Content » Preview

Clinical Report

High Prevalence of Human Papillomavirus on Anal and Oral Samples from Men and Women with External Anogenital Warts: The HERCOLES Study

Carmen Lisboa, Irene Santo, Jacinta Azevedo, Luis Azevedo, Angela Pista, Camila Dias, Maria Joaõ Cunha
DOI: 10.2340/00015555-3136

Preview of a paper in the copy-editing process

This article has been accepted for publication in Acta Dermato-Venereologica and is currently being edited and typeset. Readers should note that article shown below have been fully refereed, but have not been through the copy-editing and proof correction process. Only Abstract is possible to read. When this process is finalized the complete paper will be able to find.


Human papillomavirus (HPV) infection is highly prevalent in the sexually active population. This study estimates the prevalence of HPV DNA in anal and oral samples from a cohort of men and women with incident anogenital warts. Anal and/or oral samples from 541 patients with anogenital warts were tested for 35 HPV genotypes using a PCR (polymerase chain reaction) assay. The overall prevalence of anal HPV and oral HPV DNA was 59.9% (n = 305/509; 95% confidence interval (CI) 55.6–64.1%) and 14.5% (n = 78/538; 95% CI 11.8–17.7%), respectively. Among patients with perianal warts, the anal HPV prevalence was 92.3 and the anal HPV DNA prevalence was 92.3% (95% CI 87.0–95.5%). Anal HPV DNA prevalence in patients with genital warts but perianal warts [AQ1] was 55.7% (95% CI 50.6–60.7%). Both anal and oral HPV infections were more common in men who have sex with men than in heterosexual men (90.4% versus 38.5% and 20.8% versus 11.8%, respectively). Anal high risk-HPV infection was more common in women (58.8%) and in men who have sex with men (67.7%). We found that anogenital warts represent a clinical marker for both anal and oral HPV infections, including anal high risk-HPV infections, particularly among women and men who have sex with men.

Supplementary content


Not logged in! You need to login/create an account to comment on articles. Click here to login/create an account.