Content - Volume 62, Issue 6

All articles

Corneocyte morphology and formation rate in lichen planus and experimental parakeratosis in subjects with and without psoriasis
Johannesson A, Hammar H.
In a recent paper changes in corneocyte morphology and formation rate in psoriasis have been established. In the present study the specificity of these alternations were analysed in two situations. Early lichen planus papules were chosen as a model of hyperproliferation with hypergranulosis and orthohyperkeratosis. Hyperproliferation with parakeratosis was induced by nonanoic acid (CH3(CH2)7COOH) ...
Pages: 463-470
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The inhibitory effect of zinc pyrithione on the epidermal proliferation of animal skins
Imokawa G, Okamoto K.
The hypothesis that zinc pyrithione, a highly active anti-dandruff agent, exerts an anti-biosynthetic effect and reduces the epidermal turnover has been tested using guinea pig and hairless mouse skins. It has been found that enhanced mitosis caused by both stripping off the horny layers and sodium dodecyl sulphate, could be suppressed by approximately 50% by the topical application of zinc pyrith ...
Pages: 471-475
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Subpopulations of mononuclear cells in lesions of psoriasis, lichen planus and discoid lupus erythematosus studied using monoclonal antibodies
Bjerke JR.
Mononuclear cells in skin lesions were characterized using an indirect immunofluorescence test with monoclonal antibodies. Most cells in the dermal infiltrates were stained with OKT3 (pan T cell) antibodies and with OKT4 (helper/inducer T cell) antibodies. Fewer cells were stained with OKT8 (suppressor/cytotoxic T cell) antibodies. Results obtained using a double marking technique with monoclonal ...
Pages: 477-483
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T lymphocyte subsets in the duodenal epithelium in dermatitis herpetiformis
Ljunghall K, Lööf L, Forsum U.
Monoclonal antibodies to human T lymphocyte subsets and HLA-DR antigens were used to characterize the intra-epithelial T lymphocytes and HLA-DR reactive cells in the duodenal epithelium in dermatitis herpetiformis (DH). The expression of HLA-DR antigens on the epithelial cells was similar in patients and controls. There were significantly more Leu 2a (suppressor/ cytotoxic phenotype) reactive cell ...
Pages: 485-489
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Pemphigus: an epidemiological study of patients treated in Finnish hospitals between 1969 and 1978
Hietanen J, Salo OP.
Between 1969 and 1978, 44 pemphigus (p.) patients were treated in Finnish hospitals. The number of new cases was 36, giving an annual incidence of 0.76 cases per million inhabitants. The male/female ratio was 0.9:1. Nine patients had p. vulgaris (; one p. vegetans (; 9, p. foliaceus (; 22, p. erythematodes (; and 3, p.NUD (p.NUD). One patient with also had myasthenia ...
Pages: 491-496
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Puva photohyposensitization in polymorphous light eruptions: evaluation of systemic immunological factors
Karvonen J, Viander M, Ilonen J, Jansén CT.
Systemic immunological parameters were monitored in 26 polymorphous light eruption (PMLE) patients prior to, during and after photochemotherapy by either an oral or topical (bath) regimen. Pre-therapy investigations showed a normal immune status as regards the numbers of peripheral T-cells as well as the response of peripheral blood lymphocytes to PHA, ConA and PPD. Measurement of the immunologica ...
Pages: 497-500
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Ophthalmological study of patients undergoing long-term PUVA therapy
Rönnerfält L, Lydahl E, Wennersten G, Jahnberg P, Thyresson-Hök M.
In the present study 46 patients with severe psoriasis maintained on long-term PUVA therapy have been followed up to 6 1/2 years after the initiation of treatment. Repeated ophthalmological examinations were performed in order to detect any early sign of lens changes. No ocular side effects attributed to the photochemotherapy were revealed during this period. Continued use of appropriate eye shiel ...
Pages: 501-505
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Is UVB treatment of psoriasis safe? A study of extensively UVB-treated psoriasis patients compared with a matched control group
Larkö O, Swanbeck G.
The aim of the study was to investigate whether or not extensively UVB-treated psoriatics ran a greater risk of developing skin cancer than did controls. The 85 most extensively UVB-treated psoriasis patients during recent decades have been investigated with regard to premalignant and malignant skin lesions and compared with a population matched for age, sex, and geographic region. The prevalence ...
Pages: 507-512
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Diurnal fluctuations of cell kinetic parameters in the epidermis and the sebaceous gland of the hamster ear
Wirth H, Spannagel M, Gloor M.
By using the colcemid method, the presence of a diurnal variation for the mitosis index was confirmed, showing a definite minimum during the night in the sebaceous gland of the Syrian hamster ear. Furthermore, the number of all labelled cells and the quotient "single-labelled 14C-cells + double-labelled cells/single-labelled 3H-cells" determined with double-labelling autoradiography ([3H] and [14C ...
Pages: 514-516
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Immunofluorescence studies on complement components in lichen amyloidosus
Sudo S, Igarashi R, Morohashi M.
Immunofluorescence studies were carried out in 7 cases of lichen amyloidosus, chiefly to detect deposition of complement components in the cutaneous lesions. Examination of skin biopsy specimens revealed deposition of Clq, C3, C9 and IgM in all the patients studied. Complement and immunoglobulin levels by assays of simultaneously obtained serum samples were found to be almost within the normal lim ...
Pages: 516-519
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Lymphocytotoxic autoantibodies in pemphigus and systemic lupus erythematosus
Furukawa F, Imamura S, Inoue S, Yoshida H, Hamashima Y.
Lymphocytotoxic autoantibody (LCTA) was studied in 9 patients with active pemphigus and 19 patients with active systemic lupus erythematosus (SLE). All patients with SLE showed high titres of LCTA but only one patient with pemphigus had LCTA. In this paper we discuss the immunological significance of LCTA and the difference in the incidence of LCTA between pemphigus and SLE. In addition we present ...
Pages: 519-521
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Leukoderma syphiliticum: ultrastructural observations on melanocyte function
Frithz A, Lagerholm B, Kaaman T.
A case of genital leukoderma syphiliticum was analysed submicroscopically. No treponema pallidum organisms could be detected intra- or extracellularly in the epidermis or in the dermis. The melanocytes were only slightly reduced in number and had mostly normal outlines. The melanogenesis was impaired and small melanosomes with decreased deposition of melanin were mostly produced at the expense of ...
Pages: 521-525
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Sensitization to cobalt associated with nickel allergy: clinical and statistical studies
van Joost T, van Everdingen JJ.
In 76 cases (5.8%) of a population of 1310 cases (examined by patch tests for possible contact dermatitis) a combined (coupled) allergy was found to nickel and cobalt. In 37 out of the 76 cases this combined allergy was associated with clinical dermatitis of the hands. Statistical chi-square analysis revealed that in the original population of patients examined, apart from a strong association bet ...
Pages: 525-529
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Transient lymphomatoid papulosis in mycosis fungoides
Aronsson A, Jonsson N, Tegner E.
During PUVA treatment a 66-year-old woman with mycosis fungoides in stage III suddenly developed widespread papulonodular lesions of alarming clinical and histological appearance. There was rapid spontaneous and complete regression of the eruptions, which was probably an expression of transient lymphomatoid papulosis in connection with MF.
Pages: 529-531
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Actinic granulomas and relapsing polychondritis
Pierard GE, Henrijean A, Foidart JM, Lapiere CM.
A patient developed concomitantly chondritis of the two auricles, diffuse cutaneous vasculitis and actinic granulomas. Alterations in skin and cartilage were prominent in the elastic tissue. Anticollagen type II antibodies were absent from the serum and there was no deposit of immunoreactants in cartilages. In this form of relapsing polychondritis, the pathomechanism resembles that of diffuse acti ...
Pages: 531-533
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Pemphigus foliaceus in a haemophilic child: cytomegalovirus induction?
Ruocco V, Rossi A, Satriano RA, Sacerdoti G, Astarita C, Pisani M.
A 3 1/2-year-old haemophilic child, repeatedly transfused with blood products, developed pemphigus foliaceus with presence in serum of both intercellular and anti-cytomegalovirus antibodies at high titre. The locus A26, which seems to be a genetic marker of pemphigus, was detected in his haplotype. Cytomegalovirus infection of transfusional origin is suspected to have triggered the outbreak of pem ...
Pages: 534-537
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Multiple comedones confined to xanthelasma
Tsuji T, Furukawa M, Soejima R, Hamada T.
No abstract available.
Pages: 537-539
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The changing clinical picture of Microsporum canis infections in Sweden
Emtestam L, Kaaman T.
All 22 cases of infections with Microsporum canis verified by culture during a five-year period were surveyed. Only tinea corporis was found. The clinical picture was varied and in more than half of the cases the preliminary diagnosis was other than tinea. The classical tinea capitis was not found in any case. Direct KOH-mounts showed poor correlation to the cultural findings (positive in 33%). It ...
Pages: 539-541
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"Herpetiform eruption with leukocytoclasis" = Sweet´s Syndrome?
M Harms, P Chavaz, J H Saurat
No abstract available.
Page: 542
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