Content

Content - Volume 94, Issue 1

Editors choice in this issue

CLINICAL REPORT
Association of Pain Level, Health and Wound Status in Patients with Chronic Leg Ulcers
Regina Renner, Kurt Seikowski, Jan C. Simon
Pain is a ubiquitous problem in patients with chronic leg wounds. The pain may be caused by the underlying pathology of the leg ulceration, the wound, wound treatment, or complications such as skin irritation around the ulcer. The objectives of this research were to evaluate the level of suffering endured by patients because of their ulcer-related pain, and to evaluate whether and how this pain is ...
Pages: 50-53
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CLINICAL REPORT
Immunocryosurgery for Non-superficial Basal Cell Carcinoma: A Pro­spective, Open-label Phase III Study for Tumours ≤ 2 cm in Diameter
Georgios Gaitanis, Ioannis D. Bassukas
Cryosurgery and topical imiquimod are established mono-therapies for superficial basal cell carcinoma (BCC) but are often insufficient for thicker BCCs. We present here a phase III, prospective, interventional, single-arm (cases only) study (trial registration: NCT01212562) to evaluate the feasibility and efficacy of cryosurgery (liquid nitrogen, open spray, 2 × 15 s; day 14) during ...
Pages: 38-44
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CLINICAL REPORT
Ipilimumab in Melanoma Patients with Brain Metastasis: A Retro­spective Multicentre Evaluation of Thirty-eight Patients
Maria-Polina Konstantinou, Caroline Dutriaux, Caroline Gaudy-Marqueste, Laurent Mortier, Christophe Bedane, Céline Girard, Sophie Thellier , Thomas Jouary, Jean-Jacques Grob, Marie-Aleth Richard, Caroline Templier, Lilia Sakji, Bernard Guillot, Carle Paul, Nicolas Meyer
Treatment with ipilimumab, a monoclonal antibody that antagonizes cytotoxic T-lymphocyte antigen-4 (CTLA-4), results in improved survival of patients with stage IIIc–IV melanoma. However, there is a lack of data on the efficacy of ipilimumab in patients with brain metastases. To evaluate the efficacy of ipilimumab for the treatment of brain metastasis in melanoma, a multicentre, retrospective an ...
Pages: 45-49
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INVESTIGATIVE REPORT
Personality Traits, Depression and Itch in Patients with Atopic Dermatitis in an Experimental Setting: A Regression Analysis
Christina Schut, Simon Bosbach, Uwe Gieler, Jörg Kupfer
It is known that itch is associated with psychological variables, but it is not known whether personality characteristics, depression or anxiety are predictors of experimentally induced itch in patients with atopic dermatitis (AD). In this study itch was induced in 27 patients with AD and 28 healthy controls by the presentation of an experimental video on crawling insects and skin diseases. Itch i ...
Pages: 20-25
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All articles

EDITORIAL
Old Co-workers Leave, New Ones Come and the Journal’s Impact Factor Continues to Rise
Anders Vahlquist
Abstract is missing (Editorial)
Page: 3
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INVESTIGATIVE REPORT
Long-term Topical Oestrogen Treatment of Sun-exposed Facial Skin in Post-menopausal Women Does Not Improve Facial Wrinkles or Skin Elasticity, But Induces Matrix Metalloproteinase-1 Expression
Hyun-Sun Yoon, Se-Rah Lee, Jin Ho Chung
It is controversial whether treatment with oestrogen stimulates collagen production or accumulation in sun-exposed skin. The aim of this study was to determine the effect of long-term treatment with topical oestrogen on photoaged facial skin, with regard to wrinkle severity, and expression of procollagen and matrix metalloproteinase-1 enzyme. Two groups of 40 post-menopausal women applied either 1 ...
Pages: 4-8
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INVESTIGATIVE REPORT
Serum Levels of Angiopoietin-2, but not Angiopoietin-1, are Elevated in Patients with Erythrodermic Cutaneous T-cell Lymphoma
Makiko Kawaguchi , Makoto Sugaya, Hiraku Suga, Tomomitsu Miyagaki, Hanako Ohmatsu, Hideki Fujita, Yoshihide Asano, Yayoi Tada, Takafumi Kadono, Shinichi Sato
Angiogenesis is a crucial process in the growth and progression of cancer, correlating with the metastatic potential of tumour cells. Angiopoietins are ligands for the endothelium-specific tyrosine kinase Tie2 receptor, which comprise 4 structurally related proteins, termed angiopoietin (Ang)-1, Ang-2, Ang-3 and Ang-4. The roles of Ang-1 and Ang-2 have recently been clarified as crucial in angioge ...
Pages: 9-13
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INVESTIGATIVE REPORT
Distribution and Quantitation of Skin Iron in Primary Haemochromatosis: Correlation with Total Body Iron Stores in Patients Undergoing Phlebotomy
Teresa Pinheiro, Raquel Silva, Rita Fleming, Afonso Gonçalves, Maria A. Barreiros, João N. Silva, Patrice Morlière, René Santus, Paulo Filipe
Measurement of the concentration of iron in the skin, if correlated with total body iron stores, may enable better informed decisions on when to initiate, change or stop therapy in hereditary heamochromatosis. Naïve haemochromatosis patients with iron overload and with C282Y and/or H63D HFE mutations were evaluated at the following time-points: disease diagnosis, end of the therapy programme, ...
Pages: 14-19
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INVESTIGATIVE REPORT
Personality Traits, Depression and Itch in Patients with Atopic Dermatitis in an Experimental Setting: A Regression Analysis
Christina Schut, Simon Bosbach, Uwe Gieler, Jörg Kupfer
It is known that itch is associated with psychological variables, but it is not known whether personality characteristics, depression or anxiety are predictors of experimentally induced itch in patients with atopic dermatitis (AD). In this study itch was induced in 27 patients with AD and 28 healthy controls by the presentation of an experimental video on crawling insects and skin diseases. Itch i ...
Pages: 20-25
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INVESTIGATIVE REPORT
Infliximab Does Not Lead to Reduction in the Interferon-gamma and Lymphoproliferative Responses of Patients with Moderate to Severe Psoriasis
Luciena C.M Ortigosa, Léia C.R. Silva, Alberto J.S. Duarte, Maria D. F. Takahashi, Gil Benard
Treatment of patients with immune-mediated inflammatory diseases with anti-tumour necrosis factor (anti-TNF) agents increases the risk of tuberculosis reactivation, suggesting that it may affect their cellular immune responses. We evaluated cellular immune responses of 12 severe psoriasis patients before and during infliximab treatment. Peripheral blood mononuclear cells were stimulated with phyto ...
Pages: 26-31
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INVESTIGATIVE REPORT
Correlation of Botulinum Toxin Dose with Neurophysiological Parameters of Efficacy and Safety in the Glabellar Muscles: A Double-blind, Placebo-controlled, Randomized Study
Mohammad Alimohammadi, Mats Andersson, Anna Rostedt Punga
Despite the extensive use of botulinum toxin type A (BoNT-A) in treatments for glabellar frown lines, the dose-response effect in the glabellar muscles remains unknown. The aim of this randomized, double-blind, placebo-controlled prospective study was to characterize the neurophysiological parameters that correlate with the effect of BoNT-A in the glabellar muscles and its diffusion to surroundi ...
Pages: 32-37
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CLINICAL REPORT
Immunocryosurgery for Non-superficial Basal Cell Carcinoma: A Pro­spective, Open-label Phase III Study for Tumours ≤ 2 cm in Diameter
Georgios Gaitanis, Ioannis D. Bassukas
Cryosurgery and topical imiquimod are established mono-therapies for superficial basal cell carcinoma (BCC) but are often insufficient for thicker BCCs. We present here a phase III, prospective, interventional, single-arm (cases only) study (trial registration: NCT01212562) to evaluate the feasibility and efficacy of cryosurgery (liquid nitrogen, open spray, 2 × 15 s; day 14) during ...
Pages: 38-44
Abstract  HTML  PDF
CLINICAL REPORT
Ipilimumab in Melanoma Patients with Brain Metastasis: A Retro­spective Multicentre Evaluation of Thirty-eight Patients
Maria-Polina Konstantinou, Caroline Dutriaux, Caroline Gaudy-Marqueste, Laurent Mortier, Christophe Bedane, Céline Girard, Sophie Thellier , Thomas Jouary, Jean-Jacques Grob, Marie-Aleth Richard, Caroline Templier, Lilia Sakji, Bernard Guillot, Carle Paul, Nicolas Meyer
Treatment with ipilimumab, a monoclonal antibody that antagonizes cytotoxic T-lymphocyte antigen-4 (CTLA-4), results in improved survival of patients with stage IIIc–IV melanoma. However, there is a lack of data on the efficacy of ipilimumab in patients with brain metastases. To evaluate the efficacy of ipilimumab for the treatment of brain metastasis in melanoma, a multicentre, retrospective an ...
Pages: 45-49
Abstract  HTML  PDF
CLINICAL REPORT
Association of Pain Level, Health and Wound Status in Patients with Chronic Leg Ulcers
Regina Renner, Kurt Seikowski, Jan C. Simon
Pain is a ubiquitous problem in patients with chronic leg wounds. The pain may be caused by the underlying pathology of the leg ulceration, the wound, wound treatment, or complications such as skin irritation around the ulcer. The objectives of this research were to evaluate the level of suffering endured by patients because of their ulcer-related pain, and to evaluate whether and how this pain is ...
Pages: 50-53
Abstract  HTML  PDF
CLINICAL REPORT
Primary Cutaneous Follicular Helper T-cell Lymphoma Treated with Allogeneic Bone Marrow Transplantation: Immunohistochemical Comparison with Angioimmunoblastic T-cell Lymphoma
Hanako Ohmatsu, Makoto Sugaya, Hideki Fujita, Takafumi Kadono, Shinichi Sato
Primary cutaneous follicular helper T (TFH)-cell lym-phoma has recently been proposed, and is characterized by proliferation of malignant T cells expressing TFH-cell markers, such as CXCL13, accompanied by numerous reactive B cells. We report here a patient whose skin histology showed massive infiltration of both T and B cells, with a proliferation of arborizing high endothelial venules and follic ...
Pages: 54-57
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CLINICAL REPORT
In vitro Cytokine Expression by Peripheral Mononuclear Cells in Herbal Drug-induced Skin Eruption
Osamu Norisugi, Yoko Yoshihisa, Kyoko Shimizu, Tadamichi Shimizu
Herbal medicine is widely used worldwide and is associated with side-effects such as skin eruptions. Herbal drugs are often produced by combining multiple crude drugs, mostly of plant origin. Determining which medi-cinal plants are associated with the herbal drugs that induce skin eruptions can therefore be difficult. This study investigated mRNA expression of several cytokines in peripheral monon ...
Pages: 58-62
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CLINICAL REPORT
Interventional Three-year Longitudinal Study of Melanocytic Naevus Development in Pre-school Children in Dresden, Saxony
Uwe Wollina, Catherine Helm, Annett Bennewitz, Rainer Koch, Kathrin Schaff, Marco Burroni
Acquired melanocytic naevi (MN) are considered a risk factor for melanoma. Exposure to ultraviolet light (UV) is the major environmental factor for MN. UV protection is most critical in pre-school children. This 3-year interventional longitudinal study examined 395 3-year-old children attending daycare centres (DCC) in Dresden, Germany. Photo-skin type, eye and hair colour were recorded. DCC were ...
Pages: 63-66
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CLINICAL REPORT
Onychophagia and Onychotillomania: Prevalence, Clinical Picture and Comorbidities
Przemysław Pacan, Magdalena Grzesiak, Adam Reich, Monika Kantorska-Janiec, Jacek C. Szepietowski
Onychophagia is defined as chronic nail biting behaviour, which usually starts during childhood. Onychotillomania results from recurrent picking and manicuring of the fingernails and/or toenails, leading to visual shortening and/or estraction of nails. The aim of this study was to assess the prevalence of onychophagia and onychotillomania in young adults, and the comorbidity of these conditions wi ...
Pages: 67-71
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SHORT COMMUNICATION
Home-sampling as a Tool in the Context of Chlamydia trachomatis Partner Notification: A Randomized Controlled Trial
Lars Falk, Sabina Hegic, Daniel Wilson, Ann-Britt Wiréhn
Abstract is missing (Short)
Pages: 72-74
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SHORT COMMUNICATION
Venous Lakes of the Lips: Prevalence and Associated Factors
Silvano Menni, Marco Marconi, Daniela Boccardi, Roberto Betti
Abstract is missing (Short)
Pages: 74-75
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SHORT COMMUNICATION
Cardiovascular Risk Factors in Children and Adolescents with Psoriasis: A Case-control Study
Peter Jensen, Claus Zachariae, Lars Iversen, Peter Riis Hansen, Lone Skov
Abstract is missing (Short)
Pages: 76-78
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SHORT COMMUNICATION
Olopatadine Hydrochloride Decreases Tissue Interleukin-31 Levels in an Atopic Dermatitis Mouse Model
Hiroyuki Murota, Mostafa Abd El-latif, Tadafumi Tamura, Ichiro Katayama
Abstract is missing (Short)
Pages: 78-79
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SHORT COMMUNICATION
Analysis of Contact Allergens in Korean Polysensitized Patients by Patch Testing: A Pilot Study
Dae Suk Kim, Jung Min Bae, Hyunjoong Jee , Hemin Lee, Do-Young Kim, Soo Min Kim, Min-Geol Lee
Abstract is missing (Short)
Pages: 80-81
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SHORT COMMUNICATION
Acne in Pregnant Women: A French Survey
Brigitte Dréno, Eric Blouin, Dominique Moyse , Isaac Bodokh, Anne Chantal Knol, Amir Khammari
Abstract is missing (Letter)
Pages: 82-83
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SHORT COMMUNICATION
Significance of Two Skin Biopsy Performances with Consecutive Deeper Sections in the Differential Diagnosis Between Cutaneous Polyarteritis Nodosa and Livedo Vasculopathy
Tamihiro Kawakami, Satoko Kimura, Sora Takeuchi, Yoshinao Soma
Abstract is missing (Short)
Pages: 84-85
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SHORT COMMUNICATION
Using CD40 Ligand Expression to Detect Antigen-specific T Cells in Patients with Drug Eruptions
Tetsuya Higuchi, Takahiro Satoh, Hiroo Yokozeki
Abstract is missing (Short)
Pages: 86-87
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SHORT COMMUNICATION
Familial Atypical Cold Urticaria Localized on the Face: A Case Report
Laura Huilaja, Riitta Riekki, Pekka T. Leinonen, Aarne Oikarinen, Kaisa Tasanen
Abstract is missing (Short)
Pages: 88-89
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SHORT COMMUNICATION
CD4/CD8 Double-negative Mycosis Fungoides Mimicking Erythema Gyratum Repens in a Patient with Underlying Lung Cancer
Kotaro Nagase, Reiko Shirai, Takeshi Okawa, Takuya Inoue, Noriyuki Misago, Yutaka Narisawa
Absract is missing (Short)
Pages: 89-90
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SHORT COMMUNICATION
Treatment of an Intractable Cutaneous Ulcer in the Right Lateral Malleolus in Fibrodysplasia Ossificans Progressiva
Kaho Matsuda, Mizuki Goto, Yukako Ito, Fumiaki Shimizu, Yutaka Hatano, Sakuhei Fujiwara
Abstract is missing (Short)
Pages: 91-92
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SHORT COMMUNICATION
Skin Discoloration Caused by Iron Salts
Iara Trocoli Drakensjö, Ingvar Lengstam, Mari-Anne Hedblad
Abstract is missing (Short)
Pages: 92-93
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SHORT COMMUNICATION
Denileukin Diftitox plus Total Skin Electron Beam Radiation in Patients with Treatment-refractory Cutaneous T-cell Lymphoma (Mycosis Fungoides): Report of Four Cases
Kristina Buder, Philip A. Müller, Gabriele Beckmann, Selma Ugurel, Eva-Bettina Bröcker, Jürgen C. Becker
Abstract is missing (Short)
Pages: 94-96
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SHORT COMMUNICATION
Dermoscopy of Peristomal Polyps and Metastasis of Colon Cancer
Takamichi Ito, Yuichi Yoshida, Nanako Yamada, Masutaka Furue, Osamu Yamamoto
Abstract is missing (Short)
Pages: 96-97
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SHORT COMMUNICATION
Long-term Follow-up of Cultured Epidermal Autograft in a Patient with Recessive Dystrophic Epidermolysis Bullosa
Satoru Shinkuma, Daisuke Sawamura, Yasuyuki Fujita, Hiroyuki Kawasaki, Hiroyuki Nakamura, Masukazu Inoie, Wataru Nishie, Hiroshi Shimizu
Abstract is missing (Short)
Pages: 98-99
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SHORT COMMUNICATION
Annular Atrophic Plaques on the Face in a Father and a Son: Christianson’s Disease, a Real Entity?
Wiebke K. Peitsch, Azadeh Orouji, Theo M. Starink, Ingrid Hausser, Robert Figl, Sergij Goerdt
Abstract is missing (Short)
Pages: 100-101
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SHORT COMMUNICATION
Prurigo Pigmentosa-like Persistent Papules and Plaques in a Patient with Adult-onset Still’s Disease
Yung-Tsu Cho, Yi-Hua Liao
Abstract is missing (Short)
Pages: 102-103
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SHORT COMMUNICATION
Induction of CD163+ M2 Macrophages in the Lesional Skin of Eosinophilic Pustular Folliculitis
Akiko Hagiwara, Taku Fujimura, Sadanori Furudate, Yumi Kambayashi, Saori Kagatani, Setsuya Aiba
Abstract is missing (Short)
Pages: 104-106
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SHORT COMMUNICATION
Acute Localized Exanthematous Pustulosis on Inguinal Area Secondary to Piperacillin/tazobactam
Laura Huilaja, Matti Kallioinen, Minna Soronen, Riitta Riekki, Kaisa Tasanen
Abstract is missing (Short)
Pages: 106-107
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SHORT COMMUNICATION
Remission of Bullous Pemphigoid after Rituximab Treatment in a Psoriasis Patient on Regular Low-dose Methotrexate
Ting-Shun Wang, Tsen-Fang Tsai
Abstract is missing (Short)
Pages: 108-109
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SHORT COMMUNICATION
Onset of Psoriatic Arthritis at the Hip Joint Without Spondylitis
Hideki Maejima, Akira Watarai, Tomonori Taniguchi, Kensei Katsuoka
Abstract is missing (Short)
Pages: 110-111
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SHORT COMMUNICATION
Elevated Serum Levels of TARC/CCL17, Eotaxin-3/CCL26 and VEGF in a Patient with Kimura’s Disease and Prurigo-like Eruption
Sei-ichiro Motegi, Mai Hattori , Akira Shimizu, Masatoshi Abe, Osamu Ishikawa
Abstract is missing (Short)
Pages: 112-113
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SHORT COMMUNICATION
Tubular Spitz Naevus Mimicking Eccrine Spiradenoma
Yasuyuki Fujita, Satoru Aoyagi, Masumi Tsujiwaki, Erina Homma, Hideyuki Ujiie, Hiromi Fujita, Kanako C. Hatanaka, Hiroshi Shimizu
Abstract is missing (Short)
Pages: 114-115
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SHORT COMMUNICATION
Alopecia Universalis Associated with Vitiligo in an 18-year-old HIV-positive Patient: Highly Active Anti-retroviral Therapy as First Choice Therapy?
Damjan S. Nikolic, Daniela Viero, Vanessa Christinet Yana Tijé, Laurence Toutous-Trellu
Absract is missing (Short)
Pages: 116-117
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SHORT COMMUNICATION
Successful Treatment of Anal and Perianal Condyloma Acuminata with Imiquimod
Chisato Tawada, Yoko Oshitani, Masaki Kimura, Mariko Seishima
Abstract is missing (Short)
Pages: 118-119
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LETTER TO THE EDITOR
Change in Dermoscopic Pattern of Naevi in Children: A Commentary
Alon Scope, Ashfaq A. Marghoob, Stephen W. Dusza, Susan A. Oliveria, Allan C. Halpern
Abstract is missing (Letter)
Pages: 120-122
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LETTER TO THE EDITOR
Report from the Inaugural Australian Pruritus Symposium, Sydney, Australia, August 10, 2013
Frank Brennan, Dedee F. Murrell
Abstract is missing (Letter)
Pages: 123-123
Abstract  HTML  PDF
QUIZ
Sudden Eruption of Tender Nodules and Plaques in a Three-year-old girl: A Quiz
Uffe Koppelhus, Torben Steiniche, Yeyanthiny Kanagiah, Jens Veirum, Mette S. Deleuran
Abstract is missing (Quiz)
Pages: 125-128
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QUIZ
Linear Eruptions on the Calf in a Six-week-old Boy: A Quiz
Anette Bygum, Martin Hulgaard
Abstract is missing (Quiz)
Pages: 125-128
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QUIZ
Indurated Nodules Within a Tattoo: A Quiz
Karl K. Vance, Patricia M. Fishman, Sujata S. Gaitonde, Aleksandar L. Krunic
Abstract is missing (Letter)
Pages: 125-128
Abstract  HTML  PDF