Content

Content - Volume 79, Issue 3

Editor's choice in this issue

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Inhibitory Effect of Vasoactive Intestinal Peptide on the Challenge Phase of Allergic Contact Dermatitis in Humans
L. Lundeberg, V. Mutt, K. Nordlind
There is increasing evidence that the nervous system has influence on the immune response. The effect of vasoactive intestinal peptide (VIP) and of serotonin and its antagonists on the challenge phase of allergic contact dermatitis in humans were tested. The substances were injected intracutaneously shortly before and 6 h after application of patch tests with nickel sulphate in nickel-allergic pa ...
Pages: 178-182
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Eccrine Sweat Glands: Expression of Transforming Growth Factor-beta and Bone Morphogenetic Protein Type I Receptors and Their Intracellular Signalling Smad Proteins
Uwe Wollina, Dirk Lange, Peter Ten Dijke, Carl-Henrik Heldin, Keiko Funa
The transforming growth factor-β superfamily is thought to be involved in the regulation and control of growth and differentiation. These growth factors signal through transmembrane serine/threonine kinase receptors. The activation of type I receptor kinase phosphorylates a family of intracellular signalling proteins called Smads. In the present study, we wanted to localize type I and type II re ...
Pages: 183-186
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Eicosanoid and Cytokine Levels in Acute Skin Irritation in Response to Tape Stripping and Capsaicin
D. M. Reilly, M. R. Green
We assessed the effects of physical and chemical irritants on a profile of acute inflammatory mediators in normal human skin. Skin damage in both cases is accompanied by a flux of inflammatory processes and repair mechanisms, which remain imprecisely understood. We used 10 sequential cellotape strips or topical application of 0.075% capsaicin as skin irritants and characterized the subsequent pro ...
Pages: 187-190
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Suction Blister Formation in Skin after Acute and Repeated Mast Cell Degranulation
Renata Kaminska, Anita Naukkarinen, Maija Horsmanheimo, Ilkka T. Harvima
Mast cells and their proteases are thought to participate in the development of skin blisters in various pathological conditions. In this study, suction blistering was used as an experimental model to evaluate the significance of mast cells in blister formation after pre-treatment of normal skin with intradermal injections of 100 μg/ml compound 48/80 (a mast cell degranulator) or with 0.1% capsa ...
Pages: 191-194
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Expression of p53 Protein Before and After PUVA Treatment in Psoriasis
Anna Hannuksela-Svahn, Paavo Pääkkö, Pekka Autio, Timo Reunala, Jaakko Karvonen, Kirsi Vähäkangas
We investigated the effect of the potentially carcinogenic psoralen plus UVA radiation (PUVA) therapy on the expression of p53 in skin of psoriatic patients. p53 antibodies DO7 and Pab240, antibodies against PCNA and Ki67 and the avidin-biotin immunoperoxidase complex method were used in the immunohistochemical staining of biopsy samples from non-lesional and lesional skin of 23 patients who rece ...
Pages: 195-199
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Epidermal Urocanic Acid Concentration and Photoisomerization Reactivity in Patients with Cutaneous Malignant Melanoma or Basal Cell Carcinoma
Erna Snellman, Christer T. Jansen, Tapio Rantanen, Paavo Pasanen
The relationship of epidermal urocanic acid concentration and photoisomerization reactivity to human skin cancer was studied. Twelve cutaneous malignant melanoma patients, 10 basal cell carcinoma patients and 22 healthy matched controls were enrolled in the study. A solar simulating ultraviolet irradiator was used for phototesting the minimal erythema dose. Using the Finn Chamber® tec ...
Pages: 200-203
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Photodynamic Therapy by Topical Aminolevulinic Acid, Dimethylsulphoxide and Curettage in Nodular Basal Cell Carcinoma: a One-year Follow-up Study
Ana Maria Soler, Trond Warloe, Johan Tausjø, Aasmund Berner
Fifty-eight patients with 119 nodular (2 mm or more in thickness) basal cell carcinomas successfully treated with photodynamic therapy were included in this 1-year follow-up study. The initial cure rate at 3-6 months was 92% after photodynamic therapy, which included an initial debulking procedure and topical application of dimethylsulphoxide in order to enhance penetration of 5-aminolevulinic ac ...
Pages: 204-206
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Serum Levels of Soluble TNFa Receptor Type I and the Severity of Systemic Sclerosis
Slawomir Majewski, Anna Wojas-Pelc, Magdalena Malejczyk, Elzbieta Szymanska, Stefania Jablonska
Several abnormalities of cytokines have been shown to occur in systemic scleroderma; however their correlation with clinical parameters is controversial. Since serum concentrations of cytokine receptors have been shown to correlate with inflammatory processes, including systemic sclerosis, the aim of our study was to compare serum concentrations of TNFα receptor type 1 with the concentrations of ...
Pages: 207-210
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Sunscreen Sensitization: a 5-year Study
Fabienne Journe, Marie-Claude Marguery, Josiane Rakotondrazafy, Fouad El Sayed, Jacques Bazex
The purpose of this study was to evaluate the prevalence of sunscreen contact allergy and/or contact photoallergy in 370 patients with suspected photodermatitis. Patch and photopatch tests were performed using the French Society of Photodermatology (SFPD) standard series. A total of 57 cases of contact allergy and/or photocontact allergy to sunscreens were diagnosed (15.4%). Amongst these, 27 rea ...
Pages: 211-213
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Quantitative Image Analysis of Hair Follicles in Alopecia Areata
Il-Hwan Kim, Ho-Yeon Jo, Chang Geun Cho, Hyan-Chul Choi, Chil-Hwan Oh
We took biopsies from similar sites on the scalps of normal controls, normal looking and hair loss areas of patients with alopecia areata. The specimens were sectioned serially and horizontally. We measured morphological parameters, such as the diameter of the hair shaft, the thickness of the inner root sheath, the diameter of the outer root sheath, the irregularity of the outer root sheath and t ...
Pages: 214-216
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Cultured Allogeneic Skin Cells are Effective in the Treatment of Chronic Diabetic Leg and Foot Ulcers
Ilkka T. Harvima, Suoma Virnes, Leena Kauppinen, Maria Huttunen, Petri Kivinen, Leo Niskanen, Maija Horsmanheimo
Diabetic ulcers on the lower extremities present a difficult treatment problem, and some ulcers respond poorly to conventional topical and cast treatment. The purpose of this study was to assess the effect of cultured allogeneic keratinocyte epithelium and fibroblast-gelatin sponge on the healing of chronic, refractory diabetic leg and foot ulcers. Non-diabetic chronic leg ulcers were treated for ...
Pages: 217-220
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Randomized Double-blind Comparison of Short-term Itraconazole and Terbinafine Therapy for Toenail Onychomycosis
Hugo DeGreef, Amalia Del Palacio, Søren Mygind, Gabriele Ginter, António Pinto Soares, Angela Zuluaga de Cadena
Previous studies evaluating short-term itraconazole and terbinafine therapy for onychomycosis have varied in protocol and size; this double-blind study enabled a large-scale, standardized, direct comparison. Patients with toenail onychomycosis were randomized to itraconazole 200 mg daily (n=146) or terbinafine 250 mg daily (n=146) for 12 weeks, with a 36-week follow-up. Mycological ...
Pages: 221-223
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Treatment of Digital Mucous Cysts with a Carbon Dioxide Laser
Sigrid Karrer, Ulrich Hohenleutner, Rolf-Markus Szeimies, Michael Landthaler
Digital mucous cysts are common tumours of the distal interphalangeal joint, causing pain, cosmetic disfigurement and nail deformities. This study describes six patients suffering from digital mucous cysts, some of which recurred after surgery. Carbon dioxide laser vaporization was performed under local anaesthesia, resulting in complete remission in four out of six patients. In two patients, the ...
Pages: 224-225
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HPV Prevalence in Anal Warts Tested with the MY09/MY11 SHARP Signal System
Anders Strand, Sonja Andersson, Ingeborg Zehbe, Erik Wilander
Anal warts are, from an aetiological point of view, a diverse category of lesions including condylomata acuminata, fibroepithelial polyps and seborrhoeic keratosis. Human papillomavirus induced anal warts, in contrast to other types of warts, are contagious and not infrequently sexually transmitted, they therefore need to be accurately identified. A total of 24 anal warts were randomly collected ...
Pages: 226-229
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Irritancy of Scrubbing Up for Surgery With or Without a Brush
Katsuko Kikuchi-Numagami, Toshio Saishu, Mariko Fukaya, Etsuko Kanazawa, Hachiro Tagami
Hand washing is an indispensable procedure for surgical nurses. Although scrubbing up with a brush is preferable to prevent infections, it is not clear how irritating to the skin scrubbing with a brush is compared with hand washing without a brush. TEWL, high frequency conductance and pH were measured on the hand skin of the same group of nurses before and after daily hand washing for 11 days in ...
Pages: 230-232
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Drug-induced Erythema Multiforme-like Bullous Pemphigoid
Mehrdad Mehravaran, Rolland Gyulai, Sándor Husz, Attila Dobozy.
This article does not have an abstract.
Page: 233
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Cardiovascular Complications of Psoriasis: Does Obstructive Sleep Apnoea Play a Role?
Michael Buslau, Kada Benotmane
This article does not have an abstract.
Page: 234
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Paternal and Maternal Atopic Dermatitis Have the Same Influence on Development of the Disease in Children
Masami Uehara, Hisashi Sugiura, Mitsuyoshi Omoto
This article does not have an abstract.
Page: 235
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Cicatricial Alopecia Following Therapeutic Embolization
L. Toutous-Trellu, P. Chavaz, P. Piletta
This article does not have an abstract.
Pages: 236-237
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Syringocystadenoma Papilliferum without an Antecedent Naevus Sebaceous
Tetsuya Koga, Yumiko Kubota, Juichiro Nakayama
This article does not have an abstract.
Page: 237
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Angiodermatitis Associated with Congenital Arteriovenous Malformation on the Elbow
Ji Ho Lee, Chul Jong Park, Jong Yuk Yi
This article does not have an abstract.
Pages: 238-239
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Pityriasis Lichenoides Chronica with Acral Distribution Mimicking Palmoplantar Syphilid
Han Gil Chung, Soo-Chan Kim
This article does not have an abstract.
Page: 239
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Spiegler-Fendt Type Lymphocytoma Cutis: a Case Report of Two Patients Successfully Treated with Interferon Alpha-2b
Kaisa Hervonen, Tuula Lehtinen, Annikki Vaalasti
This article does not have an abstract.
Pages: 241-242
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Lichen Simplex Chronicus with a Cutaneous Horn
Binod K. Khaitan, Apra Sood, Manoj K. Singh
This article does not have an abstract.
Page: 243
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Cutaneous Alternariosis due to Alternaria chlamydospora After Bone Marrow Transplantation
B. Bartolome, R. Valks, J. Fraga, V. Buendía, J. Fernández-Herrera, A. García-Díez
This article does not have an abstract.
Page: 244
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Secondary Anetoderma in People with Down's Syndrome
Carmelo Schepis, Maddalena Siragusa
This article does not have an abstract.
Page: 245
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Difference in Ceramide Composition between "Dry" and "Normal" Skin in Patients with Atopic Dermatitis
Motonobu Matsumoto, Naoka Umemoto, Hisashi Sugiura, Masami Uehara
This article does not have an abstract.
Pages: 246-247
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Clinical and Virological Comparison of 3 Patients with Erythema Multiforme
H. Kokuba, C. L. Kauffman, J. W. Burnett, L. Aurelian
This article does not have an abstract.
Pages: 247-248
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Mycobacterium Avium Complex: Cutaneous Infection in an Immunocompetent Host
Rosanna Satta, Giorgio Retanda, Francesca Cottoni
This article does not have an abstract.
Pages: 249-250
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Herpetic Pharyngitis with Mammary and Genital Herpes due to Sexual Contact
Masami Yoshida
This article does not have an abstract.
Page: 250
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Angiosarcoma of the Lower Leg in Chronic Lymphoedema
V. Simonetti, M. Folgaresi, A. Motolese
This article does not have an abstract.
Pages: 251-252
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Fournier's Gangrene: a Case Report
M. Folgaresi, V. Simonetti, A. Motolese, A. Giannetti
This article does not have an abstract.
Pages: 252-253
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Buschke-Loewenstein Tumour is not a Lo-grade Carcinoma but a Giant Verruca
Rana Anadolu, Ayte Boyvat, Emel Calikoglu and Aysel Gürler
Pages: 253-254
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BOOKS RECEIVED
Anders Vahlquist
This article does not have an abstract.
Page: 255
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ANNOUNCEMENTS
This article does not have an abstract.
Page: 255
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