Content

Content - Volume 96, Issue 1

Editor's choice in this issue

REVIEW
The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma
Catherine A. Harwood, Charlotte M. Proby, Gareth J. Inman, Irene M. Leigh
Targeted therapies for melanoma and basal cell carcinoma have evolved from deciphering the molecular mechanisms involved in their tumorigenesis. Mutations in BRAF have led to clinical use of BRAF-inhibitors in advanced melanoma, and mutations in Hedgehog signaling to smoothened inhibitors in basal cell carcinoma. The development of tumor resistance to these treatments is leading to many new drug d ...
Pages: 3-16
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CLINICAL REPORT
Targeting IgE in Severe Atopic Dermatitis with a Combination of Immunoadsorption and Omalizumab
Alexander Zink, Anna Gensbaur, Michael Zirbs, Florian Seifert, Isabel Leon Suarez, Vagkan Mourantchanian, Stephan Weidinger, Martin Mempel, Johannes Ring, Markus Ollert
Patients with atopic dermatitis (AD) tend to have greatly elevated levels of serum immunoglobulin E (IgE). However, the role of IgE in the pathogenesis of AD is debated. This investigator-initiated open-label pilot study evaluates an anti-IgE-treatment approach by combining extracorporeal immunoadsorption and anti-IgE antibody omalizumab in 10 patients with severe, therapy-refractory AD. IgE level ...
Pages: 72-76
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SHORT COMMUNICATION
Cushing’s Syndrome in a 6-month-old Boy: A Rare Side-effect due to Inadequate use of Topical Corticosteroids
Sara Ciccone, Romana Marini, Carla Bizzarri, Maya El Hachem, Marco Cappa
Abstract is missing (Short communication)
Pages: 138-139
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All articles

REVIEW
The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma
Catherine A. Harwood, Charlotte M. Proby, Gareth J. Inman, Irene M. Leigh
Targeted therapies for melanoma and basal cell carcinoma have evolved from deciphering the molecular mechanisms involved in their tumorigenesis. Mutations in BRAF have led to clinical use of BRAF-inhibitors in advanced melanoma, and mutations in Hedgehog signaling to smoothened inhibitors in basal cell carcinoma. The development of tumor resistance to these treatments is leading to many new drug d ...
Pages: 3-16
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SPECIAL REPORT
New Topical Treatment Options for Actinic Keratosis: A Systematic Review
Eggert Stockfleth, Gillian C. Sibbring, Ivette Alarcon
This systematic review compared the relative efficacy of 5-fluorouracil 0.5% in salicylic acid 10% (5-FU/SA), ingenol mebutate (IMB) and imiquimod 2.5%/3.75% (IMI) for actinic keratosis on the face, forehead or scalp. Only 11 publications, relating to 7 randomised controlled trials, met inclusion criteria and it was only possible to compare the effect of all 3 treatments on complete clinical clear ...
Pages: 17-22
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CLINICAL REPORT
Methotrexate Dosing Regimen for Plaque-type Psoriasis: A Systematic Review of the Use of Test-dose, Start-dose, Dosing Scheme, Dose Adjustments, Maximum Dose and Folic Acid Supplementation
Stef P. Menting, Paul M. Dekker, Jacqueline Limpens, Lotty Hooft, Phyllis I. Spuls
There is a range of methotrexate dosing regimens for psoriasis. This review summarizes the evidence for test-dose, start-dose, dosing scheme, dose adjustments, maximum dose and use of folic acid. A literature search for randomized controlled trials and guidelines was performed. Twenty-three randomized controlled trials (29 treatment groups) and 10 guidelines were included. Two treatment groups use ...
Pages: 23-28
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INVESTIGATIVE REPORT
Identification of a Circulating MicroRNA Profile as a Biomarker of Metastatic Cutaneous Melanoma
Virginie Armand-Labit, Nicolas Meyer, Anne Casanova, Henri Bonnabau, Valérie Platzer, Emilie Tournier, Benoît Sansas, Stéphane Verdun, Benoit Thouvenot, Benoit Hilselberger, Andrei Doncescu, Laurence Lamant, Magali Lacroix-Triki, Gilles Favre, Anne Pradines
No specific biomarkers for prognostication or evaluation of tumour load in melanoma have been reported to our knowledge. MicroRNAs (miRNAs) are strongly implicated in oncogenesis and tumour progression, and their circulating forms have been studied as potential biomarkers in oncology. The aim of this prospective study was to identify a melanoma-specific profile of plasma miRNAs. A screening phase, ...
Pages: 29-34
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INVESTIGATIVE REPORT
Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study
Ann Sophie Lønnberg , Lone Skov, David Lorenzo Duffy, Axel Skytthe, Kirsten Ohm Kyvik, Ole Birger Pedersen, Simon Francis Thomsen
The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20–71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard e ...
Pages: 35-38
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INVESTIGATIVE REPORT
Psoriasis and New-onset Depression: A Danish Nationwide Cohort Study
Peter Jensen, Ole Ahlehoff, Alexander Egeberg, Gunnar Gislason, Peter R. Hansen, Lone Skov
Psoriasis is associated with an increased risk of depression, but results are inconsistent. This study examined the risk of new-onset depression in patients with psoriasis in a nationwide Danish cohort including some 5 million people in the period 2001–2011. A total of 35,001 patients with mild psoriasis and 7,510 with severe psoriasis were identified. Incidence rates per 1,000 person-years and ...
Pages: 39-42
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INVESTIGATIVE REPORT
Propionic Acid Produced by Propionibacterium acnes Strains Contri­butes to Their Pathogenicity
Gábor Tax, Edit Urbán, Zsuzsanna Palotás, Róbert Puskás, Zoltán Kónya, Tamás Bíró, Lajos Kemény, Kornélia Szabó
Propionibacterium acnes is an important member of the skin microbiome. The bacterium can initiate signalling events and changes in cellular properties in keratinocytes. The aim of this study was to analyse the effect of the bacterium on an immortalized human keratinocyte cell line. The results show that various P. acnes strains affect the cell-growth properties of these cells differentially, induc ...
Pages: 43-49
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INVESTIGATIVE REPORT
Prevalence and Characteristics of Pruritus: A One-Week Cross-sectional Study in a German Dermatology Practice
Michaela E.R. Kopyciok, Hartmut F. Ständer, Nani Osada, Sabine Steinke, Sonja Ständer
Pruritus is a frequent sensation in dermatoses, but its prevalence in patients in dermatological practices has not been fully studied. The aim of this cross-sectional study is to investigate its prevalence and characteristics in all patients attending a dermatology practice in Germany over a period of one week (n = 334; 52.7% female; median age 45.0 years). The point prevalence of pruritus in ...
Pages: 50-55
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INVESTIGATIVE REPORT
Rupatadine 20 mg and 40 mg are Effective in Reducing the Symptoms of Chronic Cold Urticaria
Marina Abajian, Laia Curto-Barredo, Karoline Krause, Eva Santamaria, Iñaki Izquierdo, Martin K. Church, Marcus Maurer, Ana Giménez-Arnau
Chronic cold urticaria (ColdU) is a rare disease characterized by mast cell-mediated wheals and angioedema following cold exposure. Second-generation H1-antihistamines, such as rupatadine, are the recommended first-line therapy. As of yet, the effects of rupatadine up-dosing on development of ColdU symptom have only been partially characterized. Two-centre, randomized, double-blind, 3-way crossove ...
Pages: 56-59
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INVESTIGATIVE REPORT
Relationship Between Psychosocial Burden of Skin Conditions and Symptoms: Measuring the Attributable Fraction
Francesca Sampogna, Stefano Tabolli, Patrizia Giannantoni, Andrea Paradisi, Damiano Abeni
Skin conditions often have a severe impact on the physical and psychosocial domains of patients’ quality of life, but the relationship between these domains has been studied little. This study estimated the fraction of psychosocial burden that may be attributable to symptoms, using the Skindex-17 quality of life questionnaire (symptoms and psychosocial scales) in 2,487 outpatients. The excess pr ...
Pages: 60-63
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CLINICAL REPORT
A Retrospective Study of Treatment of Squamous Cell Carcinoma In situ
Meri Övermark, Sari Koskenmies, Sari Pitkänen
Squamous cell carcinoma in situ is an intra-epidermal malignancy of the skin with potential to progress to invasive carcinoma. Commonly used treatments are surgical excision, cryotherapy, photodynamic therapy, laser ablation, curettage with cautery, radiotherapy, topical 5-fluorouracil, and topical imiquimod. The efficacies of these different treatment modalities are compared in this retrospective ...
Pages: 64-67
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CLINICAL REPORT
A Population- and Hospital-based Cross-sectional Study of Renal Function in Hidradenitis Suppurativa
Iben M. Miller, Nicholas Carlson, Ulla B. Mogensen, Christina Ellervik, Gregor B.E. Jemec
The chronic inflammatory skin diseases hidradenitis suppurativa (HS) and psoriasis have been linked to cardiovascular risk factors and the latter has also been linked to possible renal dysfunction. Since basement membrane thinning in the skin of HS patients has been described, we speculated whether similar basement membrane defects might occur in renal tissue. Our objective was to investigate a po ...
Pages: 68-71
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CLINICAL REPORT
Targeting IgE in Severe Atopic Dermatitis with a Combination of Immunoadsorption and Omalizumab
Alexander Zink, Anna Gensbaur, Michael Zirbs, Florian Seifert, Isabel Leon Suarez, Vagkan Mourantchanian, Stephan Weidinger, Martin Mempel, Johannes Ring, Markus Ollert
Patients with atopic dermatitis (AD) tend to have greatly elevated levels of serum immunoglobulin E (IgE). However, the role of IgE in the pathogenesis of AD is debated. This investigator-initiated open-label pilot study evaluates an anti-IgE-treatment approach by combining extracorporeal immunoadsorption and anti-IgE antibody omalizumab in 10 patients with severe, therapy-refractory AD. IgE level ...
Pages: 72-76
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CLINICAL REPORT
Kaposiform Haemangioendothelioma-spectrum Lesions with Kasabach-Merritt Phenomenon: Retrospective Analysis and Long-term Outcome
Olivia Boccara, Sylvie Fraitag, Dominique Lasne, Juliette Fontaine, Valérie Bughin, Dominique Hamel-Teillac, Daniel Orbach, Francis Brunelle, Yves de Prost, Smail Hadj-Rabia, Christine Bodemer
Kasabach-Merritt phenomenon (KMP) is a rare life-threatening vascular condition of infancy. Prognosis factors and long-term follow-up data are lacking. We retrospectively analysed the records of 24 infants (10 females, 14 males) treated for KMP in the Department of Dermatology of Necker-Enfants Malades Hospital, Paris, France, from 1984 to 2012. Mean duration of thrombocytopaenia (2,000−38,0 ...
Pages: 77-81
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CLINICAL REPORT
Dermatitis Herpetiformis Refractory to Gluten-free Dietary Treatment
Kaisa Hervonen, Teea T. Salmi, Tuire Ilus, Kaija Paasikivi, Martine Vornanen, Kaija Laurila, Katri Lindfors, Keijo Viiri, Päivi Saavalainen, Pekka Collin, Katri Kaukinen, Timo Reunala
Dermatitis herpetiformis (DH) is a blistering skin disease, which is regarded as an extra-intestinal manifestation of coeliac disease. Refractory cases of coeliac disease, that do not respond to a gluten-free diet and which carry an increased risk of lymphoma, are well-known in coeliac disease. To determine whether refractory cases of DH with active rash and persistent small bowel atrophy occur w ...
Pages: 82-86
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CLINICAL REPORT
Fractional Microneedling Radiofrequency Treatment for Acne-related Post-inflammatory Erythema
Seonguk Min, Seon Yong Park, Ji Young Yoon, Hyuck Hoon Kwon, Dae Hun Suh
Post-inflammatory erythema is a common result of acne inflammation and is cosmetically unacceptable without effective treatment. Fractional microneedling radiofrequency (FMR) has potential for treatment of post-inflammatory erythema. The aim of this study was to evaluate the efficacy and safety of this treatment. A retrospective chart review was undertaken of 25 patients treated with 2 sessions of ...
Pages: 87-91
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CLINICAL REPORT
Vulvovaginal-gingival Lichen Planus: Association with Lichen Planopilaris and Stratified Epithelium-specific Antinuclear Antibodies
Malgorzata Olszewska, Agnieszka Banka-Wrona, Anna Skrok, Adriana Rakowska, Renata Górska, Lynn W. Solomon, Lidia Rudnicka
Vulvovaginal-gingival lichen planus (VVG-LP) consists of a triad of symptoms: vulval, vaginal and gingival lichen planus lesions. The aim of this study was to analyse the prevalence of lesions in various anatomical locations in patients with VVG-LP. The study included 126 consecutive patients with lichen planus. Sixteen (12.7%) patients fulfilled the criteria of VVG-LP. In 12/16 (75%) patients wit ...
Pages: 92-96
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CLINICAL REPORT
High Frequency of Severe Telaprevir-associated Skin Eruptions in Clinical Practice
Raquel Carrascosa, Tania-Marusia Capusan, Mar Llamas-Velasco, Luisa García-Buey, Carlos Gordillo, Javier Sánchez-Pérez
Since the introduction of telaprevir, administered in combination with pegylated interferon and ribavirin for the treatment of patients with chronic hepatitis C, the incidence and severity of skin eruptions have increased significantly. The aim of this prospective study is to assess the frequency of drug-induced skin eruptions and their clinical and histological characteristics in patients who rec ...
Pages: 97-99
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SHORT COMMUNICATION
Clinicopathological Manifestations of Ichthyosiform Mycosis Fungoides
Min Soo Jang, Dong Young Kang, Jong Bin Park, Sang Hwa Han, Kang Hoon Lee, Joon Hee Kim, Jae Won Ko, Kee Suck Suh
Abstract is missing (Short communication)
Pages: 100-101
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SHORT COMMUNICATION
Methotrexate in Severe Childhood Alopecia Areata: Long-term Follow-up
Philippine Lucas, Christine Bodemer, Sébastien Barbarot, Pierre Vabres, Marie Royer, Juliette Mazereeuw-Hautier
Abstract is missing (Short communication)
Pages: 102-103
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SHORT COMMUNICATION
Chromium Dermatitis in a Metal Worker Due to Leather Gloves and Alkaline Coolant
Yolanda S. Hedberg, Carola Lidén, Magnus Lindberg
Abstract is missing (Short communication)
Pages: 104-105
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SHORT COMMUNICATION
Prediction of the Occurrence of Melanoma and Non-melanoma Skin Cancer in Patients with Vitiligo
Shedia M. Hammoud, Rosalie W.J. Kruis, Vigfús Sigurdsson
Abstract is missing (Short communication)
Pages: 106-107
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SHORT COMMUNICATION
Safety of Novel Amino-5-laevulinate Photosensitizer Precursors in Photodynamic Therapy for Healthy Human Skin
Noora Neittaanmäki-Perttu, Eerika Neittaanmäki, Ilkka Pölönen, Erna Snellman, Mari Grönroos
Abstract is missing (Short communication)
Pages: 108-110
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SHORT COMMUNICATION
Tetrazepam Allergy: A Case Series of Cutaneous Adverse Events
Inga Huseynov, Mirja Wirtz, Nicolas Hunzelmann
Abstract is missing (Short communication)
Pages: 110-111
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SHORT COMMUNICATION
Synergistic Effects of Mycoplasma pneumoniae Infection and Drug Reaction on the Development of Atypical Stevens-Johnson Syndrome in Adults
Maiko Kurata, Yoko Kano, Yohei Sato, Kazuhisa Hirahara, Tetsuo Shiohara
Abstract is missing (Short communication)
Pages: 111-113
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SHORT COMMUNICATION
Involvement of Human Herpesvirus 6 Infection in Renal Dysfunction Associated with DIHS/DRESS
Kazuya Miyashita, Chinatsu Shobatake, Fumi Miyagawa, Nobuhiko Kobayashi, Rie Onmori, Shinsuke Yonekawa, Kaori Tanabe, Kenji Kawate, Kohei Morita, Hideo Asada
Abstract is missing (Short communication)
Pages: 114-115
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SHORT COMMUNICATION
Cutaneous Cryptococcosis Mimicking Pyoderma Gangrenosum: A Report of Four Cases
Nobuyuki Kikuchi, Tomoko Hiraiwa, Masato Ishikawa, Tatsuhiko Mori, Shohei Igari, Yuka Hanami, Takako Miura, Mikio Ohtsuka, Toshiyuki Yamamoto
Abstract is missing (Short communication)
Pages: 116-117
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SHORT COMMUNICATION
Mycetoma Caused by Aspergillus nidulans
Stefano Veraldi, Anna Grancini, Luigia Venegoni, Valentina Merlo, Elena Guanziroli, Claudia Menicanit, Gianluca Nazzaro, Annamaria Tortorano
Abstract is missing (Short communication)
Pages: 118-119
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SHORT COMMUNICATION
Anti-laminin-gamma 1 Pemphigoid with Generalized Pustular Psoriasis and Psoriasis Vulgaris
Yu Fujimura, Ken Natsuga, Yohei Hamade, Yukiko Nomura, Yo Kaku, Ryuichi Muramatsu, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 120-121
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SHORT COMMUNICATION
Botulinum Toxin A: An Effective Treatment for Linear Immunoglobulin A Bullous Dermatosis Located in the Axillae
Laureline Legendre, Aude Maza, Aïcha Almalki, Cristina Bulai-Livideanu, Carle Paul, Juliette Mazereeuw-Hautier
Abstract is missing (Short communication)
Pages: 122-123
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SHORT COMMUNICATION
Successful Treatment of Multicentric Reticulohistiocytosis with Adalimumab, Prednisolone and Methotrexate
Sei-ichiro Motegi, Yukio Yonemoto, Shinya Yanagisawa, Sayaka Toki, Akihiko Uchiyama, Kazuya Yamada, Osamu Ishikawa
Abstract is missing (Short communication)
Pages: 124-125
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SHORT COMMUNICATION
Interferon-γ Release Assay and Reverse Blot Hybridization Assay: Diagnostic Role in Cutaneous Tuberculosis
Hee-Chul Chung, Bo-Kyung Kim, Hannah Hong, Hye-Young Wang, Yeun Kim, Hyeyoung Lee, Minseob Eom, Eung Ho Choi
Abstract is missing (Short communication)
Pages: 126-127
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SHORT COMMUNICATION
Melanoma with BRAF Mutation in Circulating Cell-free DNA despite no Mutation in the Primary Lesion: A Case Report
Atsuko Ashida, Hisashi Uhara, Asuka Mikoshiba, Kaori Sakaizawa, Naomi Kumagai, Hiroshi Koga, Ryuhei Okuyama
Abstract is missing (Short communication)
Pages: 128-129
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SHORT COMMUNICATION
A Case of Noonan Syndrome with Multiple Subcutaneous Tumours with MAPK-ERK/p38 Activation
Tetsuya Honda, Tatsuki R. Kataoka, Chiyuki Ueshima, Yoshiki Miyachi, Kenji Kabashima
Abstract is missing (Short communication)
Pages: 130-131
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SHORT COMMUNICATION
Disseminated Mycobacterium chelonae Infection Identified by Repeated Skin Sampling and Molecular Methods in a Patient with Rheumatoid Arthritis
Reiko Tsutsumi, Nanako Yamada, Yuichi Yoshida, Kazue Nakanaga, Norihisa Ishii, Osamu Yamamoto
Abstract is missing (Short communication)
Pages: 132-133
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SHORT COMMUNICATION
Number, Distribution and Dermoscopic Pattern of Melanocytic Naevi in a Chinese Population
Wei Zhang, Bin Lu, Rotao Cui, Hongguang Lu
Abstract is missing (Short communication)
Pages: 134-135
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SHORT COMMUNICATION
A Case of Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma Misdiagnosed as Febrile Ulceronecrotic Mucha-Habermann Disease
Nan Sheng, Zhiliang Li, Wei Su, Weijun Liu, Wenkai Zong, Baoxi Wang, Suying Feng
Abstract is missing (Short communication)
Pages: 136-137
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SHORT COMMUNICATION
Cushing’s Syndrome in a 6-month-old Boy: A Rare Side-effect due to Inadequate use of Topical Corticosteroids
Sara Ciccone, Romana Marini, Carla Bizzarri, Maya El Hachem, Marco Cappa
Abstract is missing (Short communication)
Pages: 138-139
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SHORT COMMUNICATION
Epidermolysis Bullosa Pruriginosa Excoriée: A Deceptive Pruritic Variant in Two Female Patients
Katarzyna B. Gostyńska, Marcel F. Jonkman
Abstract is missing (Short communication)
Pages: 140-141
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SHORT COMMUNICATION
Ectopic Adipose Tissue with Vasculitis in the Calf Muscle Explaining Systemic Symptoms in Leg-limited Cutaneous Polyarteritis Nodosa
Masahiro Aoshima, Kensuke Fukuchi, Kazuki Tatsuno, Taisuke Ito, Yoshiki Tokura
Abstract is missing (Short communication)
Pages: 142-143
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BOOK REVIEW
Surgery of the Skin. Third Edition
Lisa Naysmith
Abstract is missing (Book review)
Page: 144
Abstract  PDF