Content

Content - Volume 86, Issue 5

Editor's choice in this issue

All articles

REVIEW
Review of Scalp Alopecia due to a Clinically Unapparent or Minimally Apparent Neoplasm (SACUMAN)
Noah Scheinfeld
Neoplastic cells, both malignant and benign, local occurring and metastatic, can cause alopecia of the scalp. However, the infiltration of neoplastic cells is sometimes not florid; a condition known as “scalp alopecia due to a clinically unapparent or minimally apparent neoplasm” (SACUMAN). Neoplastic cells can nevertheless destroy hair follicles by inducing fibroplasias via inflammatory media ...
Pages: 387-392
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INVESTIGATIVE REPORT
Glucocorticoid-induced Tumour Necrosis Factor Receptor (GITR) and its Ligand (GITRL) in Atopic Dermatitis
Jane Baumgartner-Nielsen, Christian Vestergaard, Kristian Thestrup-Pedersen, Mette Deleuran and Bent Deleuran
The glucocorticoid-induced tumour necrosis factor receptor-related gene (GITR) is expressed on regulatory T-cells (Treg), which are CD4+CD25+ lymphocytes. Binding of the GITR-ligand (GITRL) leads to downregulation of the regulatory function of Tregs. Patients suffering from a defect in their Tregs exhibit a condition in their skin resembling atopic dermatitis. GITR also exists in a soluble form, a ...
Pages: 393-398
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INVESTIGATIVE REPORT
Electrical Ear Acupuncture Reduces Histamine-induced Itch (Alloknesis)
Marco Rainer Kesting, Petra Thurmüller, Frank Hölzle, Klaus-Dietrich Wolff, Tim Holland-Letz and Markus Stücker
In order to assess an objective measure for the outcome of ear acupuncture, we evaluated the effect of electrical ear acupuncture on areas of histamine-induced allo­knesis in 32 healthy volunteers. In a first assessment 5 min after histamine application on both volar forearms, 16 subjects received right ear and 16 left ear acupuncture. Immediately before and 5 min after acupuncture, all­oknesis ...
Pages: 399-403
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CLINICAL REPORT
Important Factors for Pain during Photodynamic Therapy for Actinic Keratosis
Carin Sandberg, Bo Stenquist, Inger Rosdahl, Anne-Marie Ros, Ingrid Synnerstad, Maria Karlsson, Fredrik Gudmundson, Marica B. Ericson, Olle Larkö and Ann-Marie Wennberg
Photodynamic therapy (PDT) is an efficient treatment for actinic keratosis. A common problem, however, is pain. The aim of this study was to investigate pain during PDT for actinic keratosis. The possibility of using capsaicin cream for pain relief was also assessed. Pain was investigated during aminolaevulinic acid PDT in 91 patients. Size, redness, scaling and induration of the lesions were reco ...
Pages: 404-408
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CLINICAL REPORT
Morphine Gel 0.3% Does Not Relieve Pain During Topical Photodynamic Therapy: A Randomized, Double-blind, Placebo-controlled Study
Jette Skiveren, Merete Haedersdal, Peter Alshede Philipsen, Stine Regin Wiegel and Hans Christian Wulf
There is a demand for pain relief during photodynamic therapy. We therefore investigated the efficacy and side-effects of topical morphine gel 0.3% for pain relief during topical photodynamic therapy in a randomized, double-blind, placebo-controlled study. The study involved 28 patients with actinic keratoses or basal cell carcinomas. Each patient was treated with photodynamic therapy after superf ...
Pages: 409-411
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CLINICAL REPORT
Topical 5-Aminolevulinic Acid Mediated Photodynamic Therapy of Superficial Basal Cell Carcinoma Using Two Light Fractions with a Two-hour Interval: Long-term Follow-up
Willem M. Star, Albert J. van ‘t Veen, Dominic J. Robinson, Kai Munte, Ellen R. M. de Haas and Henricus J. C. M. Sterenborg
Photodynamic therapy (PDT) of superficial basal cell carcinoma using topical 5-aminolaevulinic acid (ALA) and 75–100 J/cm2 light dose yields unsatisfactory long-term results. In several animal models, illumination with two light fractions approximately 2 h apart was considerably more effective than single illumination, suggesting the need for a pilot clinical study. Fifteen patients with a total ...
Pages: 412-417
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CLINICAL REPORT
Penile Intraepithelial Neoplasia: Results of Photodynamic Therapy
John Paoli, Annika Ternesten Bratel, Gun-Britt Löwhagen, Bo Stenquist, Ola Forslund and Ann-Marie Wennberg
Failure of response to treatment or recurrent disease is often noted in patients with penile intraepithelial neoplasia. Photodynamic therapy has recently been added to the list of treatment modalities used for this diagnosis. Our primary objective was to study the results of photo­dynamic therapy in the treatment of penile intraepithelial neoplasia in men over the age of 40 years. Ten patients ...
Pages: 418-421
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CLINICAL REPORT
Inosiplex for Treatment of Alopecia Areata: a Randomized Placebo-controlled Study
Sofia Georgala, Alexander C. Katoulis, Angeliki Befon, Katerina Georgala and Panagiotis G. Stavropoulos
Treatment of alopecia areata remains unsatisfactory. We decided to test if systemic therapy with inosiplex (Isoprinosine®), an immunomodulator could influence the disease. Thirty-two subjects with recalcitrant alopecia areata, aged 16–48 years (mean 30.3±5.1 years), were randomized into two treatment groups of 16 subjects each. They were assigned to receive either oral inosiplex (group 1), or ...
Pages: 422-424
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CLINICAL REPORT
Prevalence of Toe Nail Onychomycosis in Diabetic Patients
Ditte Marie L. Saunte, Jane B. Holgersen, Merete Hædersdal, Gitte Strauss, Mikael Bitsch, Ole L. Svendsen, Maiken C. Arendrup and Else L. Svejgaard
Onychomycosis among diabetic patients has been report­ed in some studies to be of high prevalence. This study aimed to investigate the prevalence of onychomycosis among diabetic patients at a Danish University Hospital. Clinical and mycological examinations were performed on type 1 and 2 diabetic patients from in- and out-patient clinics. A total of 271 patients were enrolled, 72% males, mean ...
Pages: 425-428
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CLINICAL REPORT
Pulse Methylprednisolone Therapy for Threatening Periocular Haemangiomas of Infancy
Franck Delesalle, Delphine Staumont, Mohamed Ali Houmany, Georges Marie Breviere and Frederic Piette
Periocular haemangiomas of infancy can cause severe and rapid ocular damage. Oral corticosteroids remain the front-line treatment to minimize the consequences of these haemangiomas. The aim of this report is to summari­ze our experience with pulse intravenous methylprednisolone as an alternative therapy for periocular haemangioma when visual prognosis is engaged. Fifteen infants, who presented ...
Pages: 429-432
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CLINICAL REPORT
Unexpectedly High Frequency of Genital Involvement in Women with Clinical and Histological Features of Oral Lichen Planus
Olga Di Fede, Pina Belfiore, Daniela Cabibi, Stefano De Cantis, Emiliano Maresi, Alexander Ross Kerr and Giuseppina Campisi
The main aims of this cross-sectional study were: (i) to assess the frequency of genital (vulval) lichen planus (VLP) and vulval lichen sclerosus (VLS) in women affect­ed with oral lichen planus (OLP), regardless of the genital symptoms reported; and (ii) to verify whether any demographic, clinical, or histological features of OLP are associated with a higher risk of vulvo-vaginal involve­ment. ...
Pages: 433-428
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CLINICAL REPORT
Genital Ulcers as Initial Manifestation of Epstein-Barr Virus Infection: Two New Cases and a Review of the Literature
Jon Anders Halvorsen, Trine Brevig, Torkild Aas, Anne Grete Skar, Ellen Margrethe Slevolden and Harald Moi
Genital ulceration is an uncommon manifestation of primary Epstein-Barr virus (EBV) infection. We present here two cases of genital ulcers probably caused by EBV. The first case is a 12-year-old girl with a genital ulcer appearing before specific EBV serology could identify a primary infection. However, serology was positive 13 days after the ulcer appeared. Polymerase chain reaction for EBV was p ...
Pages: 439-442
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CLINICAL REPORT
Penicillin-induced Anti-p200 Pemphigoid: An Unusual Morphology
Katarzyna Wozniak, Cezary Kowalewski, Takashi Hashimoto, Norito Ishii, Maria Glinska-Wielochowska and Robert A. Schwartz
We report here a case of a 52-year-old woman with ery­thema gyratum repens-like lesions appearing during anti-p200 pemphigoid, probably induced by oral penicillin. The diagnosis of anti-p200 pemphigoid was made by the presence of in vivo bound and circulating IgG anti-base­ment membrane zone auto-antibody reactive with the dermal side of salt-split skin and with 200 kDa protein in dermal extra ...
Pages: 443-446
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LETTER TO THE EDITOR
Intrinsic Atopic Dermatitis is Associated with a Beta-2 Adrenergic Receptor Polymorphism
Anne-Marie Roguedas, Marie-Pierre Audrezet, Virginie Scotet, Dominique Dupré-Goetghebeur, Claude Ferec and Laurent Misery
This article does not have an abstract.
Pages: 447-448
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LETTER TO THE EDITOR
Oral Corticosteroids did not Prevent AGEP due to Terbinafine
Vrinda Bajaj and Nick Simpson
This article does not have an abstract.
Pages: 448-449
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LETTER TO THE EDITOR
Hydroxychloroquine in Psoriasis: Is it Really Harmful?
Stefania Sorbara, Emanuele Cozzani, Alfredo Rebora and Aurora Parodi
This article does not have an abstract.
Pages: 450-451
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LETTER TO THE EDITOR
Bamboo Spine Mimicking Bekhterev’s Disease Caused by Long-term Acitretin Treatment
Nils-Jørgen Mørk, Joar Austad and Alf Kolbenstvedt
This article does not have an abstract.
Pages: 452-453
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LETTER TO THE EDITOR
Depot Leuprorelin Acetate-induced Granulomas Manifested as Persistent Suppurative Nodules
Marta Ferran, Ana Giménez-Arnau, Augustí Toll, Mireia Yébenes, Verónica Baena, Josep Lloreta and Ramon M. Pujol
This article does not have an abstract.
Pages: 453-455
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LETTER TO THE EDITOR
Severe Exacerbation of Psoriatic Arthritis during Treatment with Efalizumab. A Case Report
Bo Bang and Robert Gniadecki
This article does not have an abstract.
Pages: 456-457
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LETTER TO THE EDITOR
Primary Non-essential Cutis Verticis Gyrata Revealed with 3-D Magnetic Resonance Imaging
Doo Jin Oh, Jeong Hoon Park, Seung Hoon Kang, Seon Wook Hwang and Sung Wook Park
This article does not have an abstract.
Pages: 458-459
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LETTER TO THE EDITOR
Keratoacanthoma-like Cutaneous Metastasis of Lung Cancer: a Learning Point
Adam Reich, Monika Kobierzycka, Zdzisław Woźniak, Maria Cisło and Jacek C Szepietowski
This article does not have an abstract.
Pages: 459-460
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LETTER TO THE EDITOR
Chemical Burns to the Scalp from Hair Bleach and Dye
Charlotte D. Jensen and Heidi Sosted
This article does not have an abstract.
Pages: 461-462
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LETTER TO THE EDITOR
Multiple Panniculitis Caused by Actinobacillus and Actinomyces Infections
Esben Techau Jörgensen
This article does not have an abstract.
Pages: 462-463
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LETTER TO THE EDITOR
Human Papilloma Virus Testing of Vaginal Smear Obtained with a Novel Self-Sampling Device
Harriet Stenvall, Ingrid Wikström and Erik Wilander
This article does not have an abstract.
Pages: 465-467
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LETTER TO THE EDITOR
Pemphigus Vulgaris Induced by Honeybee Sting?
Ülker Gül, Müzeyyen Gönül, Seray Külcü Çakmak and Arzu Kiliç
This article does not have an abstract.
Pages: 467-468
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LETTER TO THE EDITOR
Acquired Unilateral Naevoid Telangiectasia in a Healthy Boy
Miriam Grimaldi, Guglielmo Pranteda, Caterina Talerico Giulia Pranteda1 and Arianna Di Napoli
This article does not have an abstract.
Page: 469
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LETTER TO THE EDITOR
Additional Test Evaluating the Psychosocial Status of Psoriasis Patients
Sandra R. Leichtman and Joseph W. Burnett
This article does not have an abstract.
Pages: 470-470
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LETTER TO THE EDITOR
4th Georg Rajka International Symposium on Atopic Dermatitis. Meeting Report
Kristian Thestrup-Pedersen, Klaus Ejner Andersen and Masahiro Takigawa
This article does not have an abstract.
Pages: 471-475
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