Content » Vol 94, Issue 6

Clinical Report

Chronic Hand Eczema: Perception and Knowledge in Non-affected Individuals from General and Dermatological Practice

Valerie Letulé1#, Thomas Herzinger1#, Astrid Schirner2, Frank Hertrich3, Dirk Lange4, Thomas Ruzicka1 and Sonja Molin1

1Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, 2Dermatology Practice, Erlangen, 3Internal Medicine Practice, Lebach, and 4Dermatology Practice, Gera, Germany

#Both authors contributed equally and should be considered as first authors.

Misunderstanding and stigmatisation are common problems encountered by patients with hand eczema. Various misconceptions about the disease circulate in the general population. Although hand eczema has gained more attention in dermatology during the past years, information on public perception of the disease is still lacking. The aim of our study was to investigate perception of and level of knowledge on the subject hand eczema. There were 624 patients included from 2 general medicine practices and 2 dermatological practices. A self-administered questionnaire was filled out by the participants, covering issues on history of hand eczema, level of knowledge and attitude towards a clinical photograph of hand eczema. We found that a larger proportion of individuals from dermatological practice were more familiar with hand eczema as a disease than those from general medical practice. Women knew significantly more about and had a more positive perception of the disease than men. Our results imply that the level of knowledge on hand eczema in the general public is rather low and influenced by prejudice. Key words: hand eczema; public awareness; level of knowledge; perception; stigmatisation; prejudice.

Accepted Feb 4, 2014; Epub ahead of print Feb 17, 2014

Acta Derm Venereol 2014

Dr. med. Sonja Molin, Department of Dermatology and Allergy, Ludwig Maximilian University, Frauenlobstrasse 9–11, DE-80337 Munich, Germany. E-mail: sonja.molin@med.uni-muenchen.de

Chronic hand eczema (CHE) is a common skin disease with an estimated one-year prevalence of up to 10% (1, 2). As a clinically heterogeneous disease it presents with many different aetiologies and morphologies (3, 4). There­fore, classification of hand eczema is challenging, as is the management of this chronic and relapsing disease (5).

The hands play a fundamental part in our everyday activities and social interactions (6). Therefore it is easy to understand why patients with chronic hand eczema are strongly impaired by their disease and suffer a lot from stigmatisation. Pain and itch further aggravate the burden of disease and add to the huge negative impact on the quality of life.

In the last few years, interest in CHE began to grow when scientific research and knowledge about its pathogenesis and epidemiology increased. With new therapeutic options (5) and several new national guidelines on the management of hand eczema (4, 7–10) the disease became more and more a centre of interest in dermatology. In addition, CHE is the most common occupational disease and therefore of high socioeconomic impact (11, 12). Health-related costs and quality of life in CHE have also been investigated in several studies during the past years (13–16). It has become clear that prevention of this costly and disabling disease is an issue of great importance.

There are several studies looking at the awareness and level of knowledge in CHE patients or in occupations with high risk for developing hand eczema (17–20). A common approach of these studies is the use of questionnaires to investigate the level of perception of the disease as well as the knowledge of prevention in cohorts especially at risk, such as hairdressers (17) and health care workers (18, 19). These studies were aimed predominately at the targeted prevention in exposed individuals.

Research data on the knowledge of CHE in the general population beyond risk cohorts is, however, lacking. To date, there are no studies investigating the perception of CHE in non-affected individuals. Many patients report a lack of understanding and tolerance in the environment they have to face every day, and how they often feel rejected by their peers. In order to raise public awareness, improve acceptance and reduce stigmatisation for CHE patients, specific educational work is necessary. The aim of this study was to investigate the perception of CHE in the general public by a short self-administered questionnaire.

METHODS

The study was designed as a cross-sectional study. Patients visiting a general medical practice irrespective of the reason why they came, were chosen as cohort representative of the general population. Their results were compared to those from patients from dermatological practice. The ratio of patients of both medical specialities was intended to be 1:1, with a number of approximately 300 participants for each group. A short one-page self-administered questionnaire was sent to 4 private practices in Germany, 2 of them being general medical or internal medicine practices and 2 of them being dermatological practices. All men and women over the age of 18 were eligible to participate randomly, regardless of the reason for consulting their physician. While sitting in the waiting room, patients were filling out the anonymous questionnaire for self-administration. The questionnaires were sent back to the study centre, where they were analysed. Sources of potential bias in this cross-sectional questionnaire study were manifold and had been taken into account. Questionnaires with a huge amount of missing data led to the exclusion of the subject from the study.

The questionnaire consisted of 10 questions, which are shown in Table I. The possible answers were: yes, no, prior, 1–5, 5–10 and > 10. At first, subjects gave short general information about their gender and age. They were then asked about their history of hand eczema and atopic disorders. In a third part they provided information about their perception of CHE in general and their attitude towards a clinical photograph of severe hand dermatitis in particular (Fig. 1). Finally, they estimated the prevalence of CHE in the general population.

4126fig1.tif

Fig. 1. Clinical picture of a patient with severe hand eczema shown to the participants.

The study was approved by the local ethics committee and carried out in accordance with the principles of the Declaration of Helsinki.

Table I. The questionnaire consisted of 10 questions on general information, history of hand eczema and atopic disorders and perception of hand eczema. Questions 7–9 refer to a clinical picture of a patient with hand eczema

Question

Answer

Gender

Male/female

Do you know what hand eczema is?

Yes/no

Do you yourself suffer from hand eczema?

Yes/no/prior

Do you have hay fever, flexural eczema or allergic asthma?

Yes/no/prior

Do you use hand cream regularly?

Yes/no

If you use hand cream regularly, how often per day?

1–5 times/5–10 times/day

Would you shake hands with this person?

Yes/no

Do you think that this skin disease is contagious?

Yes/no

Do you feel disgusted by these hands?

Yes/no

What is your estimation about the prevalence of this disease?

1–5%/5–10%/>10%

Statistics

Statistical analysis was performed by bilateral analysis using χ²-test. p < 0.05 was considered to be statistically significant. Due to the explorative character of our study, p-values are cited without correction for multiple testing. The significant results of this investigation have primarily an explorative quality.

RESULTS

Characterisation of the collective

In total, 624 subjects participated in the study, 52.9% (n = 330) were women and 44.9% (n = 280) were men; 2.2% (n = 14) provided no information about their gender. The range of age was 18–88 years (mean age 52 years).

Forty-seven percent (n = 293; n1 = 67, n2 = 226) were patients from 4 general medical/internal medicine practice, and 53% (n = 331; n3 = 225, n4 = 106) from 2 dermatological practices. A total of 13.3% (n = 83) had a history of hand eczema with 6.6% (n = 41) having hand eczema at time of questioning and 6.7% (n = 42) having had hand eczema previously (i.e. before questioning). Of the subjects, 22.6% (n = 141) had active atopic disorders at time of questioning, 3.5% (n = 22) before that time and 72.9% (n = 455) had no history of atopic disorders at all. Hand cream was used routinely by 58% (n = 362) of the participants. Looking at the clinical photograph of the CHE patient, 45.4% (n = 283) of all subjects felt disgusted, 53.2% (n = 332) did not, and 1.4% (n = 9) subjects refused to answer the question. Only 33.8% (n = 211) of the participants would shake hands with the patient from the photograph, whilst 63.3% (n = 395) would refuse to do so; 2.9% (n = 18) did not answer this question. Of the participants, 34.9% (n = 218) suspected the skin lesions to be infectious whereas 62.5% (n = 390) did not think so and 2.6% (n = 16) did not give any information. The prevalence of hand eczema was estimated by the subjects as follows: 1–5% prevalence: 29.2% (n = 182) , 5–10% prevalence: 38.8% (n = 242), and > 10% prevalence: 29.9% (n = 187). The question was not answered by 2.1% (n = 13). Table II gives an overview on the data from the following paragraphs.

Table II. Results of questionnaire in the patient collective

Indicators

Participants

Significance of differences

From dermato­logical practice % (n)

From general medical practice % (n)

With history of HE % (n)

Without history of HE % (n)

Dermatological vs. general practice

With vs. without HE history

Females

56.3 (183)

51.6 (147)

70.4 (57)

51.8 (269)

Not significant

p < 0.05

Males

43.7 (142)

48.4 (138)

29.6 (24)

48.2 (250)

Knowledge of HE

66.2 (219)

57.7 (169)

92.8 (77)

58.8 (311)

p < 0.05

p < 0.05

History of HE

15.1 (50)

11.3 (33)

100 (83)

0 (0)

Not significant

Subjects using hand cream

54.7 (181)

61.8 (181)

69.9 (58)

56.1 (297)

Not significant

p < 0.05

History of atopic disorders

26.3 (87)

25.9 (76)

43.4 (36)

21.0 (111)

Not significant

p < 0.05

Subjects feeling disgust

42.6 (141)

48.5 (142)

47 (39)

44.8 (237)

Not significant

Not significant

Subjects agreeing in hand shaking

35 (116)

32.4 (95)

50 (40)

32.1 (170)

Not significant

p < 0.05

Subjects suspecting the disease to be infectious

32.6 (108)

37.5 (110)

20.5 (17)

37.6 (199)

Not significant

p < 0.05

1–5% prevalence

27.8 (90)

32.1 (92)

16 (13)

32 (167)

Not significant

p < 0.05

5–10% prevalence

42.9 (139)

35.8 (103)

38.3 (31)

39.7 (207)

Not significant

>10% prevalence

29.3 (95)

32.1 (92)

45.7 (37)

28.3 (148)

p < 0.05

Total

n = 331a

n = 293a

n = 83a

n = 529a

aTotal numbers for different indicators vary, because not all participants gave answer to all questions. HE; hand eczema.

Results from general medical/internal medicine practice compared to dermatological practice

Only 57.7% (169/293) of the individuals from general medical practices knew about the disease entity CHE compared to 66.2% (219/331) of the subjects from dermatological practices (p < 0.05; 95% CI 1.02–2.01).

None of the other features of the questionnaire reached statistical significance when comparing the 2 cohorts.

Differences between female and male participants

Of all 388 participants knowing about hand eczema, 57.7% (n = 224) were female and 40.2% (n = 156) male (p < 0.05; 95% CI 1.19–2.37). Women were more frequently using hand cream than men [76.4% (252/330) compared to 36.8% (103/280); p < 0.05; 95% CI 3.85–8.02]. Female participants knowing about hand eczema were using cream more frequently than their male counterparts [female: 76.3% (171/224) male: 35.9% (56/156); p < 0.05; 95% CI 3.59–9.27]. Men suspected the disease more often to be infectious [43.2% (121/280) compared to 28.5% (94/330) for women; p < 0.05; 95% CI 1.35–2.71]. Women would agree to hand shaking more often than men [40.3% (133/330) compared to 31.8% (89/280); p < 0.05; 95% CI 1.02–2.05].

Participants with or without history of hand eczema

Compared to participants without history of hand eczema, women were significantly more frequent in the group of participants with history of hand eczema [70.3% (57/81) vs 51.8% (269/519); p < 0.05; 95% CI 1.29–3.78], as were individuals with a history of atopic disorders [43.4% (36/83) compared to 21% (111/329); p < 0.05; 95% CI 1.69–4.72].

Participants with history of hand eczema were using hand cream significantly more frequently than those without CHE history [69.9% (58/83) compared to 56.1% (297/529); p < 0.05; 95% CI 1.07–3.08]. They also knew more about their disease than non-affected participants [92.8% (77/83) vs. 58.8% (311/329); p < 0.05; 95% CI 3.66–23.13].

Participants who had previously suffered from hand eczema themselves were significantly less convinced that the skin lesions on the clinical photograph might be infectious (20.5%; 17/83) than those without history of hand eczema [37.6% (199/529); p < 0.05; 95% CI 1.30–4.31]. In addition, they were also more likely to shake hands with the patient from the picture [50% (40/80) compared to 32.1% (170/529); p < 0.05; 95% CI 1.18–3.18]. When asked about their estimation of CHE prevalence, individuals with history of hand eczema rated more correctly than those without; they significantly knew more often that CHE is very frequent and less often considered CHE a rare disease (see Table II). No differences were found comparing feeling of disgust towards hand eczema.

DISCUSSION

The aim of this study was to investigate the level of knowledge on CHE in the general population. As far as we know, this is the first study addressing this topic.

Subjects from dermatological practice knew significantly more about CHE compared to subjects from general medical/internal medicine practice. Moreover, female participants knew more frequently what CHE is than male participants. They also would agree more likely to hand shaking with an affected individual and did not suspect the disease to be infectious as often as did men.

Approximately 1/5 (20.5%) of subjects with history of hand eczema considered the disease to be contagious. Although this was significantly less frequent than participants without CHE history, it shows that some patients are not properly informed about their disease. The fact that 7.2% of participants with CHE history negated knowledge on hand eczema supports this impression.

Compared to the participants that had never themselves suffered from HE before, those individuals with experience in hand eczema more often agreed in hand shaking with the patient from clinical picture, but, interestingly, showed the same disgust towards the disease as the prior group.

These results suggest that individuals who have some kind of pre-knowledge on CHE might be less prejudiced towards the disease, but still educational work needs to be done.

Our study design has several limitations: though the cohorts can be seen as a cross-section from the general population regarding gender and age distribution, the sample size is relatively small. In addition, the answers of the participants have a subjective character.

Patients with different chronic skin diseases, like psoriasis and atopic dermatitis, experience social rejection by their peers or have to face misunderstanding and prejudice. There are several studies that investigate the awareness of those patients (21–24) but information on disease perception of non-affected individuals is lacking. Studies on this issue would be required in order to detect knowledge gaps and perform targeted educational work for improving tolerance. Such data have become available for a number of non-dermatological conditions, e.g. HIV infection (25–27).

Our results implicate that the level of knowledge on hand eczema in the general public is low and affected by prejudice. In addition, the general perception of the disease shows a gender-specific difference, and depends on the amount of previous knowledge on the subject. This leads to the conclusion that a better knowledge on hand eczema might help to reduce intolerance and in consequence improve health-related quality of life in patients with CHE.

ACKNOWLEDGEMENTS

The authors would like to thank B. Block for recruting participants for the study in his clinic.

The authors declare no conflict of interest.

REFERENCES

1. Coenraads PJ. Hand eczema is common and multifactorial. J Invest Dermatol 2007; 127; 1568–1570.

2. Agner T, Andersen KE, Brandao FM, Bruynzeel DP, Bruze M, Frosch P, et al.Hand eczema severity and quality of life: a cross-sectional, multicentre study of hand eczema patients. Contact Dermatitis 2008; 59: 43–47.

3. Coenraads PJ. Hand eczema. N Engl J Med 2012; 367: 1829–1837.

4. Molin S, Diepgen TL, Ruzicka T and Prinz JC. Diagnosing chronic hand eczema by an algorithm: a tool for classification in clinical practice. Clin Exp Dermatol 2011; 36: 595–601.

5. Bisonnette R, Diepgen TL, Elsner P, English J, Graham-Brown R, Homey B, et al. Redefining treatment options in chronic hand eczema (CHE). J Eur Acad Dermatol Venereol 2010; 24 (Suppl. 3): 1–20.

6. Seghal VN, Srtivastava G, Aggarwal AK, Sharma AD. Hand dermatitis/eczema: Current management strategy. J Dermatol 2010; 37: 593–610.

7. Diepgen TL, Elsner P, Schliemann S, Fartasch M, Köllner A, Skudlik C, et al. Guideline on the management of hand eczema ICD-10 Code: L20. L23. L24. L25. L30. J Dtsch Dermatol Ges 2009; 7 (Suppl 3): 1–16.

8. Johansen JD, Hald M, Andersen BL, Laurberg G, Danielsen A, Avnstorp C, et al. Classification of hand eczema: clinical and aetiological types. Based on the guideline of the Danish Contact Dermatitis Group. Contact Dermatitis 2011; 65: 13–21.

9. English J, Aldridge R, Gawkrodger D J, Kownacki S, Statham B, White JM, et al. Consensus statement on the management of chronic hand eczema. Clin Exp Dermatol 2009; 34: 761–769.

10. Fowler J. Chronic hand eczema: diagnosis, management, and prevention of a challenging condition. Cutis 2008; 82: 3.

11. Diepgen TL. Chronisches Handekzem. Hautarzt 2008; 59: 683–689.

12. Van Gils RF, Boot CRL, Knol DL, Rustemeyer T, van Mechelen W, van der Valk PGM, et al. The effectiveness of integrated care for patients with hand eczema: results of a randomized, controlled trial. Contact Dermatitis 2012; 66: 197–204.

13. Augustin M, Kuessner D, Purwins, S, Hieke K, Posthumus J, Diepgen TL. Cost-of-illness of patients with chronic hand eczema in routine care: results from a multicenter study in Germany. Br J Dermatol 2011; 165: 845–851.

14. Bingefors K, Lindberg M, Isacson D. Quality of life, use of topical medications and socio-economic data in hand eczema: A Swedish nationwide survey. Acta Derm Venereol 2011; 91: 452–458.

15. Apfelbacher CJ, Diepgen TL. Versorgungsforschung am Beispiel des Handekzems. Hautarzt 2011; 62: 196–200.

16. Van der Meer EW, Boot CR, Jungbauer FH, van der Klink JJ, Rustemeyer T, Coenraads PJ, et al. Hands 4U: a multifaceted strategy to implement guideline-based recommendations to prevent hand eczema in health care workers: design of a randomised controlled trial and (cost) effectiveness evaluation. BMC Public Health 2011; 11: 669.

17. Ling TC and Coulson IH. What do hairdressers know about hand dermatitis? Contact Dermatitis 2002; 47: 227–231.

18. Stutz N, Becker D, Jappe U, John SM, Ladwig A, Spornraft-Ragaller P, et al. Nurses’ perceptions of the benefits and adverse effects of hand disinfection: alcohol-based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by German Contact Dermatitis Research Group. Br J Dermatol 2009; 160: 565–572.

19. Ibler KS, Jemec GBE, Flyvholm MA, Diepgen TL, Jensen A, Agner T. Hand eczema: prevalence and risk factors of hand eczema in a population of 2274 healthcare workers. Contact Dermatitis 2012; 67: 200–207.

20. Mälkönen T, Alanko K, Jolanki R, Luukkonen R, Aalto-Korte K, Lauerma A, et al. Long-term follow-up study of occupational hand eczema. Br J Dermatol 2010; 163: 999–1006.

21. Hrehorów E, Salomon J, Matusiak L, Reich A, Szepietowski JC. Patients with psoriasis feel stigmatized. Acta Derm Venereol 2012; 92: 67–72.

22. Hong J, Koo B, Koo J. The psychological and occupational impact of chronic skin disease. Dermatol Ther 2008; 21: 54–59.

23. Schmid-Ott G, Burchard R, Niederauer HH, Lamprecht F, Künsebeck HW. Stigmatization and quality of life of patients with psoriasis and atopic eczema. Hautarzt 2003; 54: 852–857.

24. Magin P, Adams J, Heading G, Pond D, Smith W. Experiences of appearance-related teasing and bullying in skin diseases and their psychological sequelae: results of a qualitative study. Scand J Caring Sci 2008; 22: 430–436.

25. Bos AE, Kok G, Dijker AJ. Public reactions to people with HIV/AIDS in the Netherlands. AIDS Educ Prev 2001; 13: 219–228.

26. Balabanova Y, Coker R, Atun RA, Drobniewski F. Stigma and HIV infection in Russia. AIDS Care 2006; 18: 846–852.

27. Dias SF, Matos MG, Gonçalves AC. AIDS-related stigma and attitudes towards AIDS-infected people among adolescents. AIDS Care 2006; 18: 208–214.

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