Content - Volume 78, Issue 5

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Morphological Assessment of the Effects of Cyclosporin A on Mast Cell - Nerve Relationship in Atopic Dermatitis: Investigative Reports
Masahiko Toyoda, Masaaki Morohashi
There is considerable clinical and experimental evidence that cyclosporin A has powerful therapeutic effects on severe, therapy-resistant atopic dermatitis. To further clarify the mechanism of beneficial action of cyclosporin A for atopic dermatitis, we assessed its effects on mast cell morphology and on the topographical relationship between mast cells and cutaneous nerves in lesional skin of at ...
Pages: 321-325
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Decreased Staining of Heparan Sulfate in Non-lesional Skin of a Subgroup of Patients with Systemic Lupus Erythematosus
M. M. B Seyger, M. C. J. van Bruggen, H. K Hardeman, F. H. J van den Hoogen, J. H. M Berden, J van den Born, E. M. G. J de Jong
Heparan sulfate proteoglycans (HSPGs) are components of the basement membrane of various tissues. They are composed of a core protein and of the negatively charged glycosaminoglycan side chain heparan sulfate, which is covalently bound to the core protein. We previously found that in both human and murine lupus nephritis, heparan sulfate staining in the basement membrane of the glomerulus is almo ...
Pages: 326-330
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Tenascin-C is not a Useful Marker for Disease Activity in Psoriasis
Mieke A.H.E. Latijnhouwers, Mieke Bergers, Astrid L.A. Kuijpers, Carine J.M. van der Vleuten, Henri Dijkman, Peter C.M. van de Kerkhof, Joost Schalkwijk
Tenascin-C is an extracellular matrix glycoprotein that is markedly upregulated in the dermis of psoriatic skin. In this study, we have addressed the question whether the presence of tenascin-C in the lesion or in serum is a marker for disease activity. Immunohistochemical staining of tenascin-C before and after treatment with different topical and systemic medication showed that tenascin-C remai ...
Pages: 331-334
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Catalase in the Stratum Corneum of Patients with Polymorphic Light Eruption
M. Guarrera, P. Ferrari, A. Rebora
UV radiation generates reactive oxygen species, which may be involved in polymorphic light eruption. The endogenous enzymatic defense system includes catalase in the epidermis. Thirteen patients with a history of polymorphic light eruption, but free from lesions, and 13 controls were investigated from November to March. Catalase was analysed in the upper horny layer according to Colin et al.'s sp ...
Pages: 335-336
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The Effects of Fibroblast Growth Factors 1 and 2 on Fibre Growth of Wool Follicles in Culture
J. J. Bond, P. C. Wynn, G. P. M. Moore
The effects of fibroblast growth factor-1 (FGF-1) and FGF-2 on fibre growth and follicle function were examined using a previously described procedure to culture wool follicles. Because the FGFs bind to glycosaminoglycan components of the extra-cellular matrix, we also investigated interactions between FGF-1 and FGF-2 with heparin on wool fibre growth.
Individual follicles were microdissected ...
Pages: 337-342
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Expression of Stratum Corneum Chymotryptic Enzyme in Human Sebaceous Follicles
Elisabeth Ekholm, Björn Sondell, Per Strandén, Maria Brattsand, Torbjörn Egelrud
Stratum corneum chymotryptic enzyme (SCCE) may be involved in desquamation, a process necessary for maintaining a normal anatomy at all sites where there is continuous turnover of cornified epithelia. Using immunohistochemistry and in situ hybridization, we have, in this work, analysed SCCE expression in the sebaceous follicle. We found expression of SCCE in luminal parts of the pilary can ...
Pages: 343-347
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Cis-Urocanic Acid Down-regulates Histamine-mediated Activation of Adenylate Cyclase in the Pig Epidermis
Tadamichi Shimizu, Hiroko Koizumi, Hideaki Nishino, Riichiro Abe, Akira Ohkawara
Urocanic acid (UCA), one of the skin's major components for absorbing UV radiation, is present naturally in the stratum corneum as a trans-isomer. On absorption of UVB radiation either in vitro or in the skin, UCA undergoes trans-to cis-isomerization in a dose-dependent manner. Although the mechanism by which cis-UCA suppresses immunity remains unelucidated, rec ...
Pages: 348-350
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Chilblains and Raynaud Phenomenon are Usually not a Sign of Hereditary Protein C and S Deficiencies: Clinical Reports
H. Benchikhi, J. C. Roujeau, M. Levent, M. Gouault-Heilmann, J. Revuz, A. Cosnes
Hereditary protein C and S deficiencies are risk factors for thrombosis. They are associated with purpura fulminans and coumarin-induced skin necrosis. Recently, necrotic livedo of the extremities, severe chilblains and severe frostbite have been observed in protein C or S deficient patients. Our study was designed to evaluate the prevalence of cold-induced acral manifestations in patients with p ...
Pages: 351-352
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Post-Kala-Azar Dermal Leishmaniasis - An Unusual Presentation
Shruti Lakhanpal, R. K. Pandhi, Binod Khaitan
Post-kala-azar dermal leishmaniasis can present as hypopigmented macules, erythematous to skin-coloured papules, nodules and photosensitive butterfly erythema on the face. We present a patient with disseminated annular lesions of post-kala-azar dermal leishamaniasis. The patient was treated with daily intravenous injections of sodium antimony gluconate for 120 days at a dose of 20 mg/kg body weig ...
Pages: 353-354
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Systematic Cutaneous Examination in Hepatitis C Virus Infected Patients
Bernard Cribier, Florence Samain, Denis Vetter, Ernest Heid, Edouard Grosshans
The purpose of this study was to evaluate the frequency of skin changes among 100 patients from the Hepatogastroenterology Department of the University Hospital, Strasbourg, France who were hepatitis C virus-positive (HCV) and HIV-negative. Their clinical data were compared to those of 50 HCV-, and HIV-negative patients from the same Department, who suffered from various liver diseases.
Psori ...
Pages: 355-357
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Contact Allergies in Healthcare Workers. Results from the IVDK
A. Schnuch, W. Uter, J. Geier, P. J. Frosch, T. Rustemeyer
Healthcare workers often suffer from occupational skin disease frequently caused by allergic sensitization. Therefore the patch-test results and important patient history items of 31,849 patients recorded between 1992 and 1995 in the 24 allergy departments participating in the Information Network of Departments of Dermatology (IVDK) were evaluated. Significantly increased sensitization rates comm ...
Pages: 358-363
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The Quantification of Patch Test Responses: A Comparison Between Echographic and Colorimetric Methods
Stefania Seidenari, Barbara Belletti
Patch testing is widely used both for clinical and experimental purposes. Although the clinical grading employed routinely is of practical value, the lack of objectivity makes it unsuitable for research purposes and dose-response analysis studies. Instrumental measuring techniques have been applied to patch test evaluation, because they enable objective quantification of different biophysical asp ...
Pages: 364-366
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The Significance of Previous Contact Dermatitis for Elicitation of Contact Allergy to Nickel
Monica Hindsén, Magnus Bruze
In 2 earlier studies, we found increased nickel re-test reactivity at earlier experimentally induced nickel eczema sites. The aim of this study was to investigate if earlier contact dermatitis caused by another allergen or earlier irritant contact dermatitis also influenced the reactivity when nickel was applied topically on earlier but healed dermatitis sites. Twenty-three females with contact a ...
Pages: 367-370
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Prevalence of Self-reported Hand Dermatosis in Upper Secondary School Pupils
Maria Yngveson, Åke Svensson, Åke Isacsson
The purpose of the present study was to estimate the prevalence of self-reported hand dermatosis among upper secondary school pupils. All pupils in grades 1 and 3 from the four upper secondary schools in Växjö, southern Sweden, were invited to participate in the study. A previously validated questionnaire was used. Of the 2609 invited pupils, 2572 (98.6%) responded to the questionnaire. The poi ...
Pages: 371-374
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Kimura's Disease Associated with Ulcerative Colitis: Detection of IL-5 mRNA Expression of Peripheral Blood Mononuclear Cells and Colon Lesion
Makoto Sugaya, Takehisa Suzuki, Akihiko Asahina, Koichiro Nakamura, Mamitaro Ohtsuki, Kunihiko Tamaki
Kimura's disease is considered to be a Th2 type allergic reaction based on the presence of eosinophilia and IgE hyperimmunoglobulinemia. We report a 26-year-old Japanese male with this disorder associated with ulcerative colitis. IL-5 is a selective stimulator for the production of eosinophilia and is considered to play an important role in Kimura's disease. IL-5 mRNA from peripheral blood mononu ...
Pages: 375-377
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Naevi Spili, Café-au-lait Spots and Melanocytic Naevi Aggregated Alongside Blaschko's Lines, with a Review of Segmental Melanocytic Lesions
Nicole Langenbach, Alexander Pfau, Michael Landthaler, Wilhelm Stolz
This is the first case in the literature describing naevi spili, café-au-lait spots and melanocytic naevi aggregated alongside Blaschko's lines. The pattern of melanocytic lesions in our patient is different from the congenital pigmentary syndromes and the segmental distribution of melanocytic naevi, the quadrant distribution of dysplastic naevi or the partial unilateral lentiginosis which here ...
Pages: 378-380
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Sporotrichoid Tuberculoid Leprosy
V. Ramesh, Sudhir B.L. Kulkarni, R. S. Misra, A. S. Rathore
This article does not have an abstract.
Page: 381
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Familial Acne Keloidalis
Paschal D'Souza, Venkateshwaran Iyer, M. Ramam
This article does not have an abstract.
Page: 382
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Acute Generalized Exanthematous Pustulosis upon Ingestion of a Progesterone Preparation
Y. Kuno, T. Tsuji
This article does not have an abstract.
Page: 383
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Higher Incidence of Rolled Hairs in Renal Transplant Recipients: a Possible Complication of Corticosteroid and Cyclosporine Therapy
Deniz Seçkin, Tülin O<uz Güleç, Mehmet Haberal
This article does not have an abstract.
Page: 384
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Comparison of Betamethasone Valerate Solution with Phototherapy (UVB Comb) in Scalp Psoriasis Treatment
Rosemarie Braun, Lars Kåre Dotterud, Edvard Falk
This article does not have an abstract.
Page: 385
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A Follicular Lichenoid Eruption as Manifestation of Chronic Graft-vs-Host Disease
R. Valks, E. Vargas, J. Fraga, P. F. Peñas, J. Fernández-Herrera
This article does not have an abstract.
Page: 386
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The Number of Diagnostic Features in Patients with Atopic Dermatitis Correlates with Dryness Severity
Marie Lodén, Anna-Carin Andersson, Magnus Lindberg
This article does not have an abstract.
Pages: 387-388
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Treatment of Acne Vulgaris with Colchicine
S. J. Sadjadi, M. Moshir
This article does not have an abstract.
Page: 388
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Co2 Laser Eradication of Recalcitrant Condyloma Acuminatum Does Not Influence T-lymphocyte Subsets
Carsten Petersen, Steffen Munkvad, Claus Bohn Christiansen
This article does not have an abstract.
Page: 389
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The So-called Striated Muscle Hamartoma is a Hamartoma of Cutaneous Adnexa and Mesenchyme, But Not of Striated Muscle
Renato Grilli, Pilar Escalonilla, M. Luisa Soriano, Carmen Fariña, Guadalupe Renedo, Lucía Martin, Luis Requena
This article does not have an abstract.
Page: 390
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Adnexal Polyp of Neonatal Skin Observed Beyond the Neonatal Period
Hiroko Koizumi, Eri Itoh, Akira Ohkawara
This article does not have an abstract.
Pages: 391-392
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Erythema Multiforme Combined with Legionellosis
C. Toledano, L. Machet, N. Gironet, V. Jan, N. Van der Mee-Marquet, L. Vaillant, G. Lorette
This article does not have an abstract.
Page: 392
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Severe Drug-induced Pneumonitis Associated with Minocycline and Nicotinamide Therapy of a Bullous Pemphigoid
Hiroyuki Hara, Ayako Fujitsuka, Chizuko Morishima, Nobuyuki Kurihara, Zen-Ichi Yamaguchi, Takafumi Morishima
This article does not have an abstract.
Pages: 393-394
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Delayed Pressure Urticaria Causing Obstruction of Urinary Flow
E. Poon, A. Kobza-Black
This article does not have an abstract.
Page: 394
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Chronic Urticaria and IgA Myeloma
Dan Lipsker, Bernard Cribier, Frederic Maloisel, Ernest Heid, Edouard Grosshans
This article does not have an abstract.
Page: 395
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The Anti-BRCA1 Peptide Antibody C-20 Recognizes Smooth Muscle Cells
Sumihisa Imakado, Toshihiko Hoashi, Takeshi Tateishi, Fujio Otsuka
This article does not have an abstract.
Pages: 396-397
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A Case of Pigmented Purpuric Eruption Associated with Hereditary Spherocytosis
Oktay Taykapan, Bilal Do<an, Gökhan Kandemir, önder Bozdo<an, Yavuz Harmanyeri
This article does not have an abstract.
Pages: 397-398
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Lichen Amyloidosis in an HIV-infected Patient. A Case Report and Review of the Literature
Ashok Vaghjimal, Hussain Ahmad, Norberto Soto, Khodadad Mehrein, Edward Chapnick
This article does not have an abstract.
Page: 399
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