Content

Content - Volume 95, Issue 5

Editor's choice in this issue

REVIEW
Metastatic Melanoma – A Review of Current and Future Treatment Options
Emanual Maverakis, Lynn A. Cornelius, Glen M. Bowen, Tiffany Phan, Falin B. Patel, Sarah Fitzmaurice, Young He, Barbara Burrall, Christopher Duong, April M. Kloxin, Hawa Sultani, Reason Wilken, Steve R. Martinez, Forum Patel
Despite advances in treatment and surveillance, melanoma continues to claim approximately 9,000 lives in the US annually (SEER 2013). The National Comprehensive Cancer Network currently recommends ipilumumab, vemurafenib, dabrafenib, and high-dose IL-2 as first line agents for Stage IV melanoma. Little data exists to guide management of cutaneous and subcutaneous metastases despite the fact that t ...
Pages: 516-524
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CLINICAL REPORT
Clinical Spectrum of Skin Manifestations of Lyme Borreliosis in 204 Children in Austria
Martin Glatz, Astrid Resinger, Kristina Semmelweis, Christina M. Ambros-Rudolph, Robert R. Müllegger
The spectrum of skin manifestations of Lyme borreliosis in children is not well characterized. We conducted a retrospective study to analyze the clinical characteristics, seroreactivity to Borrelia burgdorferi sensu lato, and outcome after treatment in 204 children with skin manifestations of Lyme borreliosis seen in 1996–2011. Solitary erythema migrans was the most common manifestation (44.6%), ...
Pages: 565-571
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CLINICAL REPORT
Cyclosporine Treatment in Severe Gestational Pemphigoid
Laura Huilaja, Kaarin Mäkikallio, Katariina Hannula-Jouppi, Liisa Väkevä, Johanna Höök-Nikanne, Kaisa Tasanen
Gestational pemphigoid, a rare autoimmune skin disease typically occurring during pregnancy, is caused by autoantibodies against collagen XVII. Clinically it is characterised by severe itching followed by erythematous and bullous lesions of the skin. Topical or oral glucocorticoids usually relieve symptoms, but in more severe cases systemic immunosuppressive treatments are needed. Data on immunosu ...
Pages: 593-595
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All articles

REVIEW
Metastatic Melanoma – A Review of Current and Future Treatment Options
Emanual Maverakis, Lynn A. Cornelius, Glen M. Bowen, Tiffany Phan, Falin B. Patel, Sarah Fitzmaurice, Young He, Barbara Burrall, Christopher Duong, April M. Kloxin, Hawa Sultani, Reason Wilken, Steve R. Martinez, Forum Patel
Despite advances in treatment and surveillance, melanoma continues to claim approximately 9,000 lives in the US annually (SEER 2013). The National Comprehensive Cancer Network currently recommends ipilumumab, vemurafenib, dabrafenib, and high-dose IL-2 as first line agents for Stage IV melanoma. Little data exists to guide management of cutaneous and subcutaneous metastases despite the fact that t ...
Pages: 516-524
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REVIEW
Effective Strategies for the Management of Pyoderma Gangrenosum: A Comprehensive Review
Forum Patel, Sarah Fitzmaurice, Christopher Duong, Young He, Jonathan Fergus, Siba P. Raychaudhuri, Miki Shirakawa Garcia, Emanual Maverakis
Pyoderma gangrenosum (PG) is an inflammatory disease characterized by painful skin ulcerations with undermined and erythematous borders. The etiology of PG is not well understood, but it is generally considered to be an aberrant immune response characterized by a dermal neutrophilc infiltrate. Given the existence of only a few PG clinical trials, treatment options are largely based upon anecdotal ...
Pages: 525-531
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INVESTIGATIVE REPORT
A Retrospective Analysis of Skin Bacterial Colonisation, Susceptibility and Resistance in Atopic Dermatitis and Impetigo Patients
Louai A. Salah, Jan Faergemann
Atopic dermatitis (AD) and impetigo are skin conditions where bacterial colonisation and infection, especially with Staphylococcus aureus play an important role. We compared skin bacterial population, resistance patterns and choice of antimicrobial agents in patients diagnosed with AD and impetigo during 2005 and 2011 in our department. Number of positive cultures in the AD group were 40 and 53 in ...
Pages: 532-535
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INVESTIGATIVE REPORT
Experimentallu Induced Psoriatic Lesions Associate with Rapid but Transient Decrease in Interleukin-33 Immunostaining in Epidermis
Mireille-Maria Suttle, Mattias Enoksson, Anna Zoltowska, Madhumita Chatterjee, Gunnar Nilsson, Ilkka T. Harvima
A slight epidermal damage can induce the Köbner reaction in psoriasis, and the “alarmin”, interleukin-33 (IL-33), may be involved in this process. Therefore, the uninvolved psoriatic skin was tape-stripped, and skin biopsies were collected at 0d, 2h and 3d or at 0d, 1d and 7d for immunohistochemistry. Eight patients out of 18 with the positive Köbner reaction showed a decrease in epidermal t ...
Pages: 536-541
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INVESTIGATIVE REPORT
Topical TrkA Kinase Inhibitor CT327 is an Effective, Novel Therapy for the Treatment of Pruritus due to Psoriasis: Results from Experimental Studies, and Efficacy and Safety of CT327 in a Phase 2b Clinical Trial in Patients with Psoriasis
David Roblin, Gil Yosipovitch, Brent Boyce, John Robinson, James Sandy, Valentina Mainero, Ro Wickramasinghe, Uma Anand, Praveen Anand
Pruritus is an important symptom in psoriasis with no targeted treatment. Tropomyosin-receptor kinase A (TrkA) is associated with pruritus and psoriatic plaque formation. We report the efficacy of a TrkA inhibitor, CT327, on pruritus in psoriasis. A randomised, double-blind, vehicle-controlled Phase 2b clinical trial was conducted in 160 subjects. No effect was found on psoriasis severity using In ...
Pages: 542-548
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INVESTIGATIVE REPORT
Delineating Margins of Lentigo Maligna Using a Hyperspectral Imaging System
Noora Neittaanmäki-Perttu, Mari Grönroos, Leila Jeskanen, Ilkka Pölönen, Annamari Ranki, Olli Saksela, Erna Snellman
Lentigo maligna (LM) is an in situ form of melanoma which can progress into invasive lentigo maligna melanoma (LMM). Variations in the pigmentation and thus visibility of the tumour make assessment of lesion borders challenging. We tested hyperspectral imaging system (HIS) in in vivo preoperative delineation of LM and LMM margins. We compared lesion margins delineated by HIS with those estimated c ...
Pages: 549-552
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INVESTIGATIVE REPORT
Stigmatisation, Avoidance Behaviour and Difficulties in Coping are Common Among Adult Patients with Vitiligo
Christian Krüger, Karin U. Schallreuter
Vitiligo is a non-contagious skin disorder with loss of pigmentation, often impairing patients’ well-being. This study used Dermatology Life Quality Index (DLQI), Adjustment to Chronic Skin Disorders Questionnaire (ACS), Beck Depression Inventory (BDI) and additional questions to explore quality of life (QoL), coping, depression and stigmatisation and included 96 patients with vitiligo and 23 co ...
Pages: 553-558
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INVESTIGATIVE REPORT
Autoantibody Levels and Clinical Disease Severity in Patients with Pemphigus: Comparison of Aggregated Anti-desmoglein ELISA Values and Indirect Immunofluorescence Titres
Doris Weiss, Robin Ristl, Johannes Griss, Christine Bangert, Dagmar Foedinger, Georg Stingl, Patrick M. Brunner
Detecting serum-autoantibodies by anti-Desmoglein-1 (anti-Dsg1) and anti-Dsg3 ELISAs as well as indirect immunofluorescence (IIF) are established complementary methods to diagnose pemphigus. Whether autoantibody levels also reflect clinical disease activity is still a matter of debate, as head-to-head comparisons of ELISA values and IIF titres with clinical activity over a longer treatment period ...
Pages: 559-564
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CLINICAL REPORT
Clinical Spectrum of Skin Manifestations of Lyme Borreliosis in 204 Children in Austria
Martin Glatz, Astrid Resinger, Kristina Semmelweis, Christina M. Ambros-Rudolph, Robert R. Müllegger
The spectrum of skin manifestations of Lyme borreliosis in children is not well characterized. We conducted a retrospective study to analyze the clinical characteristics, seroreactivity to Borrelia burgdorferi sensu lato, and outcome after treatment in 204 children with skin manifestations of Lyme borreliosis seen in 1996–2011. Solitary erythema migrans was the most common manifestation (44.6%), ...
Pages: 565-571
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CLINICAL REPORT
Treatment Satisfaction of Patients with Psoriasis
Marthe-Lisa Schaarschmidt, Christian Kromer, Raphael Herr, Astrid Schmieder, Sergij Goerdt, Wiebke K. Peitsch
Treatment satisfaction of patients with psoriasis largely depends on the treatment modality, but evidence on preferences for specific medications is scarce. Here we assessed treatment satisfaction of 200 participants with moderate-to-severe psoriasis from a German University hospital with a 5-point scale and the Treatment Satisfaction Questionnaire for Medication (TSQM) and determined sociodemogra ...
Pages: 572-578
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CLINICAL REPORT
Empowering Heliotherapy Improves Clinical Outcome and Quality of Life of Psoriasis and Atopic Dermatitis Patients
Toni T Karppinen, Lasse Ylianttila, Hannu Kautiainen, Timo Reunala, Erna Snellman
Empowering heliotherapy aims at clinical healing and improved coping with psoriasis and atopic dermatitis, but evidence of long-term effects is scarce. We studied the effect of 2-week empowering heliotherapy in the Canary Islands on clinical outcome and quality of life in 22 psoriasis and 13 atopic dermatitis patients. Empowerment consisted of meeting peers, sharing experiences and performing phys ...
Pages: 579-582
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CLINICAL REPORT
Children with Atopic Dermatitis Should Always be Patch-tested if They Have Hand or Foot Dermatitis
Marléne Isaksson, Sanna Olhardt, Jeanette Rådehed, Åke Svensson
Atopic dermatitis is the most common chronic inflammatory disease among children in industrialised countries. Many factors influence this disease in a negative way and contact allergy is one such factor. The aim of the study was to examine the frequency of contact allergy among children with the diagnosis atopic dermatitis. Contact allergy was found in 22/82 children (26.8%), the most common from ...
Pages: 583-586
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CLINICAL REPORT
Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial
Ulf Åkerström, Sakari Reitamo, Tor Langeland, Mats Berg, Lisbeth Rustad, Laura Korhonen, Marie Lodén, Karin Wirén, Mats Grände, Petra Skare, Åke Svensson
Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence in ...
Pages: 587-592
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CLINICAL REPORT
Cyclosporine Treatment in Severe Gestational Pemphigoid
Laura Huilaja, Kaarin Mäkikallio, Katariina Hannula-Jouppi, Liisa Väkevä, Johanna Höök-Nikanne, Kaisa Tasanen
Gestational pemphigoid, a rare autoimmune skin disease typically occurring during pregnancy, is caused by autoantibodies against collagen XVII. Clinically it is characterised by severe itching followed by erythematous and bullous lesions of the skin. Topical or oral glucocorticoids usually relieve symptoms, but in more severe cases systemic immunosuppressive treatments are needed. Data on immunosu ...
Pages: 593-595
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CLINICAL REPORT
Mepacrine in Recalcitrant Cutaneous Lupus Erythematosus: Old-fashioned or Still Useful?
Sandrine Benoit, Matthias Goebeler
Treatment of recalcitrant cutaneous lupus erythematosus (CLE) is challenging. In situations where conventional treatment approaches fail mepacrine – an antimalarial/antiinflammatory drug that has fallen into oblivion in the last decades – might still be a promising option. We retrospectively analysed medical records of 10 patients with refractory CLE that were treated with mepacrine (100–200 ...
Pages: 596-599
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SHORT COMMUNICATION
Comparison of CD163+ Macrophages and CD206+ Cells in Lesional Skin of CD30+ Lymphoproliferative Disorders of Lymphomatoid Papulosis and Primary Cutaneous Anaplastic Large-cell Lymphoma
Aya Kakizaki, Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Mitsuko Kawano, Kouetsu Ogasawara, Setsuya Aiba
Abstract is missing (Short communication)
Pages: 600-602
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SHORT COMMUNICATION
Disseminated Primary Cutaneous CD8+ Small/Medium-sized Pleomorphic T-cell Lymphoma Responding to Hydroxychloroquine
Valerie C. Amann, Jil Dreier, Desislava Ignatova, Jivko Kamarashev, Katrin Kerl, Werner Kempf, Steve Pascolo, Reinhard Dummer, Antonio Cozzio, Emmanuella Guenova
Abstract is missing (Short communication)
Pages: 602-603
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SHORT COMMUNICATION
Counting Actinic Keratosis – Is Photographic Assessment a Reliable Alternative to Physical Examination in Clinical Trials?
Sudipta Sinnya, Peter O'Rourke, Emma Ballard, Jean M. Tan, Conrad Morze, Azadeh Sahebian, Sam C. Hames, Tarl W. Prow, Adèle C. Green, H. Peter Soyer
Abstract is missing (Short Communication)
Pages: 604-605
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SHORT COMMUNICATION
Stevens-Johnson Syndrome Associated with Mogamulizumab-induced Deficiency of Regulatory T cells in an Adult T-cell Leukaemia Patient
Tetsuya Honda, Masakatsu Hishizawa, Tatsuki R. Kataoka, Katsuyuki Ohmori, Akifumi Takaori-Kondo, Yoshiki Miyachi, Kenji Kabashima
Abstract is missing (Short communication)
Pages: 606-607
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SHORT COMMUNICATION
Lipoid Proteinosis Resulting from a Large Homozygous Deletion Affecting Part of the ECM1 Gene and Adjacent Long Non-coding RNA
Ming-Yang Lee, Hui-Jun Wang, Ying Han, Yun Zhou, Jia-Hui Zhao, Li-Na Duo, Cheng Feng, Hong Hua, Hong-Wei Liu, Zhi-Miao Lin, Yong Yang
Abstract is missing (Short communication)
Pages: 608-610
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SHORT COMMUNICATION
Bullous Pemphigoid in Infancy Showing Epitope-spreading Phenomenon: Recovery with Topical Therapy
Hiromasa Matsuda, Naoki Oiso, Norito Ishii, Masako Sato, Megumi Tatebayashi, Takashi Hashimoto, Akira Kawada
Abstract is missing (Short communication)
Pages: 610-611
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SHORT COMMUNICATION
Adult Staphylococcal Scalded Skin Syndrome Successfully Treated with Plasma Exchange
Takeshi Kato, Noriki Fujimoto, Gen Nakanishi, Yasuyuki Tsujita, Kazuhiro Matsumura, Yutaka Eguchi, Toshihiro Tanaka
Abstract is missing (Short communication)
Pages: 612-613
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SHORT COMMUNICATION
A Male with Group B Streptococcal Necrotizing Fasciitis at Multiple Sites Secondary to Multifocal Septic Arthritis
Hiroshi Umemura, Keita Hiragushi, Susumu Sasaki, Hiroko Doi, Naofumi Shiota, Koji Kabutan, Kenji Asagoe
Abstract is missing (short communication)
Pages: 614-615
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SHORT COMMUNICATION
Bilateral Auricular Involvement: A Rare Presenting Sign of Chronic Lymphocytic Leukemia, and Successful Treatment with Electron Beam Therapy
Joanna L. Walker, Lisa M. Cohen, George Kroumpouzos
Abstract i missing (Short communication)
Pages: 616-617
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SHORT COMMUNICATION
Epidermal Cyst Formation and Hyperkeratosis in a Patient Treated with Vismodegib for Locally Advanced Basal Cell Carcinoma
Marie G.H.C. Reinders, Tjinta Brinkhuizen , Patricia M.M.B. Soetekouw, Nicole W.J. Kelleners-Smeets, Myrurgia A. Abdul Hamid, Klara Mosterd
Abstract is missing (Short communication)
Pages: 618-619
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SHORT COMMUNICATION
TRPS1 Haploinsufficiency Results in Increased STAT3 and SOX9 mRNA Expression in Hair Follicles in Trichorhinophalangeal Syndrome
Akitaka Shibata, Kana Tanahashi, Kazumitsu Sugiura, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 620-621
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SHORT COMMUNICATION
Recurrent Finkelstein-Seidlmayer Disease in Four First-degree Relatives
Alessandro Ostini, Gian Paolo Ramelli, Carlo Mainetti , Mario G. Bianchetti, Alessandra Ferrarini
Abstract is missing (Short communication)
Pages: 622-623
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SHORT COMMUNICATION
Melasma Improving Spontaneously upon Switching from a Combined Oral Contraceptive to a Hormone-releasing Intrauterine Device: A Report of Four Cases
Natalie Locci-Molina, Annie Wang, George Kroumpouzos
Abstract i missing (Short communication)
Pages: 624-625
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SHORT COMMUNICATION
Successful Elimination of Methotrexate by Continuous Veno-venous Haemofiltration in a Psoriatic Patient with Methotrexate Intoxication
Chien-Chih Wu, Chih-Fen Huang, Li-Jiuan Shen, Fe-Lin Lin Wu
Abstract is missing (Short Communication)
Pages: 626-627
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SHORT COMMUNICATION
Contact Urticaria Due to a Face Mask Coated with Disinfectant Liquid Spray
Masashi Iwata, Hideaki Tanizaki, Hiroko Fujii, Yuichiro Endo, Akihiro Fujisawa, Miki Tanioka, Yoshiki Miyachi, Kenji Kabashima
Abstract is missing (Short communication)
Pages: 628-629
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SHORT COMMUNICATION
Localised Dominant Dystrophic Epidermolysis Bullosa with a Novel de Novo Mutation in COL7A1 Diagnosed by Next-generation Sequencing
Makoto Nagai, Hiroshi Nagai, Chiharu Tominaga, Yoshiko Sakaguchi, Orie Jitsukawa, Noriko Ohgo, Chikako Nishigori, Kiyofumi Yamanishi
Abstract is missing (Short communication)
Pages: 629-631
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QUIZ
Widespread Crusted Skin Ulcerations in a Man with Type II Diabetes: A Quiz
Jiu-Hong Li, Hao Guo, Song Zheng, Bo Li, Xing-Hua Gao, Hong-Duo Chen
Abstract is missing (Quiz)
Pages: 632-638
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QUIZ
Self-healing Eyelid Nodule: A Quiz
Lidia Maroñas-Jiménez, Diana Menis, Vanessa Gargallo-Moneva, Jose Luis Rodríguez-Peralto, Pablo Luis Ortiz-Romero
Abstract is missing (Quiz)
Pages: 632-638
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QUIZ
A Painful Nodule on the Leg: A Quiz
Fernando Cammisuli, Vito Catania, Maria Rita Nasca, Andrea Failla, Giuseppe Micali
Abstract is missing (Quiz)
Pages: 632-638
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QUIZ
Multiple Perianal Nodules in an HIV-positive Man: A Quiz
Risa Suzuki, Shiro Niiyama, Yuki Yokouchi, Hideki Mukai
Abstract is missing (Quiz)
Pages: 632-638
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