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Content - Volume 77, Issue 4

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Minocycline induces an increase in the number of excreting pilosebaceous follicles in acne vulgaris. A randomised study
Bodokh I, Jacomet Y, Lacour JP, Ortonne JP
The effects of treatment with minocycline 100 mg per day on sebaceous excretion in acne vulgaris using lipometry and Sebutape were studied in 45 patients in an open study as well as in a randomised placebo-controlled study. In both studies a subclinical increase in sebaceous excretion was noted from the 28th day of treatment. This effect continued for 1 month after the end of treatment. The increa ...
Pages: 255-259
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Substance P binding to peripheral blood mononuclear leukocytes in atopic dermatitis.
Ostlere LS, Gordon DJ, Ayliffe MJ, Rustin MH, Pereira RS, Holden CA.
Substance P has various immunomodulatory effects, including in vitro modification of lymphocyte proliferation and cytokine release. Elevated levels of substance P and increased staining of substance P-positive nerve fibres have been reported in atopic dermatitis patients. We examined fluoresceinated substance P binding to a range of lymphocyte subsets and compared the results in atopic dermatitis, ...
Pages: 260-263
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Terpene-enhanced transdermal permeation of water and ethanol in human epidermis
Magnusson BM, Runn P, Koskinen LO.
The study was performed to investigate the effect of penetration enhancers on the stratum corneum barrier. Epidermal membranes were prepared from freeze-stored (-70 degrees C) Caucasian breast skin and mounted in a flow-through diffusion cell. The validity of the freeze storage procedure was verified by measurement of [3H]-water penetration. The effect of the cyclic terpene, carveol, on the transd ...
Pages: 264-267
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Topical calcitriol (1,25-dihydroxyvitamin D3) treatment of psoriasis: an immunohistological evaluation
Reichrath J, Perez A, Müller SM, Chen TC, Kerber A, Bahmer FA, Holick MF.
The potent calciotropic hormone calcitriol (1,25-dihydroxyvitamin D3, 1,25(OH)2D3) has been shown to be very effective and safe in the topical treatment of psoriasis. In vitro, 1,25(OH)2D3 inhibits proliferation and stimulates differentiation of human keratinocytes. Increasing evidence suggests an immunoregulatory function of this potent steroid hormone. To further characterize the biological effe ...
Pages: 268-272
Abstract  PDF
Evidence that HLA-Cw6 determines early onset of psoriasis, obtained using sequence-specific primers (PCR-SSP)
Enerbäck C, Martinsson T, Inerot A, Wahlström J, Enlund F, Yhr M, Swanbeck G.
Psoriasis vulgaris has previously been shown to associate with certain HLA alleles. HLA-Cw6 is considered to be the primary association, based on calculations of relative risk after serological typing. This association is reportedly more pronounced in early- than in late-onset psoriasis. We performed a PCR-based typing with sequence-specific primers, which has been shown to give a more complete re ...
Pages: 273-276
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Dominant dystrophic epidermolysis bullosa albopapuloidea Pasini -- ultrastructural observations of albopapuloid lesions and a type VII collagen DNA polymorphism study of a family
Nomura K, Umeki K, Sawamura D, Hashimoto I.
We describe a case of dominant dystrophic epidermolysis bullosa (DDEB) albopapuloidea Pasini. The patient was a 42-year-old female with albopapuloid lesions on her back, which had developed when she was 17. Histological examination of the albopapuloid lesions showed prominent proliferation of immature collagen bundles and deposition of amorphous material, which stained positively with Alcian blue. ...
Pages: 277-280
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Insulin inhibits tyrosinase activity and 5-S-cysteinyldopa formation in human melanoma cells
Benathan M, Labidi F.
The effects of insulin on melanogenesis were examined in human Swift melanoma cells. When these cells were grown in a chemically defined culture medium containing insulin (5 microg/ml), they showed a low pigmentation in association with a high activity of glutathione peroxidase (GPO) and a low activity of tyrosinase. In Eagle's minimum essential medium supplemented with foetal calf serum (EMEM-FCS ...
Pages: 281-284
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Cutaneous adverse reaction to ciprofloxacin: demonstration of specific lymphocyte proliferation and cross-reactivity to ofloxacin in vitro.
Rönnau AC, Sachs B, von Schmiedeberg S, Hunzelmann N, Ruzicka T, Gleichmann E, Schuppe HC.
Ciprofloxacin (CPFX) is a widely used fluoroquinolone antibiotic, inducing cutaneous adverse drug reactions in about 1 to 2% of the treated patients. Conclusive diagnosis of drug allergy, however, still remains a major problem in daily clinical practice. Here, we present 2 patients with drug allergy to CPFX. In both cases the clinical suspicion for CPFX as the causative agent was confirmed in vitr ...
Pages: 285-288
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Paraneoplastic pemphigus associated with pancreatic carcinoma
Matz H, Milner Y, Frusic-Zlotkin M, Brenner S.
A case of paraneoplastic pemphigus associated with pancreatic carcinoma is presented. The histopathological and immunological features of the case, which are consistent with and differ from the accepted diagnostic criteria, are discussed.
Pages: 289-291
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Rapid cytological diagnosis of primary skin tumours and tumour-like conditions
Daskalopoulou D, Gourgiotou K, Thodou E, Vaida S, Markidou S.
This study presents the results of fine needle aspiration cytology performed on 1,263 skin lesions which were clinically suspicious for neoplasia. The purpose of the study was to investigate the accuracy of fine needle aspiration cytology for the diagnosis of skin tumours and to assess its clinical value. Twenty-one to 27 Gauge needles were used and the specimens were stained by a quick Giemsa sta ...
Pages: 292-295
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Stress and alopecia areata: a psychodermatologic study
Gupta MA, Gupta AK, Watteel GN.
Psychosocial stress has been reported to play a role in the onset and/or exacerbation of alopecia areata. Little is known about the clinical characteristics of alopecia areata patients whose alopecia is stress-reactive. We examined the relation between the stress reactivity of alopecia areata and a wide range of psychosocial measures among 16 patients with alopecia areata/totalis and 28 patients w ...
Pages: 296-298
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No evidence for Borrelia burgdorferi infection in lesions of morphea and lichen sclerosus et atrophicus in Spain. A prospective study and literature review
Alonso-Llamazares J, Persing DH, Anda P, Gibson LE, Rutledge BJ, Iglesias L.
The possible association of Borrelia burgdorferi with morphea and lichen sclerosus et atrophicus has been the focus of research and discussion in dermatology during the last 10 years. To investigate the etiopathogenic role of B. burgdorferi in morphea and lichen sclerosus et atrophicus lesions in Spain, we studied 14 cases: 8 patients with lichen sclerosus et atrophicus and 6 with morphea. For the ...
Pages: 299-304
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Markers in cutaneous lupus erythematosus indicating systemic involvement. A multicenter study on 296 patients
Tebbe B, Mansmann U, Wollina U, Auer-Grumbach P, Licht-Mbalyohere A, Arensmeier M, Orfanos CE.
Lupus erythematosus (LE) is an autoimmune disorder, involving the skin and/or other internal organs. As cutaneous variants, chronic discoid LE (CDLE) and subacute cutaneous LE (SCLE) usually have a better prognosis, however, involvement of internal organs with transition into systemic disease may occur. The aim of this study was to assess the significance of some clinical and laboratory criteria t ...
Pages: 305-308
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Refractory ulcerative lupus vulgaris associated with CD4 lymphocytopenia, inversion of chromosome 14, primary amenorrhoea and mental retardation
Ozarmagan G, Ozgüroglu EZ, Maden MU, Oztürk S.
A case of ulcerative lupus vulgaris, confirmed by polymerase chain reaction (PCR) is reported. The initial lesion of our case was a papule on the nose, which progressed during antituberculous treatment and caused cartilage destruction and ectropion. Immunological analysis revealed CD4 lymphocytopenia, and the possibility of idiopathic CD4 lymphocyte deficiency was considered. In addition, the pati ...
Pages: 309-310
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Low-frequency ultrasound treatment of chronic venous leg ulcers in an outpatient therapy
Peschen M, Weichenthal M, Schöpf E, Vanscheidt W.
Low-dose ultrasound seems to be an effective method to enhance wound healing, particularly in chronic venous leg ulcers. The aim of our investigation was to examine the effect of 30 kHz low-dose ultrasound in local treatment of chronic venous leg ulcers, when added to conventional therapy of outpatients. Twenty-four patients with chronic ulcerations of the leg due to chronic venous insufficiency w ...
Pages: 311-314
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Effect of ebastine on mosquito bites
Reunala T, Brummer-Korvenkontio H, Petman L, Palosuo T, Sarna S.
Mosquito bites usually cause wealing and delayed bite papules. Cetirizine decreases wealing, bite papules and pruritus but the effect of other antihistamines on mosquito bites is unknown. We studied the effect of ebastine in 30 mosquito bite-sensitive adult subjects. Ebastine 10 mg or 20 mg and placebo were given for 4 days in a cross-over fashion. Aedes aegypti bites were given on forearms. The s ...
Pages: 315-316
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Semi-quantitative measurements of body hair in hirsute women compare well with direct diameter measurements of hair shafts
Barth JH.
No standards exist for the evaluation of hair in hirsute women. This study compared the semi-quantitative visual scoring of body hair, using the Ferriman & Gallwey scale, in 88 hirsute women with direct objective measurements of hair shaft diameter and daily linear growth rates of hair growing on the pre-auricular area of the face, the forearm, the anterior abdominal wall and the anterior thigh. T ...
Pages: 317-318
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Is vulvar vestibulitis an inflammatory condition? A comparison of histological findings in affected and healthy women
Lundqvist EN, Hofer PA, Olofsson JI, Sjöberg I.
Vulvar vestibulitis, as defined by Friedrich, is considered to be inflammatory, despite the fact that the normal histology of this specific area has previously not been characterized. The aim of the present study was to compare the normal histology of the vulvar vestibulum with findings in localized vulvar vestibulitis. Biopsies were taken at the area of the vestibulitis, i.e. at the openings of t ...
Pages: 319-322
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Urticaria-like follicular mucinosis in a young female patient.
Tupker RA, van der Meer JB, Groote AD, Hartman A, Elema JD, de Jong MC, Starink TM.
No Abstract available
Pages: 323-324
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Cutaneous leukocytoclastic vasculitis in a case of ankylosing spondylitis
Machet L, Jan V, Ouakil H, Vaillant L, Estève E, Lorette G.
No abstract available
Page: 324
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Substance P is not involved in primary and secondary erythermalgia
Drenth JP, Michiels JJ, Van Joost T.
No abstract available
Pages: 325-326
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Localized crusted scabies in a patient with acquired immunodeficiency syndrome
Porras-Luque JI, Valks R, Daudén E, Fernández-Herrera J.
No abstract available
Pages: 326-327
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Immunohistochemical detection of cathepsins in Merkel cell carcinomas
Thewes M, Engst R, Ring J.
No abstract available
Pages: 328-329
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Kawasaki syndrome or atypical measles mimicking Kawasaki syndrome?
Martin L, Goudeau A, Lanotte P, Besnier JM, Lorette G, Vaillant L.
No abstract available
Page: 329
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"Complex regional pain syndrome" after trauma from high-heeled shoe
Engelhart M, Bliddal H.
No abstract available
Pages: 331-332
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