Content

Content - Volume 91, Issue 4

Editor's choice in this issue

INVESTIGATIVE REPORT
Scalp Stratum Corneum Histamine Levels: Novel Sampling Method Reveals Association with Itch Resolution in Dandruff/Seborrhoeic Dermatitis Treatment
Kathy Kerr, James R. Schwartz, Thomas Filloon, Angela Fieno, Ken Wehmeyer, Jacek C. Szepietowski, Kevin J. Mills
Dandruff and seborrhoeic dermatitis are accompanied by bothersome itch. We have established a novel non-invasive methodology to sample histamine levels in the stratum corneum in order to facilitate an understanding of pruritogenesis in this condition. Histamine levels were assessed in two groups of subjects with dandruff before and after 3 weeks of treatment with a commercial potentiated zinc pyri ...
Pages: 404-408
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INVESTIGATIVE REPORT
Fluorescence Diagnostics of Basal Cell Carcinomas Comparing Methyl-aminolaevulinate and Aminolaevulinic Acid and Correlation with Visual Clinical Tumour Size
Carin Sandberg, John Paoli, Martin Gillstedt, Christina B. Halldin, Olle Larkö, Ann-Marie Wennberg, Marica B. Ericson
Fluorescence diagnostics based on aminolaevulinic acid (ALA) fluorescence has been suggested as an in vivo pre-surgical tool for tumour demarcation. We performed fluorescence diagnostics of 35 basal cell carcinomas (BCCs) undergoing photodynamic therapy (PDT) using methylaminolaevulinate (MAL). In addition, a semi-automated thresholding algorithm was implemented to detect the potential tumour regi ...
Pages: 398-403
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INVESTIGATIVE REPORT
Effect of Narrow-band Ultraviolet B Phototherapy on p63 and MicroRNA (miR-21 and miR-125b) Expression in Psoriatic Epidermis
Xiaolian Gu, Elisabet Nylander, Philip J. Coates, Karin Nylander
Psoriasis is an inflammatory skin disease in which dysregulation of p63, a member of the p53 family that is crucial for skin development and maintenance, has been demonstrated. Involvement of miR-203, miR-21 and miR-125b, small non-coding RNAs implicated in the regulation of p63 or p53, has been suggested in the patho­genesis of psoriasis. To elucidate the roles of p63 and p63-related microRNAs i ...
Pages: 392-397
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INVESTIGATIVE REPORT
A Case-control Study on Family Dysfunction in Patients with Alopecia Areata, Psoriasis and Atopic Dermatitis
Francoise Poot, Enora Antoine, Marion Gravellier, Jennifer Hirtt, Stefania Alfani, Giulia Forchetti, Dennis Linder, Damiano Abeni, Stefano Tabolli, Francesca Sampogna
Family history can provide important information about a patient’s psychological status, and thus their disease risk. A multicentric case-control study on family dysfunction was performed on 59 patients with psoriasis (63.7%), atopic dermatitis (11.9%) or alopecia areata (25.4%), and 47 patients with minor skin problems (controls), all attending a dermatological clinic or a psychodermatological ...
Pages: 415-421
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All articles

INVESTIGATIVE REPORT
Standardized, Defined Serum-free Culture of a Human Skin Equivalent on Fibroblast-populated Collagen Scaffold
William Ng, Shigaku Ikeda
The defined, serum-free media used in the cultivation of skin equivalents are liable to inter-laboratory variations, require the preparation of multiple additives, and are potentially difficult to replicate. In this study, we assessed the use of standardized, serum-free and bovine pituitary extract-free keratinocyte culture media in the development of a human skin equivalent. After culture at the ...
Pages: 387-391
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INVESTIGATIVE REPORT
Effect of Narrow-band Ultraviolet B Phototherapy on p63 and MicroRNA (miR-21 and miR-125b) Expression in Psoriatic Epidermis
Xiaolian Gu, Elisabet Nylander, Philip J. Coates, Karin Nylander
Psoriasis is an inflammatory skin disease in which dysregulation of p63, a member of the p53 family that is crucial for skin development and maintenance, has been demonstrated. Involvement of miR-203, miR-21 and miR-125b, small non-coding RNAs implicated in the regulation of p63 or p53, has been suggested in the patho­genesis of psoriasis. To elucidate the roles of p63 and p63-related microRNAs i ...
Pages: 392-397
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Fluorescence Diagnostics of Basal Cell Carcinomas Comparing Methyl-aminolaevulinate and Aminolaevulinic Acid and Correlation with Visual Clinical Tumour Size
Carin Sandberg, John Paoli, Martin Gillstedt, Christina B. Halldin, Olle Larkö, Ann-Marie Wennberg, Marica B. Ericson
Fluorescence diagnostics based on aminolaevulinic acid (ALA) fluorescence has been suggested as an in vivo pre-surgical tool for tumour demarcation. We performed fluorescence diagnostics of 35 basal cell carcinomas (BCCs) undergoing photodynamic therapy (PDT) using methylaminolaevulinate (MAL). In addition, a semi-automated thresholding algorithm was implemented to detect the potential tumour regi ...
Pages: 398-403
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Scalp Stratum Corneum Histamine Levels: Novel Sampling Method Reveals Association with Itch Resolution in Dandruff/Seborrhoeic Dermatitis Treatment
Kathy Kerr, James R. Schwartz, Thomas Filloon, Angela Fieno, Ken Wehmeyer, Jacek C. Szepietowski, Kevin J. Mills
Dandruff and seborrhoeic dermatitis are accompanied by bothersome itch. We have established a novel non-invasive methodology to sample histamine levels in the stratum corneum in order to facilitate an understanding of pruritogenesis in this condition. Histamine levels were assessed in two groups of subjects with dandruff before and after 3 weeks of treatment with a commercial potentiated zinc pyri ...
Pages: 404-408
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Are Treatment Satisfaction, Quality of Life, and Self-assessed Disease Severity Relevant Parameters for Patient Registries? Experiences from Finnish and Swedish Patients with Psoriasis
Catharina Hjortsberg, Annika Bergman, Anton Bjarnason, Hannele Heikkilä, Jonas Hjelmgren, Åke Svensson, Gunnel Ragnarson Tennvall
Patient registries often lack indicators of the disease as experienced by patients, e.g. treatment satisfaction and self-assessed disease severity. There is scarce information about the relationship between these assessments and currently existing instruments used in treatment evaluation. Our objective was to explore the importance of these indicators among patients with psoriasis in Finland and S ...
Pages: 409-414
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INVESTIGATIVE REPORT
A Case-control Study on Family Dysfunction in Patients with Alopecia Areata, Psoriasis and Atopic Dermatitis
Francoise Poot, Enora Antoine, Marion Gravellier, Jennifer Hirtt, Stefania Alfani, Giulia Forchetti, Dennis Linder, Damiano Abeni, Stefano Tabolli, Francesca Sampogna
Family history can provide important information about a patient’s psychological status, and thus their disease risk. A multicentric case-control study on family dysfunction was performed on 59 patients with psoriasis (63.7%), atopic dermatitis (11.9%) or alopecia areata (25.4%), and 47 patients with minor skin problems (controls), all attending a dermatological clinic or a psychodermatological ...
Pages: 415-421
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Patch Testing with a Textile Dye Mix in a Baseline Series in Two Countries
Kristina Ryberg, An Goossens, Marléne Isaksson, Birgitta Gruvberger, Erik Zimerson, Magnus Bruze
Disperse dyes are the most common contact sensitizers among textile dyes. The main aim of this study was to investigate the outcome of patch testing with a textile dye mix 6.6%. A total of 2,049 patients from Sweden and 497 from Belgium were tested with the mix, consisting of Disperse (D) Blue 35, D Yellow 3, D Orange 1 and 3, D Red 1 and 17, 1.0% each, and D Blue 106 and D Blue 124, 0.3% each. Of ...
Pages: 422-427
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INVESTIGATIVE REPORT
Impact of Dermoscopy on the Management of High-risk Patients From Melanoma Families: A Prospective Study
Jasper I. van der Rhee, Wilma Bergman, Nicole A. Kukutsch
Few studies have investigated the impact of dermoscopy on the management of relatives from melanoma families. The objective of this study was to assess the impact of dermoscopy on clinical diagnosis and management decisions in high-risk familial melanoma patients. In a prospective study 132 consecutive patients were recruited from the pigmented lesions clinic of a tertiary reference centre for fam ...
Pages: 428-431
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CLINICAL REPORT
Imiquimod and Lymphatic Field Clearance: A New Hypothesis Based on a Remote Immune Action on Skin Cancer
Merve Akkilic-Materna, Cesare Massone, Peter Komericki
Basal cell carcinoma and actinic keratosis are frequent neoplasms. Topical treatments include the recently approved imiquimod cream. We describe here the case of a 68-year-old man with multiple actinic keratosis on the forehead, upper trunk and on the left cheek. In addition, an exulcerated basal cell carcinoma was observed. The patient was advised only to treat lesions on the forehead with imiqui ...
Pages: 432-435
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CLINICAL REPORT
Oral Lesions in Four Cases of Subacute Cutaneous Lupus Erythematosus
Marcello Menta.S. Nico, Ricardo Romiti, Silvia V. Lourenço
Patients with subacute cutaneous lupus erythematosus (SCLE) present with intense photosensitivity. Clinical patterns comprise papulosquamous or annular lesions on sun-exposed areas; although the face is usually spared. Intraoral lesions have not been reported in most case series of SCLE, but are well-documented in other forms of lupus erythematosus. This study included four female patients diagnos ...
Pages: 436-439
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CLINICAL REPORT
Ten-year Audit of Melanoma in a Central England Population*
Joseph Hardwicke, A. Murray Brunt, Gwen Rylands, Sukh Rayatt
The incidence of melanoma in the North Staffordshire region has more than doubled over the last 10 years, and nearly tripled in the “thin” melanoma group (≤ 1 mm). A retrospective audit was performed to investigate the overall management of melanoma, with a focus on thin melanomas. A total of 507 patients was identified between 1999 and 2009. The incidence of melanoma is increasing in the ...
Pages: 440-443
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CLINICAL REPORT
Patients with Psoriasis are More Likely to be Treated for Latent Tuber­culosis Infection Prior to Biologics than Patients with Inflammatory Bowel Disease
Ioannis D. Bassukas, Maria Kosmidou, Georgios Gaitanis, Georgia Tsiouri, Epameinondas Tsianos
Screening for latent tuberculosis infection (LTBI) is recommended before treatment with biologics is initiated in patients with psoriasis or inflammatory bowel disease (IBD). Our objective was to evaluate the effect of underlying disease (psoriasis or IBD) on the risk of LTBI diagnosis prior to anti-tumor necrosis factor-alpha (TNF-α) therapy. During a two-year period LTBI diagnosis rate was comp ...
Pages: 444-446
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CLINICAL REPORT
Positive Effect of Modified Goeckerman Regimen on Quality of Life and Psychosocial Distress in Moderate and Severe Psoriasis
Erick Chern, Diana Yau, Ji-Chen Ho, Wei-Ming Wu, Cheng-Yu Wang, Hsueh-Wen Chang, Yu-Wen Cheng
Psoriasis is a chronic inflammatory skin disease with a profound effect on quality of life and psychosocial stress. The relationship between clinical improvement and psycho­social impact after treatment is complex. The objective of this study was to compare changes in quality of life and psychosocial distress, and overall cost-effective­ness, in patients with psoriasis receiving the modified Goe ...
Pages: 447-451
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CLINICAL REPORT
Quality of Life, Use of Topical Medications and Socio-economic Data in Hand Eczema: A Swedish Nationwide Survey
Kerstin Bingefors, Magnus Lindberg, Dag Isacson
Hand eczema is common and has an adverse impact on the lives of patients. There is a need for population-based surveys on the pharmacoepidemiological aspects, quality of life and impact of socioeconomic factors in hand eczema. The aim of this cross-sectional study was to investigate these factors. A questionnaire-based nationwide survey of health was performed, including questions on hand eczema, ...
Pages: 452-458
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CLINICAL REPORT
Concomitant Manifestation of Pili Annulati and Alopecia Areata: Coincidental Rather than True Association
Kathrin A. Giehl , Matthias Schmuth, Antonella Tosti, David A. De Berker, Alexander Crispin, Hans Wolff, Jorge Frank
The autosomal dominantly inherited hair disorder pili annulati is characterized by alternating light and dark bands of the hair shaft. Concomitant manifestation of pili annulati with alopecia areata has been reported previously on several occasions. However, no systematic evaluation of patients manifesting both diseases has been performed. We studied the simultaneous or sequential occurrence of pi ...
Pages: 459-462
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LETTER TO THE EDITOR
Cold Panniculitis in Finnish Horse Riders
Anu Pekki, Riitta Sauni, Annikki Vaalasti, Pauliina Toivio, Riitta Huotari-Orava, Taina Hasan
Abstract is missing (letter)
Pages: 463-464
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LETTER TO THE EDITOR
Difficulty to Identify Sentinel Lymph Nodes with Computed Tomography-lymphography in Patients with Cutaneous Melanoma
Yuichi Yoshida, Koji Adachi, Keiko Nakashima, Takefumi Yamane, Osamu Yamamoto
Abstract is missing (Letter)
Pages: 465-466
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LETTER TO THE EDITOR
Absence of Functional Mutations in the Ferroportin-encoding SLC40A1 Gene in Porphyria Cutanea Tarda: A Series of 37 Cases from Southern France
Aurélie Du Thanh, Patricia Martinez, Séverine Cunat, Didier Bessis, Bernard Guillot, Olivier Dereure
Abstract is missing (Letter)
Pages: 467-467
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LETTER TO THE EDITOR
Sarcoidosis, Hypercalcemia and Calcium-sensing Receptor Mutation: A Case Report
Shreya Dixit , Pablo Fernandez Peñas
Abstract is missing (Letter)
Pages: 468-468
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LETTER TO THE EDITOR
Psoriasiform Eruption Localized to a Previously Irradiated Area
Atsuko Ohashi , Minoru Saiki , Ryuhei Okuyama
Abstract is missing (letter)
Pages: 469-469
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LETTER TO THE EDITOR
Detection of Tuberculous Lymphadenopathy by Positron Emission Tomography/Computed Tomo­graphy in a Patient with Behçet’s Disease
Suhyun Cho, Kyung Jong Lee, Jong Doo Lee, Dongsik Bang, Sung Bin Cho
Abstract is missing (letter)
Pages: 470-471
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LETTER TO THE EDITOR
Cutaneous Intravascular Natural Killer-cell Lymphoma: A Rare Case and Review of the Literature
Jia-Bin Liao, Pin-Pen Hsieh, Yu-Ching Hwang, Shong-Ling Lin, Chieh-Shan Wu
Abstract is missing (letter)
Pages: 472-473
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LETTER TO THE EDITOR
Primary Cutaneous Mantle Cell Lymphoma
Edoardo Zattra, Renato Zambello, Filippo Marino, Matteo Bordignon, Mauro Alaibac
Abstract is missing (Letter)
Pages: 474-475
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LETTER TO THE EDITOR
Primary Cutaneous B-cell Lymphoma: Subtypes, Treatment and Outcome of 10 Cases
Nahide Onsun, Ozlem Su, Yasemin Balsever Kural, Yeliz Erdemoglu, Nesimi Buyukbabani, Cuyan Demirkesen, Yildiz Aydin
Abstract is missing (Letter)
Pages: 476-478
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LETTER TO THE EDITOR
Positive Effect of Low-dose Imatinib Mesylate in a Patient with Nephrogenic Systemic Fibrosis
Tina Rask Elmholdt, Michael Pedersen, Bettina Jørgensen, Mette Ramsing, Anne Braae Olesen
Abstract is missing (Letter)
Pages: 478-479
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LETTER TO THE EDITOR
Eruptive Keloids Associated with Breast Cancer: A Paraneoplastic Phenomenon?
Yong He, Melissa Reyes Merin, Victoria R. Sharon, Emanual Maverakis
Abstract is missing (letter)
Pages: 480-481
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LETTER TO THE EDITOR
Atypical Fibrous Histiocytoma of the Skin with Necrobiotic Granuloma-like Features
Yosuke Ishitsuka, Kunuaki Ohara, Fujio Otsuka
Abstract is missing (letter)
Pages: 482-483
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LETTER TO THE EDITOR
Quality of Life in a Population of Patients With Hand Eczema: A Six-month Follow-up Study
Marianne Hald, Tove Agner, Jette Blands, Jeanne D. Johansen
Abstract is missing (letter)
Pages: 484-486
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LETTER TO THE EDITOR
Hair Shaft Abnormalities in Localized Autosomal Recessive Hypotrichosis 2 and A Review of Other Non-syndromic Human Alopecias
Hiraku Suga, Yuichiro Tsunemi, Makoto Sugaya, Satoru Shinkuma, Masashi Akiyama, Hiroshi Shimizu, Shinichi Sato
Abstract is missing (Letter)
Pages: 486-488
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LETTER TO THE EDITOR
No Evidence for ErbB4 Gene Amplification in Malignant Melanoma
Gero Brockhoff, Marietta Bock, Susanne Gantner, Christian Hafner
Abstract is missing (Letter)
Pages: 488-490
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QUIZ
Single Nodular Lesion on the scalp: A Quiz
Yong Hyun Jang, Ji Hyun Sim, You Chan Kim, Eun-So Lee
Abstract is missing (Quiz)
Pages: 491-494
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QUIZ
Violaceous Papules of the Back: A Quiz
Rym Benmously-Mlika, Houda Hammami, Incaf Mokhtar
Abstract is missing (Quiz)
Pages: 491-494
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QUIZ
Acute Disseminated Erythematous Papulovesicular Skin Lesions in a 7-year-old Child: A Quiz
Miriam Linke, Cyrill Géraud, Stefan W. Schneider, Sergij Goerdt, Jochen Utikal
Abstract is missing (Quiz)
Pages: 491-494
Abstract  HTML  PDF