Content » Vol 68, Issue 5

Pemphigus-like eruption induced by d-penicillamine and captopril, in the same patient

Blanken R, Doeglas HM, de Jong MC, Kardaun SH, van Leeuwen M.
DOI: 10.2340/0001555568456457


A patient suffering from rheumatoid arthritis and hypertension is described who developed pemphigus foliaceus during simultaneous treatment with d-penicillamine and captopril. Discontinuation of the d-penicillamine afforded some improvement, but skin symptoms still persisted after 3 months. When the captopril was discontinued as well, all lesions healed within 2 weeks. Our findings suggest that both these chemically related drugs might have been responsible for the pemphigus-like eruption in this patient.


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