Content » Vol 96, Issue 5

Short communication

Erythema Induratum in a Patient with Pulmonary Mycobacterium avium Infection

Mai Hattori1, Akira Shimizu1*, Takeshi Hisada2, Takaya Fukumoto3, and Osamu Ishikawa1

Departments of 1Dermatology and 2Medicine and Molecular Science, Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma 371-8511, and 3Sapporo Dermatopathology Institute, Sapporo, Japan. *E-mail:

Accepted Jan 21, 2016; Epub ahead of print Jan 25, 2016

Erythema induratum (EI) is a disease of multiple aetiologies, which mainly affects women, causing erythematous nodules and plaques on the lower extremities. Nodular vasculitis has been regarded as synonymous with EI (1). In contrast, erythema induratum of Bazin (EIB) has been recognized as a tuberculid reaction to Mycobacterium tuberculosis with tuberculin hypersensitivity (2). We report here a case of EI in a patient potentially associated with pulmonary M. avium infection.


A 77-year-old woman presented with a one-month history of tender erythematous nodules on her lower legs in June 2014. On physical examination, indurated erythemas 1–3 cm in diameter were observed scattered mainly on the flexor and lateral sides of her lower legs (Fig. 1a). Her body temperature was normal. There was no family history of tuberculosis and her past history was unremarkable. All laboratory results were normal except for an elevated C-reactive protein level (1.67 mg/dl: normal < 0.1 mg/dl). A skin biopsy taken from the right lower leg showed mixed septal and lobular panniculitis (Fig. 1b) and epithelioid granulomas with caseous necrosis and many multinucleated giant cells and eosinophils in the lesion (Fig. 1c). There was no vasculitis. We suspected a diagnosis of EIB caused by M. tuberculosis infection, and therefore referred the patient to a pulmonologist. Chest computed tomography revealed multiple small nodules and pulmonary infiltrates in the bilateral lower lobe of her lung. A tuberculin skin test and the QuantiFERON®-TB Gold (QIAGEN, Hilden, Germany) test were negative. The biopsied skin, gastric aspirate, and sputum were all negative for Ziehl-Neelsen staining and PCR analysis for both M. tuberculosis and M. avium. Bacterial culture of the cutaneous tissue and sputum were also negative; however, M. avium was isolated only from the gastric aspirate after incubation for one month. We suspected a diagnosis of EI caused by pulmonary M. avium infection. One month later without any medication, numerous indurated erythemas developed suddenly on her trunk (Fig. 1d) and upper legs. Histopathologically, caseous necrosis surrounded by epithelioid granuloma with mononuclear cells and eosinophil infiltrations were also seen as in the leg lesion. We considered that the eruptions had been caused by the same mechanism and treated her with rifampicin 450 mg/day, ethambutol 750 mg/day and clarithromycin 600 mg/day. The erythemas quickly resolved within a few weeks and the subcutaneous nodules in the legs finally improved after 6 months.

Fig. 1. (a) Erythematous subcutaneous nodule on the patient’s right lower leg. (b) Histopathological examination reveals mixed septal and lobular panniculitis (haematoxylin and eosin stain, 8×). (c) High-power magnifica­tion reveals caseous necrosis surrounded by mononuclear cells and eosinophils accompanied by giant cells (haematoxylin and eosin stain, 100×). (d) Light pink erythema scattered on the patient’s trunk.



EI is typically caused by M. tuberculosis; however, it has also been reported that non-tuberculous agents, such as Nocardia, Pseudomonas, and Fusarium, may be associated with EI (3, 4). To the best of our knowledge, there have been no previous reports of EI associated with M. avium infection. The negative results of the tuberculin skin test, QuantiFERON®-TB Gold test and the PCR analysis for M. tuberculosis excluded the possibility of a M. tuberculosis infection. The fact that the patient responded well to therapy for pulmonary M. avium infection also supports our diagnosis.

The histopathology of the trunk rash was the same as that of the lower legs. We speculate that EI might manifest as an id reaction to M. avium components in our patient. To confirm our hypothesis, an immunohistochemical study of M. avium antigens is warranted; however, no appropriate M. avium antibody is currently available.


1. Lever WF, Elder DE. Lever’s histopathology of the skin. 10th edn. Philadelphia: Lippincott Williams & Wilkins; 2009.

2. Inoue T, Fukumoto T, Ansai S, Kimura T. Erythema induratum of Bazin in an infant after Bacille Calmette-Guerin vaccination. J Dermatol 2006; 33: 268–272.

3. Patterson JW, Brown PC, Broecker AH. Infection-induced panniculitis. J Cutan Pathol 1989; 16: 183–193.

4. Heidi G, James WP. Erythema nodosum and erythema induratum (nodular vasculitis): diagnosis and management. Dermatol Ther 2010; 23: 320–327.

Supplementary content
Appendix S1