Content

Content - Volume 95, Issue 6

Editor's choice in this issue

INVESTIGATIVE REPORT
Cerebral Networks Linked to Itch-related Sensations Induced by Histamine and Capsaicin
Verena Vierow , Clemens Forster, Rebekka Vogelgsang , Arnd Dörfler , Herman O. Handwerker
This functional magnetic resonance imaging (fMRI) study explored the central nervous processing of itch induced by histamine and capsaicin, delivered via inactivated cowhage spicules, and the influence of low-dose naltrexone. Scratch bouts were delivered at regular intervals after spicule insertion in order temporarily to suppress the itch. At the end of each trial the subjects rated their itch an ...
Pages: 645-652
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INVESTIGATIVE REPORT
Dermoscopy of Naevus-associated Melanomas
Danielle Shitara, Mauricio Nascimento, Priscila Ishioka , Cristina Carrera, Llúcia Alós, Josep Malvehy, Susana Puig
In order to determine dermoscopic parameters, a case-control test set of naevus-associated melanomas vs de novo melanomas paired by Breslow thickness and histopathological subtype was analysed by 2 blinded experienced dermoscopists, according to presence of naevus, pattern analysis and ABCD dermoscopy score. The ability to identify naevus-associated melanomas by pattern analysis was low for both b ...
Pages: 671-675
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CLINICAL REPORT
Maternal and Perinatal Factors of Importance for Occurrence and Severity of Infantile Haemangioma
Eun Jee Kim, Hyun Sun Park , Hyun-Sun Yoon, Soyun Cho
To determine which patient and maternal factors are associated with the occurrence and the severity of infantile haemangioma (IH), a single-centre retrospective observational study was conducted with 96 haemangioma patients and 143 age-matched control babies, born in the same hospital between March 2012 and March 2013. The IH patients were selected according to diagnosis from dermatologists, eithe ...
Pages: 696-699
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All articles

IN THIS ISSUE
IFN-γ in vitiligo, is it the fuel or the fire?
John E. Harris
Abstract is missing (In this Issue...)
Pages: 643-644
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IN THIS ISSUE
Therapy for Gonococcal and Non-gonococcal Genital Infections is a Major Problem for Clinicians
Marco Cusini
Abstract is missing (In this Issue...)
Page: 644
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Cerebral Networks Linked to Itch-related Sensations Induced by Histamine and Capsaicin
Verena Vierow , Clemens Forster, Rebekka Vogelgsang , Arnd Dörfler , Herman O. Handwerker
This functional magnetic resonance imaging (fMRI) study explored the central nervous processing of itch induced by histamine and capsaicin, delivered via inactivated cowhage spicules, and the influence of low-dose naltrexone. Scratch bouts were delivered at regular intervals after spicule insertion in order temporarily to suppress the itch. At the end of each trial the subjects rated their itch an ...
Pages: 645-652
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Comparing the Effect of a Twice-weekly Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis
John Chittock, Kirsty Brown, Michael J. Cork, Simon G. Danby
The proactive use of topical anti-inflammatory (TAI) therapy to address subclinical inflammation is an effective, contemporary clinical strategy for the management of atopic dermatitis (AD). The interaction of a proactive TAI dose with the subclinical epidermal barrier defect in AD is yet to be determined. A randomised, observer-blind, functional mechanistic study in 17 subjects with quiescent AD ...
Pages: 653-658
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INVESTIGATIVE REPORT
Acid-coated Textiles (pH 5.5–6.5) – a New Therapeutic Strategy for Atopic Eczema?
Teresa Jaeger, Markus Rothmaier, Holger Zander, Johannes Ring, Jan Gutermuth, Mark D. Anliker
Increased transepidermal water loss (TEWL) and decreased skin capacitance are characteristic features of the disturbed epidermal barrier in atopic eczema (AE). The “acid mantle”, which is a slightly acidic film on the surface of the skin has led to the development of acidic emollients for skin care. In this context, the effect of citric acid-coated textiles on atopic skin has not been examined ...
Pages: 659-663
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INVESTIGATIVE REPORT
Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes: A Pivotal Role of CD8+ Cytotoxic T Lymphocytes in Vitiligo
Lili Yang, Yi Wei, Yue Sun, Weimin Shi, Ji Yang, Lubing Zhu, Ming Li
Increased expression of the cytokine interferon (IFN)-γ plays a pivotal role in vitiligo-induced depigmentation. However, the major source of IFN-γ in vitiligo patients and the mechanisms underlying melanocyte destruction are unknown. In this study, a large number of skin infiltrating IFN-γ+ cells and CD8+ T cells were detected in progressive vitiligo. Among the peripheral blood mon ...
Pages: 664-670
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INVESTIGATIVE REPORT
Dermoscopy of Naevus-associated Melanomas
Danielle Shitara, Mauricio Nascimento, Priscila Ishioka , Cristina Carrera, Llúcia Alós, Josep Malvehy, Susana Puig
In order to determine dermoscopic parameters, a case-control test set of naevus-associated melanomas vs de novo melanomas paired by Breslow thickness and histopathological subtype was analysed by 2 blinded experienced dermoscopists, according to presence of naevus, pattern analysis and ABCD dermoscopy score. The ability to identify naevus-associated melanomas by pattern analysis was low for both b ...
Pages: 671-675
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Low-dose Anti-thymocyte Globulin Inhibits Human B-cell Differentiation into Antibody-Secreting Cells
Pascal Klaus, Guido Heine, Claudia Rasche, Margitta Worm
Anti-thymocyte globulin (ATG) is used in the treatment of acute organ rejection. We studied in vitro the effect of low-dose ATG on B-cell activation and differentiation to antibody-secreting cells, as this may have an effect on B cell-driven autoimmune diseases, such as pemphigus vulgaris. Immunoglobulin production was analysed in the supernatants of peripheral blood mononuclear cells (PBMC) and C ...
Pages: 676-680
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INVESTIGATIVE REPORT
Viewing Exemplars of Melanomas and Benign Mimics of Melanoma Modestly Improves Diagnostic Skills in Comparison with the ABCD Method and Other Image-based Methods for Lay Identification of Melanoma
Ella Cornell, Karen Robertson, Robert D. McIntosh, Jonathan L. Rees
Using an experimental task in which lay persons were asked to distinguish between 30 images of melanomas and common mimics of melanoma, we compared various training strategies including the ABC(D) method, use of images of both melanomas and mimics of melanoma, and alternative methods of choosing training image exemplars. Based on a sample size of 976 persons, and an online experimental task, we sh ...
Pages: 681-685
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CLINICAL REPORT
Malignant Melanoma Arising in Patients with a Large Congenital Melanocytic Naevus: Retrospective Study of 10 Cases with Cytogenetic Analysis
Caroline Lacoste, Marie-Françoise Avril, Annonciade Frassati-Biaggi, Nicolas Dupin, Bertrand Chrétien-Marquet, Emmanuel Mahé, Christine Bodemer, Béatrice Vergier, Arnaud de la Fouchardière, Sylvie Fraitag
Large congenital melanocytic naevi (LCMN) represent the main risk factor for development of melanoma in childhood. This retrospective study of 10 cases of melanoma in patients with LCMN used fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) (6 cases) to elucidate the clinical, histological, and cytogenetic characteristics of this rare disorder. Six melanomas wer ...
Pages: 686-690
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CLINICAL REPORT
Psychological Stress and Immunological Modulations in Early-stage Melanoma Patients
Erika Richtig, Eva Maria Trapp, Alexander Avian, Hans Peter Brezinsek, Michael Trapp, Josef Wilhelm Egger, Hans Peter Kapfhammer, Peter Michael Rohrer, Andrea Berghold, Clara Curiel-Lewandrowski, Ulrike Demel
Mental stress may have a negative impact on the immune state of cancer patients, in whom immunologic surveillance is essential for survival. This study investigated the immunological response of 19 patients with early-stage melanoma and a matched control group undergoing the Determination Stress Test before surgery. Cytokine and chemokine levels and lymphocyte subpopulations were measured at basel ...
Pages: 691-695
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CLINICAL REPORT
Maternal and Perinatal Factors of Importance for Occurrence and Severity of Infantile Haemangioma
Eun Jee Kim, Hyun Sun Park , Hyun-Sun Yoon, Soyun Cho
To determine which patient and maternal factors are associated with the occurrence and the severity of infantile haemangioma (IH), a single-centre retrospective observational study was conducted with 96 haemangioma patients and 143 age-matched control babies, born in the same hospital between March 2012 and March 2013. The IH patients were selected according to diagnosis from dermatologists, eithe ...
Pages: 696-699
Abstract  HTML  PDF
CLINICAL REPORT
Atopic Dermatitis Burden Scale for Adults: Development and Validation of a New Assessment Tool
Alain Taïeb, Franck Boralevi, Julien Seneschal, Stephanie Merhand, Victor Georgescu, Charles Taieb, Khaled Ezzedine
Atopic dermatitis (AD) occurs in approximately 2–3% of adults. The aim of this study was to develop and validate the self-administered Atopic Dermatitis Burden Scale for Adults (ABS-A). Patients were enrolled consecutively from those attending the Station Thermale Avène for a diagnosis of AD. ABS-A was developed using standard methodology, and consisted of 3 phases: exploratory, development, an ...
Pages: 700-705
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CLINICAL REPORT
Burden of Illness in Hereditary Angioedema: A Conceptual Model
Anette Bygum, Emel Aygören-Pürsün, Kathleen Beusterien, Emily Hautamaki, Zlatko Sisic, Suzanne Wait, Henrik B. Boysen, Teresa Caballero
The objective of the Hereditary Angioedema Burden of Illness Study in Europe was to assess the real-world experience of hereditary angioedema (HAE) from the patient perspective. Based on open-ended qualitative interviews with 30 patients from Spain, Germany and Denmark, 5 key themes emerged characterizing the impact of HAE on health-related quality of life (HRQoL): (i) unnecessary treatments and p ...
Pages: 706-710
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CLINICAL REPORT
Risk Factor Analysis for the Immunogenicity of Adalimumab Associated with Decreased Clinical Response in Chinese Patients with Psoriasis
Hsien-Yi Chiu, Ting-Shun Wang, Chih-Chieh Chan, Sung-Jan Lin, Tsen-Fang Tsai
Although anti-drug antibodies against biologics have been associated with decreased clinical efficacy, the immunogenicity of biologics seems to vary between drugs, diseases and ethnicities. This study aims to investigate the predictors for the formation of anti-adalimumab antibodies (AAA) and the clinical consequences of AAA formation. In 53 Chinese psoriatic patients treated with adalimumab, AAA ...
Pages: 711-716
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CLINICAL REPORT
Swedish Experiences From Patch Testing Methylisothiazolinone Separately
Malin Engfeldt, Johanna Bråred-Christensson, Marléne Isaksson, Mihály Matura, Kristina Ryberg, Berndt Stenberg, Cecilia Svedman, Magnus Bruze
The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a well-known sensitiser and present in the Swedish baseline series since the 1980s. The proportions of MCI/MI are 3:1. MI alone has been used as a preservative since less than 10 years. This study was conducted on behalf of the Swedish Contact Dermatitis Research Group to evaluate inclusion of MI in the Swedish baseline ...
Pages: 717-719
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CLINICAL REPORT
Ichthyosis Linearis Circumflexa as the Only Clinical Manifestation of Netherton Syndrome
Liliana Guerra, Paola Fortugno, Cristina Pedicelli, Cinzia Mazzanti, Vittoria Proto, Giovanna Zambruno, Daniele Castiglia
Ichthyosis linearis circumflexa (ILC) presents as serpiginous and migratory erythematous patches with double-edged scales. ILC is rarely an isolated skin manifestation, but most commonly a part of Netherton syndrome (NS). NS is caused by SPINK5 mutations, which lead to absent or sometimes reduced expression of the serine protease inhibitor LEKTI. NS is characterised by congenital ichthyosiform ery ...
Pages: 720-724
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CLINICAL REPORT
A Repeat Validated Population Questionnaire of a Defined Swedish Population Verifies Reduction in Leg Ulcer Prevalence Over Time
Alexandra Forssgren, Olle Nelzén
This study was performed to measure if the introduced interventions in leg ulcer care in a selected Swedish county yield a detectable reduction in leg ulcer prevalence in the population. A validated postal questionnaire sent to 10,000 (9,868) randomly selected 30–89 year olds in the Skaraborg county (255,042 inhabitants). All positive responders were telephone interviewed and verified ulcer pati ...
Pages: 725-729
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SHORT COMMUNICATION
Five-day Azithromycin Treatment Regimen for Mycoplasma genitalium Infection Also Effectively Eradicates Chlamydia trachomatis
Magnus Unemo, Kim M.A. Endre, Harald Moi
Abstract is missing (Short communication)
Pages: 730-732
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SHORT COMMUNICATION
Spontaneous Regression of Untreatable Mycoplasma genitalium Urethritis
Harald Moi, Aase Haugstvedt, Jørgen Skov Jensen
Abstract is missing (Short communication)
Pages: 732-733
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SHORT COMMUNICATION
Mass Spectrometry of Flame Figures
Jasper Wouters, Etienne Waelkens, Sandy Vandoninck, Siegfried Segaert, Joost J. van den Oord
Abstract is missing (Short communication)
Pages: 734-735
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SHORT COMMUNICATION
Chitinase-3-like Protein 1 (YKL-40): Novel Biomarker of Hidradenitis Suppurativa Disease Activity?
Łukasz Matusiak, Joanna Salomon, Danuta Nowicka-Suszko, Andrzej Bieniek, Jacek C. Szepietowski
Abstract is missing (Short communication)
Pages: 736-737
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SHORT COMMUNICATION
Ultrastructural Investigations in an Autosomal Recessively Inherited Case of Dyschromatosis Universalis Hereditaria
Aayush Gupta, Yugal Sharma, Kedar Nath Dash, Sampurna Verma, Vivek T. Natarajan, Archana Singh
Abstract is missing (Short communication)
Pages: 738-740
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SHORT COMMUNICATION
Transdermal Methyl Alcohol Intoxication: A Case Report
Burcu Hizarci, Cem Erdoğan, Pelin Karaaslan, Aytekin Unlukaplan, Huseyin Oz
Abstract is missing (Short communication)
Pages: 740-741
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SHORT COMMUNICATION
Tick Attachment Cement with a Feeding Cavity in the Deep Dermis of the Penis
Kazunori Okahashi, Naoki Oiso, Yasuhiro Yano, Akira Kawada
Abstract is missing (Short communication)
Pages: 741-742
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SHORT COMMUNICATION
Acquired Idiopathic Generalized Anhidrosis: An Immunohistopathological Investigation of Peri-glands Infiltrated with Immunoreactive Cells
Eimei Iwama, Taku Fujimura, Kayo Tanita, Masaya Ishibashi, Akiko Watabe, Setsuya Aiba
Abstract is missing (Short communication)
Pages: 743-744
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SHORT COMMUNICATION
Detection of Human Papillomavirus Type 67 in Subungual Bowen’s Disease Presenting as Longitudinal Melanonychia
Akira Shimizu, Masahito Yasuda, Keiko Hoshijima, Madoka Kato, Ayumi Takahashi, Atsushi Tamura, Osamu Ishikawa
Abstract is missing (Short communication)
Pages: 745-746
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SHORT COMMUNICATION
ABCA12-deficient Congenital Ichthyosiform Erythroderma in a Boy with an Intellectual Developmental Delay
Yukako Inoue, Masaaki Yamamoto, Yoshiko Sakaguchi, Orie Jitsukawa, Katsunori Hayano, Masayuki Yamane, Michiko Sakamoto, Kiyofumi Yamanishi
Abstract is missing (Short communication)
Pages: 747-749
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SHORT COMMUNICATION
Screening for Neuropathic Pain, Anxiety and Other Associated Chronic Pain Conditions in Vulvodynia: A Pilot Study
Anne-Clémence Tersiguel, Céline Bodéré, Martine Schollhammer, Edith Postec, Pierre Tandéo, Bertrand Quinio, Emilie Brenaut, Laurent Misery
Abstract is missing (Short communication)
Pages: 749-751
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SHORT COMMUNICATION
Skin Abnormalities in CHILD Syndrome Successfully Treated with Pathogenesis-based Therapy
Alexandra Golabek Christiansen, Uffe Koppelhus, Mette Sommerlund
Abstract is missing (Short Communication)
Pages: 752-753
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SHORT COMMUNICATION
A Case of Felty’s Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma
En Shu, Hiroyuki Kanoh, Yusuke Kito, Mariko Seishima
Abstract is missing (Short communication)
Pages: 754-755
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SHORT COMMUNICATION
Annular Elastolytic Giant Cell Granuloma Successfully Treated with Minocycline Hydrochloride
Ai Nanbu, Kazumitsu Sugiura, Michihiro Kono, Yoshinao Muro, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 756-757
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SHORT COMMUNICATION
Cutaneous Rosai-Dorfman Disease Located on the Breast: Rapid Effectiveness of Methotrexate After Failure of Topical Corticosteroids, Acitretin and Thalidomide
Marion Nadal, Thibault Kervarrec, Marie-Christine Machet, Tony Petrella, Laurent Machet
Abstract is missing (Short communication)
Pages: 758-759
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SHORT COMMUNICATION
Bilateral Sporotrichoid Cutaneous Infection by Mycobacterium haemophilum in a Chinese Patient with Systemic Lupus Erythematosus
Wei Gao, Hao Chen, Hongsheng Wang, Haiqing Jiang, Weijun Liu, Danfeng Hao, Meiyu Tang
Abstract is missing (Short commmunication)
Pages: 760-761
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QUIZ
Linear Skin-coloured Papules on Scrotum: A Quiz
Joonsoo Park, Inyong Kim, Hyo Chan Jang, In Soo Chae, Kyungduck Park, Youngil Kim, Hyun Chung
Abstract is missing (Quiz)
Pages: 763-766
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QUIZ
Yellow Changes of the Skin: A Quiz
Roberto Verdolini, Evdokia Arkoumani, Darshna Pandya, Sanjay Parmar, Davide Altamura
Abstract is missing (Quiz)
Pages: 763-766
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QUIZ
Pruritic Papules Following Lumbar Corset Use: A Quiz
Toshinari Miyauchi, Yasuyuki Fujita, Shota Takashima, Yusuke Morita, Shotaro Suzuki, Osamu Mizuno, Nao Saito, Toshifumi Nomura, Hiroshi Shimizu
Abstract is missing (Quiz)
Pages: 763-766
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ERRATUM
ERRATUM
Anne B. Simonsen, Mette Sommerlund, Mette Deleuran, Charlotte G. Mortz and Jeanne D. Johansen
Abstract is missing (Erratum)
Pages: 766-767
Abstract  PDF