Content - Volume 68, Issue 4

All articles

The water barrier function of the skin in relation to the water content of stratum corneum, pH and skin lipids. The effect of alkaline soap and syndet on dry skin in elderly, non-atopic patients
Thune P, Nilsen T, Hanstad IK, Gustavsen T, Lövig Dahl H.
Clinical dryness of the skin is a common problem among elderly, dermatological patients. In the present investigation, hydration, surface lipids, skin pH and water barrier function as expressed by the transepidermal water loss (TEWL) were studied in both dry and normal skin. Using these parameters, a comparison of the local effects of acid and alkaline cleansing products was made. In non-atopic el ...
Pages: 277-283
Abstract  PDF
Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss
Blichmann CW, Serup J.
Experiments on skin moisture, i.e. the hydration state of the outer epidermis, were undertaken using three different types of equipment, i.e. the Skicon-100 and Corneometer CM 420 hydrometers and the Servo Med EPI evaporimeter. The studies included 10 healthy volunteers. Water was applied to test sites on the forearm and the palm of the hand, and effects monitored by the three methods. Parallel in ...
Pages: 284-290
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UV irradiation and topical vitamin A modulate retinol esterification in hairless mouse epidermis
Törmä H, Berne B, Vahlquist A.
The formation of fatty acyl esters of retinol, the major form of vitamin A in epidermis, is catalysed by microsomal enzymes. To study the regulation of retinol esterification, we exposed hairless mice to ultraviolet (UV) irradiation which destroys vitamin A and to topical retinol treatment. Vitamin A (retinol and retinyl esters) in serum and epidermis was analysed by high-performance liquid chroma ...
Pages: 291-299
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Serum lipid changes during acitretin (etretin) treatment of psoriasis and palmo-plantar pustulosis
Vahlquist C, Selinus I, Vessby B.
The effects of acitretin (free acid of etretinate) on the serum lipoprotein pattern and on the fat elimination in serum of 8 patients with psoriasis and 4 with palmo-plantar pustulosis were studied. The drug was given for 12 weeks; the average daily dose was 40 mg. Lipoprotein analyses and an intravenous fat tolerance test (IVFTT) were performed on three occasions (before, after 8 weeks´ treatmen ...
Pages: 300-305
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Fc gamma-receptors and HLA-DR antigens on endothelial cells in psoriatic skin lesions
Bjerke JR, Livden JK, Matre R.
Receptors for the Fc-part of IgG (FcR) and HLA-DR antigens on endothelial cells in normal and lesional skin from patients with psoriasis were studied in cryostat sections, using soluble immune complexes and monoclonal antibodies. FcR and HLA-DR antigens were detected on endothelial cells of dermal vessels both in sections of normal and lesional skin. The expression of FcR varied from one vessel to ...
Pages: 306-311
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Plasma melatonin levels in psoriasis
Mozzanica N, Tadini G, Radaelli A, Negri M, Pigatto P, Morelli M, Frigerio U, Finzi A, Esposti G, Rossi D, et al.
Melatonin is synthesized and secreted by the pineal gland. A daily rhythm of melatonin secretion, with high plasma values during the dark period, has been found in all vertebrates studied so far. In psoriatics, several hormones, including GH and prolactin, have altered chronobiology, and some studies in humans suggest that melatonin affects the levels of GH and prolactin. We investigated circadian ...
Pages: 312-316
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Metal allergy in cashiers. An in vitro and in vivo study for the presence of metal allergy
Gilboa R, Al-Tawil NG, Marcusson JA.
Thirty healthy cashiers continuously exposed to nickel in coins were tested in vivo and in vitro for the presence of metal contact allergy. A traditional epicutaneous test and lymphocyte transformation test were used. We tested for nickel, cobalt and chromium sensitivity. Seven of the 30 cashiers were patch test positive and 3 were in vitro positive to nickel sulphate. Two were in vivo positive to ...
Pages: 317-324
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Eosinophilic cellulitis: five cases
Lindskov R, Illum N, Weismann K, Thomsen OF.
Five cases of eosinophilic cellulitis or Wells´ syndrome are described. While only few children have been included in earlier reports, 4 of the 5 patients in the present paper were below 10 years of age, with the youngest being only 20 months when the disease started. One of the children developed hard and tender subcutaneous swellings on the scalp, the histology of which showed extensive subcuta ...
Pages: 325-330
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Percutaneous absorption of hydrocortisone during exacerbation and remission of atopic dermatitis in adults
Turpeinen M, Mashkilleyson N, Björkstén F, Salo OP.
Percutaneous absorption of hydrocortisone was studied in 18 young adults during and after the acute phase of atopic dermatitis using the direct hydrocortisone absorption test. In the acute phase the post-application increase in serum cortisol concentration ranged between 18 and 711 nmol/l (median 125 nmol/l). In remission the increase in serum cortisol ranged between 0 and 114 nmol/l (median 16 nm ...
Pages: 331-335
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Prognosis and atopic background of juvenile plantar dermatosis and gluteo-femoral eczema
Svensson A.
A 10-year follow-up of patients with juvenile plantar dermatosis and gluteo-femoral eczema disclosed a worse prognosis than previously assumed, with a course in some cases protracted into adult age. The presence of atopy was established with a clinical point score system. It was found that 52% of the patients with juvenile plantar dermatosis and 80% of those with gluteo-femoral eczema were atopic. ...
Pages: 336-340
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Hyperkeratosis lenticularis perstans (Flegel´s disease). In situ characterization of T cell subsets and Langerhans´ cells
Büchner SA.
We report a patient with hyperkeratosis lenticularis perstans (HLP) manifesting as multiple reddish-brown hyperkeratotic papules on the lower extremities. Typical histologic features of HLP include hyperkeratosis, thinning or absence of the granular layer and a band-like infiltrate in the upper dermis underlying an atrophic epidermis. In order to determine the cellular composition of the infiltrat ...
Pages: 341-345
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Punctate palmoplantar keratoderma associated with morbus Bechterew and HLA B 27. A family study
Gamborg Nielsen P.
Four patients in a family with punctate palmoplantar keratoderma (Buschke-Fischer) associated with Morbus Bechterew and HLA B 27 in 3 of the family members are reported. Without severe side effect, the proband was successfully treated with 50 mg etretinate per day for 6 weeks.
Pages: 346-350
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Acne fulminans with bone lesions
Pauli SL, Kokko ML, Suhonen R, Reunala T.
We present 5 young men who developed acne fulminans. During the acute, febrile illness, all had musculoskeletal symptoms, and X-ray and bone scan examinations revealed that 4 of the patients had osteolytic bone lesions. The disease was resistant to various antibiotics and one patient needed surgical trepanation of the sternum. No evidence of sepsis or bacterial osteomyelitis was found, as all bact ...
Pages: 351-355
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Paraffin section light-chain immunostaining of large-cell lymphocytoma
Winkelmann RK, Banks PM.
Sixteen biopsy specimens from 11 patients with cutaneous large-cell lymphocytoma were studied by a peroxidase method using monospecific antisera to kappa and lambda Ig light chains. Five specimens had polyclonal presence of both kappa and lambda chains. Four specimens were graded as devoid of immunoreactivity, and eight were graded as non-specific because the albumin control staining was as intens ...
Pages: 356-358
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Electron microscopy of tubuloreticular structures in allergic patch test. Observations with 2,3-epoxypropyl trimethyl ammonium chloride
Kanerva L.
Tubuloreticular structures (TRS) are intracellular tubular inclusions that can be detected by means of electron microscopy. TRS have earlier been found in autoimmune, viral and neoplastic diseases. Here the occurrence of TRS is for the first time described in allergic patch tests, where they were detected in dermal macrophages. TRS are believed to be reaction products of metabolically active cells ...
Pages: 359-361
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Patch testing with nickel sulphate under occlusion for five hours
Bruze M.
Routine patch testing is usually performed with the allergens under occlusion for 48 h, but a shorter occlusion time would of course be more convenient for the patient. In this study, nickel was chosen as the substance with which to investigate whether routine patch testing with allergen exposure for 5 h is possible. Patch testing, using dilutions of nickel sulphate under occlusion for 48 h and 5 ...
Pages: 361-364
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Skin blood flow in necrobiosis lipoidica during treatment with low-dose acetylsalicylic acid
Beck HI, Bjerring P.
Skin blood flow was measured by the laser Doppler technique in lesional and clinically normal skin of 10 diabetic patients with necrobiosis lipoidica during and after treatment with 40 mg acetylsalicylic acid (ASA) daily. The measurements showed that the blood flow during ASA treatment was significantly decreased in the central lesional skin without changes in the peripheral part of the lesions an ...
Pages: 364-365
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Proliferation of Merkel cells in the skin
Merot Y, Saurat JH.
No Abstract is available
Pages: 366-367
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Skin tags are more closely related to fasting insulin than fasting glucose levels
Norris PG, McFadden J, Gale E, Griffiths WA.
No Abstract is available
Pages: 367-368
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