Content

Content - Volume 99, Issue 6

Editor's choice in this issue

REVIEW
Drug-induced Linear IgA Bullous Dermatosis: A Case Report and Review of the Literature
Judith Lammer, Rüdiger Hein, Sophie Roenneberg, Tilo Biedermann, Thomas Volz
Linear IgA bullous dermatosis (LABD) is a rare subepidermal autoimmune blistering disease which is idiopathic in most cases, although there is a subset of patients with LABD found to be drug-induced. An overview on pathogenesis, diagnosis and treatment of drug-induced LABD is given accompanied by presenting the clinical course of a 77-year-old male patient with LABD induced by vancomycin. A comprehensive literature search revealed a multitude of different drugs having been described to elicit linear IgA dermatosis with vancomycin being the most frequent one.
Pages: 508-515
Abstract  HTML  PDF
REVIEW
Nail Psoriasis: An Updated Review and Expert Opinion on Available Treatments, Including Biologics
Federico Bardazzi, Michela Starace, Francesca Bruni, Michela Magnano, Bianca Maria Piraccini, Aurora Alessandrini
Nail psoriasis affects 50–79% of patients with skin psoriasis and up to 80% of patients with psoriatic arthritis, and can also represent a negative prognostic factor in individuals with plaque psoriasis. Nail psoriasis is often not recognized and difficult to treat with topical therapies alone, and relapse is common. The treatment of nail psoriasis is not standardized, ranging from topical therapy to systemic therapy, according to the severity and extension of the disease. Biologic therapies have also been introduced as a treatment option for nail psoriasis. This review analysed the different therapeutic options for nail psoriasis, focusing on new treatments that have shown promising results in this field.
Pages: 516-523
Abstract  HTML  PDF

All articles

REVIEW
Drug-induced Linear IgA Bullous Dermatosis: A Case Report and Review of the Literature
Judith Lammer, Rüdiger Hein, Sophie Roenneberg, Tilo Biedermann, Thomas Volz
Linear IgA bullous dermatosis (LABD) is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. Although most reported cases are idiopathic, there is a subset of patients with drug-induced LABD. Various drugs have been associated with the drug-induced form of the disease. This paper reviews the literature on drugs reported to el ...
Pages: 508-515
Abstract  HTML  PDF
REVIEW
Nail Psoriasis: An Updated Review and Expert Opinion on Available Treatments, Including Biologics
Federico Bardazzi, Michela Starace, Francesca Bruni, Michela Magnano, Bianca Maria Piraccini, Aurora Alessandrini
Nail psoriasis affects 50–79% of patients with skin psoriasis and up to 80% of patients with psoriatic arthritis, and can also represent a negative prognostic factor in individuals with plaque psoriasis. Treatments for nail psoriasis are limited, as nails are often difficult to treat with topical therapies alone, and relapse is common. Among different systemic agents, secukinumab, a fully human ...
Pages: 516-523
Abstract  HTML  PDF
CLINICAL REPORT
Strong Associations Between Inflammation, Pruritus and Mental Health in Dialysis Patients
Severin Schricker, Thorsten Heider, Moritz Schanz, Jürgen Dippon, Mark Dominik Alscher, Heinz Weiss, Thomas Mettang, Martin Kimmel
Pruritus, impaired mental health and inflammation contribute to morbidity in end-stage renal disease. There are no studies on all 3 conditions. We therefore obtained inflammatory parameter data (C-reactive protein and interleukin-6), pruritus data and psychological test data (36-Item Short-Form Health Survey, “Allgemeine Depressionsskala” and Toronto Alexithymia Scale-20) for 19 dialysis patie ...
Pages: 524-529
Abstract  HTML  PDF
CLINICAL REPORT
Epidemiology of Depression in Patients with Psoriasis: A Nationwide Population-based Cross-sectional Study
Stephen Chu-Sung Hu, Gwo-Shing Chen, Hung-Pin Tu
The epidemiology of depression in patients with psoriasis has not been well defined in the Asian population. This study evaluated the epidemiological features of, and risk factors for, depression among patients with psoriasis in Taiwan. A nationwide population-based cross-sectional study was undertaken using the National Health Insurance Research Database. This study included 17,086 patients with ...
Pages: 530-538
Abstract  HTML  PDF
CLINICAL REPORT
Clinical Profile of Methotrexate-resistant Juvenile Localised Scleroderma
Juliette Hardy, Franck Boralevi, Stéphanie Mallet, Natalia Cabrera, Alexandre Belot, Alice Phan, Sébastien Barbarot, Audrey Duriez-Lasek, Christine Chiaverini, Thomas Hubiche, Emmanuel Mahé, Edouard Bégon, Emmanuelle Bourrat, Olivia Boccara, Hélène Aubert, Martine Grall Lerosey, Catherine Droitcourt, Maryam Piram, Juliette Mazereeuw-Hautier, and Research Group of the French Society of Paediatric Dermatology (SDFP in French)
Methotrexate has demonstrated its efficiency for the treatment of juvenile localized scleroderma but some patients may be resistant. The aim of our study was to define the profile of such patients. We performed an observational retrospective multicenter study between 2007 and 2016 and included all children seen in the French Paediatric Dermatology and Rheumatology departments with active localized ...
Pages: 539-543
Abstract  HTML  PDF
CLINICAL REPORT
Low- vs. Middle-dose Total Skin Electron Beam Therapy for Mycosis Fungoides: An Efficiency-based Retrospective Survey of Skin Response
Annelies Taverniers, Aurélie Du-Thanh, Marie Charissoux, Christine Kerr, Olivier Dereure
Optimal doses of total skin electron beam therapy for mycosis fungoides remain to be established. Clinical efficiency and adverse effects of middle-dose (25 Gy) vs. low-dose (10–12 Gy) total skin electron beam therapy were retrospectively compared in a series of 14 and 12 mycosis fungoides, respectively. Overall skin response rate was 96.2% (92.9% middle-dose and 100% low-dose; not significant ( ...
Pages: 544-550
Abstract  HTML  PDF
CLINICAL REPORT
Topical Steroid Withdrawal: A Case Series of 10 Children
Belinda Sheary
Concerns about topical steroid withdrawal are causing some patients to cease long-term topical corticosteroid therapy, however, little is known about the ensuing clinical outcomes. This qualitative case series studied 10 children whose parents stopped their chronic topical corticosteroid use and subsequently developed features typically reported in adults experiencing topical steroid withdrawal. P ...
Pages: 551-556
Abstract  HTML  PDF
CLINICAL REPORT
High Prevalence of Human Papillomavirus on Anal and Oral Samples from Men and Women with External Anogenital Warts: The HERCOLES Study
Carmen Lisboa, Irene Santo, Jacinta Azevedo, Luis Azevedo, Angela Pista, Camila Dias, Maria Joaõ Cunha
Human papillomavirus (HPV) infection is highly prevalent in the sexually active population. This study estimates the prevalence of HPV DNA in anal and oral samples from a cohort of men and women with incident anogenital warts. Anal and/or oral samples from 541 patients with anogenital warts were tested for 35 HPV genotypes using a PCR assay. The overall prevalence of anal HPV and oral HPV DNA was ...
Pages: 557-563
Abstract  HTML  PDF
CLINICAL REPORT
Emotional Ability and Skin-restricted Lupus Evolution: A Longitudinal Study
Isabelle Jalenques, Fabien Rondepierre, Aurélien Mulliez, Michel D'Incan, Silla M. Consoli and The LuPsy cohort investigators
Impaired emotional abilities (higher scores of alexithymia and lower levels of emotional awareness) were found in patients with skin-restricted lupus, warranting examination of the relationship between these abilities and the evolution of skin-restricted lupus, using longitudinal data. A total of 75 consecutive outpatients with skin-restricted lupus were recruited and assessed by a dermatologist a ...
Pages: 564-570
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Serum miR-125a-5p and CCL17 Upregulated in Chronic Spontaneous Urticaria and Correlated with Treatment Response
Liming Zhang, Ruiqun Qi, Yang Yang, Xinghua Gao, Hongduo Chen, Ting Xiao
Chronic spontaneous urticaria (CSU) is a common skin disorder associated with autoimmunity. MicroRNAs (miRNAs) are endogenous noncoding RNA molecules reported to be potential biomarkers for some autoimmune diseases. In this study, we investigated the association of miRNAs with CSU. A quantitative PCR (qPCR)-based array was generated from sera as obtained from 20 active CSU patients and 20 healthy ...
Pages: 571-578
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Aberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis
Weilong Zhong, Xia Wu, Wei Zhang, Jie Zhang, Xiaofan Chen, Shihong Chen, Haiyan Huang, Yong Yang, Bo Yu, Xia Dou
Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in chronic itch and inflammation. This study investigated the mRNA levels and immunoreactivity of the nerve growth factor, IL-31, thymic stromal lymphopoi ...
Pages: 579-586
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons
Sarah Ehling, Tomoki Fukuyama, Mei-Chuan Ko, Thierry Olivry, Wolfgang Bäumer
Neuromedin B is expressed in nociceptive and itch-sensitive dorsal root ganglia neurons, but its peripheral pruritogenic potential is not well described. The potential of neuromedin B as a pruritogen and pro-inflammatory peptide in the skin was tested in vivo in an acute model in mice and monkeys as well as an allergic dermatitis model in mice. To identify the underlying mechanisms in vitro real t ...
Pages: 587-893
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice
Sun-Hye Shin, Kyung-Ah Cho, Soojung Hahn, Younghay Lee, Yu-He Kim, So-Youn Woo, Kyung-Ha Ryu, Woo-Jae Park, Joo-Won Park
Sphingosine-1-phosphate (S1P) is a signalling sphingolipid metabolite that regulates important cell processes, including cell proliferation and apoptosis. Circulating S1P levels have been reported to be increased in patients with psoriasis relative to healthy patients. The aim of this study was to examine the potency of S1P inhibition using an imiquimod-induced psoriasis mouse model. Both topical ...
Pages: 594-601
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Gliptin-associated Bullous Pemphigoid and the Expression of Dipeptidyl Peptidase-4/CD26 in Bullous Pemphigoid
Outi Lindgren, Outi Varpuluoma, Jussi Tuusa, Jorma Ilonen, Laura Huilaja, Nina Kokkonen, Kaisa Tasanen
Dipeptidyl peptidase-4 inhibitors (DPP-4i or gliptins) increase the risk of developing bullous pemphigoid (BP). To clarify, whether gliptin-associated BP has special features, we analyzed the clinical, histopathological and immunological features of 27 BP patients, 10 of which previously used gliptin medication. Compared to those who had not previously received gliptins, subjects who had, showed h ...
Pages: 602-609
Abstract  HTML  PDF
SHORT COMMUNICATION
Progressive Nodular Histiocytosis with Large Nodules and a Bulky Mass
Takahiro Kiyohara, Kaoru Makimura, Mari Miyamoto, Takako Shijimaya, Naoko Nagano, Sei Nakamaru, Hirotsugu Tanimura
Abstract is missing (Short Communication)
Pages: 610-611
Abstract  HTML  PDF
SHORT COMMUNICATION
Therapeutic Effectiveness of Immunoradiotherapy on Brain-metastatic BRAF/MEK Inhibitor-resistant Melanoma with Balloon Cell Change
Haruka Goto, Takatoshi Shimauchi, Kensuke Fukuchi, Naoki Yokota, Shinichiro Koizumi, Masahiro Aoshima, Yuno Endo, Yurika Masuda, Hidehiko Miyazawa, Akira Kasuya, Katsumasa Nakamura, Taisuke Ito, Yoshiki Tokura
Abstract is missing (Short communication)
Pages: 612-613
Abstract  HTML  PDF
SHORT COMMUNICATION
Nevus Count Associations with Thinner Nodular or Superficial Spreading Melanoma
Clio Dessinioti, Alan C. Geller, Arabella Stergiopoulou, Susan M. Swetter, Eszter Baltás, Jonathan E. Mayer, Timothy M. Johnson, Alexander J. Stratigos
Abstract is missing (Short communication)
Pages: 614-615
Abstract  HTML  PDF
SHORT COMMUNICATION
Economic Analysis of Herpes Zoster in a Hospital Setting in Hong Kong
Wai-kit Ming, Wing-yin Yu, Owen Tak-yin Tsang, Paul Kay-sheung Chan, Joyce Hoi-sze You
Abstract is missing (Short communication)
Pages: 616-617
Abstract  HTML  PDF
SHORT COMMUNICATION
Agreement Between Self-reported and Dermatologists’ Diagnosis for Alopecia Areata and Atopic Dermatitis: A Bi-centric Prospective Study
Marie-Aleth Richard, Khaled Ezzedine
Abstract is missing (Short communication)
Pages: 618-619
Abstract  HTML  PDF
CORRESPONDENCE
Antipruritic vs. Antitumour Action of Aprepitant: A Question of Dose
Miguel Muñoz, Julio Parrilla, Marisa Rosso, Rafael Coveñas
Abstract is missing (Correspondence)
Pages: 620-621
Abstract  HTML  PDF
QUIZ
Erythematous Rash in a Transgender Patient: A Quiz
Francisco Galeano-Valle, Jeehea Sonya Haw
Abstract is missing (Quiz)
Pages: 623-624
Abstract  HTML  PDF
QUIZ
Disseminated Small Papules on the Face: A Quiz
Victor Olsavszky, Cyrill Géraud, Moritz Felcht
Abstract is missing (Quiz)
Pages: 625-626
Abstract  HTML  PDF
QUIZ
Vascular Mass of the Scalp in a Newborn: A Quiz
Afi-Emiliène Edee, Matthias Tallegas, Anne Jourdain, Antoine Listrat, Baptiste Morel, Annabel Maruani
Abstract is missing (Quiz)
Pages: 627-628
Abstract  HTML  PDF
QUIZ
Ulcers and Scars on the Trunk of a 20-month-old Boy: A Quiz
Tal Goldberger, Alexander Maly, Tamar Harel, Vered Molho-Pessach
Abstract is missing (Quiz)
Pages: 629-630
Abstract  HTML  PDF
QUIZ
Stable Firm Pink Papules on a Woman in her 60s: A Quiz
Catherine Baker, Katherine R. Lee, Anh Khoa Pham, Robert E. LeBlanc, Joi B. Carter
Abstract is missing (Quiz)
Pages: 631-632
Abstract  HTML  PDF