Content

Content - Volume 93, Issue 4

Editor's choice in this issue

REVIEW
Expression of Hypothalamic–Pituitary–Adrenal Axis in Common Skin Diseases: Evidence of its Association with Stress-related Disease Activity
Jung Eun Kim, Baik Kee Cho, Dae Ho Cho, Hyun Jeong Park
Hypothalamic–pituitary–adrenal (HPA) axis hormones and their receptors expressed in the skin are known to function locally, but how these hormones affect the maintenance of skin homeostasis or the pathogenesis of skin diseases is not fully understood. We comprehensively reviewed the distribution and function of the central and peripheral HPA axis in various stress-related skin diseases. Previo ...
Pages: 387-393
Abstract  HTML  PDF

All articles

Neurodermatology and skin cancer
Hanna Norsted
Four papers in this issue of ADV relate to itch and pain, skin pain as a side-effect of treating cutaneous premalignancies with photodynamic therapy and prognostic factors for the two most serious types of skin neoplasms: malignant melanoma and squamous cell carcinoma.
Page: 0
Abstract  HTML  PDF
REVIEW
Expression of Hypothalamic–Pituitary–Adrenal Axis in Common Skin Diseases: Evidence of its Association with Stress-related Disease Activity
Jung Eun Kim, Baik Kee Cho, Dae Ho Cho, Hyun Jeong Park
Hypothalamic–pituitary–adrenal (HPA) axis hormones and their receptors expressed in the skin are known to function locally, but how these hormones affect the maintenance of skin homeostasis or the pathogenesis of skin diseases is not fully understood. We comprehensively reviewed the distribution and function of the central and peripheral HPA axis in various stress-related skin diseases. Previo ...
Pages: 387-393
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Mechano-insensitive Nociceptors are Sufficient to Induce Histamine-induced Itch
Marcus Schley, Roman Rukwied, James Blunk, Christian Menzer, Christoph Konrad, Martin Dusch, Martin Schmelz, Justus Benrath
The nerve fibres underlying histamine-induced itch have not been fully elucidated. We blocked the lateral femoral cutaneous nerve and mapped the skin area unresponsive to mechanical stimulation, but still sensitive to electrically induced pain. Nerve block induced significantly larger anaesthetic areas to mechanical (100 mN pin-prick, 402 ± 61 cm2; brush, 393 ± 63 cm2) an ...
Pages: 394-399
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Gene Expression Analysis of the Corticotrophin-releasing Hormone-proopiomelanocortin System in Psoriasis Skin Biopsies
Ulvi Loite, Külli Kingo, Ene Reimann, Paula Reemann, Eero Vasar, Helgi Silm, Sulev Kõks
The corticotrophin-releasing hormone-proopiomelano-cortin (CRH-POMC) system in the skin coordinates pigmentation and the immune response. The aim of this study was to evaluate the regulatory role of the neuroendocrine system in the pathogenesis of psoriasis. Using quantitative real-time-PCR, mRNA expression levels of 15 genes related to the CRH-POMC system were measured in punch biopsies from lesi ...
Pages: 400-405
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Xerosis is Associated with Atopic Dermatitis, Hand Eczema and Contact Sensitization Independent of Filaggrin Gene Mutations
Jacob P. Thyssen, Jeanne D. Johansen, Claus Zachariae, Torkil Menné, Allan Linneberg
Atopic dermatitis, hand eczema and contact sensitization are prevalent disorders, and may, in many cases, be secondary to skin barrier abnormality. The aim of this study was to investigate the association between self-reported generalized xerosis, atopic dermatitis, hand eczema and contact sensitization, taking filaggrin gene mutations into account. Questionnaire data were collected from a cross-s ...
Pages: 406-410
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Interobserver Variability of Histopathological Prognostic Parameters in Cutaneous Malignant Melanoma: Impact on Patient Management
Hanna Eriksson, Margareta Frohm-Nilsson, Mari-Anne Hedblad, Henrik Hellborg, Lena Kanter-Lewensohn, Kamilla Krawiec, Barbro Lundh Rozell, Eva Månsson-Brahme, Johan Hansson
Clinical management of primary cutaneous melanomas is based on histopathological staging of the tumour. The aim of this study was to investigate, in a non-selected population in clinical practice, the agreement rate between general pathologists and pathologists experienced in melanoma in terms of the evaluation of histopathological prognostic parameters in cutaneous malignant melanomas, and to wha ...
Pages: 411-416
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Clinical and Histological Prognostic Factors for Local Recurrence and Metastasis of Cutaneous Squamous Cell Carcinoma: Analysis of a Defined Population
Marieke H. Roozeboom, Bjorn G.P.M. Lohman, Annet Westers-Attema, Patty J. Nelemans, Anita A. Botterweck, Arienne M.W. van Marion, Nicole W.J. Kelleners-Smeets
Cutaneous squamous cell carcinomas (cSCC) can recur locally and can metastasize. The objective of this study was to identify clinical and histopathological prognostic factors for local recurrence and metastasis in cSCCs at any body site. Clinical and histopathological data were collected from 224 patients with cSCC. During the median follow-up period of 43 months (range 0–73 months) the cumulati ...
Pages: 417-421
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Risk Factors for Non-melanoma Skin Cancer in Kidney Transplant Patients in a Spanish Population in the Mediterranean Region
Josefa Bernat García, Maria Morales Suárez-Varela, Juan J. Vilata, Amparo Marquina, Luis Pallardó, Josep Crespo
Non-melanoma skin cancer (NMSC) is the most frequent malignancy in organ transplant recipients. The aetiology of NMSC after transplant is multifactorial. The aim of this study was to determine the clinical and environmen-tal factors involved in the development of NMSC in a Spanish kidney transplant population from the Mediterranean region. A total of 289 patients who had received a kidney transpla ...
Pages: 422-427
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Freezing Fingers Syndrome, Primary and Secondary Raynaud’s Phenomenon: Characteristic Features with Hand Thermography
Iwona Chlebicka, Łukasz Matusiak, Joanna Maj, Eugeniusz Baran, Jacek C. Szepietowski
The aim of the present study was to establish a thermographic model of healthy subjects’ hands and compare it with a model of the hands of patients with freezing fingers syndrome, a group usually regarded as a healthy population. A further aim was to establish the thermographic parameters that distinguish primary Raynaud’s pheno-menon (RP) from secondary RP. The study was conducted on a group ...
Pages: 428-432
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Patients’ Experiences of Pain and Pain Relief During Photodynamic Therapy on Actinic Keratoses: An Interview Study
Christina B. Halldin, Helena Gonzalez, Ann-Marie Wennberg, Margret Lepp
Photodynamic therapy (PDT) is a well-known, effective method for treating extensive areas of multiple actinic keratoses in the face and scalp. The main side-effect of PDT is the pain experienced during treatment. The objective of this study was to explore and describe patients’ experiences of PDT. The study used individual interviews, and analysis was carried out using phenomenography. The patie ...
Pages: 433-437
Abstract  HTML  PDF
CLINICAL REPORT
Self-reported Lifetime Prevalence of Atopic Dermatitis and Co-morbidity with Asthma and Eczema in Adulthood: A Population-based Cross-sectional Survey
Kerstin Bingefors, Åke Svensson, Dag Isacson, Magnus Lindberg
Atopic dermatitis and its co-morbidity with asthma and allergy is well described in younger age groups. However, population-based studies on adults with atopic dermatitis in childhood are sparse. The aims of this study were to determine: (i) the prevalence of self-reported childhood atopic dermatitis in the population; and (ii) its association with present self-reported hand eczema, eczema, allerg ...
Pages: 438-441
Abstract  HTML  PDF
CLINICAL REPORT
Treatment Patterns, Treatment Satisfaction, Severity of Disease Problems, and Quality of Life in Patients with Psoriasis in Three Nordic Countries
Gunnel Ragnarson Tennvall, Catharina Hjortsberg, Anton Bjarnason, Robert Gniadecki, Hannele Heikkilä, Gregor B.E. Jemec, Knud Kragballe, Iben M. Miller, Åke Svensson
Biological drugs are expensive, but can reduce symptoms and increase quality of life for patients with psoriasis. The aim of this study was to examine quality of life, disease severity and treatment satisfaction in Danish, Finnish and Swedish patients with psoriasis. Based on 12 months’ data from patient surveys and chart reviews, 3 treatment groups were identified: topical, systemic and/or biol ...
Pages: 442-445
Abstract  HTML  PDF
CLINICAL REPORT
Quality of Life and Emotional State in Vitiligo in an Estonian Sample: Comparison with Psoriasis and Healthy Controls
Maire Karelson, Helgi Silm, Külli Kingo
The impact of vitiligo on quality of life is controversial. The aim of this study was to observe the impairment of quality of life and emotional state in adults with vitiligo compared with subjects with psoriasis and unaffected controls. The study group comprised 54 subjects with vitiligo, 57 with psoriasis and 57 unaffected controls. All subjects were examined and interviewed using the Dermatolog ...
Pages: 446-450
Abstract  HTML  PDF
CLINICAL REPORT
New Insights into Associated Co-morbidities in Patients with Cutaneous T-cell Lymphoma (Mycosis Fungoides)
Emmilia Hodak, Stuart Lessin, Rivka Friedland, Tamar Freud, Michael David, Lev Pavlovsky, Jonathan Shapiro, Arnon D. Cohen
Studies of associated cancer in patients with mycosis fungoides (MF) have focused primarily on secondary cancers in North American and European populations. This study investigated the association between MF and malignancies, anxiety and depression in the Israeli population. Data on Israeli patients with MF and age- and gender-matched controls were collected from a database of population- based co ...
Pages: 451-455
Abstract  HTML  PDF
CLINICAL REPORT
Randomized Controlled Observer-blinded Treatment of Chronic Foot Eczema with Iontophoresis and Bath-PUVA
Ron A. Tupker, Pieter J. Coenraads, Pieter Zanen, Marie Louise A. Schuttelaar
The aim of this study was to investigate the effect of iontophoresis combined with local psoralen plus ultraviolet A (PUVA) therapy in chronic foot eczema. A randomized, observer-blinded, multi-centre study was conducted in 48 patients with chronic moderate-to-severe foot eczema randomized to one of 3 groups: In the iontophoresis group local bath-PUVA was preceded by iontophoresis. In the PUVA gro ...
Pages: 456-460
Abstract  HTML  PDF
CLINICAL REPORT
Lichen Planus-like Lesions as the First Manifestation of Adult T-cell Leukaemia/Lymphoma
Hayakazu Sumida, Makoto Sugaya, Masahiro Kamata, Hiraku Suga, Tomomitsu Miyagaki, Hanako Ohmatsu, Hideki Fujita, Shinichi Sato
Cutaneous involvement is frequent in adult T-cell leukaemia/lymphoma (ATLL), a peripheral T-cell neoplasm caused by human T-cell lymphotropic virus type I (HTLV-I). Patients with ATLL manifest different types of skin lesions, including nodules, plaques, ulcers, erythroderma and purpura. It has been reported that this type of skin eruption is an independent prognostic factor for ATLL. We report her ...
Pages: 461-463
Abstract  HTML  PDF
LETTER TO THE EDITOR
Serum-soluble Herpes Virus Entry Mediator Levels Reflect Disease Severity and Th2 Environment in Cutaneous T Cell Lymphoma
Tomomitsu Miyagaki, Makoto Sugaya, Hiraku Suga, Hanako Ohmatsu, Hideki Fujita, Yoshihide Asano, Yayoi Tada, Takafumi Kadono, Shinichi Sato
Abstract is missing (Letter)
Pages: 465-467
Abstract  HTML  PDF
LETTER TO THE EDITOR
Two Cases of Hand, Foot, and Mouth Disease Involving the Scalp
Ann Sophie Lønnberg , Jesper Elberling, Thea K. Fischer, Lone Skov
Abstract is missing (Letter)
Pages: 467-468
Abstract  HTML  PDF
LETTER TO THE EDITOR
Cold-induced Systemic Reactions Caused by Infusion of Intravenous Fluid
Hee Jung Park, So-Young Park, Seo Hyun Lee, Ga Hee Kim, Jee Eun Yang, Sun Young Yoon, Su-Jeong Kim, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim
Abstract is missing (Letter)
Pages: 469-470
Abstract  HTML  PDF
LETTER TO THE EDITOR
Electron-microscopy of Cherry Haemangioma in the Early Diagnosis of Fabry Disease
Atsushi Tokuriki, Takahiro Kiyohara, Masanobu Kumakiri
Abstract is missing (Letter)
Pages: 471-472
Abstract  HTML  PDF
LETTER TO THE EDITOR
Successful Treatment with Alitretinoin of Dissecting Cellulitis of the Scalp in Keratitis-Ichthyosis-Deafness Syndrome
Sumangali Chandra Prasad, Anette Bygum
Abstract is missing (Letter)
Pages: 473-474
Abstract  HTML  PDF
LETTER TO THE EDITOR
Pigmented Necrobiosis Lipoidica Accompanied by Insulin-dependent Diabetes Mellitus Induces CD163 Proinflammatory Macrophages and Interleukin-17-producing Cells
Chihiro Wakusawa, Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Akira Hashimoto, Setsuya Aiba
Abstract is missing (Letter)
Pages: 475-476
Abstract  HTML  PDF
LETTER TO THE EDITOR
Antisynthetase Syndrome: A Different Diagnosis to Dermatomyositis
Zsanett Csoma, Lászlo Kovács, Erika Varga, Zsuzsanna Bata-Csörgő, Lajos Kemény
Abstract is missing (Letter)
Pages: 477-478
Abstract  HTML  PDF
LETTER TO THE EDITOR
The One-nail Brown Band: Macro- and Micro-morphology
Lidia M. Poppe, Eva-Bettina Bröcker, Axel Trautmann
Abstract is missing (Letter)
Pages: 479-480
Abstract  HTML  PDF
LETTER TO THE EDITOR
Pigmented Epithelioid Melanocytoma: Immunohistochemical Profiles of Tumour-infiltrating Histiocytes
Anna Sadayasu, Taku Fujimura, Takahiro Haga, Yumi Kambayashi, Sadanori Furudate, Setsuya Aiba
Abstract is missing (Letter)
Pages: 481-482
Abstract  HTML  PDF
LETTER TO THE EDITOR
Recurrence of Hepatitis C Virus Infection during Pityriasis Rosea
Francesco Drago, Sanja Javor, Aurora Parodi
Abstract is missing (Letter)
Pages: 483-483
Abstract  HTML  PDF
LETTER TO THE EDITOR
Generalized Granuloma Annulare and Non-Hodgkin’s Lymphoma
Andrea Bassi, Federica Scarfi, Massimiliano Galeone, Meena Arunachalam, Elisa Difonzo
Abstract is missing (Letter)
Pages: 484-485
Abstract  HTML  PDF
LETTER TO THE EDITOR
Cabbage Allergy: A Rare Cause of Food-induced Anaphylaxis
Sabine Dölle, Stephanie Hompes, Lars Lange, Margitta Worm
Abstract is missing (Letter)
Pages: 485-486
Abstract  HTML  PDF
LETTER TO THE EDITOR
Giant Orf with Prolonged Recovery in a Patient with Psoriatic Arthritis Treated with Etanercept
Ole Martin Rørdam, Øystein Grimstad, Olav Spigset, Kristin Ryggen
Abstract is missing (Letter)
Pages: 487-488
Abstract  HTML  PDF
LETTER TO THE EDITOR
Porokeratotic Eccrine Ostial and Dermal Duct Naevus and Aberrantly Regulated Keratinization
Naoki Oiso, Ichiro Kurokawa, Masatomo Kimura, Airo Tsubura, Akira Kawada
Abstract is missing (Letter)
Pages: 489-490
Abstract  HTML  PDF
LETTER TO THE EDITOR
Remitting Seronegative Symmetrical Synovitis with Pitting Oedema (RS3PE) of Hands and Feet in an 83-year-old Man
Uffe Nygaard, Christian Vestergaard, Uffe Koppelhus
Abstract is missing (Letter)
Pages: 491-492
Abstract  HTML  PDF
QUIZ
Confluent Brownish Papules and Plaques on the Neck, Upper Chest and Back: A Quiz
Alina Jankowska-Konsur, Joanna Maj, Małgorzata Tupikowska, Jacek C. Szepietowski
Abstract is missing (Quiz)
Pages: 493-494
Abstract  HTML  PDF
QUIZ
Intertriginous Orange-to-Brownish Papules and Plaques: A Quiz
Ferdinand Toberer, Wolfgang Hartschuh, Mathias Witzens-Harig, Alexander H. Enk, Anke S. Lonsdorf
Abstract is missing (Quiz)
Pages: 493-495
Abstract  HTML  PDF