Content

Content - Volume 81, Issue 5

All articles

REVIEW
Angiotensin-converting Enzyme Inhibitors as Inducers of Adverse Cutaneous Reactions
U. M. Steckelings, M. Artuc, T. Wollschläger, S. Wiehstutz, B. M. Henz
Since adverse effects due to angiotensin-converting enzyme (ACE) inhibitors frequently occur in cutaneous locations, this review summarizes the spectrum of expected and unexpected adverse effects of these drugs, possible associated mechanisms, and their basic functions for dermatologists. ACE inhibitors block the activity of the metalloproteinase ACE by binding to its active site, thus displacing ...
Pages: 321-325
Abstract  PDF
INVESTIGATIVE REPORT
Why are Scars Pale? An Immunohistochemical Study Indicating Preservation of Melanocyte Number and Function in Surgical Scars
Shireen S. Velangi, Jonathan L. Rees
The cosmetic effect of many mature scars is largely due to their paler appearance than the surrounding skin. The aim of the study was to identify whether melanocytes are present and functioning within pale scars. Cryosections from scar and normal tissue were stained with murine monoclonal antibodies mel-5, c-kit and NKI/beteb to detect melanocytes and precursor melanocytes. The mean number of mel- ...
Pages: 326-328
Abstract  PDF
INVESTIGATIVE REPORT
Radiation Therapy Induces Tenascin Expression and Angiogenesis in Human Skin
Riitta Riekki, Arja Jukkola, Aarne Oikarinen, Matti Kallioinen
In analysing radiation-induced connective tissue changes, we studied tenascin expression, elastic fibres, angiogenesis and physio-mechanical properties in irradiated and contralateral healthy skin of radiotherapy-treated breast cancer patients. Skin biopsies were obtained from a radiotherapy-treated skin area and a corresponding non-treated skin area. Haematoxylin-eosin and Verhoeff stainings as w ...
Pages: 329-333
Abstract  PDF
INVESTIGATIVE REPORT
Role of LFA-1/ICAM-1, CLA/E-selectin and VLA-4/VCAM-1 Pathways in Recruiting Leukocytes to the Various Regions of the Chronic Leg Ulcer
Karli Rosner, Christian Ross, Tonny Karlsmark, Gunhild Lange Skovgaard
The center, edge and distant regions of the venous leg ulcer differ in inflammatory cell composition, suggesting that these represent different developmental stages. Our goal was to determine which recruitment pathways contribute to the differences in leukocyte composition between the various ulcer regions. The multiple region biopsy approach, which enables to study the different development phase ...
Pages: 334-339
Abstract  PDF
INVESTIGATIVE REPORT
The Wiskott-Aldrich Syndrome Gene as a Candidate Gene for Atopic Dermatitis
M. Bradley, C. Söderhäll, C.-F. Wahlgren, H. Luthman, M. Nordenskjöld, I. Kockum
Atopic dermatitis is a multifactorial disorder probably caused by environmental factors in combination with susceptibility genes. The clinical similarity between atopic dermatitis and the eczema manifestation in patients with Wiskott-Aldrich syndrome made the previously identified WAS gene in chromosome subband Xp11.23 an interesting candidate gene for atopic dermatitis. We studied linkage ...
Pages: 340-342
Abstract  PDF
INVESTIGATIVE REPORT
Characteristics of Self-estimated Enhanced Skin Susceptibility
Harald Löffler, Heinrich Dickel, Oliver Kuss, Thomas L. Diepgen, Isaak Effendy
A considerable number of people complain about enhanced skin sensitivity. The aim of this study was to investigate the characteristics of subjective statements and objective measurable parameters in subjects with self-estimated enhanced skin susceptibility. Four-hundred-and-twenty volunteers completed a questionnaire form with a self-estimation of skin susceptibility, possible triggering factors a ...
Pages: 343-346
Abstract  PDF
CLINICAL REPORT
Calcium Channel Blockers Intake and Psoriasis: A Case-control Study
Arnon D. Cohen, Mark Kagen, Michael Friger, Sima Halevy
In vitro evidence suggests that intracellular calcium metabolism influences keratinocyte differentiation. However, only a few reports have described exacerbation of psoriasis or psoriasiform eruptions due to intake of calcium channel blockers. We conducted a case-control study to evaluate the association between exposure to calcium channel blockers and psoriasis. Data were obtained through a retro ...
Pages: 347-349
Abstract  PDF
CLINICAL REPORT
Clinical Significance of Markedly Elevated Serum Creatine Kinase Levels in Patients with Acne on Isotretinoin
Marina Landau, Ronit Mesterman, Joseph Ophir, Barukh Mevorah, Joseph Alcalay, Avikam Harel, Yoram Nevo
Muscle-related complaints and high creatine kinase (CK) blood levels have been reported in 16-51 % of patients with acne treated with isotretinoin. It has been suggested that this retinoid and exercise have a synergistic effect on muscle. The presence of marked hyperCKemia during the treatment raises concern about rhabdomyolysis. The objective of this report was to evaluate the incidence, course a ...
Pages: 350-352
Abstract  PDF
CLINICAL REPORT
Treatment of Hyperkeratotic Dermatitis of the Palms (Eczema Keratoticum) with Oral Acitretin. A Single-blind Placebo-controlled Study
Kristian Thestrup-Pedersen, Klaus E. Andersen, Torkil Menné, Niels K. Veien
Hyperkeratotic dermatitis of the palms - also called eczema keratoticum - is a chronic, sometimes disabling condition in middle-aged persons. We carried out a single-blind, placebocontrolled study using acitretin in 29 patients. Fourteen patients received active therapy (30mg acitretin daily) and 15 placebo. All had hyperkeratotic changes of the palms with painful fissures and most had involvement ...
Pages: 353-355
Abstract  PDF
CLINICAL REPORT
Variegate Porphyria with Coexistent Decrease in Porphobilinogen Deaminase Activity
Georg Weinlich, Manfred O. Doss, Norbert Sepp, Peter Fritsch
Variegate porphyria is a rare disease caused by a deficiency of protoporphyrinogen oxidase. In most cases, the clinical findings are a combination of systemic symptoms similar to those occurring in acute intermittent porphyria and cutaneous lesions indistinguishable from those of porphyria cutanea tarda. We report on a 24-yearoldwoman with variegateporphyriawho,after intake of lynestrenol, develop ...
Pages: 356-359
Abstract  PDF
CLINICAL REPORT
A Case of Exaggerated Mosquito-bite Hypersensitivity with Epstein-Barr Virus-positive Inflammatory Cells in the Bite Lesion
Tokuya Ohsawa, Tsukasa Morimura, Yoshitaka Hagari, Tetsuji Kawakami, Motoyuki Mihara, Kazumitsu Hirai, Kazufumi Ikuta, Masanao Murakami, Takeshi Sairenji, Tomocho Matsuse
We describe a unique patient with mosquito-bite hypersensitivity who had extremely high titres of Epstein-Barr virus antibodies. For many years he developed intractable ulcers on the sites of mosquito-bite. Epstein-Barr virus infection was detected in almost all inflammatory cells in the ulcers and in the peripheral blood lymphocytes by using in situ hybridization to Epstein-Barr virus-enco ...
Pages: 360-363
Abstract  PDF
LETTER TO THE EDITOR
Ulcerative Lichen Planus: A Case Responding to Recombinant Platelet-derived Growth Factor BB and Immunosuppression
Uwe Wollina, Helga Konrad, Tim Graefe
This article does not have an abstract.
Pages: 364-365
Abstract  PDF
LETTER TO THE EDITOR
Staphylococcus aureus Colonization of Children with Atopic Eczema and Their Parents
G. K. Patel, H. Wyatt, E. M. Kubiak, S. M. Clark, C. M. Mills
This article does not have an abstract.
Pages: 366-367
Abstract  PDF
LETTER TO THE EDITOR
Fenoterol-induced Erythema Exudativum Multiforme-like Exanthem: Demonstration of Drug-specific Lymphocyte Reactivity In Vivo and In Vitro
Bernhardt Sachs, Claudia Renn, Tames Al Masaoudi, Hans Friedrich Merk
This article does not have an abstract.
Pages: 368-369
Abstract  PDF
LETTER TO THE EDITOR
Milia en plaque: Treatment with Open Spray Cryosurgery
Giuseppe Noto, Rodney Dawber
This article does not have an abstract.
Pages: 370-371
Abstract  PDF
LETTER TO THE EDITOR
Proximal Subungual Hyperkeratosis of the Big Toe due to Microsporum gypseum
Clara Romano, Lucia Massai
This article does not have an abstract.
Pages: 371-372
Abstract  PDF
LETTER TO THE EDITOR
Close Association of Dermatitis Herpetiformis and Chronic Tonsillitis in a Japanese Patient without Gluten Sensitivity
Mitsuhito Ota, Kazuko C. Sato-Matsumura, Tetsuri Matsumura, Akikatsu Kataura, Tazuko Yokota, Kinuko Kobayashi, Hiroshi Shimizu
This article does not have an abstract.
Pages: 373-374
Abstract  PDF
LETTER TO THE EDITOR
Multiple Becker's Naevi: A Rare Presentation
Binod K. Khaitan, Yashpal Manchanda, Rashmi Mittal, Manoj K. Singh
This article does not have an abstract.
Pages: 374-375
Abstract  PDF
LETTER TO THE EDITOR
Erythema Marginatum Preceding an Acute Oedematous Attack of Hereditary Angioneurotic Oedema
Henriette Farkas, George Harmat, Andrea Fáy, Béla Fekete, István Karádi, Beáta Visy, Lilian Varga
This article does not have an abstract.
Pages: 376-377
Abstract  PDF
LETTER TO THE EDITOR
Azathioprine for the Treatment of Severe Erosive Oral and Generalized Lichen Planus
Kaushal K. Verma, Rashmi Mittal, Yashpal Manchanda
This article does not have an abstract.
Pages: 378-379
Abstract  PDF
LETTER TO THE EDITOR
Possible Role of Diltiazem in a Recalcitrant Case of Darier's Disease
Henrik Lorentzen, Else Svejgaard
This article does not have an abstract.
Pages: 379-381
Abstract  PDF
LETTER TO THE EDITOR
Tinea Cruris due to Combined Infections of Trichophyton mentagrophytes and Microsporum canis. A Case Report
Hyun-Jeong Lee, Seog-Jun Ha, Ji-Hyun Ha, Baik-Kee Cho, Jin-Wou Kim
This article does not have an abstract.
Page: 381
Abstract  PDF
LETTER TO THE EDITOR
A Patient with Primary Syphilis of the Finger
Angela Bonci, Vito Di Lernia, Giovanni Lo Scocco, Giuseppe Bisighini
This article does not have an abstract.
Pages: 382-383
Abstract  PDF
LETTER TO THE EDITOR
Type 2 Segmental Cutaneous Leiomyomatosis
Arne König, Rudolf Happle
This article does not have an abstract.
Page: 383
Abstract  PDF
ANNOUNCEMENT
ANNOUNCEMENTS
This article does not have an abstract.
Page: 384
Abstract  PDF
BOOK REVIEW
BOOK REVIEW
This article does not have an abstract.
Page: 384
Abstract  PDF