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Content - Volume 78, Issue 4

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Purified Der p1 and p2 Patch Tests in Patients with Atopic Dermatitis: Evidence for Both Allergenicity and Proteolytic Irritancy: Investigative Reports
Mette Deleuran, Anne Ringer Ellingsen, Kirsten Paluldan, Carsten Schou, Kristian Thestrup-Pedersen
Atopic dermatitis has many similarities with allergic contact dermatitis. Previous studies have revealed delayed-type allergic reactions indicating specific cell-mediated immune reactions in subgroups of patients. It has recently been recognized that purified house dust mite major allergens, Der p1 and Der p2 from Dermatophagoides pteronyssinus, exhibit a proteolytic enzyme activity simila ...
Pages: 241-243
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A Twenty-four-hour Occlusive Exposure to 1% Sodium Lauryl Sulfate Induces a Unique Histopathologic Inflammatory Response in the Xerotic Skin of Atopic Dermatitis Patients
N. Tabata, H. Tagami, A. M. Kligman
Twenty-four-hour occlusive exposures of 1% aqueous sodium lauryl sulfate (SLS) produced unique functional and histological responses in patients with atopic dermatitis. Disruption of the stratum corneum barrier, measured by transepidermal water loss, was much greater and longer lasting than in normal controls. In contrast to controls the histologic pattern induced reproduced the typical features ...
Pages: 244-247
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Variable Expression of Apoptotic Phenotype in Keratinocytes Treated with Ultraviolet Radiation, Ceramide, or Suspended in Semisolid Methylcellulose
Robert Gniadecki, Barbara Gajkowska, Jacek Bartosik, Michael Hansen, Hans Christian Wulf
Apoptosis is a form of cellular suicide and is activated in various cells, including keratinocytes, in response to physiological and pathological stimuli. A current hypothesis holds that apoptotic cells in a concerted manner express characteristic phenotypic features comprising cytoplasmic budding, pyknosis, chromatin condensation, karyorhexis and internucleosomal DNA fragmentation. In this study ...
Pages: 248-257
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The Veno-arteriolar Reflex in Venous Leg Ulcer Patients Studied by Laser Doppler Imaging
Cecilia Svedman, George W. Cherry, Terence Ryan
Posture-induced microcirculatory changes in the lower leg were studied in venous leg ulcer patients and in control subjects by means of laser Doppler imaging (LDI), a technique which allows almost real-time mapping of the perfusion from a distance, each perfusion value constituting the mean of a number of measurements at separate sites. LDI values for intact skin with the subject supine were 0.39 ...
Pages: 258-261
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Skin Irritation by Dithranol Cream: A Blind Study to Assess the Role of the Cream Formulation
M. Prins, O. Q. J. Swinkels, E. G. W. Kolkman, E. W. Wuis, Y. A. Hekster, P. G. M. van der Valk
In connection with a national cost-effective evaluation study of short contact dithranol therapy for psoriasis, the question arose whether dithranol cream irritation is influenced by constituents of the vehicle. To establish the role of the different components of the vehicle in the mechanism of dithranol irritation, the dithranol 3% cream used in the evaluation study and its vehicle with nine di ...
Pages: 262-265
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Oral Isotretinoin Therapy in Severe Acne Induces Transient Suppression of Biochemical Markers of Bone Turnover and Calcium Homeostasis
Andreas Kindmark, Ola Rollman, Hans Mallmin, Marianne Petrén-Mallmin, Sverker Ljunghall, Håkan Melhus
Although dietary vitaminA is required for normal growth and development, long-term or high-dose administration of vitaminA derivatives (retinoids) may produce a variety of skeletal side-effects in man. In this study we investigated the early effects of oral isotretinoin therapy on bone turnover and calcium homeostasis in eleven consecutive patients with nodulocystic acne. The effects on bone meta ...
Pages: 266-269
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Efficacy of protective creams in a modified repeated irritation test: Methodological aspects
Walter Wigger-Albert, André Rougier, Alain Richard, Peter Elsner
The effect of 3 protective creams and petrolatum was tested in a repetitive irritation test. On 15 healthy volunteers, the irritants (sodium lauryl sulfate 10%, sodium hydroxide 0.5%, lactic acid 15%, and toluene undiluted) were applied on the paravertebral skin of the mid-back after 30 min pretreatment with the products tested. The volunteers were treated for 9 days. The irritant cutaneous react ...
Pages: 270-273
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Feasibility of Measuring Lipophilic or Protein-bound Drugs in the Dermis by In Vivo Microdialysis after Topical or Systemic Drug Administration
Eva Benfeldt, Lotte Groth
Our aim was to assess the microdialysis technique for determining in vivo drug levels of a lipophilic and a protein-bound model drug in the dermis. Forearm skin of healthy volunteers received topical 2% fusidic acid or 0.1% betamethasone-17-valerate formulations twice daily as occluded treatment on irritative dermatitis. Microdialysis sampling in the dermis after 48 h was without measurabl ...
Pages: 274-278
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Cumulative Irritation in Older and Younger Skin: a Comparison
Doris A. Schwindt, Klaus -P. Wilhelm, David L. Miller, Howard I. Maibach
Changes in stratum corneum properties due to sodium lauryl sulfate cumulative irritation were determined as a function of age. We irritated the backs of 7 younger (27.7±4.6 years, mean±standard deviation) and 10 older (69.8±5.5 years) volunteers on 5 consecutive days with open application of a 7.5% aqueous sodium lauryl sulfate solution. Water- and untreated skin served as controls. Transepide ...
Pages: 279-283
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Melanocytic Naevus or Malignant Melanoma? A Large-scale Epidemiological Study of Diagnostic Accuracy: Clinical Reports
B. Lindelöf, M.-A. Hedblad, B. Sigurgeirsson
While the early detection of malignant melanoma is important and has been emphasized widely in the past few years, it is difficult to accomplish. The purpose of this study is to assess how well dermatologists recognize malignant melanomas in patients with naevi. Information from 9,121 patients visiting two dermatological clinics in Stockholm and diagnosed melanocytic naevi was linked with the Swe ...
Pages: 284-288
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Increasing Incidence of Cutaneous Malignant Melanoma in Children and Adolescents 12-19 Years of Age in Sweden 1973-92
Pia Karlsson, Bernt Boeryd, Birgitta Sander, Per Westermark, Inger Rosdahl
One-hundred-and-seventy-seven cases of cutaneous malignant melanoma were reported to the Swedish National Cancer Registry in subjects below the age of 20 during the period 1973-92. One-hundred-and-fifty-four (87%) were re-examined histologically, and the original diagnosis of primary cutaneous malignant melanoma was verified in 88%. The age-specific mean annual incidence rate increased to 0.5/100 ...
Pages: 289-292
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Prevalence of Childhood and Adolescent Atopic Dermatitis in a Japanese Population: Comparison with the Disease Frequency Examined 20 Years Ago
Hisashi Sugiura, Naoka Umemoto, Hideki Deguchi, Yuho Murata, Keiko Tanaka, Takayuki Sawai, Mitsuyoshi Omoto, Masami Uchiyama, Takashi Kiriyama, Masami Uehara
To ascertain the prevalence of childhood and adolescent atopic dermatitis in a Japanese population, we clinically observed the total body of 5 to 6-year-old children (994 cases), 7 to 9-year-old children (1,240 cases), 10 to 12-year-old children (1,152 cases), 13 to 15-year-old children (1,670 cases), and 16 to 18-year-old adolescents (2,159 cases). The examination was performed in the spring of ...
Pages: 293-294
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Pemphigus Foliaceous Successfully Controlled with Plasma Exchange During 10 Years
J. A. Marcusson, B. Bjarnason, A. Shanwell
A case of pemphigus foliaceous is presented, where the disease has been successfully controlled with plasma exchange therapy alone for 10 years.
Pages: 295-296
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Effectiveness of Ammonium Solution in Relieving Type I Mosquito Bite Symptoms: A Double-blind, Placebo-controlled Study
Hongbo Zhai, Elias W. Packman, Howard I. Maibach
A randomized, double-blind, placebo-controlled study was conducted to compare the efficacy of ammonium solution with placebo in relieving type I symptoms caused by Aedes aegypti mosquitoes on 25 healthy subjects. Each subject was bitten once under laboratory conditions by Aedes aegypti mosquitoes on the volar aspect of each forearm, and then received the treatment with ammonium solu ...
Pages: 297-298
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Micropapular Sarcoidosis: Letters to the Editor
Yi-Hua Liao, Hsien-Ching Chiu, Guang-Hsiang Hsiao
This article does not have an abstract.
Pages: 299-300
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Zosteriform Lichen Planus: the Bizarre Consequences of a Misnomer
Rudolf Happle
This article does not have an abstract.
Page: 300
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Reply to the Letter by Happle
Charles Perniciaro, Michael Lutz, Katherine Lim
This article does not have an abstract.
Page: 300
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Reticulate Hyperpigmentation of the Skin After Topical Application of Benzoyl Peroxide
Jeffrey M. Weinberg, Tamara Moss, Sapna M. Gupta, Soren M. White, Philip C. Don
This article does not have an abstract.
Pages: 301-302
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Acquired Curly Hair: A New Paraneoplastic Symptom?
Eva Tegner, Hans Tegner
This article does not have an abstract.
Page: 302
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Onycholysis after Chemotherapy in a Patient with Lymphoma
Paraskevi Roussou, Ioannis Ilias, Elena Foufopoulou
This article does not have an abstract.
Page: 303
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Sequential Therapy with Nimesulide and Ketotifen in Delayed Pressure Urticaria
G. A. Vena, V. D'Argento, N. Cassano, M. Mastrolonardo
This article does not have an abstract.
Pages: 304-305
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Lichen Planus and Hepatitis C Virus Infection: A Clinical and Virologic Study
Javier Sánchez-Pérez, Ricardo Moreno-Otero, María Borque, Luis Rios-Buceta, Amaro García-Díez
This article does not have an abstract.
Pages: 305-306
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Anti-ribosomal Antibodies and Psychosis in Patients with Cutaneous Lupus Erythematosus
A. Parodi, M. Drosera, L. Barbieri, A. Rebora
This article does not have an abstract.
Page: 307
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White, Fibrous, Papular Lesions Associated with Systemic Lupus Erythematosus
Kazuhito Hayakawa, Tetsuo Shiohara
This article does not have an abstract.
Pages: 308-309
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Recalcitrant Molluscum Contagiosum in a Patient with AIDS Successfully Treated by a Combination of CO2-laser and Natural Interferon Beta Gel
Gerd Gross, Angelika Roussaki, Josef Brzoska
This article does not have an abstract.
Pages: 309-310
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Becker's Naevus Occurring at Birth and in Early Childhood
Apra Sood, Paschal D'Souza, Kaushal K. Verma
This article does not have an abstract.
Page: 311
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Possible Role of Epidermal Growth Factor in the Lesional Skin of Nodular Morphea
Toshiyuki Yamamoto, Sayuri Sakashita, Yasuyuki Sawada, Ichiro Katayama, Kiyoshi Nishioka
This article does not have an abstract.
Pages: 312-313
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Follicular Mucinosis Associated with Cutaneous Leishmaniasis
Patricia Abajo, Rocío Martín, Esteban Daudén
This article does not have an abstract.
Page: 315
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Treatment of Ocular Cicatricial Pemphigoid with Intravenous Gammaglobulin
Jörg Bohn, Eva Benfeldt, Erik Dabelsteen, Torkil Menné
This article does not have an abstract.
Pages: 316-317
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UVA1 Irradiation is Effective in Treatment of Chronic Vesicular Dyshidrotic Hand Eczema
Tanja Schmidt, Dietrich Abeck, Kerstin Boeck, Martin Mempel, Johannes Ring
This article does not have an abstract.
Pages: 318-319
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Failure of Gluten-free Diet in Celiac Disease-associated Alopecia Areata
P. Bondavalli, G. Quadri, A. Parodi, A. Rebora
This article does not have an abstract.
Page: 319
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