Content

Content - Volume 96, Issue 5

Editor's choice in this issue

REVIEW
Facial Erythema of Rosacea – Aetiology, Different Pathophysiologies and Treatment Options
Martin Steinhoff, Martin Schmelz, Jürgen Schauber
Rosacea is a common chronic skin condition that displays a broad diversity of clinical manifestations. Although the pathophysiological mechanisms of the four subtypes are not completely elucidated, the key elements often present are augmented immune responses of the innate and adaptive immune system, and neurovascular dysregulation. The most common primary feature of all cutaneous subtypes of rosa ...
Pages: 579-586
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REVIEW
The Role of Neuromediators and Innervation in Cutaneous Wound Healing
Mohammed Ashrafi, Mohamed Baguneid, Ardeshir Bayat
The skin is densely innervated with an intricate network of cutaneous nerves, neuromediators and specific receptors which influence a variety of physiological and disease processes. There is emerging evidence that cutaneous innervation may play an important role in mediating wound healing. This review aims to comprehensively examine the evidence that signifies the role of innervation during the ov ...
Pages: 587-594
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All articles

REVIEW
Facial Erythema of Rosacea – Aetiology, Different Pathophysiologies and Treatment Options
Martin Steinhoff, Martin Schmelz, Jürgen Schauber
Rosacea is a common chronic skin condition that displays a broad diversity of clinical manifestations. Although the pathophysiological mechanisms of the four subtypes are not completely elucidated, the key elements often present are augmented immune responses of the innate and adaptive immune system, and neurovascular dysregulation. The most common primary feature of all cutaneous subtypes of rosa ...
Pages: 579-586
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REVIEW
The Role of Neuromediators and Innervation in Cutaneous Wound Healing
Mohammed Ashrafi, Mohamed Baguneid, Ardeshir Bayat
The skin is densely innervated with an intricate network of cutaneous nerves, neuromediators and specific receptors which influence a variety of physiological and disease processes. There is emerging evidence that cutaneous innervation may play an important role in mediating wound healing. This review aims to comprehensively examine the evidence that signifies the role of innervation during the ov ...
Pages: 587-594
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SPECIAL REPORT
Eczema Trials: Quality of Life Instruments Used and Their Relation to Patient-reported Outcomes. A Systematic Review
Daniel Heinl, Joanne Chalmers, Helen Nankervis, Christian J. Apfelbacher
It is unclear which quality of life instruments have thus far been used in eczema trials. Therefore, we aimed to identify these instruments. We searched the Global Resource of Eczema Trials (GREAT) database for reports of randomized controlled trials. Information on patient-reported outcomes, particularly quality of life, was extracted from eligible studies. 287 full texts reporting on 303 trials ...
Pages: 596-601
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SPECIAL REPORT
Multidisciplinary Management of Mastocytosis: Nordic Expert Group Consensus
Sigurd Broesby-Olsen, Ingunn Dybedal, Theo Gülen, Thomas K. Kristensen, Michael B. Møller, Leena Ackermann, Maria Sääf, Maria A. Karlsson, Lone Agertoft, Kim Brixen, Pernille Hermann, Eva Stylianou, Charlotte G. Mortz, Trine Torfing, Troels Havelund, Birgitta Sander, Anna Bergström, Marie Bendix, Lene H. Garvey, Ole Weis Bjerrum, Peter Valent, Carsten Bindslev-Jensen, Gunnar Nilsson, Hanne Vestergaard, Hans Hägglund
Mastocytosis is a heterogeneous group of diseases defined by an increased number and accumulation of mast cells, and often also by signs and symptoms of mast cell activation. Disease subtypes range from indolent to rare aggressive forms. Mastocytosis affects people of all ages and has been considered rare; however, it is probably underdiagnosed with potential severe implications. Diagnosis can be ...
Pages: 602-612
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INVESTIGATIVE REPORT
Psychophysiological Processing of Itch in Patients with Chronic Post-burn Itch: An Exploratory Study
Antionette I.M. van Laarhoven, Dietmar J.O. Ulrich, Oliver H. Wilder-Smith, Nancy E.E. van Loey, Marianne Nieuwenhuis, Nic J.A. van der Wee, Andrea W.M. Evers
A substantial proportion of patients with burn injury develop chronic itch, which can severely affect their quality of life. As found in research on chronic pain, different psychophysiological processes may also play a role in chronic itch, of which central sensitization, conditioned modulation, and attentional processes have been studied most frequently. This study aimed to explore psychophysiolo ...
Pages: 613-618
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INVESTIGATIVE REPORT
Itch Perception and Skin Reactions as Modulated by Verbal Suggestions: Role of Participant’s and Investigator’s Sex
Astrid Stumpf, Volkan Zerey, Gereon Heuft, Sonja Ständer, Bettina Pfleiderer, Gudrun Schneider
This study investigated sex-specific differences in itch perception and skin reactions, as modulated by verbal suggestions, and the role of the investigator’s sex. Healthy volunteers (50 males, 50 females), divided into 4 groups, were tested by male and female investigators. Itch was induced via prick testing with sodium chloride and histamine in 4 runs; 2 control conditions (with no exaggerated ...
Pages: 619-623
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INVESTIGATIVE REPORT
Possible Antipruritic Mechanism of Cyclosporine A in Atopic Dermatitis
Kyi Chan Ko, Mitsutoshi Tominaga, Yayoi Kamata, Yoshie Umehara, Hironori Matsuda, Nobuaki Takahashi, Katsunari Kina, Mayuko Ogawa, Hideoki Ogawa, Kenji Takamori
Cyclosporine A is an immunosuppressive agent that suppresses pruritus and is currently used in the treatment of patients with severe atopic dermatitis. The aim of this study was to elucidate the antipruritic mechanism of cyclosporine A using a mouse model of atopic dermatitis. Intraperitoneal injection of cyclosporine A (5 mg/kg) significantly reduced epidermal nerve density, number of scratching ...
Pages: 624-629
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INVESTIGATIVE REPORT
Highly Concordant Results Between Immunohistochemistry and Molecular Testing of Mutated V600E BRAF in Primary and Metastatic Melanoma
Laure Manfredi, Nicolas Meyer, Emilie Tournier, David Grand, Emmanuelle Uro-Coste, Philippe Rochaix, Pierre Brousset, Laurence Lamant
This study tested the sensitivity and specificity of VE1 antibody raised against BRAFV600E protein, on 189 melanoma samples, compared with molecular testing. In addition, the therapeutic response to BRAF inhibitors was analysed in 27 patients, according to staining intensity (scored from weak to strong) and pattern (homogeneous or heterogeneous). BRAFV600E status during melanoma progression was ev ...
Pages: 630-634
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INVESTIGATIVE REPORT
Cadherin 11 Involved in Basement Membrane Damage and Dermal Changes in Melasma
Nan-Hyung Kim, Soo-Hyun Choi, Tae Ryong Lee, Chang-Hoon Lee, Ai-Young Lee
Basement membrane (BM) disruption and dermal changes (elastosis, collagenolysis, vascular ectasia) have been reported in melasma. Although ultraviolet (UV) irradiation can induce these changes, UV is not always necessary for melasma development. Cadherin 11 (CDH11), which is upregulated in some melasma patients, has previously been shown to stimulate melanogenesis. Because CDH11 action requires ce ...
Pages: 635-640
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INVESTIGATIVE REPORT
Non-invasive Imaging of Localised Scleroderma for Assessment of Skin Blood Flow and Structure
Andrea K. Murray, Tonia L. Moore, Joanne B. Manning, Graham Dinsdale, Jack Wilkinson, Monica Bhushan, Christopher E.M. Griffiths, Ariane L. Herrick
Extensive morphoea causes major morbidity, disability and disfigurement; pathophysiology is poorly understood. The aim of this study was to investigate, with non-invasive imaging, the relationship between localised abnormalities of skin structure and perfusion, which characterise morphoea. Thirty-two patients with morphoea underwent imaging at affected and unaffected sites. Skin thickness was imag ...
Pages: 641-644
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INVESTIGATIVE REPORT
Immune-mediated Skin Inflammation is Similar in Severe Atopic Dermatitis Patients With or Without Filaggrin Mutation
Zsolt Dajnoki, Gabriella Béke, Gábor Mócsai, Anikó Kapitány, Krisztián Gáspár, Krisztina Hajdu, Gabriella Emri, Bence Nagy, Ilona Kovács, Lívia Beke, Balázs Dezső, Andrea Szegedi
Inflammatory cytokines can impair the skin barrier, but the question as to whether barrier alterations affect keratinocyte immune responses remains unanswered. The aim of this study was to investigate whether immune-mediated skin inflammation differs between severe atopic dermatitis patients with or without filaggrin mutation. The levels of filaggrin, inflammatory T helper 2 polarizing cytokines ( ...
Pages: 645-650
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INVESTIGATIVE REPORT
Economic Burden of Psoriasis and Potential Cost Offsets with Biologic Treatment: A Swedish Register Analysis
Axel Svedbom, Johan Dahlén, Carla Mamolo, Joseph C. Cappelleri, Lotus Mallbris , Ingemar F. Petersson, Mona Ståhle
Estimates of direct and indirect costs of psoriasis are limited. The aim of this study was to estimate: (i) costs in patients with psoriasis compared with controls; and (ii) impact on costs from initiating biologics. The study extracted data from Swedish administrative registers and compared 31,043 patients with 111,645 sex-, age- and residency-matched referents. Mean direct and indirect costs wer ...
Pages: 651-657
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CLINICAL REPORT
Squamous Cell Carcinoma Following Photodynamic Therapy for Cutaneous Bowen’s Disease in a Series of 105 Patients
Carole Ratour-Bigot, Mireille Chemidling, Claire Montlahuc, Georges Abirached, Nika Madjlessi, Chantal Bullier, Maxime Battistella, Martine Bagot, Céleste Lebbe, Nicole Basset-Seguin
Photodynamic therapy (PDT) is an alternative to surgery for Bowen’s disease. This monocentric retrospective study included 105 patients with Bowen’s disease, treated with PDT between 2007 and 2013, who received a total of 151 different PDT fields. Comparison of immunocompromised and non-immunocompromised patients revealed that the former often had a previous history of squamous cell carcinoma ...
Pages: 658-663
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CLINICAL REPORT
Cost-utility Analysis of Supported Self-management with Motiva­tional Interviewing for Patients with Psoriasis
Marie H. Larsen, Astrid K. Wahl, Anne-Lene Krogstad, Eline Aas
There are few studies evaluating the cost-effectiveness of self-management interventions for patients with psoriasis. Motivational interviewing (MI) as a telephone follow-up after climate-heliotherapy was effective on several clinical parameters, but its cost-effectiveness is unknown. A cost-utility analysis was conducted alongside a randomized controlled trial (RCT) comparing MI with usual care. ...
Pages: 664-668
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CLINICAL REPORT
Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases
Yvonne Eklund, Annika Aronsson, Artur Schmidtchen, Thomas Relander
Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with slow disease progression. There is a lack of descriptive data from Sweden concerning patients with this diagnosis. This study extracted data on patients admitted to the dermatology department at Lund University Hospital, Sweden from 1996 to 2010. Forty-four patients with clinically and histopathologically verified MF were identifie ...
Pages: 669-673
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CLINICAL REPORT
Illness Perception and Psychological Distress in Persons with Porphyria Cutanea Tarda
Janice Andersen, Karin Nordin, Sverre Sandberg
Porphyria cutanea tarda (PCT) requires long-term treatment and follow-up, although many patients experience life-long remission. The aim of this cross-sectional postal survey was to describe and investigate the association between illness perception, health complaints, self-reported symptoms and distress in persons with PCT. The participants perceived PCT as a chronic condition with high levels of ...
Pages: 674-678
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CLINICAL REPORT
Patch Testing with Main Sensitizers Does Not Detect All Cases of Contact Allergy to Oxidized Lavender Oil
Lina Hagvall, Johanna Bråred Christensson
Lavender oil is an essential oil obtained from lavender (Lavendula angustifolia). The main components linalool and linalyl acetate have been shown to autoxidize in contact with oxygen in the air, forming sensitizing hydroperoxides. Patients with suspected allergic contact dermatitis were consecutively patch-tested with oxidized lavender oil 6% pet., oxidized linalyl acetate 6% pet., and oxidized l ...
Pages: 679-683
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CLINICAL REPORT
Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus
Lei Shi, Fei Miao, Ling-Lin Zhang, Guo-Long Zhang, Pei-Ru Wang, Jie Ji, Xiao-Jie Wang, Zheng Huang, Hong-Wei Wang, Xiu-Li Wang
The aim of this study was to evaluate the effectiveness of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for the treatment of vulvar lichen sclerosus (VLS) and compare its effectiveness with that of clobetasol propionate. Four sessions of topical photodynamic therapy (PDT) were administered at 2-week intervals (n?=?20). Clobetasol propionate (0.05%) was used daily for 8 weeks (n?=?20). The ...
Pages: 684-688
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INVESTIGATIVE REPORT
Urethritis-associated Pathogens in Urine from Men with Non-gonococcal Urethritis: A Case-control Study
Maria Frølund, Peter Lidbrink, Arne Wikström, Susan Cowan, Peter Ahrens, Jørgen Skov Jensen
The aetiology of non-gonococcal urethritis (NGU) remains unexplained in 30–40% of patients. Urine samples from men attending Swedish sexually transmitted disease clinics were examined by species-specific quantitative PCRs for Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, Ureaplasma urealyticum, U. parvum, adenovirus, herpes simplex virus, Neisseria meningitidis, Haemophilu ...
Pages: 689-694
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SHORT COMMUNICATION
Pemphigoid Gestationis Complicating an Egg Donation Pregnancy
Liliana Guerra, Cinzia Mazzanti, Valentina Calabresi, Naomi De Luca, Giovanna Zambruno, Giovanni Di Zenzo
Abstract is missing (Short communication)
Pages: 695-696
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SHORT COMMUNICATION
Itch and Pain Characteristics in Skin Carcinomas
Adèle Poulaliou, Delphine Legoupil, Patricia Schoenlaub, Mathilde Herault , Anne-Laure Dupuy-De Fonclare, Manon Poulaliou, Laurent Misery, Emilie Brenaut
Abstract is missing (Short communication)
Pages: 697-698
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SHORT COMMUNICATION
Alexithymia in Uraemic Pruritus
Monika Heisig, Adam Reich, Jacek C. Szepietowski
Abstract is missing (Short communication)
Pages: 699-700
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SHORT COMMUNICATION
Subcutaneous Phaeohyphomycosis due to Alternaria dennisii in an Immunocompromised Patient
Jon Erik Fraes Diernaes, Kasper F. Hjuler, Lise Kristensen, Mette Deleuran
Abstract is missing (Short communication)
Pages: 701-702
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SHORT COMMUNICATION
Dangerous Leg Cramps: Severe Pustular Exanthema Caused by an Over-the-Counter Drug
Ina Stolze, Axel Trautmann, Matthias Goebeler, Johanna Stoevesandt
Abstract is missing (Short communication)
Pages: 703-704
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SHORT COMMUNICATION
Erythema Induratum in a Patient with Pulmonary Mycobacterium avium Infection
Mai Hattori , Akira Shimizu, Takeshi Hisada, Takaya Fukumoto, Osamu Ishikawa
Abstract is missing (Short communication)
Pages: 705-706
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SHORT COMMUNICATION
Malignant Peripheral Nerve Sheath Tumour Arising From Solitary Sclerotic Neurofibroma
Shinga Moriya, Junpei Hirose, Yuichi Yoshida, Osamu Yamamoto
Abstract is missing (Short communication)
Pages: 706-707
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SHORT COMMUNICATION
Fibulin Protein Expression in Mid-dermal Elastolysis and Anetoderma: A Study of 23 Cases
Thilo Gambichler, Lena Reininghaus, Marina Skrygan, Hans-Joachim Schulze, Jörg Schaller, Chiara Colato, Giampiero Girolomoni
Abstract is missing (Short communication)
Pages: 708-710
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SHORT COMMUNICATION
Photoallergic Drug Eruption Caused by Certolizumab Pegol
Akiha Inoue, Yu Sawada , Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Rieko Kabashima-Kubo, Manabu Yoshioka, Daisuke Nisio, Motonobu Nakamura
Abstract is missing (Short communication)
Pages: 710-711
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SHORT COMMUNICATION
Long-term Outcome of Daylight Photodynamic Therapy with Amino-5-laevulinate Nanoemulsion vs. Methyl-5-aminolaevulinate for Actinic Keratoses
Noora Neittaanmäki-Perttu, Mari Grönroos, Taneli Tani, Erna Snellman
Abstract is missing (Short communication)
Pages: 712-713
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SHORT COMMUNICATION
Efficacy of Trimodality Therapy for Pretibial Myxoedema: A Case Series of 20 Patients
Xiaoying Chen, Xiaoqing Zhao, Xia Li, Ruofei Shi, Jie Zheng
Abstract is missing (Short communication)
Pages: 714-715
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SHORT COMMUNICATION
Long-term Follow-up of Longitudinal Melanonychia in Children and Adolescents Using an Objective Discrimination Index
Hiroshi Koga, Shunji Yoshikawa, Tetsuhiro Shinohara, Frédérique-Anne Le Gal, Begonia Cortés, Toshiaki Saida, Takayuki Sota
Abstract is missing (Short communication)
Pages: 716-717
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SHORT COMMUNICATION
Clinical and Pathological Aspects of Melanoma among Children in Finland
Emma Rousi, Ilkka Koskivuo, Outi Kaarela, Minna Kääriäinen, Veli-Matti Kähäri
Abstract is missing (Short communication)
Pages: 718-720
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ERRATUM
Erratum
Alrun Hotz, Vinzenz Oji, Emmanuelle Bourrat, Nathalie Jonca, Juliette Mazereeuw-Hautier, Regina C. Betz, Ulrike Blume-Peytavi, Karola Stieler, Fanny Morice-Picard, Ines Schönbuchner, Susanne Markus, Nina Schlipf, Judith Fischer
Abstract is missing (Erratum)
Page: 720
Abstract  PDF