Content

Content - Volume 81, Issue 5

Editor's choice in this issue

All articles

LETTER TO THE EDITOR
Angiotensin-converting Enzyme Inhibitors as Inducers of Adverse Cutaneous Reactions
Since adverse effects due to angiotensin-converting enzyme (ACE) inhibitors frequently occur in cutaneous locations, this review summarizes the spectrum of expected and unexpected adverse effects of these drugs, possible associated mechanisms, and their basic functions for dermatologists. ACE inhibitors block the activity of the metalloproteinase ACE by binding to its active site, thus displacing ...
Pages: 321-325
Abstract  PDF
CLINICAL REPORT
Why are Scars Pale? An Immunohistochemical Study Indicating Preservation of Melanocyte Number and Function in Surgical Scars
The cosmetic effect of many mature scars is largely due to their paler appearance than the surrounding skin. The aim of the study was to identify whether melanocytes are present and functioning within pale scars. Cryosections from scar and normal tissue were stained with murine monoclonal antibodies mel-5, c-kit and NKI/beteb to detect melanocytes and precursor melanocytes. The mean number of mel- ...
Pages: 326-328
Abstract  PDF
CLINICAL REPORT
Radiation Therapy Induces Tenascin Expression and Angiogenesis in Human Skin
In analysing radiation-induced connective tissue changes, we studied tenascin expression, elastic fibres, angiogenesis and physio-mechanical properties in irradiated and contralateral healthy skin of radiotherapy-treated breast cancer patients. Skin biopsies were obtained from a radiotherapy-treated skin area and a corresponding non-treated skin area. Haematoxylin-eosin and Verhoeff stainings as w ...
Pages: 329-333
Abstract  PDF
CLINICAL REPORT
Role of LFA-1/ICAM-1, CLA/E-selectin and VLA-4/VCAM-1 Pathways in Recruiting Leukocytes to the Various Regions of the Chronic Leg Ulcer
The center, edge and distant regions of the venous leg ulcer differ in inflammatory cell composition, suggesting that these represent different developmental stages. Our goal was to determine which recruitment pathways contribute to the differences in leukocyte composition between the various ulcer regions. The multiple region biopsy approach, which enables to study the different development phase ...
Pages: 334-339
Abstract  PDF
LETTER TO THE EDITOR
The Wiskott-Aldrich Syndrome Gene as a Candidate Gene for Atopic Dermatitis
Atopic dermatitis is a multifactorial disorder probably caused by environmental factors in combination with susceptibility genes. The clinical similarity between atopic dermatitis and the eczema manifestation in patients with Wiskott-Aldrich syndrome made the previously identified WAS gene in chromosome subband Xp11.23 an interesting candidate gene for atopic dermatitis. We studied linkage ...
Pages: 340-342
Abstract  PDF
LETTER TO THE EDITOR
Characteristics of Self-estimated Enhanced Skin Susceptibility
A considerable number of people complain about enhanced skin sensitivity. The aim of this study was to investigate the characteristics of subjective statements and objective measurable parameters in subjects with self-estimated enhanced skin susceptibility. Four-hundred-and-twenty volunteers completed a questionnaire form with a self-estimation of skin susceptibility, possible triggering factors a ...
Pages: 343-346
Abstract  PDF
LETTER TO THE EDITOR
Calcium Channel Blockers Intake and Psoriasis: A Case-control Study
In vitro evidence suggests that intracellular calcium metabolism influences keratinocyte differentiation. However, only a few reports have described exacerbation of psoriasis or psoriasiform eruptions due to intake of calcium channel blockers. We conducted a case-control study to evaluate the association between exposure to calcium channel blockers and psoriasis. Data were obtained through a retro ...
Pages: 347-349
Abstract  PDF
LETTER TO THE EDITOR
Clinical Significance of Markedly Elevated Serum Creatine Kinase Levels in Patients with Acne on Isotretinoin
Muscle-related complaints and high creatine kinase (CK) blood levels have been reported in 16-51 % of patients with acne treated with isotretinoin. It has been suggested that this retinoid and exercise have a synergistic effect on muscle. The presence of marked hyperCKemia during the treatment raises concern about rhabdomyolysis. The objective of this report was to evaluate the incidence, course a ...
Pages: 350-352
Abstract  PDF
LETTER TO THE EDITOR
Treatment of Hyperkeratotic Dermatitis of the Palms (Eczema Keratoticum) with Oral Acitretin. A Single-blind Placebo-controlled Study
Hyperkeratotic dermatitis of the palms - also called eczema keratoticum - is a chronic, sometimes disabling condition in middle-aged persons. We carried out a single-blind, placebocontrolled study using acitretin in 29 patients. Fourteen patients received active therapy (30mg acitretin daily) and 15 placebo. All had hyperkeratotic changes of the palms with painful fissures and most had involvement ...
Pages: 353-355
Abstract  PDF
CLINICAL REPORT
Variegate Porphyria with Coexistent Decrease in Porphobilinogen Deaminase Activity
Variegate porphyria is a rare disease caused by a deficiency of protoporphyrinogen oxidase. In most cases, the clinical findings are a combination of systemic symptoms similar to those occurring in acute intermittent porphyria and cutaneous lesions indistinguishable from those of porphyria cutanea tarda. We report on a 24-yearoldwoman with variegateporphyriawho,after intake of lynestrenol, develop ...
Pages: 356-359
Abstract  PDF
REVIEW
A Case of Exaggerated Mosquito-bite Hypersensitivity with Epstein-Barr Virus-positive Inflammatory Cells in the Bite Lesion
We describe a unique patient with mosquito-bite hypersensitivity who had extremely high titres of Epstein-Barr virus antibodies. For many years he developed intractable ulcers on the sites of mosquito-bite. Epstein-Barr virus infection was detected in almost all inflammatory cells in the ulcers and in the peripheral blood lymphocytes by using in situ hybridization to Epstein-Barr virus-enco ...
Pages: 360-363
Abstract  PDF
INVESTIGATIVE REPORT
Milia en plaque: Treatment with Open Spray Cryosurgery
This article does not have an abstract.
Pages: 370-371
Abstract  PDF
CLINICAL REPORT
Proximal Subungual Hyperkeratosis of the Big Toe due to Microsporum gypseum
This article does not have an abstract.
Pages: 371-372
Abstract  PDF
EDITORIAL COMMENT
Multiple Becker's Naevi: A Rare Presentation
This article does not have an abstract.
Pages: 374-375
Abstract  PDF
CLINICAL REPORT
Azathioprine for the Treatment of Severe Erosive Oral and Generalized Lichen Planus
This article does not have an abstract.
Pages: 378-379
Abstract  PDF
Possible Role of Diltiazem in a Recalcitrant Case of Darier's Disease
This article does not have an abstract.
Pages: 379-381
Abstract  PDF
LETTER TO THE EDITOR
A Patient with Primary Syphilis of the Finger
This article does not have an abstract.
Pages: 382-383
Abstract  PDF
LETTER TO THE EDITOR
Type 2 Segmental Cutaneous Leiomyomatosis
This article does not have an abstract.
Page: 383
Abstract  PDF
ANNOUNCEMENTS
This article does not have an abstract.
Page: 384
Abstract  PDF
BOOK REVIEW
This article does not have an abstract.
Page: 384
Abstract  PDF