Content » Vol 47, Issue 4

Short communication

Interval training-induced alleviation of rigidity and hypertonia in patients with Parkinson’s disease is accompanied by increased basal serum brain-derived neurotrophic factor

Jarosław Marusiak, Ewa Żeligowska , Joanna Mencel, Katarzyna Kisiel-Sajewicz , Joanna Majerczak , Jerzy A. Zoladz , Artur Jaskólski , Anna Jaskólska
Department of Kinesiology, Faculty of Physiotherapy, University School of Physical Education in Wroclaw, 51-612 Wroclaw, Poland. E-mail:
DOI: 10.2340/16501977-1931


Objective: To examine the effects of cycloergometric interval training on parkinsonian rigidity, relaxed biceps brachii muscle tone in affected upper extremities, and serum level of brain-derived neurotrophic factor.
Design: Case series, repeated-measures design, pilot study.
Subjects/patients: Eleven patients with mild-to-moderate Parkinson’s disease (Hoehn & Yahr scale 2. 3 ± 0. 72), recruited from a neurological clinic, underwent cycle training and were tested along with non-trained, healthy control subjects (n = 11) in a motor control laboratory.
Methods: Patients underwent 8 weeks of interval training (3 × 1-h sessions weekly, consisting of a 10-min warm-up, 40 min of interval exercise, and 10-min cool-down) on a stationary cycloergometer. Parkinsonian rigidity (Unified Parkinson’s Disease-Rating-Scale) in the upper extremity, resting biceps brachii muscle tone (myometric stiffness and frequency), and brain-derived neurotrophic factor level were measured 1–3 days before interval training cycle started and 6–10 days after the last training session.
Results: Training resulted in a decrease in rigidity (p = 0. 048) and biceps brachii myometric muscle stiffness (p = 0. 030) and frequency (p = 0. 006), and an increase in the level of brain-derived neurotrophic factor (p = 0. 035) relative to pre-training values. The increase in brain-derived neurotrophic factor level correlated with improvements in parkinsonian rigidity (p = 0. 025), biceps brachii myometric stiffness (p = 0. 001) and frequency (p = 0. 002).
Conclusion: Training-induced alleviation of parkinsonian rigidity and muscle tone decrease may be associated with neuroplastic changes caused by a training-induced increase in the level of brain-derived neurotrophic factor.

Lay Abstract


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