Content » Vol 94, Issue 2

Clinical Report

Effectiveness of Interdisciplinary vs. Dermatological Care of Moderate- to-severe Psoriasis: A Pragmatic Randomised Controlled Trial

Jochen Schmitt, Gottfried Wozel, Marlene Garzarolli, Antje Viehweg, Michael Bauer, Karolina Leopold
DOI: 10.2340/00015555-1697


Psychiatric morbidity is frequent in patients with psoriasis. We compared the effectiveness of dermatological vs. interdisciplinary dermatological and psychiatric care for psoriasis. Adults with moderate-to-severe psoriasis were randomly allocated to dermatological (n=24) or interdisciplinary care (n=23) and treated accordingly. Primary endpoint was the mean change in Dermatology Life Quality Index (DLQI) at 6 months. Data was analysed by intention-to-treat. Mean±SD change in DLQI was 7.5±7.3 and 10.5±9.9 after 6 months of dermatological and interdisciplinary care, respectively (p=0.27). At baseline, 10 patients in the interdisciplinary treatment group (43%) had at least one psychiatric disorder. These patients showed significantly better DLQI response (DLQI change 14.8±9.7) than patients receiving dermatological care only (p=0.03). Ninety percent of psoriasis patients with DLQI scores exceeding psoriasis area and severity index (PASI) scores had comorbid psychiatric disease. Although psychiatric co-treatment is not generally required for patients with moderate-to-severe psoriasis, those patients with higher DLQI scores than PASI scores might benefit from interdisciplinary care.


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