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Content - Volume 90, Issue 2

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REVIEW
Serological Studies in Bullous Pemphigoid: A Literature Review of Antibody Titers at Presentation and in Clinical Remission
Stefania Leuci, Hakan M. Gürcan, A. Razzaque Ahmed
Bullous pemphigoid is associated with antibodies to a 230 kDa and a 180 kDa protein. In a literature review we investigated the role of auto-antibodies as detected by different serological assays. Nine reports containing data on 143 patients were analyzed. Pre-treatment data showed that indirect immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and immunoblotting offer an 82.2% or grea ...
Pages: 115-121
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REVIEW
Prevention of Ulcerative Lesions by Episodic Treatment of Recurrent Herpes Labialis: A Literature Review
Johan Harmenberg, Bo Öberg, Spotswood Spruance
There are substantial difficulties involved in carrying out clinical studies of recurrent herpes labialis, since the disease has a rapid onset, short-lasting viral shedding period and is rapidly self-healing. The aim of this paper was to critically assess published reports of episodic treatment of herpes labialis and to review biological and methodological problems involved in such studies. Limite ...
Pages: 122-130
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INVESTIGATIVE REPORT
Platelet-derived Growth Factor Receptor Alpha Gene Mutations in Vitiligo Vulgaris
Shengxin Xu, Youwen Zhou, Sen Yang, Yunqing Ren, Chi Zhang, Cheng Quan, Min Gao, Caifeng He, Hui Chen, Jianwen Hhan, Jianjun Chen, Yanhua Liang, Jianqiang Yang, Liangdan Sun, Xianyong Yin, Jianjun Liu, Xuejun Zhang
Vitiligo vulgaris is an acquired depigmenting disorder resulting from the loss of melanocytes in the skin. Though several putative susceptibility loci of vitiligo have been identified in different populations, the patho­genesis of the disease remains poorly understood. Through genetic linkage analysis of a large Chinese family cohort of vitiligo, we identified a vitiligo linkage locus AIS4 withi ...
Pages: 131-135
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INVESTIGATIVE REPORT
Vitiligo in North-eastern China: An Association between Mucosal and Acrofacial Lesions
Uwesu Omari Mchepange, Xing-Hua Gao, Yue-Yang Liu, Yu-Bo Liu, Lei Ma, Li Zhang, Hong-Duo Chen
Vitiligo is a mucocutaneous pigmentary disorder with worldwide distribution. Little is known about the clinical profile of vitiligo in North-eastern China. Accordingly, we reviewed 692 vitiligo out-patients from seven government hospitals in North-eastern China via a questionnaire in a multi-centre study conducted between June 2007 and June 2008, and hence characterized the epidemiology of vitilig ...
Pages: 136-140
Abstract  PDF
INVESTIGATIVE REPORT
Increased Skin Cancer Mortality in Chile Beyond the Effect of Ageing: Temporal Analysis 1990 to 2005
Faustino T. Alonso, Maria L. Garmendia, M. E. Bogado
Chile has a medium-to-high skin cancer mortality rate. Previous studies have shown an increasing rate of skin cancer mortality. We evaluated skin cancer mortality characteristics and their temporal evolution in Chile from 1990 to 2005 in a mixed ecological study using death certificate databases. Age, sex, year and region of residence were obtained for melanoma and non-melanoma deaths. Crude and a ...
Pages: 141-146
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INVESTIGATIVE REPORT
Co-morbidity and Age-related Prevalence of Psoriasis: Analysis of Health Insurance Data in Germany
Matthias Augustin, Kristian Reich, Gerd Glaeske, Ines Schaefer, Marc Radtke
Epidemiological studies indicate an increased risk of co-morbidities and an association with other inflammatory diseases in psoriasis. However, most analyses have been performed on small samples of patients. The aim of this study was to evaluate the prevalence of co-morbidities in psoriasis based on a large set of health insurance data. The database of 1.3 million patients in a German nationwide s ...
Pages: 147-151
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INVESTIGATIVE REPORT
Is Story-based Blended Learning a Promising Avenue for Skin and Sexual Health Education? Results from the PAEDIMED Project
Christian J. Apfelbacher, Erika Deimling, Britta Wulfhorst, Frederic Adler, Thomas L. Diepgen, Dennis Linder, Holger Blenk, Nikolaus Stosiek, Gabi Reinmann
The PAEDIMED study group developed a learning and teaching scenario for school health education in the area of skin and sexual health in Italy, Romania and Germany, combining web-based and traditional learning (“blended learning”). A questionnaire-based needs assessment and context analysis were conducted, based on which an education scenario was designed. Particular emphasis was put on emotio ...
Pages: 152-158
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CLINICAL REPORT
Long-term Follow-up of In situ Extramammary Paget’s Disease in Asian Skin Types IV/V Treated with Photodynamic Therapy
Qiang Li, Tianwen Gao, Bin Jiao, Xianlong Qi, Heather Ann Long, Hongjiang Qiao, Lei Wang, Yajie Lv, Xuehui Hu, Wenjun Liao, Shengchun Wang, Chunying Li
Photodynamic therapy is a potentially advantageous treatment for non-melanoma skin cancers. We evaluated the clinical response, recurrence and adverse events of photodynamic therapy for in situ extramammary Paget’s disease in 14 male and 3 female Chinese patients with 21 lesions. Topical 20% 5-aminolevulinic acid was applied for 6 h. Each lesion was irradiated with 633 nm red light three times, ...
Pages: 159-164
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CLINICAL REPORT
Response of Intractable Skin Ulcers in Recessive Dystrophic Epidermolysis Bullosa Patients to an Allogeneic Cultured Dermal Substitute
Ken Natsuga, Daisuke Sawamura, Maki Goto, Erina Homma, Yuka Goto-Ohguchi, Satoru Aoyagi, Masashi Akiyama, Yoshimitsu Kuroyanagi, Hiroshi Shimizu
Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited skin disorder caused by mutations in the COL7A1 gene, which encodes collagen VII (COL7). Skin ulcers in RDEB patients are sometimes slow to heal. We describe here the therapeutic response of intractable skin ulcers in two patients with generalized RDEB to treatment with an allogeneic cultured dermal substitute (CDS). Skin ulcers in ...
Pages: 165-169
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CLINICAL REPORT
One-year Treatment with 0.1% Tacrolimus Ointment versus a Corticosteroid Regimen in Adults with Moderate to Severe Atopic Dermatitis: A Randomized, Double-blind, Comparative Trial
Johanna Mandelin, Anita Remitz, Hannele Virtanen, Sakari Reitamo
A one-year, randomized, double-blind study was conducted in 80 patients with atopic dermatitis treated with tacrolimus ointment or a corticosteroid regimen (hydrocortisone acetate 1% ointment for head and neck, hydrocortisone butyrate 0.1% ointment for trunk and limbs) to compare efficacy and safety, and effects on Th2-reactivity. The study was completed by 36/40 patients in the tacrolimus group ...
Pages: 170-174
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CLINICAL REPORT
Toxic Epidermal Necrolysis-like Cutaneous Lupus Erythematosus: A Series of Three Patients
Claudia G.C. Cisneros, Ricardo Romiti, Cláudia G. Santi, Valéria Aoki, Neusa Y.S. Valente, Marcello M.S. Nico
Toxic epidermal necrolysis-like lesions have been described in the setting of lupus erythematosus, and have been considered as a specific hyperacute variant of cutaneous lupus erythematosus, with features different from classical drug-related toxic epidermal necrolysis. We report here a series of three patients with lupus erythematosus who presented with severe worsening of their cutaneous disease ...
Pages: 175-178
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CLINICAL REPORT
Persistent Improvement of Previously Recalcitrant Hailey-Hailey Disease with Electron Beam Radiotherapy
Joanna Narbutt, Anna Chrusciel, Anna Rychter, Jacek Fijuth, Anna Sysa-Jedrzejowska, Aleksandra Lesiak
Hailey-Hailey disease, or familial benign chronic pemphigus, is an autosomal dominant genodermatosis. Disease symptoms may contribute to an adverse impact on quality of life and functional limitation and disability. As Hailey-Hailey disease is chronic and frequently recalcitrant to treatment, multiple therapeutic approaches, including surgical options, have been attempted. We describe here three c ...
Pages: 179-182
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LETTER TO THE EDITOR
Paradoxical Reactions to Targeted Biological Treatments: A Way to Treat and Trigger?
Alexandra M.G. Brunasso, Martin Laimer, Cesare Massone
Abstract is missing (Letter)
Pages: 183-185
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LETTER TO THE EDITOR
Erosive Lichen Planus on an Atypical Site Mimicking a Factitial Dermatitis
Carmelo Schepis, Maria Lentini, Maddalena Siragusa
Abstract is missing (Letter)
Pages: 185-186
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LETTER TO THE EDITOR
Allergic Contact Dermatitis due to Cinnamon Oil in Galenic Vaginal Suppositories
Maria Michela Lauriola, Antonio De Bitonto, Paolo Sena
Abstract is missing (Letter)
Pages: 187-188
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LETTER TO THE EDITOR
Repeated Anaphylactic Responses Induced by Oral Challenge with Ranitidine
Annett Isabel Walker, Sabine Werfel, Gerold Kick, Bernhard Przybilla
Abstract is missing (Letter)
Page: 189
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LETTER TO THE EDITOR
Development of a Prominent Granulomatous Eruption after Interferon-γ Therapy in a Patient with Mycosis Fungoides
Sanehito Haruyama, Kazunari Sugita, Chika Kawakami, Motonobu Nakamura, Yoshiki Tokura
Abstract is missing (Letter)
Pages: 190-191
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LETTER TO THE EDITOR
A Myopericytoma of the Nose
Ikuko Numata, Satoshi Nakagawa, Satoshi Hasegawa, Setsuya Aiba
Abstract is missing (Letter)
Pages: 192-193
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LETTER TO THE EDITOR
A Case of Sebaceous Naevus of the Leg with Secondarily Developed Trichoblastoma
Yoshio Kawakami, Christian Hafner, Noritaka Oyama, Toshiyuki Yamamoto
Abstract is missing (Letter)
Pages: 194-195
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LETTER TO THE EDITOR
Sebaceous Carcinoma with Actinic Keratosis
Keiko Nakashima, Koji Adachi, Ayako Yamasaki, Nanako Yamada, Yuichi Yoshida, Osamu Yamamoto
Abstract is missing (Letter)
Pages: 196-198
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LETTER TO THE EDITOR
ALK-positive Primary Systemic Anaplastic Large Cell Lymphoma with Extensive Cutaneous Manifestation
Kazuha Ando, Yasuhiko Tamada, Kazuyuki Shimizu, Yoichi Akita, Daisuke Watanabe, Shigeru Nakamura, Kazuo Hara, Yoshinari Matsumoto
Abstract is missing (Letter)
Pages: 198-200
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LETTER TO THE EDITOR
Infantile Erosive Pustular Dermatosis of the Scalp Associated with Klippel-Feil Syndrome
Ryoko Shimada, Takashi Masu, Hiroshi Hanamizu, Setsuya Aiba, Ryuhei Okuyama
Abstract is missing (Letter)
Pages: 200-201
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LETTER TO THE EDITOR
Perifollicular Xanthomas Associated with Epidermal Growth Factor Receptor Inhibitor Therapy
Tatiana Eames, Julia Kroth, Michael J. Flaig, Thomas Ruzicka, Andreas Wollenberg
Abstract is missing (Letter)
Pages: 202-203
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LETTER TO THE EDITOR
Generalized Eruptive Histiocytosis in an Infant
Erick Chern, Diana Yau, Ji-Chen Ho
Abstract is missing (Letter)
Pages: 204-205
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LETTER TO THE EDITOR
Clarithromycin Treatment Failure due to Macrolide Resistance in Treponema pallidum in a Patient with Primary Syphilis
Vladana Woznicová, Petra Matějková, Magdalena Flasarová, Hana Zákoucká, Eliska Dastychová, Zuzana Valisová, David Smajs
Abstract is missing (Letter)
Pages: 206-207
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LETTER TO THE EDITOR
Is Recurrent Pseudoepitheliomatous Keratotic Balanitis Related to Human Papillomavirus Infection?
Bong Seon Kang, Seung Dong Lee, Young Min Park, Soo Yeon Cho, Hoon Kang
Abstract is missing (Letter)
Pages: 208-209
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LETTER TO THE EDITOR
Naevus Lentiginosus Linearis: A Distinct Skin Disorder
Rudolf Happle, Dieter Metze, Ángel Vera Casaño
Abstract is missing (Letter)
Pages: 210-211
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LETTER TO THE EDITOR
Development of Segmental Superficial Actinic Porokeratosis during Immunosuppressive Therapy for Pemphigus Vulgaris
Timo Buhl, B. Gregor Wienrich, Claudia Sieblist, Michael P. Schön, Cornelia S. Seitz
Abstract is missing (Letter)
Pages: 212-213
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LETTER TO THE EDITOR
Dermacentor-borne Necrosis Erythema and Lymphadenopathy (DEBONEL): A Case Associated with Rickettsia rioja
Lidia Pérez-Pérez, Arantza Portillo, Francisco Allegue, Ander Zulaica, José A. Oteo, José-Luis Caeiro, José-María Fabeiro
Abstract is missing (Letter)
Pages: 214-215
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LETTER TO THE EDITOR
Photodynamic Therapy for Distal and Lateral Subungual Toenail Onychomycosis Caused by Trichophyton rubrum: Preliminary Results of a Single-centre Open Trial
Eleni Sotiriou, Thalia Koussidou-Eremonti, George Chaidemenos, Zoi Apalla, Demetris Ioannides
Abstract is missing (Letter)
Pages: 216-217
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LETTER TO THE EDITOR
Successful Treatment of Nail Lichen Planus with Topical Tacrolimus
Hideyuki Ujiie, Akihiko Shibaki, Masashi Akiyama, Hiroshi Shimizu
Abstract is missing (Letter)
Pages: 218-219
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LETTER TO THE EDITOR
Intravascular Papillary Endothelial Hyperplasia Simulating Malignant Melanoma
Dae Suk Kim, Dong Jin Ryu, Sang Ho Oh, Min-Geol Lee
Abstract is missing (Letter)
Pages: 220-221
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LETTER TO THE EDITOR
Papular Skin Lesions in the Retroauricular Area: A Quiz
Hei Sung Kim, Hyun Jong Lee, Jun Young Lee, Hyung Ok Kim and Young Min Park
Abstract is missing (Quiz)
Pages: 223-224
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CLINICAL REPORT
Unusual Features of Peristomal Erosion: A Quiz
Koji Adachi, Nanako Yamada, Yuichi Yoshida and Osamu Yamamoto
Abstract is missing (Quiz)
Pages: 223-224
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