Content

Content - Volume 88, Issue 4

Editors choice in this issue

All articles

INVESTIGATIVE REPORT
A Study of the Mu Opioid Receptor Gene Polymorphism A118G in Patients with Primary Biliary Cirrhosis with and without Pruritus
Lin Xiang Wei, Annarosa Floreani, Angella Variola, Cherif El Younis, Nora V. Bergasa
The increase in opioidergic tone by the central administration of morphine, which binds to the mu opioid receptor, is associated with pruritus. Pruritus is a symptom of cholestasis, which appears to result, in part, from increased opioidergic tone; a central mechanism has been proposed. The single nucleotide polymorphism Al18G in exon 1 of the opioid receptor mu 1 (OPRM1) gene, which codes for the ...
Pages: 323-326
Abstract  HTML  PDF
INVESTIGATIVE REPORT
In vitro and In vivo Characterization of a Novel Liposomal Butorphanol Formulation for Treatment of Pruritus
Grace J. Lim, Yozo Ishiuji, Aerlyn G. Dawn, Benjamin Harrison, Do Won Kim, Anthony Atala, Gil Yosipovitch
As yet no transdermal topical formulations have been developed for the treatment of chronic itch. We developed a formulation containing 2 mg butorphanol tartrate in 100 µl purified water encapsulated into multilamellar phospholipid vesicles. Drug permeation experiments were studied with Franz diffusion chambers using human skin in vitro and on rat skin in vivo. Histological analysis of rat skins ...
Pages: 327-330
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Frequency of Bacteria, Candida and Malassezia Species in Balanoposthitis
Mikael Alsterholm, Ingela Flytström, Ragna Leifsdottir, Jan Faergemann, Ing-Marie Bergbrant
Balanoposthitis is an inflammatory disorder of the prepuce and glans penis. Microbes involved in balanopos­thitis have been investigated, but no single study has cove­red the growth of both bacteria, Candida and Malassezia. We report here the prevalence of these microbes in 100 patients with balanoposthitis and in 26 control patients. Among patients with balanoposthitis there was a significantly ...
Pages: 331-336
Abstract  HTML  PDF
CLINICAL REPORT
Inflammation and Hypercoagulable State in Adult Psoriatic Men
Ozlem Karabudak, Rifat Eralp Ulusoy, Alev Akyol Erikci, Emrullah Solmazgul, Bilal Dogan, Yavuz Harmanyeri
Hyperhomocysteinaemia is a well-known risk factor for cardiovascular disease and plays a role in athero­thrombosis. Psoriasis is a common chronic and recurrent inflammatory skin disease associated with increased thrombosis. The aim of this study was to examine serum homocysteine levels and their relationships with inflammatory and atherothrombotic markers in psoriasis. Twenty patients with mild o ...
Pages: 337-340
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Measurement of Liver Iron Content by Magnetic Resonance Imaging in 20 Patients with Overt Porphyria Cutanea Tarda before Phlebotomy Therapy: A Prospective Study
Olivier Dereure, Nicolas Jumez, Didier Bessis, Benoit Gallix, Bernard Guillot
Liver iron content was evaluated by a magnetic resonance imaging-based method in 20 consecutive patients with either sporadic or familial porphyria cutanea tarda. Serum ferritin, hepatitis C infection and the presence of the 2 main mutations of the hemochromatosis gene were also investigated. All patients showed good clinical response to phlebotomy. Initial liver iron content was normal (< 40 ...
Pages: 341-345
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Atrichia with Papular Lesions: A Report of Three Novel Human Hairless Gene Mutations and a Revision of Diagnostic Criteria
Leona Yip, Liran Horev, Rodney Sinclair, Abraham Zlotogorski
Atrichia with papular lesions is a rare autosomal recessive condition characterized by complete irreversible hair loss during the first months of life and papules that appear during early childhood. Atrichia with papular lesions is frequently misdiagnosed as alopecia universalis, despite increasing reports of its prevalence and the presence of well-defined diagnostic criteria. Most cases of atrich ...
Pages: 346-349
Abstract  HTML  PDF
CLINICAL REPORT
Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and Review of the Literature
Eleni Sotiriou, Aikaterini Patsatsi, Christina Tsorova, Elisabeth Lazaridou, Dimitrios Sotiriadis
Febrile ulceronecrotic Mucha-Habermann disease is a severe variant of pityriasis lichenoides et varioliformis acuta characterized by the sudden onset of ulceronecrotic skin lesions and associated with high fever and systemic symptoms. We report here a case of a 20-year-old woman in whom the disease started as pityriasis lichenoides et varioliformis acuta and evolved to febrile ulceronecrotic Mucha ...
Pages: 350-355
Abstract  HTML  PDF
CLINICAL REPORT
Patient’s Estimation of Efficacy of Various Hyperhidrosis Treatments in a Dermatological Clinic
Mohammad Amini, Ankie M. Harmsze, Ron A. Tupker
Hyperhidrosis is a common ailment, which is accompanied by a low quality of life. There are many current treatment options. The aims of this study were to investigate: (i) the characteristics of sweating in patients referred for hyperhidrosis; (ii) their quality of life, using the Dermatology Life Quality Index and the Hyperhidrosis Disease Severity Scale; and (iii) their estimation of efficacy of ...
Pages: 356-362
Abstract  HTML  PDF
CLINICAL REPORT
Clinical Manifestations and Characteristics of Patients with Acute Generalized Exanthematous Pustulosis in Asia
Shyue-Luen Chang, Yu-Huei Huang, Chih-Hsun Yang, Sindy Hu, Hong-Shang Hong
Acute generalized exanthematous pustulosis is a rare, sterile inflammation of the skin (and mucous membranes) characterized by acute onset of generalized pustule formation, fever and leukocytosis, and a rapid resolution. A computer-based search of the literature revealed only a limited series of reports, none of them based on Asian patients. We identified and retrospectively analysed 16 biopsy-pro ...
Pages: 363-365
Abstract  HTML  PDF
CLINICAL REPORT
Cooling by Frozen Gel Pack as Pain Relief During Treatment of Axillary Hyperhidrosis with Botulinum Toxin A Injections
Jette Skiveren, Emmy Kjaerby, Heidi Nordahl Larsen
Botulinum toxin A injection is a well-described efficacious treatment for axillary hyperhidrosis. Although considered a safe treatment, many patients experience pain during injections. The purpose of the present study was to examine whether cooling by frozen gel packs applied in the axilla for 5 min before treatment could reduce pain. Thirty-six patients with axillary hyperhidrosis were included i ...
Pages: 366-369
Abstract  HTML  PDF
CLINICAL REPORT
Clinical Follow-up of 102 Anti-Ro/SSA-positive Patients with Dermatological Manifestations
Karin Popovic, Marie Wahren-Herlenius, Filippa Nyberg
Patients with Ro/SSA autoantibodies can develop cutaneous lupus erythematosus and photosensitivity. The aim of this study was to evaluate disease progression and clinical outcome in Ro/SSA-positive patients after 2 years in a prospectively followed cohort. A total of 102 previously clinically and serologically characterized Ro/SSA-positive patients received a questionnaire 2 years after the baseli ...
Pages: 370-375
Abstract  HTML  PDF
CLINICAL REPORT
Targeted Broadband Ultraviolet B Phototherapy Produces Similar Responses to Targeted Narrowband Ultraviolet B Phototherapy for Vitiligo: A Randomized, Double-blind Study
Pravit Asawanonda, Jirasin Kijluakiat, Wiwat Korkij, Wannasri Sindhupak
Narrowband ultraviolet B (NB-UVB) phototherapy, with a 308-nm xenon chloride excimer laser, and targeted UVB phototherapy have produced encouraging therapeutic results for vitiligo. However, very few studies employing broadband UVB exist. Moreover, there has been no direct comparison study between broadband UVB and NB-UVB for the treatment of vitiligo. The aims of this study were to compare the re ...
Pages: 376-381
Abstract  HTML  PDF
CLINICAL REPORT
Segmentally Arranged Basaloid Follicular Hamartomas with Osseous, Dental and Cerebral Anomalies: A Distinct Syndrome
Rudolf Happle, Sigrid Tinschert
A 39-year-old man presented with multiple basaloid follicular hamartomas involving the right side of his body in a systematized pattern following Blaschko’s lines. His right leg was 22.5 cm shorter than the left, and rudimentary pre-axial polydactyly was noted on the left hand and the right foot. The teeth of the right maxilla were hypoplastic. DNA analysis of blood lymphocytes and fibroblasts f ...
Pages: 382-387
Abstract  HTML  PDF
LETTER TO THE EDITOR
Punch-grafting to Enhance Healing and to Reduce Pain in Complicated Leg and Foot Ulcers
Annika Nordström, Carita Hansson
This article does not have an abstract.
Pages: 389-391
Abstract  HTML  PDF
LETTER TO THE EDITOR
Interaction of Human Papillomavirus DNA with Factor XIIIa-positive Dermal Dendrocytes in Vulvar Lesions
Naiura Vieira Pereira, Carla Pagliari, Elaine R. Fernandes, Fernanda Guedes, Mírian N. Sotto, Maria Irma Seixas Duarte
This article does not have an abstract.
Pages: 391-393
Abstract  HTML  PDF
LETTER TO THE EDITOR
Bullous Dermatomyositis: A Marker of Poor Prognosis and Aggressive Internal Malignancy?
Arianna Zangrilli, Marina Papoutsaki, Luca Bianchi, Miriam Teoli, Sergio Chimenti
This article does not have an abstract.
Pages: 393-394
Abstract  HTML  PDF
LETTER TO THE EDITOR
Spontaneous Regression of Generalized Angiolymphoid Hyperplasia with Eosinophilia in a 2-year-old Boy
Hiroko Koizumi, Ryuhei Okuyama, Hachiro Tagami, Setsuya Aiba
This article does not have an abstract.
Pages: 395-396
Abstract  HTML  PDF
LETTER TO THE EDITOR
Vogt-Koyanagi-Harada Syndrome Associated with Psoriasis and Autoimmune Thyroid Disease
Nicolas Kluger, Frédéric Mura, Bernard Guillot, Didier Bessis
This article does not have an abstract.
Pages: 397-398
Abstract  HTML  PDF
LETTER TO THE EDITOR
Diagnosis of Hailey-Hailey Disease Facilitated by DNA Testing: A Novel Mutation in ATP2C1
Ikue Nemoto-Hasebe, Masashi Akiyama, Rinko Osawa, Hiroyuki Nakamura, Hiroshi Shimizu
This article does not have an abstract.
Pages: 399-400
Abstract  HTML  PDF
LETTER TO THE EDITOR
Bullous Pemphigoid of the Perineum and Perianal Area: A Rare Localized Form in Adults
Aikaterini Patsatsi, Elisabeth Lazaridou, Ioannis Papagaryfallou, Dimitrios Sotiriadis
This article does not have an abstract.
Page: 401
Abstract  HTML  PDF
LETTER TO THE EDITOR
Coexistence of Diffuse Reactive Angioendotheliomatosis and Neutrophilic Dermatosis Heralding Primary Antiphospholipid Syndrome
John Kawaoka, Jason McBean, Hongmei Li, Martin C. Mihm, George Kroumpouzos
This article does not have an abstract.
Pages: 402-403
Abstract  HTML  PDF
LETTER TO THE EDITOR
Successful Treatment of an Elderly Patient with Refractory Ultraviolet-A-sensitive Atopic Eczema with Mycophenolic Acid
Michael Bär, Jochen Schmitt, Andrea Bauer, Gottfried Wozel, Michael Meurer
This article does not have an abstract.
Pages: 404-405
Abstract  HTML  PDF
LETTER TO THE EDITOR
Keratitis-Ichthyosis-Deafness Syndrome Lacking Subjective Hearing Impairment
Ikue Nemoto-Hasebe, Masashi Akiyama, Nanako Yamada, Yoshitsugu Inoue, Chizu Touge, Hiroshi Shimizu
This article does not have an abstract.
Pages: 406-408
Abstract  HTML  PDF
LETTER TO THE EDITOR
Traumatized Recurrent Melanocytic Naevus with Typical Starburst Pattern on Dermoscopy
Yuichi Yoshida, Nanako Yamada, Koji Adachi, Masaru Tanaka, Osamu Yamamoto
This article does not have an abstract.
Pages: 408-409
Abstract  HTML  PDF
LETTER TO THE EDITOR
Paraneoplastic Pemphigus Developed Shortly after Resection of Follicular Dendritic Cell Sarcoma
Sang Eun Lee, Hae Ryoung Kim, Takashi Hashimoto, Soo-Chan Kim
This article does not have an abstract.
Pages: 410-412
Abstract  HTML  PDF
LETTER TO THE EDITOR
Blue Naevus with Pigment Network-like Structure on Dermoscopy
Yuichiro Tsunemi, Hidehisa Saeki, Kunihiko Tamaki
This article does not have an abstract.
Pages: 412-413
Abstract  HTML  PDF
LETTER TO THE EDITOR
Photosensitive Psoriasis Vulgaris Inducible by a Single Suberythematous Dose of Ultraviolet B Irradiation
Timo Buhl, Ullrich Krüger, Steffen Emmert, Hans Peter Bertsch, Rotraut Mössner
This article does not have an abstract.
Pages: 414-416
Abstract  HTML  PDF
LETTER TO THE EDITOR
Staphylococcal Scalded Skin Syndrome as a Harbinger of Late-onset Staphylococcal Septicaemia in a Premature Infant of Very Low Birth Weight
Matthias Hütten, Konrad Heimann, Jens M. Baron, Tobias G. Wenzl, Hans-Friedrich Merk, Hagen Ott
This article does not have an abstract.
Pages: 416-417
Abstract  HTML  PDF
LETTER TO THE EDITOR
Psoriasis Vulgaris Associated with Acne Vulgaris: Differential Effects of Biologicals?
Andreas Colsman, Michael Sticherling
This article does not have an abstract.
Pages: 418-419
Abstract  HTML  PDF
LETTER TO THE EDITOR
Beneficial and Rapid Effect of Infliximab on the Course of Toxic Epidermal Necrolysis
Agnieszka Wojtkiewicz, Mariusz Wysocki, Jacek Fortuna, Małgorzata Chrupek, Maciej Matczuk, Andrzej Koltan
This article does not have an abstract.
Pages: 420-421
Abstract  HTML  PDF
LETTER TO THE EDITOR
Primary Cutaneous Epithelioid Angiosarcoma
Aki Kikuchi, Takahiro Satoh, Hiroo Yokozeki
This article does not have an abstract.
Pages: 422-423
Abstract  HTML  PDF
LETTER TO THE EDITOR
A BHD Germline Mutation Identified in an Asian Family with Birt-Hogg-Dubé Syndrome
Noriyuki Misago, Keiichiro Joh, Hitomi Yatsuki, Hidenobu Soejima, Yutaka Narisawa
This article does not have an abstract.
Pages: 423-425
Abstract  HTML  PDF
LETTER TO THE EDITOR
Pseudoporphyria or Porphyria Cutanea Tarda? Diagnostic and Treatment Difficulties
Sheila A.M. Fevang, Susanne Kroon, yvind Skadberg
This article does not have an abstract.
Pages: 426-427
Abstract  HTML  PDF
LETTER TO THE EDITOR
Skin Nodules in Rheumatoid Arthritis Due to Infection with Mycobacterium haemophilum
Cornelia S. Seitz, Axel Trautemann, Eva-Bettina Bröcker, Marianne Abele-Horn, Matthias Goebeler
This article does not have an abstract.
Pages: 428-429
Abstract  HTML  PDF