell subpopulations were counted in untraumatized, uninvolved skin of 27 patients with psoriasis. Eight of the patients proved to be Koebner-positive, as determined by tape stripping and punch biopsy, and 19 Koebner-negative. In the epidermis the CD4/CD8 T cell ratio was significantly higher in the Koebner-positive vis-?†-vis Koebner-negative patients (median CD4/CD8 = ...
Pages: 430-434
Abstract  PDF
The pharmacokinetics of selenium in psoriasis and atopic dermatitis
Fairris GM, Perkins PJ, Lawson AD, Blake GM.
The pharmacokinetics of [75Se-L]-selenomethionine was studied in 10 patients with psoriasis, 10 with atopic dermatitis and 10 healthy subjects. Values for the gut absorption and the rate of endogenous excretion of [75Se-L]-selenomethionine, the exchangeable total-body selenium and plasma selenium concentration showed no significant differences between either patient group and the controls. The res ...
Pages: 434-436
Abstract  PDF
Is the effect of phototherapy in psoriasis partly due to an impact on vitamin D metabolism?
Staberg B, Oxholm A, Klemp P, Hartwell D.
To elucidate the effect of phototherapy on vitamin D metabolism in psoriatics, the serum concentrations of the major vitamin D metabolites (25-hydroxy-vitamin D (25(OH)D), 1,25-dihydroxy-vitamin D (1,25(OH)2D), and 24,25-dihydroxy-vitamin D (24,25(OH)2D)) were studied in 10 patients with disseminated psoriasis, both before and after phototherapy. Some 3-4 weeks of Goeckerman therapy induced signif ...
Pages: 436-439
Abstract  PDF
Skin and oral mucosal changes in patients infected with human immunodeficiency virus
Sindrup JH, Weismann K, Sand Petersen C, Rindum J, Pedersen C, Mathiesen L, Worm AM, Kroon S, Søndergaard J, Lange Wantzin G.
During a 6-month-period, 150 patients infected with Human Immunodeficiency Virus (HIV) were repeatedly examined by dermatologists and dentists for lesions of skin and oral mucosa. The most frequently encountered diseases were: oral hairy leukoplakia (21%), dermatophytosis (including tinea unguium/tinea pedis et inguinalis) (20%), seborrheic dermatitis (19%), viral infections (10%), oral candidiasi ...
Pages: 440-443
Abstract  PDF
Eruptive seborrheic keratoses associated with erythrodermic pityriasis rubra pilaris. Possible role of retinoid therapy
Schwengle LE, Rampen FH.
A 74-year-old female patient with an erythrodermic pityriasis rubra pilaris developed multiple seborrheic keratoses during the early stage of the skin disorder. There was no evidence of an underlying internal malignancy. Initially, the patient was treated with etretinate. The seborrheic keratoses all faded away during the next 3-4 months without any specific treatment. The possible role of retinoi ...
Pages: 443-445
Abstract  PDF
The ´tape-method´: a new and simple method for quantitative culture of Pityrosporum yeasts
Wikler JR, de Haan P, Nieboer C.
A new method for quantitative culture of Pityrosporum yeasts, the ´tape-method´, is presented. Samples for culture were taken from the skin by stripping with 1 cm2 of tape, whereafter the tapes were placed over a drop of sterile olive oil which was pipetted on a Sabouraud medium. Plates were incubated at 37 degrees C, and after 7 days the numbers of Pityrosporum colonies growing under the tapes ...
Pages: 445-449
Abstract  PDF
Delayed skin hypersensitivity in man. The effect of repeated tests with low-dose antigen
Merk K, Björkholm M, Holm G, Mellstedt H.
The effects of repeated applications of low doses of antigen on subsequent delayed cutaneous hypersensitivity (DCH) responses induced by the same antigen were evaluated. Fourteen healthy individuals were tested with seven different antigens given intracutaneously with the Multitest system device (Institute M?©rieux). The procedure was repeated on four occasions at 2-week intervals. At the first t ...
Pages: 450-453
Abstract  PDF
Nickel dermatitis and diet: clinical improvement and a reduction in blood and urine nickel levels with a low-nickel diet
Gawkrodger DJ, Shuttler IL, Delves HT.
A 27-year-old nickel-sensitive female who had had continuous spontaneous flare-ups of eczema, including at sites of previous metal contact, experienced a clearing of her eruption after commencing a low-nickel diet. When on the diet, whole-blood and urinary nickel levels fell to half or less of pre-diet values and this coincided with the clinical improvement. Low-nickel diets should be considered f ...
Pages: 453-455
Abstract  PDF
Pemphigus-like eruption induced by d-penicillamine and captopril, in the same patient
Blanken R, Doeglas HM, de Jong MC, Kardaun SH, van Leeuwen M.
A patient suffering from rheumatoid arthritis and hypertension is described who developed pemphigus foliaceus during simultaneous treatment with d-penicillamine and captopril. Discontinuation of the d-penicillamine afforded some improvement, but skin symptoms still persisted after 3 months. When the captopril was discontinued as well, all lesions healed within 2 weeks. Our findings suggest that bo ...
Pages: 456-457
Abstract  PDF
Diagnosis of erectile dysfunction in etretinate treatment
Krause W.
No Abstract is available
Page: 458
Abstract  PDF
There is a linear IgM dermatosis
Alcalay J, Ingber A, David M, Hazaz B, Sandbank M.
No Abstract is available
Page: 458
Abstract  PDF
Decreased capillary resistance of the uninvolved skin in psoriasis
Kemény L, Csató M, Nyirádi J, Gábor M, Dobozy A.
No Abstract is available
Pages: 459-460
Abstract  PDF