Content - Volume 64, Issue 6

All articles

Concanavalin (ConA)-reactive human epidermal glycoproteins
Bonnefoy JY, Reano A, Ledger PW, Thivolet J.
The possibility that glycoconjugates play a role in epidermal differentiation has stimulated attempts at their biochemical identification. We have examined the Concanavalin (ConA)-binding glycoproteins present: in whole human epidermis, epidermal cells obtained by trypsinization of human skin, non dissociated layers (the most differentiated ones) remaining after preparation of these cells and huma ...
Pages: 459-465
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Immunohistochemical staining characteristics of epidermal appendages (hair follicles and eccrine sweat glands) to anti-epidermal keratin antisera
Hosokawa M, Ohkohchi K, Tagami H.
The cellular characteristics of the epidermal appendages and their differentiations in relation to those of the epidermis have been chiefly studied from the morphological points in the past. We investigated them from the immunohistochemical characteristics of the constituent keratin protein to the antiserum against total keratin isolated from human plantar stratum corneum (TKA) which stains the wh ...
Pages: 466-472
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Phenotypic characterization in situ of inflammatory cells in pityriasis (tinea) versicolor
Scheynius A, Faergemann J, Forsum U, Sjöberg O.
The cellular response in pityriasis (tinea) versicolor lesions was analysed in situ with an immunohistochemical double staining technique combined with periodic acid-Schiff staining in frozen sections of skin biopsies from 9 patients. The proportions of B and T cells and subpopulations of T cells in the blood were normal as were the proliferative responses of blood mononuclear cells against variou ...
Pages: 473-479
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Collagen in the esophageal mucosa of patients with progressive systemic sclerosis (PSS)
Hendel L, Ammitzbøll T, Dirksen K, Petri M.
Eighteen consecutive patients with an established diagnosis of Progressive Systemic Sclerosis (PSS) underwent different investigative procedures to determine possible esophageal involvement. Esophageal sclerosis was demonstrated by X-ray and manometry in 13 patients. In all patients endoscopic biopsies of esophageal mucosa were obtained. In all biopsies the concentrations of hydroxyproline, hydrox ...
Pages: 480-484
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Clinical appearance of skin lesions and disturbances of pigmentation in localized scleroderma
Serup J.
Skin manifestations of localized scleroderma were assessed clinically in 58 patients presenting 214 circumscribed scleroderma lesions (23 patients with localized morphoea plaques, 15 with generalized morphoea, 11 with linear scleroderma of trunk and extremities, 9 with scleroderma en coup de sabre). Characteristic differences between different types of localized scleroderma with respect to age at ...
Pages: 485-492
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Clinical and immunological studies in chronic dermatophytosis caused by Trichophyton rubrum
Svejgaard E, Christiansen AH, Stahl D, Thomsen K.
Twenty-six patients with chronic dermatophytosis (CD) by Trichophyton rubrum (TR) through one year were included in a double-blind clinical trial with Levamisole/Placebo. All patients were treated with griseofulvin concomitantly. Before, during and after the trial, studies of the cellular and humoral immune response were performed. The result of treatment with griseofulvin plus levamisole (62.5% c ...
Pages: 493-500
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The ultrastructural morphology of human cutaneous leishmaniasis of low parasite load
el Hassan AM, Veress B, Kutty MK.
The ultrastructural morphology of the inflammatory infiltrate in cutaneous leishmaniasis with low parasite load from seven patients was studied. Cells of the mononuclear phagocyte system (macrophages and epithelioid cells), plasma cells, and lymphocytes formed the infiltrate. Disseminated shrinkage necrosis or apoptotis as well as coagulative necrosis with loss of the plasma membrane of single mac ...
Pages: 501-505
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The spirochetal etiology of acrodermatitis chronica atrophicans Herxheimer
Asbrink E, Hovmark A, Hederstedt B
Spirochetes were recovered from the skin lesion of 1 out of 10 acrodermatitis chronica atrophicans patients (ACA). Spirochetes from this skin isolate and from Ixodes (I.) ricinus and I. dammini spirochetes were used as antigens in indirect immunofluorescence tests. All sera from 17 ACA patients showed high antibody titers to the three antigens. Seven of the 17 sera which had the highest titers had ...
Pages: 506-512
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Skin manifestations of tularemia: a study of 88 cases in northern Finland during 16 years (1967-1983)
Syrjälä H, Karvonen J, Salminen A.
88 tularemia patients with secondary skin manifestations seen in northern Finland during 1967-1983 are described in this paper. Tularemia was ulceroglandular in 57% and pulmonary in 27% of the patients. 68% of the patients were women. The most common secondary skin manifestation was papular or vesicopapular eruption which was seen in 42% of the patients. Erythema nodosum either alone or in combina ...
Pages: 513-516
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Serum total and unbound testosterone and sex hormone binding globulin (SHBG) in female acne patients treated with two different oral contraceptives
Palatsi R, Hirvensalo E, Liukko P, Malmiharju T, Mattila L, Riihiluoma P, Ylöstalo P.
Serum total an unbound testosterone (T) and sex hormone binding globulin (SHBG) levels were studied in fifty-four female acne patients before treatment and during the treatment by two different oral contraceptives, the other containing 0.150 mg desogestrel plus 0.03 mg EE and the other 0.150 mg levonorgestrel plus 0.03 mg EE. Pretreatment values were abnormal in 57% of the patients. A borderline s ...
Pages: 517-523
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Antigen-free diet in adult patients with atopic dermatitis. A double-blind controlled study
Munkvad M, Danielsen L, Høj L, Povlsen CO, Secher L, Svejgaard E, Bundgaard A, Larsen PO.
The efficacy of an antigen-free diet on the activity of atopic dermatitis was examined in a double-blind study, comprising 33 adults with severe atopic dermatitis. The antigen-free diet (Vivasorb) was compared to a placebo diet during three weeks of hospitalization. Twenty-five patients were evaluable, two of whom had their diet stopped after a few days due to exacerbation. Nine patients improved, ...
Pages: 524-528
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Dinitrochlorbenzene (DNCB) treatment of viral warts. A 5-year follow-up study
Johansson E, Förström L.
A series of 43 patients with therapy-resistant viral warts of long-duration were treated with dinitrochlorbenzene (DNCB). Of the 37 patients, who completed the treatment, 19 were cured, including five of seven patients with hyperkeratotic tumor-like warts. The majority of the patients showed a depressed cell-mediated immune response. 25 patients were reexamined 5 years later and 8 additional patie ...
Pages: 529-533
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Collagen metabolites in urine in localized scleroderma (morphoea)
Ammitzbøll T, Serup J.
Hydroxyproline (Hyp), hydroxylysine (Hyl), and proline (Pro) were assayed in the urine from 28 patients with localized scleroderma (13 with localized morphoea plaques, 13 with generalized morphoea, and two with scleroderma en coup de sabre), as well as 17 control persons. The levels of Hyp, Hyl and Pro were elevated in patients with localized morphoea plaques as compared to the controls indicating ...
Pages: 534-537
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Measurement of transepidermal water loss using an evaporimeter to follow the restitution of the barrier layer of human epidermis after stripping the stratum corneum
Frödin T, Skogh M.
The rate of evaporation after stripping a test area with adhesive tape was followed in 10 women over a period of 15 days. The much increased transepidermal water loss after stripping diminished rapidly on the first 3 days. It then decreased more slowly, approaching but not fully reaching the normal rate by the end of test period. This can be taken to reflect the repair process of the damaged barri ...
Pages: 537-540
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Failure of specific human tissue substrates to increase the sensitivity of indirect immunofluorescence testing in cicatricial pemphigoid
FC. Powell, SM. Connolly, RS. Rogers 3rd, AL. Schroeter
Indirect immunofluorescence testing was carried out on sera from 14 patients with cicatricial pemphigoid with use of both autologous and homologous human tissue substrates. The results were largely negative. The sensitivity of detection of circulating antibody is not increased with these substrates over that with animal tissue substrates.
Pages: 540-543
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In vitro migration of human mononuclear cells towards a psoriatic scale extract
Sterling JC, Lidén S.
Extracts of psoriatic scales from patients with chronic plaque psoriasis and of normal human post-mortem skin were tested for their effects on the migration of healthy human mononuclear cells in a modified Boyden chamber. A preparation of cells containing 12-32% monocytes was obtained from whole blood by a density gradient technique. The cells were allowed to migrate through a polycarbonate filter ...
Pages: 543-546
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Selenium, glutathione-peroxidase and dermatitis herpetiformis
Ljunghall K, Juhlin L, Edqvist LE, Plantin LO.
The low levels of glutathione-peroxidase in blood from patients with dermatitis herpetiformis increased after 5 months selenium and vitamin E treatment. In this double-blind study no significant clinical improvement was, however, noted.
Pages: 546-547
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Eosinophilic granuloma associated with a 16q22 chromosomal defect of cutaneous T lymphocytes
Bisballe S, Thestrup-Pedersen K, Bjerring P, Jensen JJ, Ottosen PD, Kaltoft K.
A 61-year-old woman presented with circumscribed eczematous eruptions with maceration, erosions and patchy infiltration in the perineum and inframammary regions. A diagnosis of eosinophilic granuloma (cutaneous histiocytosis X) was established. T lymphocytes from a skin biopsy were grown in vitro for three weeks after which chromosomal studies revealed a break or gap at chromosome 16q22 in 15% of ...
Pages: 548-551
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Familial discoid lupus erythematosus associated with heterozygous C4 deficiency
Voigtländer V, Bahmer F, Hauptmann G.
Low levels of the fourth component of complement (C4) were found functionally and immunochemically in two sisters (17 and 22 years of age) suffering both from discoid lupus erythematosus. C4-typing of the family revealed that the two sisters and the mother had only two, and the father three of the four genes coding for C4 expressed. All carried the null allele C4B*QO. This observation adds to the ...
Pages: 552-554
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Scleredema and monoclonal gammopathy: report of two cases
Venencie PY, Powell FC, Su WP.
Two patients had scleredema with monoclonal gammopathy, one of whom was considered to have smoldering multiple myeloma. In one patient, the scleredema cleared without treatment, while in the other, the scleredema and the monoclonal gammopathy persisted unchanged.
Pages: 554-556
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Ophthalmological manifestations in patients with psoriasis
Catsarou-Catsari A, Katsambas A, Theodoropoulos P, Stratigos J
101 patients suffering from psoriasis have been examined ophthalmologically, in order to determine the incidence of the eye symptoms. The most important finding was iridocyclitis (uveitis) which was present in 3 out of 7 patients suffering from psoriatic arthritis.
Pages: 557-559
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Acute febrile neutrophilic dermatosis with genital involvement
Lindskov R.
More than 80 cases of acute febrile neutrophilic dermatosis have been published since Sweet in 1964 described the syndrome. Besides skin eruptions, some patients have mucous membrane lesions involving mouth and lips. This report describes a patient with a pustular eruption consistent with Sweet´s syndrome, who is believed to be the first with involvement of genital mucosa.
Pages: 559-561
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Dapsone in the treatment of Kaposi´s sarcoma
Poulsen A, Hultberg B, Thomsen K, Lange Wantzin G.
Previously we observed clinical and histological regression of Kaposi´s sarcoma in the skin in a 38-year-old man with AIDS following treatment with Dapsone. This observation initiated the present study where 6 patients with Kaposi´s sarcoma in the skin without clinical signs of systemic spreading were treated with Dapsone 100 mg daily for four months. During this treatment clinical and histologi ...
Pages: 561-563
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13-cis-retinoic acid effective in mycosis fungoides. A report from the Scandinavian Mycosis Fungoides Group
Thomsen K, Molin L, Volden G, Lange Wantzin G, Hellbe L.
Twenty patients with mycosis fungoides and four with S?©zary´s syndrome were treated with 13-cis-retinoic acid as single therapy in an initial dose of 1 to 2 mg per kg body weight in most cases. Complete remission in mycosis fungoides was obtained in six cases (33%) and partial remission in another ten cases (50%). No convincing response was observed in three cases, and progression of limited no ...
Pages: 563-566
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Mutilating palmoplantar keratoderma successfully treated with etretinate
Wereide K.
Three patients, a mother and her two sons, with mutilating palmoplantar keratoderma (Vohwinkel´s syndrome) were successfully treated with oral etretinate (Tigason). All of them had keratotic constriction furrows of one or more digits (pseudo-ainhum) with threatening spontaneous amputation. Oral treatment with etretinate brought about disappearance of the pseudo-ainhums and normalization of the di ...
Pages: 566-569
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Lichen planus and the liver
Mobacken H, Nilsson LA, Olsson R, Sloberg K.
No abstract available.
Page: 570
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