Content - Volume 100, 100-year theme: Itch and pruritic disorders (Jan)

All articles

Acta Dermato-Venereologica – 100 years
Abstract is missing (Editorial)
Pages: 1-2
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Challenges in Clinical Research and Care in Pruritus
Manuel P. Pereira, Claudia Zeidler, Michael Storck, Konstantin Agelopoulos, Wolfgang G. Philipp-Dormston, Alexander Zink, Sonja Ständer
Chronic pruritus is a frequent global condition. The pathophysiology, underlying aetiology, clinical manifestation, associated burden and response to therapy of chronic pruritus varies from patient to patient, making clinical research and management of this condition challenging. There are still several unmet needs, such as the need to standardize translational research protocols, diagnostic and t ...
Pages: 45-51
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A New Generation of Treatments for Itch
Emilie Fowler, Gil Yosipovitch
For decades, antihistamines have been the mainstay of treatment for chronic pruritus, yet they often only work by making patients drowsy and forgetful of their itch. A new era of antipruritic drugs is quickly approaching, presenting more effective treatments for patients suffering from chronic itch. Several treatments have been developed targeting specific receptors in the nervous system, such as ...
Pages: 36-44
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Itch and Psyche: Bilateral Associations
Radomir Reszke, Jacek C. Szepietowski
Beginning from embryological development, skin and psyche are closely related to physiological state regardless of age. Altering the homeostasis of one of these components impacts on the other, thereby substantiating that the relationship between itch and psyche is bilateral. Itch has a complex pathogenesis, which involves the peripheral and central nervous systems, as well as various inflammatory ...
Pages: 27-35
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Non-dermatological Challenges of Chronic Itch
Andreas E. Kremer, Thomas Mettang, Elke Weisshaar
Chronic itch occurs in many skin diseases, but also in a variety of systemic, neurological, and psychogenic/psychosomatic disorders, or is caused by drug intake. When several diseases or causes co-exist, chronic itch is categorized as “mixed origin”. These patients present with unaltered skin or with chronic scratch lesions including chronic prurigo. Precise diagnostics are necessary to evalua ...
Pages: 21-26
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Mechanisms and Management of Itch in Dry Skin
Catharina Sagita Moniaga, Mitsutoshi Tominaga, Kenji Takamori
Chronic itch is a burdensome clinical problem that often accompanies pathological dry skin-based conditions, such as atopic dermatitis, and systemic disorders, such as kidney diseases, with an unclear pathomechanism and treatments. One of the basic mouse models to investigate mechanisms of itch associated with dry skin is a mixture of acetone and ether followed by water. Animal studies using the a ...
Pages: 9-20
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The Challenge of Basic Itch Research
Earl Carstens, Taylor Follansbee, Mirela Iodi Carstens
Basic mechanisms and pathways of itch signaling are reviewed, with an emphasis on the progress to date as well as remaining challenges in translating current knowledge to the clinical treatment of chronic itch. Recent studies reveal 3 subsets of pruriceptive sensory neurons highly expressing itch-related genes. Their fibers project into the spinal cord to activate neurons expressing gastrin releas ...
Pages: 2-8
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Complete ITCH theme
Pages: 1-52
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