Content

Content - Volume 96, Issue 7

Editor's choice in this issue

INVESTIGATIVE REPORT
Thromboxane A2 is Involved in Itch-associated Responses in Mice with Atopic Dermatitis-like Skin Lesions
Tsugunobu Andoh, Ai Yamamoto , Satomi Haza, Koh-ichi Yuhki, Fumitaka Ushikubi, Shu Narumiya, Yasushi Kuraishi
To investigate the mechanisms underlying itching in atopic dermatitis, we examined whether thromboxane (TX) A2, an arachidonic acid metabolite, is involved in spontaneous scratching, an itch-related response, in NC mice with atopic dermatitis-like skin lesions. The TXA2 receptor (TP) antagonist ONO-3708 inhibited the spontaneous scratching. The mRNA expression of TX synthase (TXSyn) distributed ma ...
Pages: 899-904
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INVESTIGATIVE REPORT
Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin
Leigh A. Nattkemper, Maria-Estela Martinez-Escala, Ari B. Gelman, Elisha M. Singer, Alain H. Rook, Joan Guitart, Gil Yosipovitch
Approximately 88% of cutaneous T-cell lymphoma (CTCL) patients are affected by pruritus that responds poorly to current antipruritic therapies. Interleukin (IL)-31, a Th2 cytokine, has been found to be increased in the serum of CTCL patients and to correlate with itch severity. This study investigated the role of IL-31 and its receptors (IL-31 receptor-alpha [IL-31RA] and OSMRβ) in the skin o ...
Pages: 894-898
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INVESTIGATIVE REPORT
Immunosuppressive Environment in Basal Cell Carcinoma: The Role of Regulatory T Cells
Silje H. Omland, Patricia S. Nielsen, Lise M.R. Gjerdrum, Robert Gniadecki
Interaction between tumour survival tactics and anti-tumour immune response is a major determinant for cancer growth. Regulatory T cells (T-regs) contribute to tumour immune escape, but their role in basal cell carcinoma (BCC) is not understood. The fraction of T-regs among T cells was analysed by immunohistochemistry followed by automated image analysis in facial BCC, peritumoural skin and normal ...
Pages: 917-921
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All articles

EDITORIAL
News About the Section Editor Board and a Farewell to the Printed Journal
Anders Vahlquist, Artur Schmidtchen
Abstract is missing (Editorial)
Page: 867
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REVIEW
Cutaneous Porphyrias: Causes, Symptoms, Treatments and the Danish Incidence 1989–2013
Anne L. Christiansen, Lise Aagaard, Aleksander Krag, Lars M. Rasmussen, Anette Bygum
Porphyrias are rare diseases caused by altered haem synthesis leading to the accumulation of different haem intermediates. Neurovisceral attacks may occur in acute porphyrias, while photosensitivity is the presenting symptom in cutaneous porphyrias. We present here an overview of symptoms and a flowchart for the diagnosis of cutaneous porphyrias, with recommendations for monitoring and an update o ...
Pages: 868-872
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INVESTIGATIVE REPORT
An In vitro Model for Bacterial Growth on Human Stratum Corneum
Danique A. van der Krieken, Thomas H.A. Ederveen, Sacha A.F.T. van Hijum, Patrick A.M. Jansen, Willem J.G. Melchers, Paul T.J Scheepers, Joost Schalkwijk, Patrick L.J.M. Zeeuwen
The diversity and dynamics of the skin microbiome in health and disease have been studied recently, but adequate model systems to study skin microbiotas in vitro are largely lacking. We developed an in vitro system that mimics human stratum corneum, using human callus as substrate and nutrient source for bacterial growth. The growth of several commensal and pathogenic bacterial strains was measure ...
Pages: 873-879
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INVESTIGATIVE REPORT
Barrier Function and Natural Moisturizing Factor Levels After Cumula­tive Exposure to Short-chain Aliphatic Alcohols and Detergents: Results of Occlusion-modified Tandem Repeated Irritation Test
Irena Angelova-Fischer, Tasja Stilla, Sanja Kezic, Tobias W. Fischer, Detlef Zillikens
Alcohol-based disinfectants and detergents are common workplace factors for irritant contact dermatitis (ICD). Though occlusion and water are relevant co-exposures, the tandem effects of occlusion and sequential exposure to alcohols and detergents have not been studied. We therefore investigated the combined effects of occlusion with water and repeated exposure to n-propanol and/or sodium lauryl s ...
Pages: 880-884
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INVESTIGATIVE REPORT
Intra-familial Variation in Clinical Phenotype of CARD14-related Psoriasis
Marina Eskin-Schwartz, Lina Basel-Vanagaite, Michael David, Irina Lagovsky, Dan Ben-Amitai, Pola Smirin-Yosef, Lihi Atzmony, Emmilia Hodak
Psoriasis is a multifactorial chronic inflammatory disease. Monogenic psoriasis has been described recently, including dominantly inherited plaque and generalized pustular types, related to activating mutations in the CARD14 gene. We describe here a family with CARD14-related psoriasis, exhibiting an extreme variability of clinical presentation (from mild plaque-type to generalized pustular psoria ...
Pages: 885-887
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INVESTIGATIVE REPORT
Relative Frequency, Clinical Features, and Survival Outcomes of 395 Patients with Cutaneous Lymphoma in Korea: A Subgroup Analysis per 10-year Period
Woo Jin Lee, Sang Hyung Lee, Ik Jun Moon, Chong Hyun Won, Sung Eun Chang, Jee Ho Choi, Chan-Sik Park, Cheolwon Suh, Mi Woo Lee
Long-term changes in the relative frequency of cutaneous lymphoma (CL) have not been investigated in Asian populations. The aim of this study was to investigate the relative frequency, clinical characteristics, and survival outcomes of CL in Korean patients, and to evaluate the changes in relative frequency of CL over a 20-year period. The present retrospective cohort study included 395 patients, ...
Pages: 888-893
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INVESTIGATIVE REPORT
Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin
Leigh A. Nattkemper, Maria-Estela Martinez-Escala, Ari B. Gelman, Elisha M. Singer, Alain H. Rook, Joan Guitart, Gil Yosipovitch
Approximately 88% of cutaneous T-cell lymphoma (CTCL) patients are affected by pruritus that responds poorly to current antipruritic therapies. Interleukin (IL)-31, a Th2 cytokine, has been found to be increased in the serum of CTCL patients and to correlate with itch severity. This study investigated the role of IL-31 and its receptors (IL-31 receptor-alpha [IL-31RA] and OSMRβ) in the skin o ...
Pages: 894-898
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Thromboxane A2 is Involved in Itch-associated Responses in Mice with Atopic Dermatitis-like Skin Lesions
Tsugunobu Andoh, Ai Yamamoto , Satomi Haza, Koh-ichi Yuhki, Fumitaka Ushikubi, Shu Narumiya, Yasushi Kuraishi
To investigate the mechanisms underlying itching in atopic dermatitis, we examined whether thromboxane (TX) A2, an arachidonic acid metabolite, is involved in spontaneous scratching, an itch-related response, in NC mice with atopic dermatitis-like skin lesions. The TXA2 receptor (TP) antagonist ONO-3708 inhibited the spontaneous scratching. The mRNA expression of TX synthase (TXSyn) distributed ma ...
Pages: 899-904
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INVESTIGATIVE REPORT
Effects of Topical Tacrolimus and Polyunsaturated Fatty Acids on In Vivo Release of Eicosanoids in Atopic Dermatitis During Dermal Microdialysis
Sven R. Quist, Ingrid Wiswedel , Ines Doering, Jennifer Quist, Harald P. Gollnick
Atopic dermatitis (AD) is a multifactorial inflammatory skin disease with release of distinct inflammatory signals. This study investigated the presence of eicosanoids in AD skin and the effect of topical agents with potential to suppress inflammation. Twelve patients with moderate AD received topical treatment on either arm with tacrolimus 0.1% ointment or a lotion containing 12% ω-6 fatty a ...
Pages: 905-909
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INVESTIGATIVE REPORT
Kinetic Profile of Inflammation Markers in Human Skin In vivo Following Exposure to Ultraviolet B Indicates Synchronic Release of Cytokines and Prostanoids
Sven R. Quist, Ingrid Wiswedel , Jennifer Quist, Harald P. Gollnick
Ultraviolet B (UVB) irradiation affects epidermal cells, which respond via a cascade of inflammation markers. After initial in vitro and ex vivo experiments, this study used cutaneous microdialysis to generate a kinetic profile for 16 cytokines and 4 prostanoids in human skin in vivo. Skin areas 9 cm2 were irradiated with UVB (2× minimal erythematous dose) 16 h after catheter placement in the der ...
Pages: 910-916
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INVESTIGATIVE REPORT
Immunosuppressive Environment in Basal Cell Carcinoma: The Role of Regulatory T Cells
Silje H. Omland, Patricia S. Nielsen, Lise M.R. Gjerdrum, Robert Gniadecki
Interaction between tumour survival tactics and anti-tumour immune response is a major determinant for cancer growth. Regulatory T cells (T-regs) contribute to tumour immune escape, but their role in basal cell carcinoma (BCC) is not understood. The fraction of T-regs among T cells was analysed by immunohistochemistry followed by automated image analysis in facial BCC, peritumoural skin and normal ...
Pages: 917-921
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INVESTIGATIVE REPORT
Expression of Glucocorticoid Receptors GRα and GRβ in Bullous Pemphigoid
Minna E. Kubin, Päivi M. Hägg, Nina Kokkonen, Kirsi-Maria Haapasaari, Juha P. Väyrynen, Tatsuya Uchida, Virpi Glumoff, Petri Kulmala, Tiina Hurskainen, Kaisa Tasanen
First-line treatments of bullous pemphigoid (BP) are topical and systemic glucocorticoids (GC). The actions of GC are mediated by glucocorticoid receptors (GR), which exist in several isoforms, of which GRα and GRβ are the most important. In many inflammatory diseases, up-regulation of GRβ is associated with GC insensitivity. The aims of this study were to determine the expression o ...
Pages: 922-926
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CLINICAL REPORT
Hormonal Factors and Risk of Psoriasis in Women: A Cohort Study
Shaowei Wu, Eunyoung Cho, Wenqing Li, Francine Grodstein, Abrar A. Qureshi
Previous studies suggest that hormonal factors modulate the natural course of psoriasis in women. However, the association of hormonal factors with psoriasis risk has not been assessed using prospective data. We carried out a thorough prospective analysis on the topic in 163,763 women in the Nurses’ Health Study I and II. Participants provided information on age at menarche, parity, menopause st ...
Pages: 927-931
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CLINICAL REPORT
Spectrum of Autosomal Recessive Congenital Ichthyosis in Scandinavia: Clinical Characteristics and Novel and Recurrent Mutations in 132 Patients
Maritta Hellström Pigg, Anette Bygum, Agneta Gånemo, Marie Virtanen, Flemming Brandrup, Andreas D. Zimmer, Alrun Hotz, Anders Vahlquist, Judith Fischer
Autosomal recessive congenital ichthyosis (ARCI) represents a heterogeneous group of rare disorders of cornification with 3 major subtypes: harlequin ichthyosis (HI), lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE). A 4th subtype has also been proposed: pleomorphic ichthyosis (PI), characterized by marked skin changes at birth and subsequently mild symptoms. In nationwide ...
Pages: 932-937
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CLINICAL REPORT
Chronic Kidney Disease-associated Pruritus in Children
Elzbieta Wojtowicz-Prus, Katarzyna Kiliś-Pstrusińska, Adam Reich, Katarzyna Zachwieja, Monika Miklaszewska, Maria Szczepanska, Jacek C. Szepietowski
This study evaluated the frequency and severity of pruritus and dry skin in children with chronic kidney disease (CKD). A total of 103 children were included: 72 with CKD stage 3–5 (34 on dialysis and 38 treated conservatively without dialysis) and 31 as a reference group. Pruritus was assessed using the 4-item Itch Questionnaire and a visual analogue scale. Skin dryness was evaluated clinically ...
Pages: 938-942
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CLINICAL REPORT
Drug Survival and Predictors of Drug Survival for Methotrexate Treatment in a Retrospective Cohort of Adult Patients with Localized Scleroderma
Jorre S. Mertens, Juul M. van den Reek, Wietske Kievit, Peter C.M. van de Kerkhof, Rogier M. Thurlings, Tim R.D. Radstake, Marieke M.B. Seyger, Elke M.G.J. de Jong
Data regarding the efficacy and safety of methotrexate (MTX) in adults with localized scleroderma (LoS) is scarce. This study gathered data from a retrospective cohort of adult patients with LoS (n?=?107), treated with MTX (1993–2015). MTX drug survival and predictors thereof were analysed. After 1 and 2 years, 26% and 63% of patients stopped MTX due to disease remission, respectively. Patients ...
Pages: 943-947
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CLINICAL REPORT
Efficacy of a Cream Containing Ceramides and Magnesium in the Treatment of Mild to Moderate Atopic Dermatitis: A Randomized, Double-blind, Emollient- and Hydrocortisone-controlled Trial
Sjors A. Koppes, Frank Charles, Laureen Lammers, Monique Frings-Dresen, Sanja Kezic, Thomas Rustemeyer
The aim of this randomized controlled trial was to assess the efficacy of a cream containing ceramides and magnesium (Cer-Mg) in the treatment of mild to moderate atopic dermatitis and to compare it with hydrocortisone and a commonly used emollient (unguentum leniens; cold cream). A total of 100 patients, randomized into 2 groups, were treated for 6 weeks simultaneously (left vs. right side of the ...
Pages: 948-953
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CLINICAL REPORT
Structural Defects of Laminin β3 N-terminus Underlie Junctional Epidermolysis Bullosa with Altered Granulation Tissue Response
Maya El Hachem, Paola Fortugno, Antonio Palmeri, Manuela Helmer Citterich, Andrea Diociaiuti, Vittoria Proto, Renata Boldrini, Giovanna Zambruno, Daniele Castiglia
Mutations in the laminin-332 (α3Aβ3γ2) genes cause junctional epidermolysis bullosa (JEB), a recessively inherited disease characterized by blistering and altered wound repair. In addition, specific mutations that affect the N-terminus of the α3A chain cause a JEB-related non-blistering condition characterized by chronic production of granulation tissue, suggesting a critical r ...
Pages: 954-958
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CLINICAL REPORT
Prognosis after Hospitalization for Erythroderma
Alexander Egeberg, Jacob P. Thyssen, Gunnar H. Gislason, Lone Skov
Erythrodermic psoriasis (EP) and erythroderma exfoliativa (EE) are acute and potentially life-threatening inflammatory reactions. We estimated hazard ratios (HRs) of 3-year mortality following hospitalization for EP or EE compared with general population controls, patients hospitalized for psoriasis vulgaris, and toxic epidermal necrolysis (TEN), respectively. We identified 26 and 48 patients with ...
Pages: 959-962
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CLINICAL REPORT
Skin Patterns Associated with Upper Airway Infantile Haemangiomas: A Retrospective Multicentre Study
Claire Uthurriague, Olivia Boccara, Benoît Catteau, Pierre Fayoux, Christine Léauté-Labrèze, Christine Chiaverini, Annabel Maruani, Soizick Pondaven-Letourmy, Abdulqader Alaidarous, Eve Puzenat, Thomas Hubiche, Stéphanie Mallet, Isabelle Dreyfus, Juliette Mazereeuw-Hautier
The aim of this study was to define the skin patterns at high risk for upper airway infantile haemangioma. A retrospective multicentre French observational study was conducted between January 2006 and January 2015 and all confirmed airway haemangioma were included. Thirty-eight patients with airway haemangioma from 9 centres were included. Thirty-one patients had a cutaneous or mucosal haemangioma ...
Pages: 963-966
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CLINICAL REPORT
Persistent Skin Reactions and Aluminium Hypersensitivity Induced by Childhood Vaccines
Elaha Salik, Ida Løvik, Klaus E. Andersen, Anette Bygum
There is increasing awareness of reactions to vaccination that include persistent skin reactions. We present here a retrospective investigation of long-lasting skin reactions and aluminium hypersensitivity in children, based on medical records and questionnaires sent to the parents. In the 10-year period 2003 to 2013 we identified 47 children with persistent skin reactions caused by childhood vacc ...
Pages: 967-971
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SHORT COMMUNICATION
Underdiagnosis of Cardiovascular Risk Factors in Outpatients with Psoriasis Followed at Hospital Dermatology Offices: The PSO-RISK Study
Luis Cea-Calvo, Francisco Vanaclocha, Isabel Belinchón, Óscar Rincón, Berta Juliá, Lluís Puig
Abstract is missing (Short communication)
Pages: 972-973
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SHORT COMMUNICATION
A Retrospective Study of Patients with Psoriasis Treated with Biologics: Relation to Body Mass Index and Gender
Louai A. Salah, Martin Gillstedt, Amra Osmancevic
Abstract is missing (Short communication)
Pages: 974-975
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SHORT COMMUNICATION
Heat Shock Protein 27 kDa Content in Stratum Corneum Correlates with Severity of Atopic Dermatitis
Shiro Niiyama, Takashi Yoshino, Shoko Matsukuma, Hideki Mukai
Abstract is missing (Short communication)
Pages: 976-977
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SHORT COMMUNICATION
Itch Assessment with Visual Analogue Scale and Numerical Rating Scale: Determination of Minimal Clinically Important Difference in Chronic Itch
Adam Reich, Claudia Riepe, Zografia Anastasiadou, Karolina Mędrek, Matthias Augustin, Jacek C. Szepietowski, Sonja Ständer
Abstract is missing (Short communication)
Pages: 978-980
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SHORT COMMUNICATION
Reflectance Confocal Microscopy for Diagnosis of Mammary Paget’s Disease
André Oliveira, Iris Zalaudek, Edith Arzberger, Cesare Massone, Rainer Hofmann-Wellenhof
Abstract is missing (Short communication)
Pages: 980-982
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SHORT COMMUNICATION
Severe Buruli Ulcer Treated with Minimal Surgical Excision after Prior Biopsy Mapping
Miho Kabuto, Noriki Fujimoto, Toshifumi Takahashi, Gen Nakanishi, Takeshi Nakanishi, Toshihiro Tanaka
Abstract is missing (Short communication)
Pages: 982-984
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SHORT COMMUNICATION
Epididymitis with Epididymal Cyst Indicating Immunoglobulin A Vasculitis in an AdultAi Nanbu, Kazumitsu Sugiura, Naoto Sassa, Masashi Akiyama
Ai Nanbu, Kazumitsu Sugiura, Naoto Sassa, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 985-986
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SHORT COMMUNICATION
Recalcitrant Livedoid Vasculopathy Associated with Hyperhomocysteinaemia Responding to Folic Acid and Vitamins B6/B12 Supplementation
Enzo Errichetti, Giuseppe Stinco
Abstract is missing (Short communication)
Pages: 987-988
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SHORT COMMUNICATION
Target-sequence Capture and High Throughput Sequencing Identify a De novo CARD14 Mutation in an Infant with Erythrodermic Pityriasis Rubra Pilaris
Cristina Has, Agnes Schwieger-Briel, Nina Schlipf, Ingrid Hausser, Nadja Chmel, Bernd Rösler, Kristin Technau, Thilo Jakob, Andreas Zimmer, Judith Fischer
Abstract is missing (Short communication)
Pages: 989-990
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SHORT COMMUNICATION
DOCK8 Mutation Syndrome: A Diagnostic Challenge for Dermatologists
Joséphine Moreau, Sarah Beaussant-Cohen, François Aubin, Pierre-Simon Rohrlich, Eve Puzenat
Abstract is missing (Short communication)
Pages: 991-992
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SHORT COMMUNICATION
Darier’s Disease Complicated by Schizophrenia Caused by a Novel ATP2A2 Mutation
Takuya Takeichi, Kazumitsu Sugiura, Yuki Nakamura, Yumi Fujio, Izumi Konohana, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 993-994
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SHORT COMMUNICATION
Symmetrical Intertriginous and Flexural Exanthema due to Bortezomib (a Proteasome Inhibitor) Given for Myeloma
Nausicaa Malissen, Jean-Luc Bourrain, Anca Chiriac, Aline Montet, Laure Vincent, Olivier Dereure, Aurélie Du-Thanh
Abstract is missing (Short communication)
Pages: 995-996
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SHORT COMMUNICATION
Lichenoid Drug Eruption Caused by Limaprost Alfadex
Akiha Inoue, Yu Sawada , Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura
Abstract is missing (Short communication)
Pages: 997-998
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SHORT COMMUNICATION
Do Giant Melanocytic Naevi Tend to Spare the Umbilicus?
Rudolf Happle, Aicha Salhi
Abstract is missing (Short communication)
Pages: 998-999
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SHORT COMMUNICATION
Cutaneous Adverse Reaction to Mogamulizumab May Indicate Favourable Prognosis in Adult T-cell Leukaemia-lymphoma
Kentaro Yonekura, Masahito Tokunaga, Nobuyo Kawakami, Koichiro Takeda, Tamotsu Kanzaki, Nobuaki Nakano, Ayumu Kubota, Shogo Takeuchi, Yoshifusa Takatsuka, Masao Seto, Atae Utsunomiya
Abstract is missing (Short communication)
Pages: 1000-1002
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SHORT COMMUNICATION
Human Herpes Virus 7 in a Patient with Recurrent Vulvar Ulceration
Niina Hieta, Eija Hiltunen-Back
Abstract is missing (Short communication)
Pages: 1002-1003
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SHORT COMMUNICATION
Unilateral Erythematous Lesions with Wax-like Scaling and Limb Abnormalities: A Quiz
Edyta Lelonek, Łukasz Matusiak, Andrzej Bieniek, Jacek C. Szepietowski
Abstract is missing (Quiz)
Pages: 1004-1008
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QUIZ
Reddish Nodule on the Hand: A Quiz
Adrià Panés-Rodríguez, Susana Vildósola-Esturo, Irene Rodríguez-Pérez, Anna Tuneu-Valls, Elena Del Alcázar-Viladomiu
Abstract is missing (Quiz)
Pages: 1004-1008
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QUIZ
Itchy Papules and Nodules: A Quiz
Claudia Riepe, Nina Magnolo, Dieter Metze, Sigrid Broekaert, Claudia Zeidler, Sonja Ständer
Abstract is missing (Quiz)
Pages: 1004-1008
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INDEX
INDEX 96
Page: 1009
Abstract  PDF