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Content - Volume 87, Issue 2

Editor's choice in this issue

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IN THIS ISSUE
Systemic Therapy of Severe Atopic Eczema
Kristian Thestrup-Pedersen
Section Editor
Pages: 98-99
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REVIEW
Systemic Treatment of Severe Atopic Eczema: A Systematic Review
Jochen Schmitt, Knut Schäkel, Natalie Schmitt and Michael Meurer
Systemic immunosuppressive agents are recommended for patients with atopic eczema in whom disease activity cannot be controlled adequately with topical treatments. Guidelines do not give clear advice which agents to prefer. We systematically reviewed clinical trials on systemic treatment for severe atopic eczema to provide evidence-based treatment recommendations. Standardiz­ed literature search, ...
Pages: 100-111
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INVESTIGATIVE REPORT
IP10/CXCL10 - CXCR3 Interaction: a Potential Self-recruiting Mechanism for Cytotoxic Lymphocytes in Lichen Sclerosus et Atrophicus
Joerg Wenzel, Andreas Wiechert, Christian Merkel, Thomas Bieber and Thomas Tüting
Lichen sclerosus et atrophicus is a chronic inflammatory skin disease of unknown aetiology. Recent studies have indicated that autoimmune mechanisms might be involved in its pathogenesis and have suggested a role for autoreactive cytotoxic T lymphocytes. Based on recent observations we now hypothesize that a type I interferon-driven inflammation might be involved in the pathogenesis of this diseas ...
Pages: 112-117
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INVESTIGATIVE REPORT
Skin-homing CD8+ T lymphocytes Show Preferential Growth in vitro and Suppress CD4+ T-cell Proliferation in Patients with Early Stages of Cutaneous T-cell Lymphoma
Kristian Thestrup-Pedersen, Ranjit Parhar, Kaida Wu, Per-Anders Bertilsson, Brian Meyer, Sayeda Abu-Amero, Bo Hainau, Abdullah AlEisa, Abdullah AlFadley, Issam Hamadah, Abdulmajeed AlAjlan, Khalid Al-Hussein and Futwan Al-Mohanna
A total of 27 T-lymphocyte cell strains wereb established from skin biopsies of 24 patients with various stages of cutaneous T-cell lymphoma (CTCL) by addition of the T-cell growth factors interleukin (IL)-2 and IL-4. Cellular proliferation and phenotypic changes were measured over 3 months in culture, and T-cell clones were studied using T-cell receptor-γ re-arrangement techniqu ...
Pages: 118-126
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INVESTIGATIVE REPORT
Clinical Associations of the Risk Alleles of HLA-Cw6 and CCHCR1*WWCC in Psoriasis
Sari Suomela, Kati Kainu, Päivi Onkamo, Inkeri Tiala, Johan Himberg, Lotta Koskinen, Erna Snellman, Seija-Liisa Karvonen, Jaakko Karvonen, Tutta Uurasmaa, Timo Reunala, Kristiina Kivikäs, Christer T. Jansén, Päivi Holopainen, Outi Elomaa, Juha Kere and Ulpu Saarialho-Kere
The PSORS1 locus is the consistently replicated genetic risk factor for psoriasis. Clinical associations with the main marker allele of PSORS1, HLA-Cw6, have been addressed in a number of studies, but clinical associations have not been used as a way to distinguish the effects of the neighbouring candidate genes in PSORS1. Our results show that HLA-Cw6 and CCHCR1 risk allele associations with clin ...
Pages: 127-134
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INVESTIGATIVE REPORT
Study of Psychological Stress, Sebum Production and Acne Vulgaris in Adolescents
Gil Yosipovitch, Mark Tang, Aerlyn G. Dawn, Mark Chen, Chee Leok Goh, Yiong Huak Chan and Lim Fong Seng
Sebum production is thought to play a major role in acne vulgaris in adolescents. Psychological stress may exacerbate acne; however, it is not known whether the perceived association between stress and acne exacerbation is due to increased sebum production. The aims of this study were to determine: (i) if psychological stress in adole­scents is associated with incr ...
Pages: 135-139
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INVESTIGATIVE REPORT
Pooling Samples: the Key to Sensitive, Specific and Cost-effective Genetic Diagnosis of Chlamydia trachomatis in Low-Resource Countries
Elena Shipitsyna, Kira Shalepo, Alevtina Savicheva, Magnus Unemo and Marius Domeika
The aims of this study were to compare the performance characteristics and cost-effectiveness of pooling endocervical samples for screening and diagnosis of Chlamydia trachomatis, and to investigate the prevalence of C. trachomatis infection in women in Leningrad Oblast, Russia. A total of 1500 endocervical samples were tested individ ...
Pages: 140-143
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CLINICAL REPORT
Dexamethasone Pulse Therapy for Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Sylvia H. Kardaun and Marcel F. Jonkman
Mortality in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is high. Apart from intensive supportive therapy, no generally accepted specific treatment regimen exists. The role of corticosteroids in SJS/TEN is controversial. It is possible that high-dose pulse therapy with corticosteroids might be an improvement on long-term lower dose therapy, by combining higher efficacy with ...
Pages: 144-148
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CLINICAL REPORT
Poppyfield Bleeding: a New Dermatoscopic Sign and its Histopathological Background
Henrik F. Lorentzen, Kaare Weismann, Kristian Rossen and Henrik Klem Thomsen
Dermatoscopy increases the accuracy of diagnosis of melanoma. An atypical vascular pattern may be an indicator of cutaneous malignant melanoma (CMM). During dermatoscopy of certain CMMs numerous ruby droplets of blood appear when the dermatoscope is pressed firmly against the lesion. The aim of this paper was to examine the histopathological background for this observation. CMMs from 8 patients sh ...
Pages: 149-151
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INVESTIGATIVE REPORT
Cutaneous Vascular Alterations in Psoriatic Patients Treated with Cyclosporine
Giuseppe Stinco, Stefano Lautieri, Francesca Valent and Pasquale Patrone
Videocapillaroscopy can be used to assess cutaneous microcirculation modifications in vivo, and therefore allows assessment of variations in the microvascular architecture in psoriatic subjects during treatment. The aim of this study was to observe and quantify the modifications of the superficial capillary bed in psoriatic plaques during treatment with cyclosporin ...
Pages: 152-155
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CLINICAL REPORT
CD13 and TCR Clone: Markers of Early Mycosis Fungoides
Claire Bernier, Jean Michel Nguyen, Gaëlle Quéreux, Jean Jaques Renault, Brigine Bureau and Brigitte Dreno
Making a differential diagnosis between early mycosis fungoides (MF) and parapsoriasis is often difficult at the clinical and histological level. The aim of this study was to explore markers that could help in this process. A total of 88 patients were included in 2 categories: large plaque parapsoriasis and digitiform parapsoriasis. A histological examination was performed for each patient, and ex ...
Pages: 155-159
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CLINICAL REPORT
Spectrum of Cutaneous Metastases in 1287 Cases of Internal Malignancies: A Study from Turkey
Ülker Gül, Arzu Kiliç, Müzeyyen Gönül, Seray Külcü Çakmak andCeren Erincan
Cutaneous metastases may be either the initial manifestation of an internal malignancy or represent recurrent neoplastic disease. The aim of this study was to investigate the incidence and characteristics of cutaneous metastases in cases of internal malignancy. A total of 1287 patients with internal malignancy were included in the study. Dermatological examinations were performed on all of the pat ...
Pages: 160-162
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CLINICAL REPORT
Dermatitis Herpetiformis Presenting as Ataxia in a Child
Per Helsing and Hege Frøen
Dermatitis herpetiformis and coeliac disease are gluten-sensitive diseases that share immunopathological mechanisms. Neurological disorders are reported in both diseases, being more frequent in coeliac disease. Dermatitis herpetiformis is rare in paediatric populations and only sporadic cases with neurological dysfunction are reported. Uncertainty exists as to whether early treatment may stop or r ...
Pages: 163-165
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LETTER TO THE EDITOR
Treatment of Psoriatic Nails with Tazarotene Cream 0.1% vs. Clobetasol Propionate 0.05% Cream: A Double-blind Study
Dimitris Rigopoulos, Stamatis Gregoriou and Andreas Katsambas
This article does not have an abstract.
Pages: 167-168
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LETTER TO THE EDITOR
Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type, with the Clinical Picture of Chronic Venous Ulceration
Anke Süß, Jan C. Simon and Michael Sticherling
This article does not have an abstract.
Pages: 169-170
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LETTER TO THE EDITOR
Non-Hodgkin's Lymphoma Associated with Leiomyomatosis Presenting with Intense Pruritus
Ülker Gül, Arzu Kiliç, Özlem Demirel, Müzeyyen Gönül, Seray Külcü Çakmak and Murat Demiriz
This article does not have an abstract.
Pages: 171-172
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LETTER TO THE EDITOR
Spiny Keratoderma of the Palms Successfully Treated with Topical Tacalcitol
Mami Yukawa, Takahiro Satoh, Tetsuya Higuchi and Hiroo Yokozeki
This article does not have an abstract.
Pages: 172-174
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LETTER TO THE EDITOR
Gianotti-Crosti Syndrome after Hepatitis Α Vaccination
Alexandra Monastirli, Anastassia Varvarigou, Efi Pasmatzi, George Badavanis, Sophia Georgiou, Stefanos Mantagos and Dionysios Tsambaos
This article does not have an abstract.
Pages: 174-175
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LETTER TO THE EDITOR
Extranodal NK/T-Cell Lymphoma Nasal Type Mimicking Pyoderma Gangrenosum
Yolanda Delgado-Jimenez, Silvia Pérez Gala, Syonghyun Nam-Cha, Maria Jones-Caballero, Javier Fraga, Amaro García-Díez and Jesús Fernández-Herrera
This article does not have an abstract.
Pages: 176-177
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LETTER TO THE EDITOR
Contact Vulvitis due to Pseudowintera Colorata in a Topical Herbal Medicament
Monica Corazza, Maria Michela Lauriola, Ferruccio Poli and Annarosa Virgili
This article does not have an abstract.
Pages: 178-179
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LETTER TO THE EDITOR
Adult-onset Multiple Eccrine Angiomatous Hamartoma in Enlarging Hairy Plaques
Yasushi Sugimoto, Eri Araki, Naoko Inoguchi, Yumi Matsumura, Satoshi Kore-eda, Yuri Horiguchi, Yoshiki Miyachi and Atsushi Utani
This article does not have an abstract.
Pages: 180-181
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LETTER TO THE EDITOR
Keratosis Lichenoides Chronica: Treatment with Bath-PUVA
Christian Kunte, Karin Kerschenlohr, Med Martin Röcken and C.G. Schirren
This article does not have an abstract.
Pages: 182-183
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LETTER TO THE EDITOR
Persistent Herpes Gestationis Treated with High-dose Intravenous Immunoglobulin
Carla dos Santos Rodrigues, Paulo Filipe, Maria del Mar Solana, Luis Soares de Almeida, José Cirne de Castro and Manuel Marques Gomes
This article does not have an abstract.
Pages: 184-186
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LETTER TO THE EDITOR
A Case of Generalized Argyria Caused by the Use of Silver Protein as a Disinfection Medicine
Noriyasu Sakai, Mikako Aoki, Shichiro Miyazawa, Masahiko Akita, Shinichiro Takezaki and Seiji Kawana
This article does not have an abstract.
Pages: 186-187
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LETTER TO THE EDITOR
Assessing Clinically Meaningful End Points for the Management of Actinic Keratosis with Diclofenac 3% Gel
Jason K. Rivers and John Wolf
This article does not have an abstract.
Pages: 188-189
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