Content

Content - Volume 93, Issue 3

Editors choice in this issue

REVIEW
Skin pH: From Basic SciencE to Basic Skin Care
Saba M. Ali, Gil Yosipovitch
The “acid mantle” is a topic not only of historical interest, but also of clinical significance and has recently been linked to vital stratum corneum function. Despite compelling basic science evidence placing skin pH as a key factor in barrier homeostasis, stratum corneum integrity, and antimicrobial defense, application of the acid mantle concept in clinical care is lacking. We review recent ...
Pages: 261-267
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INVESTIGATIVE REPORT
Accuracy of Clinical Skin Tumour Diagnosis in a Dermatological Setting
Ingela Ahnlide, Mats Bjellerup
The aim of this study was to evaluate the accuracy of preoperative diagnosis of skin tumours in a dermatological setting. Patients undergoing skin surgery at the Department of Dermatology without preoperative biopsy were prospectively enrolled. Preoperatively, a single clinical diagnosis was registered. The histopathological diagnosis, performed after excision, was registered as the correct diagno ...
Pages: 305-308
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LETTER TO THE EDITOR
Skin Cancer Diagnosis: Shining Light into Dark Places
Jonathan Rees
Abstract is missing (commentary)
Pages: 259-260
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REVIEW
Aetiological Factors Associated with Chronic Urticaria in Children: A Systematic Review
Carlo Caffarelli, Barbara Cuomo, Fabio Cardinale, Salvatore Barberi, Carlotta Povesi Dascola, Fabio Agostinis, Fabrizio Franceschini, Roberto Bernardini
Chronic urticaria is a distressing condition with high costs. The aim of this literature review was to assess the relative frequency of causes of chronic urticaria in childhood and to provide guidance on which laboratory tests should be performed. Using PubMed, EMBASE and Cochrane databases, the literature from 1966 to 2010 (week 25) was systematically reviewed. Data from studies conducted on chil ...
Pages: 268-272
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All articles

LETTER TO THE EDITOR
Skin Cancer Diagnosis: Shining Light into Dark Places
Jonathan Rees
Abstract is missing (commentary)
Pages: 259-260
Abstract  HTML  PDF
REVIEW
Skin pH: From Basic SciencE to Basic Skin Care
Saba M. Ali, Gil Yosipovitch
The “acid mantle” is a topic not only of historical interest, but also of clinical significance and has recently been linked to vital stratum corneum function. Despite compelling basic science evidence placing skin pH as a key factor in barrier homeostasis, stratum corneum integrity, and antimicrobial defense, application of the acid mantle concept in clinical care is lacking. We review recent ...
Pages: 261-267
Abstract  HTML  PDF
REVIEW
Aetiological Factors Associated with Chronic Urticaria in Children: A Systematic Review
Carlo Caffarelli, Barbara Cuomo, Fabio Cardinale, Salvatore Barberi, Carlotta Povesi Dascola, Fabio Agostinis, Fabrizio Franceschini, Roberto Bernardini
Chronic urticaria is a distressing condition with high costs. The aim of this literature review was to assess the relative frequency of causes of chronic urticaria in childhood and to provide guidance on which laboratory tests should be performed. Using PubMed, EMBASE and Cochrane databases, the literature from 1966 to 2010 (week 25) was systematically reviewed. Data from studies conducted on chil ...
Pages: 268-272
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Decreased miR-7 Expression in the Skin and Sera of Patients with Dermatomyositis
Yuka Oshikawa, Masatoshi Jinnin, Takamitsu Makino, Ikko Kajihara, Katsunari Makino, Noritoshi Honda, Wakana Nakayama, Kuniko Inoue, Satoshi Fukushima, Hironobu Ihn
Expression of microRNA (miRNA) in the skin in dermatomyositis has not previously been studied in detail. In this study, we performed miRNA array analysis using miRNAs purified from dermatomyositis-involved skin and normal skin, and found that several miRNAs were up- or down-regulated in dermatomyositis skin. Among them, we focused on miR-7, one of the most down-regulated miRNAs in dermatomyositis ...
Pages: 273-276
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INVESTIGATIVE REPORT
Pruritic and Vascular Responses Induced by Serotonin in Patients with Atopic Dermatitis and in Healthy Controls
Aram Rausl, Klas Nordlind, Carl-Fredrik Wahlgren
Atopic dermatitis (AD) is a chronic inflammatory skin disease with often severe itch. The aim of this study was to determine the pruritogenic and vascular effect of serotonin (5-hydroxytryptamine; 5-HT) in patients with AD and in healthy controls. A 50 µg dose of 5-HT was injected intradermally into non-lesional skin of 25 patients with AD and 25 healthy control individuals, and the effect compar ...
Pages: 277-280
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INVESTIGATIVE REPORT
Erythema Persists Longer than One Year in Split-thickness Skin Graft Donor Sites
Patricia L. Danielsen, Lars N. Jorgensen, Bo Jørgensen, Tonny Karlsmark, Magnus S. Ågren
The recovery of skin function and appearance after harvest of split-thickness skin autografts is incompletely described. We followed the kinetics of skin restoration after a partial-thickness skin excision relative to adjacent normal skin over 12 months. Standardized donor site wounds were made on the thigh using a pneumatic dermatome in 19 consecutive Caucasian patients, median age 70 years, age ...
Pages: 281-285
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INVESTIGATIVE REPORT
The Inhibition by Levocetirizine and Fexofenadine of the Histamine-induced Wheal and Flare Response in Healthy Caucasian and Japanese Volunteers
Nicole Schoepke, Martin K. Church, Marcus Maurer
This randomized, double-blind, placebo-controlled crossover study compared inhibition by one 5 mg dose of levocetirizine with two 60 mg doses of fexofenadine separated by 12 h of histamine-induced wheal and flare responses in 9 Caucasian and 9 Japanese healthy male volunteers. Levocetirizine was more inhibitory than fexofenadine on wheal, flare and pruritus (p < 0.005). Variability, ev ...
Pages: 286-293
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INVESTIGATIVE REPORT
Use of Copper Alloy for Preventing Transmission of Methicillin-resistant Staphylococcus aureus Contamination in the Dermatology Ward
Nanako Niiyama, Takeshi Sasahara, Hiroshi Mase, Michiko Abe, Haruo Saito, Kensei Katsuoka
Metallic copper has been shown significantly to reduce methicillin-resistant Staphylococcus aureus (MRSA) contamination of the ambient surroundings of the beds of MRSA-carrying patients in dermatology wards. The aim of this study was to determine whether a bed sheet made of copper-coated film will reduce the spread of MRSA contamination in the environment of a heavily-colonized patient. The bacter ...
Pages: 294-300
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INVESTIGATIVE REPORT
Tumour Necrosis Factor-alpha and Matrix Metalloproteinase-2 are Expressed Strongly in Hidradenitis Suppurativa
Elga Mozeika, Mara Pilmane, Birgit Meinecke Nürnberg, Gregor B.E. Jemec
Hidradenitis suppurativa is a chronic skin condition, charac-terized clinically by painful, recurrent, deep- seated nodules and suppuration, and histologically by hyper-trophic scarring of apocrine gland bearing skin and sinus tracts. The overall consequence of the disease is considerable tissue remodelling and the underlying alterations in innate immunity are poorly understood. The aim of this s ...
Pages: 301-304
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INVESTIGATIVE REPORT
Accuracy of Clinical Skin Tumour Diagnosis in a Dermatological Setting
Ingela Ahnlide, Mats Bjellerup
The aim of this study was to evaluate the accuracy of preoperative diagnosis of skin tumours in a dermatological setting. Patients undergoing skin surgery at the Department of Dermatology without preoperative biopsy were prospectively enrolled. Preoperatively, a single clinical diagnosis was registered. The histopathological diagnosis, performed after excision, was registered as the correct diagno ...
Pages: 305-308
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CLINICAL REPORT
Generalized and Naevoid Epidermolytic Ichthyosis in Denmark: Clinical and Mutational Findings
Anette Bygum, Marie Virtanen, Flemming Brandrup, Agneta Gånemo, Mette Sommerlund, Gitte Strauss, Anders Vahlquist
A Danish–Swedish collaboration was established to identify and classify a Danish cohort of patients with epidermolytic ichthyosis, also known as epidermolytic hyperkeratosis. Patients were recruited from 5 dermatology departments in Denmark, and data were obtained using a structured questionnaire and a systematic examination together with photographs, histopathological descriptions and blood sam ...
Pages: 309-313
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CLINICAL REPORT
Lymphopaenia, Anti-Ro/Anti-RNP Autoantibodies, Renal Involvement and Cyclophosphamide Use Correlate with Increased Risk of Herpes Zoster in Patients with Systemic Lupus Erythematosus
Stephen Chu-Sung Hu, Chi-Ling Lin, Yi-Wei Lu, Gwo-Shing Chen, Hsin-Su Yu, Ching-Shuang Wu, Cheng-Che E. Lan
Herpes zoster occurs with increased frequency in patients with systemic lupus erythematosus (SLE). The aim of this study was to identify and evaluate clinical and laboratory risk factors associated with development of herpes zoster in patients with SLE. A retrospective case-control study was performed in a population of patients with SLE. Patients were identified as cases if their first episode of ...
Pages: 314-318
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CLINICAL REPORT
Cutaneous Myeloid Sarcoma: Natural History and Biology of an Uncommon Manifestation of Acute Myeloid Leukemia
M. Yadira Hurley, Grant K. Ghahramani , Stephanie Frisch, Eric S. Armbrecht , Anne C. Lind, TuDung T. Nguyen, Anjum Hassan, Friederike H. Kreisel, John L. Frater
We conducted a retrospective study of patients with cutaneous myeloid sarcoma, from 2 tertiary care institutions. Eighty-three patients presented, with a mean age of 52 years. Diagnosis of myeloid sarcoma in the skin was difficult due to the low frequency of myeloperoxidase and/or CD34+ cases (56% and 19% of tested cases, respectively). Seventy-one of the 83 patients (86%) had ≥ 1 bone ...
Pages: 319-324
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CLINICAL REPORT
Clinical and Histopathological Features of Folliculotropic Mycosis Fungoides: A Norwegian Patient Series
Panagiota Mantaka, Per Helsing, Petter Gjersvik, Assia Bassarova, Ole Petter F. Clausen, Jan Delabie
Folliculotropic mycosis fungoides is a variant of cutaneous T-cell lymphoma with distinct clinicopathological features. We describe here the clinical presentation, pathology findings and treatment outcome in 15 Norwegian patients. All patients were diagnosed between 1997 and 2010 at Oslo University Hospital. A spectrum of skin lesions, both typical and atypical, such as leonine facies, acneiform l ...
Pages: 325-329
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CLINICAL REPORT
Improvement in Psoriasis Area and Severity Index Score Predicts Improvement in Skin Pain Over Time in Patients with Psoriasis
Tone Marte Ljosaa, Audun Stubhaug, Cato Mork, Torbjorn Moum, Astrid K. Wahl
Pain and discomfort are common and often severe skin symptoms in patients with psoriasis. However, no studies have investigated skin pain and discomfort over time, or factors that explain changes in these symptoms. The aims of the present study were to describe the changes in skin pain, skin discomfort and Psoriasis Area and Severity Index (PASI) over time, and to investigate whether change in PAS ...
Pages: 330-334
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CLINICAL REPORT
Botulinum Toxin Type A and B Improve Quality of Life in Patients with Axillary and Palmar Hyperhidrosis
Karolina Rosell, Kristina Hymnelius, Carl Swartling
Hyperhidrosis is a common disorder that may have a severe impact on quality of life. The aim of this study was to investigate the clinical effect of two novel botulinum toxins, Xeomin®, a type A botulinum toxin, and Neuro-bloc®, a type B botulinum toxin, in the treatment of axillary and palmar hyperhidrosis. A total of 84 patients, 58 with axillary and 26 with palmar hyperhidrosis, were includ ...
Pages: 335-339
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CLINICAL REPORT
Sensitization to Skin-associated Microorganisms in Adult Patients with Atopic Dermatitis is of Importance for Disease Severity
Andreas Sonesson, Jacek Bartosik, Julie Christiansen, Ingrid Roscher, Fredrik Nilsson, Artur Schmidtchen, Ove Bäck
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Environmental and genetic factors, as well as microbial products from yeasts and bacteria, play a role in triggering the disease. A cohort of 619 adult patients with AD was screened for severity of AD, sensitization to Malassezia sympodialis, Candida albicans, Staphylococcus aureus enterotoxins and Dermatophagoides pteronyssinus. Serum ...
Pages: 340-345
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CLINICAL REPORT
Analysis of High-dose Intravenous Immunoglobulin Therapy in 16 Patients with Refractory Autoimmune Blistering Skin Disease: High Efficacy and No Serious Adverse Events
Vera Seidling, Jochen H. O. Hoffmann, Alexander H. Enk, Eva N. Hadaschik
High-dose intravenous immunoglobulin (IVIG) therapy is used in patients with severe autoimmune blistering diseases that are refractory to standard immunosuppressive therapy. To determine the efficacy and frequency of adverse events of IVIG therapy, we retrospectively analysed data for 16 patients with pemphigus vulgaris, pemphigus foliaceus, paraneoplastic pemphigus, bullous pemphigoid and paraneo ...
Pages: 346-349
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LETTER TO THE EDITOR
Development of a Clinical Scandinavian Registry for Hidradenitis Suppurativa; HISREG
Gisli Ingvarsson, Deidre Nathalie Dufour, Hassan Killasli, Karin Sartorius, Jan Lapins, Philip A. Skau, Dagfinn Moseng, Darjosh Dinparvar, Anne-Sofie Furberg, Gregor B.E. Jemec, Lennart Emtestam
Abstract is missing (Letter)
Pages: 350-351
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LETTER TO THE EDITOR
Does Anti-Tumour Necrosis Factor-Alpha Increase Oral Candida Colonization? A Case-control Study in Psoriatic Patients
Monica Corazza, Stefania Zauli, Michela Ricci, Alessandro Borghi, Rita Rossi, Anna Virgili
Abstract is missing (Letter)
Pages: 352-353
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LETTER TO THE EDITOR
The Utility of Serum Tryptase as a Marker in Chronic Spontaneous Urticaria
Roxana Siles, Meng Xu, Fred H. Hsieh
Abstract is missing (letter)
Pages: 354-355
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LETTER TO THE EDITOR
Disseminated Subcutaneous Phaeohyphomycosis caused by Exophiala oligosperma in a Patient with Wegener’s Granulomatosis
Takanobu Kan, Shunsuke Takahagi, Akiko Kamegashira, Hiroshi Ooiwa, Takashi Yaguchi, Michihiro Hide
Abstract is missing (Letter)
Pages: 356-357
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LETTER TO THE EDITOR
Deep Pseudocystic Dermatophytosis Caused by Trichophyton rubrum in a Patient with Myasthenia Gravis
Yasushi Matsuzaki, Kazuko Ota, Kentaro Sato, Syoetsu Nara, Takashi Yagushi, Hajime Nakano, Daisuke Sawamura
Abstract is missing (Letter)
Pages: 358-359
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LETTER TO THE EDITOR
Allogeneic Haematopoietic Stem Cell Transplantation in a Patient with Cutaneous γ/δ-T-cell Lymphoma
Sarah Terras, Rose K. C. Moritz, Markus Ditschkowski, Dietrich W. Beelen, Peter Altmeyer, Markus Stücker, Alexander Kreuter
Abstract is missing (Letter)
Pages: 360-361
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LETTER TO THE EDITOR
Paediatric Acute Generalized Exanthematous Pustulosis Induced by Paracetamol with High Serum Levels of Interleukin-8 and -22: A Case Report
Takatsune Umayahara , Takatoshi Shimauchi, Toshiharu Fujiyama, Taisuke Ito, Satoshi Hirakawa, Yoshiki Tokura
Abstract is missing (Letter)
Pages: 362-363
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LETTER TO THE EDITOR
Combination Therapy of Infliximab and Granulocyte/Monocyte Adsorption Apheresis for Refractory Pustular Psoriasis with Psoriatic Arthritis
Tomomi Fujisawa, Chie Moriya, Yoshinao Shibuya , Hiroyuki Kanoh, Mariko Seishima
Abstract is missing (Letter)
Pages: 364-365
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LETTER TO THE EDITOR
Are BIC (miR-155) Polymorphisms Associated with Eczema Susceptibility?
Annika Sääf, Ingrid Kockum, Carl-Fredrik Wahlgren, Ning Xu, Enikö Sonkoly, Mona Ståhle, Magnus Nordenskjöld, Maria Bradley, Andor Pivarcsi
Abstract is missing (Letter)
Pages: 366-367
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LETTER TO THE EDITOR
Ustekinumab in the Treatment of Refractory Chronic Cutaneous Lupus Erythematosus: A Case Report
Christine Dahl, Claus Johansen, Knud Kragballe, Anne Braae Olesen
Abstract is missing (Letter)
Pages: 368-369
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LETTER TO THE EDITOR
Recognized Occupational Skin Cancer in Denmark – Data From the Last Ten Years
Tanja K. Carøe, Niels E. Ebbehøj, Hans Christian Wulf, Tove Agner
Abstract is missing (Letter)
Pages: 369-371
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LETTER TO THE EDITOR
Subcutaneous Benign Fibrous Histiocytoma Showing Nerve Involvement on the Eyebrow Region
Takamichi Ito, Yuichi Yoshida, Masutaka Furue, Osamu Yamamoto
Abstract is missing (Letter)
Pages: 371-372
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LETTER TO THE EDITOR
Entecavir and Intermittent Etanercept Therapy in a Patient with Concurrent Hepatitis B Virus Infection and Psoriasis
Graziella Babino , Maria Esposito, Annamaria Mazzotta, Sergio Chimenti, Alessandro Giunta
Abstract is missing (Letter)
Pages: 373-374
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LETTER TO THE EDITOR
Wells’ Syndrome Associated with Chronic Myeloid Leukaemia
Shinichi Nakazato, Yasuyuki Fujita, Yohei Hamade, Ikue Nemoto-Hasebe, Junichi Sugita, Wataru Nishie, Hiroshi Shimizu
Abstract is missing (Letter)
Pages: 375-376
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LETTER TO THE EDITOR
Porphyria Cutanea Tarda and Spherocytosis: A Non-random Association?
Aurélie Du Thanh, Patricia Aguilar-Martinez, Cecilia Enescu, Séverine Cunat, Bernard Guillot, Olivier Dereure
Abstract is missing (Letter)
Pages: 377-378
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QUIZ
Solitary Nodule on the Nose: A Quiz
Takamichi Ito, Yuichi Yoshida, Masutaka Furue, Osamu Yamamoto
Abstract is missing (Quiz)
Pages: 379-380
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QUIZ
Lung Nodule and Facial Erythematous Plaques: A Quiz
Isabella Carboni, Marzia Montaldo, Sergio Chimenti, Alessandro Di Stefani , Vincenzo Ambrogi
Abstract is missing (Quiz)
Pages: 379-381
Abstract  PDF