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Content - Volume 81, Issue 4

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EDITORIAL
A Spectrum of Dermato-venereological Research
Anders Vahlquist A1
This article does not have an abstract.
Page: 241
Abstract  PDF
INVESTIGATIVE REPORT
Microsatellite Instability in Malignant Melanomas
Maximilian M. Kroiss A1, Thomas M. M. Vogt A1, Jürgen Schlegel A2, Michael Landthaler A1, Wilhelm Stolz A1
Microsatellite instability (MSI) is caused by deficient DNA mismatch repair, and results in a ''mutator'' phenotype. Recent studies have produced contradictory results about the frequency and significance of MSI in malignant melanomas. In this study, we therefore determined the time of onset and relative frequency of MSI during the progression of melanocytic tumours, including benign melanocytic ...
Pages: 242-245
Abstract  PDF
INVESTIGATIVE REPORT
Can Autofluorescence Demarcate Basal Cell Carcinoma from Normal Skin? A Comparison with Protoporphyrin IX Fluorescence
Renhua Na A1, Ida-Marie Stender A1, Hans Christian Wulf A1
Fluorescence detection may help to demarcate skin cancer from normal skin, thus to reduce the potential of incomplete treatment resulting from unawareness of tumour extension in surrounding skin. In this study we evaluated the difference between autofluorescence of basal cell carcinomas (n = 21) and the normalappearing skin surrounding them. Referring to the difference found, a point-by-po ...
Pages: 246-249
Abstract  PDF
INVESTIGATIVE REPORT
Scratch Induction in the Rat by Intradermal Serotonin: a Model for Pruritus
J. S. Thomsen A1, M. B. Petersen A2, E. Benfeldt A1, S. B. Jensen A3, J. Serup A4
Eight substances (histamine, compound 48/80, kallikrein, trypsin, papain, substance P, serotonin and platelet activating factor) were injected intradermally (volume 50 w l) into the rostral back (neck) of rats in order to establish an animal model for peripherally elicited pruritus. While serotonin induced excessive scratching at the site of injection, the other su ...
Pages: 250-254
Abstract  PDF
INVESTIGATIVE REPORT
Cytokine Profile of Patients with Mycosis Fungoides and the Immunomodulatory Effect of AS101
M. Shohat A1, E. Hodak A1, B. Sredni A2, B. Shohat A3, D. Sredni A2, M. David A1
Cytokines are known to play a major role in the pathogenesis of mycosis fungoides, a cutaneous malignant neoplasm of CD 4 T cells. In the present study, we investigated the effect of AS101, a tellurium-based compound with immunomodulating properties, on the pattern of lymphokine production by peripheral blood mononuclear cells (PBMCs) from patients with mycosis fungoides. PBMCs were isolated from ...
Pages: 255-257
Abstract  PDF
INVESTIGATIVE REPORT
Stereological Quantification of Lymphocytes in Skin Biopsies from Atopic Dermatitis Patients
Anne Ringer Ellingsen A1, Flemming Brandt Sørensen A2, Jytte Overgaard Larsen A3, Mette Søndergaard Deleuran A4, Kristian Thestrup-Pedersen A4
Atopic dermatitis (AD) is histologically characterized by lymphocytic infiltration of the skin and quantitative assessment is required. This study introduces stereological techniques to quantify the number of lymphocytes in skin biopsies. Fourmillimetre punch biopsies were taken from skin with active eczema in 8 adults with AD and from clinically normal skin from 4 of the patients. Five persons w ...
Pages: 258-262
Abstract  PDF
INVESTIGATIVE REPORT
Expression and Function of CD43 and CDw60 on T Cells from Patients with Atopic Dermatitis
Naoyuki Higashi A1, Kaida Wu A2, Christian Grønhøj Larsen A2, Mette Deleuran A2, Seiji Kawana A3, Kazuya Yamamoto A4, Kristian Thestrup-Pedersen A2
Signalling via the CD43 and CDw60 epitopes has been reported as providing two novel pathways of T-lymphocyte activation. In Wiskott-Aldrich syndrome, which has atopic eczema-like skin symptoms, there is a defective expression of CD43, while CDw60 is strongly expressed on T cells from rheumatoid arthritis synovial fluid and from psoriatic skin lesions, and on blood mononuclear cells from patients ...
Pages: 263-267
Abstract  PDF
CLINICAL REPORT
Increasing Incidence Rates of Squamous Cell Carcinoma of the Skin in Sweden
Cecilia Wassberg A1, Magnus Thörn A2, Anna-Maria Johansson A3, Reinhold Bergström A4, Berit Berne A1, Ulrik Ringborg A5
The incidence of squamous cell carcinoma of the skin is increasing world-wide, and in Sweden this tumour is one of the most rapidly increasing malignancies. The aim of this study was to investigate incidence trends of squamous cell carcinoma in Sweden. For the 39,805 tumours registered in the Swedish Cancer Registry 1961-1995, incidence rates were calculated according to gender, age, anatomical s ...
Pages: 268-272
Abstract  PDF
CLINICAL REPORT
Clinical Scoring of Cutaneous Mastocytosis
Rogier Heide A1, Maritza A. Middelkamp Hup A1, Paul G. H. Mulder A2, Arnold P. Oranje A3
There are still many controversies in defining and evaluating mastocytosis. One of the aspects that is missing is a system for clinical evaluation of mastocytosis of the skin. A calculation based on a semi-quantitative analysis of three aspects of mastocytosis was designed. The method is called the scoring index of mastocytosis (SCORMA). The clinical use of SCORMA is advocated.
Pages: 273-276
Abstract  PDF
CLINICAL REPORT
Development and Validation of a Questionnaire for Diagnosing Atopic Dermatitis
Anne B. Olesen A1, Karen Bang A1, Svend Juul A2, Kristian Thestrup-Pedersen A1
In this paper we describe the development and validation of a questionnaire for atopic dermatitis used in population surveys in Denmark. The Danish questionnaire was developed from the UK Working Party's questionnaire for atopic dermatitis and includes a severity score. The study included 61 children aged 3 to 14 years recruited from our Department of Dermatology, two kindergartens and a primary ...
Pages: 277-281
Abstract  PDF
CLINICAL REPORT
Sugar is Not an Aggravating Factor in Atopic Dermatitis
Imke Ehlers A1, Margitta Worm A1, Wolfram Sterry A1, Torsten Zuberbier A1
Patients with atopic dermatitis frequently blame food for worsening their eczema. Recently, a sugar-free diet has become very popular among German patients. In order to investigate whether sucrose is an aggravating factor in atopic dermatitis, we conducted a prospective study in 30 patients. Double-blind, placebo-controlled food challenges with sugar were performed during a sugar-free diet period ...
Pages: 282-284
Abstract  PDF
CLINICAL REPORT
Cervical, Urine and Vaginal Specimens for Detection of Chlamydia trachomatis by Ligase Chain Reaction in Women: A Comparison
Eva Hjelm A1, Anders Hallén A2, Marius Domeika A1
Screening for Chlamydia trachomatis in women is generally done using only one specimen from each patient in order to minimize costs. In this study the aim was to compare the performances of vaginal, cervical and urinary specimens in a population of young women with sparse symptoms. During 1998, specimens from 1,001 women at the Departments of Venereology and Youth Health Care at the Univer ...
Pages: 285-288
Abstract  PDF
CLINICAL REPORT
Human Herpesvirus 6 and 7 DNA in Peripheral Blood Leucocytes and Plasma in Patients with Pityriasis Rosea by Polymerase Chain Reaction: A Prospective Case Control Study
Antonio An Tung Chuh A1, Susan Shui Seng Chiu A2, Joseph Sriyal Malik Peiris A3
An association between pityriasis rosea and human herpesvirus 7 (HHV-7) has been reported but remains controversial. The purpose of the present study was to investigate the association between HHV-6 and HHV-7 with pityriasis rosea. Fifteen patients aged 6-54 years with a diagnosis of pityriasis rosea and 15 age-matched controls were recruited. None of the patients had HHV-6 or HHV-7 DNA detected ...
Pages: 289-290
Abstract  PDF
CLINICAL REPORT
Cutaneous Infection with Mycobacterium fortuitum after Localized Microinjections (Mesotherapy) Treated Successfully with a Triple Drug Regimen
Eduardo Nagore A1, Pilar Ramos A2, Rafael Botella-Estrada A1, José A. Ramos-Ñíguez A2, Onofre Sanmartín A3, Pilar Castejón A4
Mesotherapy is a treatment method devised for controlling pain syndromes or diseases by subcutaneous microinjections given at or around the involved areas at short intervals of time. Different adverse effects have been described due to this modality of treatment. This report describes 3 patients with cutaneous infection caused by Mycobacterium fortuitum after mesotherapy. Three women, aged ...
Pages: 291-293
Abstract  PDF
CLINICAL REPORT
Systemic Sclerosis-related Raynaud's Phenomenon: Effects of Iloprost Infusion Therapy on Serum Cytokine, Growth Factor and Soluble Adhesion Molecule Levels
M. Mittag A1, P. Beckheinrich A1, U.-F. Haustein A1
Microvascular damage occurs in systemic sclerosis and is associated with increased serum levels of endothelial adhesion molecules and endothelium-associated cytokines, including vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin, endothelin-1 and vascular endothelial growth factor (VEGF). Iloprost, a prostacyclin analogue, induces clinical benefit i ...
Pages: 294-297
Abstract  PDF
CLINICAL REPORT
Angiooedema Due to Acquired Deficiency of C1-Esterase Inhibitor Associated with Leucocytoclastic Vasculitis
Henriette Farkas A1, Mariann Szongoth A2, Miklós Bély A3, Lilian Varga A4, Béla Fekete A5, István Karádi A5, George Füst A5
A hereditary and an acquired type of C1-esterase inhibitor deficiency have been described. Manifestations characteristic of both forms include recurrent subcutaneous and submucosal angiooedema. Acquired C1-esterase inhibitor deficiency has been observed in association with lymphoproliferative disorders, malignancy, autoimmune diseases and infections. We report on a case with the acquired form of ...
Pages: 298-300
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LETTER TO THE EDITOR
Topical Imiquimod Treatment of Human Papillomavirus in a Patient with Human Immunodeficiency Virus
Jeffrey Gilbert A1, Molly M. Drehs A2, Jeffrey M. Weinberg A2
This article does not have an abstract.
Pages: 301-302
Abstract  PDF
LETTER TO THE EDITOR
Delayed Granulomatous Lesion at the Bacillus Calmette-Guérin Vaccination Site
Barbara Gasior-Chrzan A1
This article does not have an abstract.
Pages: 302-304
Abstract  PDF
LETTER TO THE EDITOR
Ketoprofen-induced Pemphigus-like Dermatosis: Localized Contact Pemphigus?
Jean Kanitakis A1, Anne-Laure Souillet A1, Michel Faure A1, Alain Claudy A1
This article does not have an abstract.
Pages: 304-305
Abstract  PDF
LETTER TO THE EDITOR
Squamous Cell Carcinoma of the Nail Bed: A Rare Disease or Only Misdiagnosed?
Annarosa Virgili A1, Maria Rosaria Zampino A1, Sandra Bacilieri A1, Vincenzo Bettoli A1, Michele Chiarelli A2
This article does not have an abstract.
Pages: 306-307
Abstract  PDF
LETTER TO THE EDITOR
Malignant Granular Cell Tumour with Generalized Metastases and Polymyositis
U.-F. Haustein A1
This article does not have an abstract.
Pages: 307-308
Abstract  PDF
LETTER TO THE EDITOR
Chronic Giardia intestinalis Infection Presenting with Clinical Features Mimicking Lichen Planus
Camilla Vassallo A1, Valeria Brazzelli A1, Sara Martinoli A1, Marco Ardigò A1, Michela Quaglini A1, Massimo Scaglia A2, Giovanni Borroni A1
This article does not have an abstract.
Pages: 309-310
Abstract  PDF
LETTER TO THE EDITOR
A Patient with a Mucocutaneous Eruption and Intestinal Giardiasis
K. Lammintausta A1, P. Kotilainen A2, U. Hohenthal A2, L. Talve A3
This article does not have an abstract.
Pages: 310-311
Abstract  PDF
LETTER TO THE EDITOR
Specific Human Papillomaviruses Could Participate in Epidermal Hyperproliferation and Autoimmune Phenomena in Psoriasis
Slawomir Majewski A1, Michel Favre A2, Gerard Orth A2, Stefania Jablonska A1
This article does not have an abstract.
Page: 312
Abstract  PDF
LETTER TO THE EDITOR
Intravenous Pyogenic Granuloma of the Hand
Hiromiki Hayashi A1, Tadamichi Shimizu A1, Tetsuri Matsumura A1, Hiroshi Shimizu A1
This article does not have an abstract.
Pages: 313-314
Abstract  PDF
LETTER TO THE EDITOR
Treatment of Lichenified Atopic Eczema with Tacrolimus Ointment
Ha˚kan Granlund A1, Anita Remitz A1, Hannele Kyllönen A1, Antti I. Lauerma A1, Sakari Reitamo A1
This article does not have an abstract.
Pages: 314-315
Abstract  PDF
LETTER TO THE EDITOR
Inflammation of Seborrheic Keratoses due to Docetaxel Treatment
Chia-Yu Chu A1, Chih-Hsin Yang A2, Hsien-Ching Chiu A1
This article does not have an abstract.
Pages: 316-317
Abstract  PDF
LETTER TO THE EDITOR
Increased Serum Level of Vascular Endothelial Growth Factor in Crow-Fukase Syndrome
Toshiyuki Yamamoto A1, Mieko Kuroda A1, Kiyoshi Nishioka A1
This article does not have an abstract.
Pages: 317-318
Abstract  PDF
LETTER TO THE EDITOR
Discoid Lupus Erythematosus in a Patient Receiving Cyclosporine for Liver Transplantation
Gerlinde Obermoser A1, Florian Weber A1, Norbert Sepp A1
This article does not have an abstract.
Page: 319
Abstract  PDF