Content - Volume 100, 100-year theme: Atopic dermatitis (June)

All articles

Prevention of Atopic Dermatitis
Hywel C. Williams, Joanne Chalmers
Despite advances in atopic dermatitis (AD) treatments, research into AD prevention has been slow. Systematic reviews of prevention strategies promoting exclusive and prolonged breastfeeding, or interventions that reduce ingested or airborne allergens during pregnancy and after birth have generally not shown convincing benefit. Maternal/infant supplements such as Vitamin D have also not shown any b ...
Pages: 380-388
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A Therapeutic Renaissance - Emerging Treatments for Atopic Dermatitis
Chan Ho Na, Wenelia Baghoomian, Eric L. Simpson
Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease that is characterized by complex immune dysregulation and skin barrier dysfunction with a wide variety of clinical phenotypes. Until recently, conventional therapeutic modalities for AD remained rather non-specific despite AD’s complex etiology. Failing to take into account the underlying inflammatory pathways led to treatments ...
Pages: 367-379
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Skin Microbiome in Atopic Dermatitis
Sofie M. Edslev, Tove Agner, Paal S. Andersen
Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing d ...
Pages: 358-366
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Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects
Sara J. Brown, Martina S. Elias, Maria Bradley
Atopic dermatitis (AD) is a common, complex trait, arising from the interplay of multiple genetic and environmental factors. This review provides an overview of developments in the field of AD genetics. AD shows high heritability; strategies to investigate genetic risk include linkage, candidate gene studies, genome-wide association and animal modelling. Loss-of-function mutations in FLG, encoding ...
Pages: 349-357
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Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors
Jacob P. Thyssen, Maria Rasmussen Rinnov, Christian Vestergaard
Atopic dermatitis is a prevalent inflammatory skin condition characterized by itch and dry skin, which affects 15–20% of children and 3–5% of adults. This article reviews epidemiological, clinical and experimental data to provide an overview of the most important disease mechanisms in atopic dermatitis. Genetic predisposition, environmental insults, atopic triggers, complex host immune respons ...
Pages: 340-348
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Counting the Burden: Atopic Dermatitis and Health-related Quality of Life
Faraz Ali, Jui Vyas, Andrew Y. Finlay
Atopic dermatitis is the most prevalent chronic inflammatory skin condition globally. The burden of atopic dermatitis on children and adults is extensive and there is also significant impact on the lives of patient caregivers and family members. It is important to be able to measure this impact to inform clinical decisions and to plan appropriate patient and carer support. The current impact of at ...
Pages: 330-340
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Prevalence and Incidence of Atopic Dermatitis: A Systematic Review
Simon Bylund, Laura B. von Kobyletzki, Marika Svalstedt, Åke Svensson
The primary objective of this study was to systematically review and analyse epidemiological studies of the prevalence and incidence of atopic dermatitis (AD) during childhood and adulthood, focusing on data from the 21st century. A systematic search of PubMed, EMBASE and Google (manual search) was performed in June 2019, followed by data abstraction and study quality assessment (Newcastle–Ottaw ...
Pages: 320-329
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Pages: 320-388
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