Content

Content - Volume 94, Issue 6

Editors choice in this issue

REVIEW
Current Concepts in Psoriatic Arthritis: Pathogenesis and Management
Kurt de Vlam, Alice B. Gottlieb, Philip J. Mease
Psoriatic arthritis occurs in a subset of psoriasis patients and is therefore commonly encountered in dermatology practice. Although its exact pathogenesis is unknown, psoriatic arthritis is thought to share common mechanisms with psoriatic skin symptoms. Innate and adaptive immune responses are abnormally activated in psoriasis and may acquire the ability to attack peripheral joints and other sit ...
Pages: 627-634
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INVESTIGATIVE REPORT
Debio 0932, A New Oral Hsp90 Inhibitor, Alleviates Psoriasis in a Xenograft Transplantation Model
Karin Stenderup, Cecilia Rosada, Bruno Gavillet, Grégoire Vuagniaux, Tomas Norman Dam
Debio 0932 is a novel oral heat shock protein 90 (Hsp90) inhibitor developed for anti-cancer therapy. Surprising-ly, during the first clinical trial, one psoriasis patient experienced complete remission of his skin manifestation. However, a possible therapeutic utility of Hsp90 in psoriasis has not previously been reported. The objective of the present study was to explore the ability of Debio 093 ...
Pages: 672-676
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CLINICAL REPORT
High Magnification Digital Dermoscopy of Basal Cell Carcinoma: A Single-centre Study on 400 cases
Stefania Seidenari, Claudia Bellucci, Sara Bassoli, Federica Arginelli, Cristina Magnoni, Giovanni Ponti
The aim of this study was to assess the frequency of classic dermoscopic basal cell carcinoma (BCC) features and the sensitivity of new descriptors, such as light brown nests (homogeneous and structured) only visible employing a high magnification digital videomicroscope. A retrospective analysis of 2,024 highly magnified digital images referring to 400 BCCs was performed by 3 independent observer ...
Pages: 677-682
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All articles

REVIEW
Current Concepts in Psoriatic Arthritis: Pathogenesis and Management
Kurt de Vlam, Alice B. Gottlieb, Philip J. Mease
Psoriatic arthritis occurs in a subset of psoriasis patients and is therefore commonly encountered in dermatology practice. Although its exact pathogenesis is unknown, psoriatic arthritis is thought to share common mechanisms with psoriatic skin symptoms. Innate and adaptive immune responses are abnormally activated in psoriasis and may acquire the ability to attack peripheral joints and other sit ...
Pages: 627-634
Abstract  HTML  PDF
INVESTIGATIVE REPORT
A New Ten-Item Questionnaire For Assessing Sensitive Skin: The Sensitive Scale-10
Laurent Misery, Catherine Jean-Decoster, Sophie Mery, Victor Georgescu, Vincent Sibaud
Sensitive skin is common but until now there has been no scale for measuring its severity. The Sensitive Scale is a new scale with a 14-item and a 10-item version that was tested in 11 countries in different languages on 2,966 participants. The aim of this study was to validate the pertinence of using the Sensitive Scale to measure the severity of sensitive skin. The internal consistency was high. ...
Pages: 635-639
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INVESTIGATIVE REPORT
Skin Barrier Integrity and Natural Moisturising Factor Levels After Cumulative Dermal Exposure to Alkaline Agents in Atopic Dermatitis
Irena Angelova-Fischer, Irena Dapic, Anne-Karin Hoek, Ivone Jakasa, Tobias W. Fischer, Detlef Zillikens, Sanja Kezic
Dermal exposure to alkaline agents may lead to skin barrier damage and irritant contact dermatitis. The objective of this study was to investigate the effects of cumulative exposure to 0.5% sodium lauryl sulphate (SLS) and 0.15% NaOH on the barrier function and natural moisturising factor (NMF) levels in atopic dermatitis and healthy volunteers with known filaggrin genotype. The skin response was ...
Pages: 640-644
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INVESTIGATIVE REPORT
Surfactant-induced Chronic Pruritus: Role of L-Histidine Decarboxylase Expression and Histamine Production in Epidermis
Yoshihiro Inami, Atsushi Sasaki, Tsugunobu Andoh, Yasushi Kuraishi
Shampoo and cleansers containing anionic surfactants including sodium dodecyl sulphate (SDS) often cause pruritus in humans. Daily application of 1–10% SDS for 4 days induced hind-paw scratching (an itch-related behaviour) in a concentration-dependent manner, and 10% SDS also caused dermatitis, skin dryness, barrier disruption, and an increase in skin surface pH in mice. SDS-induced scratching w ...
Pages: 645-650
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INVESTIGATIVE REPORT
Implementation of Recommendations for Hand Eczema Through a Multifaceted Strategy. A Process Evaluation Among Health Care Workers
Esther W.C. van der Meer, Cécile R.L. Boot, Frank H.W. Jungbauer, Pieter Jan Coenraads, Joost W.J. van der Gulden, Johannes R. Anema
Process data give important insights into how an intervention is implemented. The aim of the present study is to conduct a process evaluation, alongside a randomised controlled trail, on the implementation of recommendations for the prevention of hand eczema. The intervention was carried out in healthcare workers’ departments and consisted of working groups and role models. The role models were ...
Pages: 651-657
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INVESTIGATIVE REPORT
Assessing Health-related Quality of Life in Hand Eczema Patients: How to Overcome Psychometric Faults when Using the Dermatology Life Quality Index
Robert F. Ofenloch, Thomas L. Diepgen, Elke Weisshaar, Peter Elsner, Christian J. Apfelbacher
Health-related quality of life (HRQOL) has become an important patient reported outcome in health service research. The dermatology life quality index (DLQI) is the most commonly used instrument in dermatology. In recent years, the psychometric properties of the DLQI have been a subject of debate as requirements of modern test theory seem not to be fulfilled. The aim of this study was to test whet ...
Pages: 658-662
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INVESTIGATIVE REPORT
Neurofibromatosis Type 1 Gene Mutation Analysis Using Sequence Capture and High-throughput Sequencing
Elina Uusitalo, Anna Hammais, Elina Palonen, Annika Brandt, Ville-Veikko Mäkelä, Roope Kallionpää, Eeva-Mari Jouhilahti, Minna Pöyhönen, Juhani Soini, Juha Peltonen, Sirkku Peltonen
Neurofibromatosis type 1 syndrome (NF1) is caused by mutations in the NF1 gene. Availability of new sequencing technology prompted us to search for an alternative method for NF1 mutation analysis. Genomic DNA was isolated from saliva avoiding invasive sampling. The NF1 exons with an additional 50bp of flanking intronic sequences were captured and enriched using the SeqCap EZ Choice Library protoco ...
Pages: 663-666
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INVESTIGATIVE REPORT
Genotype–Phenotype Correlations in a Prospective Cohort Study of Paediatric Plaque Psoriasis: Lack of Correlation Between HLA-C*06 and Family History of Psoriasis
Annet M. Oostveen, Judith G.M. Bergboer, Peter C.M. van de Kerkhof, Patrick L.J.M. Zeeuwen, Elke M.G.J. de Jong, Joost Schalkwijk, Marieke M.B. Seyger
This study aims to investigate associations between observed clinical parameters and known genetic risk factors of psoriasis in a well-defined prospective cohort of paediatric patients with plaque psoriasis (n = 151). Significant associations were found for paediatric-onset psoriasis with ERAP1 (p = 0.002), IL23R (p = 0.01), LCE3C_LCE3B-del (p = 0.00 ...
Pages: 667-671
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INVESTIGATIVE REPORT
Debio 0932, A New Oral Hsp90 Inhibitor, Alleviates Psoriasis in a Xenograft Transplantation Model
Karin Stenderup, Cecilia Rosada, Bruno Gavillet, Grégoire Vuagniaux, Tomas Norman Dam
Debio 0932 is a novel oral heat shock protein 90 (Hsp90) inhibitor developed for anti-cancer therapy. Surprising-ly, during the first clinical trial, one psoriasis patient experienced complete remission of his skin manifestation. However, a possible therapeutic utility of Hsp90 in psoriasis has not previously been reported. The objective of the present study was to explore the ability of Debio 093 ...
Pages: 672-676
Abstract  HTML  PDF
CLINICAL REPORT
High Magnification Digital Dermoscopy of Basal Cell Carcinoma: A Single-centre Study on 400 cases
Stefania Seidenari, Claudia Bellucci, Sara Bassoli, Federica Arginelli, Cristina Magnoni, Giovanni Ponti
The aim of this study was to assess the frequency of classic dermoscopic basal cell carcinoma (BCC) features and the sensitivity of new descriptors, such as light brown nests (homogeneous and structured) only visible employing a high magnification digital videomicroscope. A retrospective analysis of 2,024 highly magnified digital images referring to 400 BCCs was performed by 3 independent observer ...
Pages: 677-682
Abstract  HTML  PDF
CLINICAL REPORT
Diagnosis of Pigmented Skin Tumours in a Dermatological Setting: Different Aspects of the Number Needed to Excise as a Measure of Efficiency
Ingela Ahnlide, Kari Nielsen, Mats Bjellerup
The increasing incidence of melanoma prompts a need for efficient management of this patient group. In this study, we use the number needed to excise (NNE), as a measurement of the efficiency of diagnosing melanoma. From January 2009 to December 2012, postoperative records from all patients were prospectively registered. All excised tumours with the histopathological diagnosis of naevus, melanoma ...
Pages: 683-686
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CLINICAL REPORT
Chronic Hand Eczema: Perception and Knowledge in Non-affected Individuals from General and Dermatological Practice
Valerie Letulé, Thomas Herzinger, Astrid Schirner, Frank Hertrich, Dirk Lange, Thomas Ruzicka, Sonja Molin
Misunderstanding and stigmatisation are common problems encountered by patients with hand eczema. Various misconceptions about the disease circulate in the general population. Although hand eczema has gained more attention in dermatology during the past years, information on public perception of the disease is still lacking. The aim of our study was to investigate perception of and level of knowle ...
Pages: 687-690
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CLINICAL REPORT
Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis
Peter Jensen, Claus Zachariae, Robin Christensen, Nina R.W. Geiker, Bente K. Schaadt, Steen Stender, Arne Astrup, Peter R. Hansen, Lone Skov
Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers ...
Pages: 691-694
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CLINICAL REPORT
Atopic Dermatitis in Israeli Adolescents – A Large Retrospective Cohort Study
Yonit Wohl, Julio Wainstein, Yosefa Bar-Dayan
Prevalence of atopic dermatitis (AD) has been studied mainly in infants and young children. Surveys on AD in adolescents and adults are based largely on self-reported questionnaires and cohorts of different ages, precluding meaningful comparisons and conclusions. We aimed to provide data on the prevalence of AD and its relation to demographic factors in adolescents. A large database of youths elig ...
Pages: 695-698
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CLINICAL REPORT
Bacteriology of Hidradenitis Suppurativa – Which Antibiotics are the Treatment of Choice?
Łukasz Matusiak, Andrzej Bieniek, Jacek C. Szepietowski
The bacterial superinfection in hidradenitis suppurativa (HS), although it does not initiate the disease itself, seems to be one of the major contributors to an inflammatory vicious circle. Antibiotic therapy is therefore commonly prescribed in HS. This study was undertaken to evaluate the prescription of systemic antibiotics in the light of bacteriological cultures and antibiograms. The study was ...
Pages: 699-702
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CLINICAL REPORT
Onychophagia is Associated with Impairment of Quality of Life
Przemysław Pacan, Adam Reich, Magdalena Grzesiak, Jacek C. Szepietowski
Onychophagia is defined as a chronic nail biting behaviour affecting about 20–30% of the general population. However, nail biting seems to be an ignored problem in a daily clinical practice. We have analysed the influence of onychophagia on quality of life (QoL) and stigmatisation level among 339 medical students with and without nail biting. Those with onychophagia demonstrated significantly hi ...
Pages: 703-706
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CLINICAL REPORT
Palmoplantar Keratoderma of the Gamborg-Nielsen Type is Caused by Mutations in the SLURP1 Gene and Represents a Variant of Mal de Meleda
Linshu Zhao, Anders Vahlquist, Marie Virtanen, Lena Wennerstrand, Lisbet Lind, Anita Lundström, Maritta Hellström Pigg
Palmoplantar keratoderma of the Gamborg-Nielsen type (PPK-GN) is a rare autosomal recessive skin disorder described in patients from Sweden. Mal de Meleda (MDM) is also a rare autosomal recessive inherited PPK first reported in 5 families from the island of Meleda. The 2 conditions phenotypically overlap and are characterised by palmoplantar erythematous hyperkeratotic plaques. The genetic backgro ...
Pages: 707-710
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SHORT COMMUNICATION
Circulating Anti-BP180 NC16a and Anti-BP230 Autoantibodies in Patients with Genital Lichen Sclerosus Do Not Correlate with Disease Activity and Pruritus
Aikaterini Patsatsi, Aikaterini Kyriakou, Athanasios Mantas, Dimitrios Vavilis, Christos Patsialas, Dimitrios Sotiriadis
Abstract is missing (Short Communication)
Pages: 711-712
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SHORT COMMUNICATION
Qualitative Interviews on Chronic Pruritus in Haemodialysis Patients
Melanie Weiss, Elke Weisshaar
Abstract is missing (Short Communication)
Pages: 713-714
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SHORT COMMUNICATION
The Potential Effect of the Tumour Necrosis Factor-α Inhibitors on Vitamin D Status in Psoriatic Patients
Giulia Ganzetti, Anna Campanati, Vitangelo Scocco, Marina Brugia , Massimo Tocchini , Giulia Liberati , Katia Giuliodori, Valerio Brisigotti, Annamaria Offidani
Abstract is missing (Short)
Pages: 715-717
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SHORT COMMUNICATION
External Beam Radiation Therapy for Recalcitrant Dermatitis
Terence T. Sio, Mark R. Pittelkow, Marjorie A. Nagle, James A. Martenson
Abstract is missing (Short Communication)
Pages: 717-719
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SHORT COMMUNICATION
Can Median Nail Dystrophy be an Adverse Effect of Alitretinoin Treatment?
Anna Hillert Winther, Anette Bygum
Abstract is not available (Short Communication)
Pages: 719-720
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SHORT COMMUNICATION
Unresectable Perineal Cuniculatum Carcinoma: Partial Remission Using Systemic Isotretinoin and Interferon-α2a Therapy
Marie Tauber, Gentiane Monsel, Lucie Bonnecarrère, Maxime Battistella, Nadège Cordel, Carla Honein, François Aubin, Martine Bagot, Antoine Petit, Céleste Lebbé, Manuelle Viguier
Abstract is missing (Short Communication)
Pages: 721-722
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SHORT COMMUNICATION
Idiopathic Pure Sudomotor Failure Responding to Oral Antihistamine with Sweating Activities
Akari Suma, Hiroyuki Murota, Shun Kitaba, Toshifumi Yamaoka, Kenichi Kato, Saki Matsui, Aya Takahashi, Akinori Yokomi , Ichiro Katayama
Abstract is missing (Short Communication)
Pages: 723-724
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SHORT COMMUNICATION
Interstitial Granulomatous Dermatitis Associated with Myelodysplastic Syndrome – Complete Clearance Under Therapy with 5-azacytidine
Nikolaos Patsinakidis, Laura Susok, Schapoor Hessam, Nick Othlinghaus, Katrin Möllenhoff , Markus Stücker, Peter Altmeyer, Alexander Kreuter
Abstract is missing (Short Communication)
Pages: 725-726
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SHORT COMMUNICATION
Disseminated Cutaneous Infection Caused by Mycobacterium colombiense
Wei Gao, Hao Chen, Haiqing Jiang, Qiulin Wang, Meiyu Tang, Hong-Sheng Wang
Abstract is missing (Short Communication)
Pages: 727-728
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SHORT COMMUNICATION
Exacerbation of Pemphigus Foliaceus After Electron-beam Radiation
Kazuhiro Kikuchi, Daisuke Inokuma, Reine Moriuchi, Hanako Koguchi-Yoshioka, Chikako Yasui, Satoko Shimizu
Abstract is missing (Short)
Pages: 729-730
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SHORT COMMUNICATION
Asparagus-induced Fixed Food Eruptions Mimicking Cutaneous Lupus
Barbara Maria Gaus, Nina Scheiba, Knut Schäkel
Abstract is missing (Short)
Pages: 731-732
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SHORT COMMUNICATION
Rejection-mediated Regression of Melanocytic Naevi in an Immunosuppressed Organ Transplant Recipient
Elisa Zonta, Marta Benedetta Brumana, Andreina Montin , Stefano Piaserico, Anna Belloni-Fortina, Mauro Alaibac
Abstract is missing (Short)
Pages: 733-734
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SHORT COMMUNICATION
Characterization of Two Cases of Bullous Pemphigoid Reactive Only with BP230 on Japanese Enzyme-linked Immunosorbent Assays
Shu Sasai, Ryuhei Nishikawa, Ayaka Ohzono, Taihei Hayakawa, Daisuke Tsuruta, Kazuhiro Kudoh, Tsuyoshi Kikuchi, Masahiro Hashiguchi, Chika Ohata, Minao Furumura , Hiroshi Koga, Norito Ishii, Takashi Hashimoto
Abstract is missing (Short Communication)
Pages: 734-736
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SHORT COMMUNICATION
IgA/IgG Pemphigus with Infiltration of Neutrophils and Eosinophils in an Ulcerative Colitis Patient
Ryuhei Uchiyama, Norito Ishii, Fuyuko Arakura, Yukiko Kiniwa, Koh Nakazawa, Hisashi Uhara, Takashi Hashimoto, Ryuhei Okuyama
Abstract is missing (Short Communication)
Pages: 737-738
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SHORT COMMUNICATION
In transit Recurrence of Merkel Cell Carcinoma Associated with Polyarthritis Effectively Treated with Immunocryosurgery
Paraskevi V. Voulgari, Georgios Gaitanis, Theodora E. Markatseli, Werner Kempf, Ioannis D. Bassukas
Abstract is missing (Short Communication)
Pages: 739-740
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SHORT COMMUNICATION
Neutrophil-rich Anaplastic Large Cell Lymphoma Expressing Interleukin-8
Takuya Miyagawa, Makoto Sugaya, Asako Okada, Yoshihide Asano, Takafumi Kadono, Shinichi Sato
Abstract is missing (Short Communication)
Pages: 741-742
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SHORT COMMUNICATION
Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyperlaxity and Urticarial Neutrophilic Dermatosis
Nicolas Kluger, Jean-Pierre Molès, Olivier M. Vanakker, Charlotte Pernet, Marie Beylot-Barry, Didier Bessis
Abstract is missing (Short Communication)
Pages: 743-744
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SHORT COMMUNICATION
Onychotillomania in the Course of Depression: A Case Report
Magdalena Grzesiak, Przemysław Pacan, Adam Reich, Jacek C. Szepietowski
Abstract is missing (Short)
Pages: 745-746
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QUIZ
Periungual Swelling and Nail Dystrophy in a Healthy Male: A Quiz
Heather M. Holahan, Ronda S. Farah, Gary E. Quinby, Mary Seabury Stone
Abstract is missing (Quiz)
Pages: 747-749
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QUIZ
Arc-shaped Plaque on the Forehead: A Quiz
Yukari Kawakami, Makoto Kunisada, Chikako Nishigori
Abstract is missing (Quiz)
Pages: 747-749
Abstract  HTML  PDF