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Content - Volume 77, Issue 2

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Three-dimensional demonstration of melanocyte distribution of human hair follicles: special reference to the bulge area.
Narisawa Y, Kohda H, Tanaka T.
Melanocytes of human hair follicles were histochemically and immunohistochemically examined in two and three dimensions. EDTA-treated extracted anagen vellus and intermediate hair follicles showed that monoclonal murine antibody (MoAb) NKI/ beteb-reactive melanocytes were distributed from the infundibulum to the bulb. Melanocytes of the infundibulum and bulb were larger and more strongly stained w ...
Pages: 97-101
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Influence of epidermal permeability barrier disruption and Langerhans' cell density on allergic contact dermatitis.
Proksch E, Brasch J.
Previously, we have showed that artificial epidermal permeability barrier disruption leads to an increase in epidermal Langerhans' cell (LC) density within 24 h. We now asked if this is accompanied by an enhancement of allergic contact dermatitis. Barrier disruption was induced by acetone on the upper arms in 6 volunteers with known sensitization to nickel, fragrance mix, or p-phenylenediamine. Tw ...
Pages: 102-104
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Altered distribution of heparan sulfate proteoglycans in psoriasis
Seyger MM, van den Born J, Schalkwijk J, van de Kerkhof PC, de Jong EM
Heparan sulfate proteoglycans (HSPGs) are components of the basement membrane (BM) of various tissues. They consist of a core protein and negatively charged glycosaminoglycan side chains: the heparan sulfate (HS) moieties. In psoriasis, uninvolved skin of psoriasis patients and in normal skin, the distribution of HSPGs was studied immunohistochemically by means of three different monoclonal antibo ...
Pages: 105-109
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Effect of data normalization for age on the correlations between corneometric values and serum molecule levels in plaque-type psoriatic patients.
Carducci M, Mussi A, Bonifati C, Pietravalle M, Alemanno L, Fazio M, Ameglio F.
Corneometry has been considered useful both to evaluate disease severity and to monitor psoriatic patients during treatment. However, a limitation of this technique is that the patient's age influences the corneometric determinations, thus reducing their clinical usefulness. The aim of this study was, therefore, to establish whether age normalization of the corneometric results may provide more re ...
Pages: 110-114
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Comparative nuclear morphometric analysis of aggressive and non-aggressive squamous cell carcinomas of the skin.
Narvaez D, Kanitakis J, Euvrard S, Schmitt D, Faure M, Claudy A.
Squamous cell carcinomas (SCC) are the most frequent tumours complicating organ transplantation. Whereas most SCC can be successfully treated with conventional surgery, other lesions show an aggressive course with recurrence and metastases. We assessed the value of nuclear morphometry in detecting tumours with an ab initio potential for aggressive course. Nuclear perimeter, area, feret X and feret ...
Pages: 115-117
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DNA-ploidy abnormalities are a reflection of the metastatic potential of malignant melanoma. Microfluorometric DNA analysis
Umebayashi Y, Otsuka F.
Using DAPI (4',6-diamidino-2-phenylindole)-DNA microfluorometry, we examined the nuclear DNA-ploidy abnormalities of 15 primary malignant melanomas and their 20 corresponding metastases. They all presented the aneuploid DNA histographic pattern. When the DNA index value was calculated as the reflection of DNA-ploidy abnormalities, it was found to be significantly higher in the metastases (2.07 +/- ...
Pages: 118-121
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Light and electron microscopic findings in human epidermis reconstructed in vitro upon topical application of liposomal tretinoin
Schaller M, Steinle R, Korting HC.
The topical application of tretinoin is a well-established approach to the treatment of acne vulgaris. However, induced inflammation, clinically addressed as a "flare-up", is a major drawback. Recently, clinical and experimental investigations have hinted at a better tolerability, with equal efficacy, if the active compound is liposomally encapsulated. Using epidermis reconstructed in vitro, we co ...
Pages: 122-126
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Two hydrocolloid dressings evaluated in experimental full-thickness wounds in the skin.
Agren MS, Everland H.
Hydrocolloid occlusive dressings are beneficial in wound management in many respects, although the adhesive matrix may disintegrate when in contact with wounds. The purpose of this study was to determine: (1) if material from two hydrocolloid dressings-Comfeel and Duoderm-showing differences in adhesive cohesion, can be chemically identified in granulation tissue; and (2) if the presence of this m ...
Pages: 127-131
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Effect of ketoconazole 2% shampoo on scalp sebum level in patients with seborrhoeic dermatitis.
Dobrev H, Zissova L.
Twenty patients with scalp seborrhoeic dermatitis were treated twice weekly with ketoconazole 2% shampoo for 4 weeks. Clinical assessment, culture for P. ovale on Dixon broth and lipid measurement at two places were made before treatment and after 2 and 4 weeks. Significant improvement of the severity of seborrhoeic dermatitis (p < 0.001) and negative mycological tests by 19 (95%) of patients were ...
Pages: 132-134
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Melanosis naeviformis of Becker and scoliosis: a coincidence?
Maessen-Visch MB, Hulsmans RF, Hulsmans FJ, Neumann HA.
Melanosis naeviformis of Becker (MNB) can be associated with hypoplasia of soft tissue or extremities, spina bifida and scoliosis of the vertebral column. We have investigated 50 patients (42 men, 8 women) with MNB radiologically. Scoliosis was diagnosed in 13 patients (26%). The curves of scoliosis varied from 11 degrees to 17 degrees. Physical examination revealed no gross asymmetries of the tru ...
Pages: 135-136
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Low-dose (1.25 mg/kg) cyclosporin A: treatment of psoriasis and investigation of the influence on lipid profile
Meffert H, Bräutigam M, Färber L, Weidinger G.
This study was designed to investigate the therapeutical efficacy of a comparatively low dose cyclosporin A (1.25 mg/kg/day) in the treatment of psoriasis and to assess the influence of cyclosporin A on lipid profiles. In the first, double-blind part of the study, 133 patients with moderate to severe psoriasis were randomized to receive a daily dose of 1.25 or 2.5 mg cyclosporin A/kg or placebo fo ...
Pages: 137-141
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Sebum and water content in the skin of aged immobilized patients.
Aisen E, Shafran A, Gilhar A.
In the present study we investigated the sebum content and hydration of the skin in aged immobilized patients. Healthy aged as well as young and aged immobilized patients were evaluated by photometry, using a sebum tester and capacitance meter to detect sebum and hydration, respectively, in various skin areas. Sebum content was significantly higher in the young groups as compared to the aged ones, ...
Pages: 142-143
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Efficacy of pinch grafting in leg ulcers of different aetiologies.
Ahnlide I, Bjellerup M.
The prevalence of leg ulcer disease is high and the health care costs are extensive. Effective therapy is essential to minimise the health care costs and suffering on the part of the patient. If possible, first and foremost, therapy should be aimed at correcting the underlying aetiological defect causing the ulcer. After this has been considered, one of the local therapeutic options is skin grafti ...
Pages: 144-145
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Cutaneous necrosis associated with recombinant interferon injection. Report of three cases with interferon beta-1b and review of the literature
Weinberg JM, Wolfe JT, Sood S, Saruk M, Rook AH, Spiers EM
Interferons are cytokines produced by cells in response to stimulation by certain antigens and infectious agents. In recent years, recombinant interferons have been developed, which have antiviral, antiproliferative, and immunomodulatory functions. Several cutaneous reactions have been reported, including cutaneous ulceration at injection sites. We now report three cases of cutaneous ulceration ca ...
Pages: 146-148
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Patch testing with markers of fragrance contact allergy. Do clinical tests correspond to patients' self-reported problems?
Johansen JD, Andersen TF, Veien N, Avnstorp C, Andersen KE, Menné T.
The aim of the present study was to investigate the relationship between patients' own recognition of skin problems using consumer products and the results of patch testing with markers of fragrance sensitization. Eight hundred and eighty-four consecutive eczema patients, 18-69 years of age, filled in a questionnaire prior to patch testing with the European standard series. The questionnaire conta ...
Pages: 149-153
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A controlled trial of acupuncture in psoriasis: no convincing effect
Jerner B, Skogh M, Vahlquist A.
Several uncontrolled studies have suggested that acupuncture is an effective treatment for psoriasis. To test this hypothesis, 56 patients suffering from long-standing plaque psoriasis were randomized to receive either active treatment (electrostimulation by needles placed intramuscularly, plus ear-acupuncture) or placebo (sham, 'minimal acupuncture') twice weekly for 10 weeks. The severity of the ...
Pages: 154-156
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Localized bullous pemphigoid after radiation therapy: two cases.
Ohata C, Shirabe H, Takagi K, Kawatsu T, Hashimoto T.
No abstract available.
Pages: 157-157
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The effect of topical capsaicin on substance P immunoreactivity: a clinical trial and immunohistochemical analysis
Munn SE, Burrows NP, Abadia-Molina F, Springall DR, Polak JM, Russell Jones R.
No abstract available.
Pages: 158-159
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Scleredema adultorum associated with anaphylactoid purpura
Okuyama R, Tagami H.
No abstract available.
Pages: 159-159
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Linear steatocystoma multiplex
D'Souza P, Joshi A, Gujral S, Ramam M.
No abstract available.
Pages: 161-161
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Familial pityriasis rotunda.
Guberman D, Lichtenstein DA, Gilead L, Vardy DA, Klaus SN.
No abstract available.
Pages: 162-162
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Lentigo maligna treated with ruby laser
Thissen M, Westerhof W.
No abstract available.
Pages: 163-163
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Hyperpigmentation of the flexures and pancytopenia during treatment with folate antagonists
Jucgla A, Sais G, Berlanga J, Servitje O.
No abstract available.
Pages: 165-166
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Increased concentrations of plasma endothelin-1 and fibronectin in psoriasis
Yildiz L, Akçay F, Aktas A, Yildiz F, Sahin YN.
No abstract available.
Pages: 166-167
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Spontaneous photo-onycholysis in a West Indian with type V skin
Baran R, Jeanmougin M, Cesarini JP.
No abstract available.
Pages: 169-170
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Scedosporium apiospermum skin infection in a patient with nephrotic syndrome
Ichikawa T, Saiki M, Tokunaga S, Saida T.
No abstract available.
Pages: 172-173
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Argas reflexus (the pigeon tick) – a household pest
Thewes M, Engst R, Hofmann H, Ring J.
No abstract available.
Pages: 173-174
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