Content

Content - Volume 80, Issue 4

Editors choice in this issue

All articles

Intracutaneous Injection of Lysophosphatidylcholine Induces Skin Inflammation and Accumulation of Leukocytes
A. K. Ryborg, B. Deleuran, H. Søgaard, K. Kragballe
Various cell stimuli act through activation of phospholipase A2, which hydrolyses fatty acids from membrane phospholipids, resulting in the formation of fatty acids and lysophospholipids. One of the lysophospholipid classes, lysophosphatidylcholine, is a chemoattractant for monocytes and T-lymphocytes and induces the expression of adhesion molecules on cultured endothelial cells. The p ...
Pages: 242-246
Abstract  PDF
Role of Nerve Growth Factor in RANTES Expression by Keratinocytes
Siba P. Raychaudhuri, Eugene M. Farber, Smriti K. Raychaudhuri
A role of neurogenic inflammation induced by the neuropeptides and nerve growth factor (NGF) has been attributed to the pathogenesis of several cutaneous disorders such as psoriasis, wound healing and eczematous dermatitis. The underlying mechanisms of the inflammatory process induced by NGF are not clearly established. This study explored whether NGF influences the inflammatory process by induci ...
Pages: 247-250
Abstract  PDF
Expression of p21WAF1/CIP1, p53, bcl-2 and Ki-67 in Venous Leg Ulcers with and without Squamous Cell Carcinoma
Baldur Baldursson, Stina Syrjänen, Harry Beitner
In order to gain understanding of the cellular mechanisms of malignant transformation in chronic venous leg ulcers, we analysed by immunohistochemistry the presence of p21, p53, bcl-2 and Ki-67 in ulcers with and without squamous cell carcinoma. The material consisted of 41 archived histopathological samples from 33 patients with chronic venous leg ulcers and 28 samples from 21 patients suffering ...
Pages: 251-255
Abstract  PDF
Comparison of the Sensitivities of the Buehler Test and the Guinea Pig Maximization Test for Predictive Testing of Contact Allergy
Søren Frankild, Aage Vølund, Jan E. Wahlberg, Klaus E. Andersen
International test guidelines, such as the Organisation for Economic Cooperation and Development (OECD) guideline #406, recommend 2 guinea pig methods for testing of the contact allergenic potential of chemicals: the Guinea Pig Maximization Test (GPMT) and the Buehler test. Previous comparisons between the methods suggested that the Buehler test was less sensitive than the GPMT although modified ...
Pages: 256-262
Abstract  PDF
In vivo Study of Skin Mechanical Properties in Psoriasis Vulgaris
H. Dobrev
The aim of this study was to investigate the mechanical properties of the skin in psoriatic plaques before and after treatment with dithranol and in clinically uninvolved psoriatic skin in comparison with the skin of healthy controls. In total, 82 psoriatic plaques in 19 in-patients and 51 age-matched control subjects were studied with a non-invasive suction device (Cutometer). The plaques were c ...
Pages: 263-266
Abstract  PDF
Surgical Removal of Ulcer and Lipodermatosclerosis Followed by Split-Skin Grafting (Shave Therapy) Yields Good Long-term Results in "Non-healing" Venous Leg Ulcers
Wilfried Schmeller, Yvonne Gaber
The purpose of this study was to evaluate the long-term effects of shave therapy in non-healing venous leg ulcers. Forty-one patients with 75 recalcitrant leg ulcers caused by primary deep vein incompetence or post-thrombotic syndrome were operated by shave therapy (removal of ulcer and surrounding lipodermatosclerosis with a Schink skin-grafting knife and covering of the wounds with meshed split ...
Pages: 267-271
Abstract  PDF
Dermatology Life Quality Index: Data from Danish Inpatients and Outpatients
Robert Zachariae, Claus Zachariae, Hans Ibsen, Janne Touborg Mortensen, Hans Christian Wulf
The aim of the present study was to provide data on the reliability and validity of a Danish translation of the Dermatology Life Quality Index (DLQI), a short measure of the impact of dermatological diseases on quality of life. The DLQI was administered to 200 outpatients and 100 hospitalized patients suffering from a range of dermatological diseases and to 100 sex- and age-matched healthy contro ...
Pages: 272-276
Abstract  PDF
LETTER TO THE EDITOR
Increased Coexpression of Eotaxin and Interleukin 5 in Bullous Pemphigoid
While the presence of eosinophils in the skin lesions of bullous pemphigoid is well documented, the chemotactic factors responsible for eosinophil recruitment into the tissue still remain to be defined. In this study, eotaxin and interleukin-5 (IL-5) concentrations were determined in the blister fluid and sera of patients with bullous pemphigoid (acute and remission phase, n=6) in comparis ...
Pages: 277-280
Abstract  PDF
LETTER TO THE EDITOR
Bullous Eruption Associated with Scabies: Evidence for Scabetic Induction of True Bullous Pemphigoid
Some patients with scabies develop bullae concomitantly with, or subsequently after, the occurrence of scabetic lesions. Although several immunofluorescence studies have demonstrated immunoglobulin deposition in the basement membrane zone of bullous lesions, it remained unclear whether these antibodies are directed to bullous pemphigoid antigens. We clearly show that two scabetic patients with bu ...
Pages: 281-283
Abstract  PDF
Comparison of Severity Scoring of Atopic Dermatitis Values and Serum Levels of Eosinophil Cationic Protein and Mast Cell Tryptase for Routine Evaluation of Atopic Dermatitis
In this study the routine use of different parameters for evaluation of the overall therapeutic outcome in atopic dermatitis was investigated. The disease activity of 117 randomly selected hospitalized patients suffering from atopic dermatitis was routinely assessed using the Severity Scoring of Atopic Dermatitis (SCORAD) index on admission and at discharge. Serum levels of eosinophil cationic pr ...
Pages: 284-286
Abstract  PDF
LETTER TO THE EDITOR
Expression and Functional Role of Co-stimulatory Molecules in CD40+IL-4-Stimulated B Cells from Atopic and Non-atopic Donors
As immunological dysregulation is a possible key defect in atopic diseases, we have studied the expression and function of costimulatory molecules in atopic dermatitis (AD) patients compared with normal controls. Using flow cytometry, we showed that CD80 and CD86 are expressed at increased levels on human peripheral B cells in both groups after stimulation with anti-CD40 and interleukin 4 (IL-4), ...
Pages: 287-291
Abstract  PDF
LETTER TO THE EDITOR
Papular Palmoplantar Hyperkeratosis Following Chronic Medical Exposure to Arsenic: Human Papillomavirus as a Co-factor in the Pathogenesis of Arsenical Keratosis?
This study presents the case of a 38-year-old patient from Pakistan with vitiligo, who developed multiple verrucous papules on the palms and soles several years after receiving "herbal treatment" from a travelling Indian doctor for a period of 12 months. Histopathological examination showed changes consistent with the diagnosis of arsenical keratosis. Molecular-biological examination of a skin bi ...
Pages: 292-293
Abstract  PDF
Histological Diagnosis of Cutaneous "Warty" Carcinoma on a Pre-existing HPV Lesion
Kiriaki Aroni, Andreas Ch. Lazaris, Anna Ioakim-Liossi, Helen Paraskevakou, Panayiotis S. Davaris
A middle-aged man with an 8-year history of a fungating tumour mass on his thigh was histologically diagnosed as having an invasive "warty" carcinoma at the location of a pre-existing human papillomavirus (HPV) lesion. The tumour surface had a verruciform appearance with papillae containing fibrovascular cores. Many of the malignant cells displayed changes consistent with koilocytotic atypia. We ...
Pages: 294-296
Abstract  PDF
LETTER TO THE EDITOR
Pigmented Median Raphe Cysts of the Penis
Two cases of median raphe cysts of the penis with melanosis are presented. The presence of melanocytes was observed in the lining of the cysts by light and electron microscopy. The possible mechanism of the embryological development of the cysts is discussed in the context of the published literature.
Pages: 297-298
Abstract  PDF
LETTER TO THE EDITOR
Oral Involvement in Mycosis Fungoides: Report of Two Cases and a Literature Review
Oral involvement is uncommon in cutaneous T-cell lymphomas and usually associated with poor prognosis. The clinicopathological and immunohistochemical findings of 2 new cases are described along with a literature review. The first patient had a 10-year history of mycosis fungoides when she developed lesions in the oral tissues. She died 6 months later despite treatment. The immunophenotype was CD ...
Pages: 299-301
Abstract  PDF
Porokeratosis in the Elderly: A New Subtype of Disseminated Superficial Actinic Porokeratosis
Annalisa Patrizi, Carmine D'acunto, Beatrice Passarini, Iria Neri
In a review of all cases of porokeratosis histologically diagnosed in our Department during the period 1991-98 we found that 12 patients (22%) were in their seventh to ninth decade. In all 12 (2 males and 10 females) the age of onset of the disease varied between 58 and 89 years (mean age 68.6 years). The clinical picture was similar in all the patients, with the number of lesions varying from a ...
Pages: 302-304
Abstract  PDF
LETTER TO THE EDITOR
Fulminant Mucormycosis in a Renal Transplant Recipient
This article does not have an abstract.
Page: 305
Abstract  PDF
Electron Beam Therapy in Patients with Scleredema
This article does not have an abstract.
Pages: 307-308
Abstract  PDF
Radiation Myo-Fasciitis
François Desruelles, Jean-Philippe Lacour, Patrick Chevallier, Adel Courdi, Thierry Passeron, Jean-Paul Ortonne
This article does not have an abstract.
Pages: 310-311
Abstract  PDF
Efficacy of Cidofovir in the Treatment of Recalcitrant Molluscum Contagiosum in an AIDS Patient
Valvanera Ibarra, J. R. Blanco, J. A. Oteo, L. Rosel
This article does not have an abstract.
Pages: 315-316
Abstract  PDF
Response to the Letter by Dr Safer
This article does not have an abstract.
Page: 318
Abstract  PDF