Content

Content - Volume 94, Issue 4

Editors choice in this issue

REVIEW
Phosphoinositide-3 Kinase/Protein Kinase-B/Mammalian Target of Rapamycin Pathway in Psoriasis Pathogenesis. A Potential Therapeutic Target?
Tian Huang, Xiran Lin, Xianmin Meng, Mao Lin
Psoriasis is a common chronic inflammatory disease of the skin. Its pathogenesis has not been completely elucidated. Phosphoinositide-3 kinase/protein kinase-B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway has been identified as a key signaling pathway for important cellular functions. The data collected in this review suggest that overexpression of the PI3K/Akt/mTOR pathway may play an im ...
Pages: 371-379
Abstract  HTML  PDF
CLINICAL REPORT
The Risk of Skin Cancer in Psoriasis Patients Treated with UVB Therapy
Amra Osmancevic, Martin Gillstedt, Ann-Marie Wennberg, Olle Larkö
Phototherapy is an effective and widely used treatment for generalised plaque psoriasis. Despite the mutagenic effects of UVB this type of therapy is still assumed to be a safe treatment option. We have performed a cross sectional study to assess the risk of skin cancer in the cohort of psoriasis patients treated with UVB. A total of 162 white patients (116 men and 46 women, mean ± st ...
Pages: 425-430
Abstract  HTML  PDF
SHORT COMMUNICATION
Sun-induced Pustular Dermatosis of the Scalp – A New Variant of Erosive Pustular Dermatosis of the Scalp?
Birgit Aigner, Franz J. Legat, Christian Schuster, Laila El Shabrawi-Caelen
Abstract is missing (Short)
Pages: 457-458
Abstract  HTML  PDF

All articles

REVIEW
Phosphoinositide-3 Kinase/Protein Kinase-B/Mammalian Target of Rapamycin Pathway in Psoriasis Pathogenesis. A Potential Therapeutic Target?
Tian Huang, Xiran Lin, Xianmin Meng, Mao Lin
Psoriasis is a common chronic inflammatory disease of the skin. Its pathogenesis has not been completely elucidated. Phosphoinositide-3 kinase/protein kinase-B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway has been identified as a key signaling pathway for important cellular functions. The data collected in this review suggest that overexpression of the PI3K/Akt/mTOR pathway may play an im ...
Pages: 371-379
Abstract  HTML  PDF
CLINICAL REPORT
Regulatory Networks Contributing to Psoriasis Susceptibility
Kornélia Szabó, Zsuzsanna Bata-Csörgő, Attila Dallos, Attila Bebes, László Francziszti, Attila Dobozy, Lajos Kemény, Márta Széll
The non-involved, healthy-looking skin of psoriatic patients displays inherent characteristics that make it prone to develop typical psoriatic symptoms. Our primary aim was to identify genes and proteins that are differentially regulated in the non-involved psoriatic and the normal epidermis, and to discover regulatory networks responsible for these differences. A cDNA microarray experiment was pe ...
Pages: 380-385
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Expression of Class II Cytokine Genes in Children’s Skin
Paula Reemann, Ene Reimann, Siim Suutre, Maarjaliis Paavo, Ulvi Loite, Orm Porosaar, Kristi Abram, Helgi Silm, Eero Vasar, Sulev Kõks, Külli Kingo
Immune regulation of the skin plays an important role in susceptibility and development of illnesses. The aim of our study was to localise the interleukin (IL)-10 family of cytokines, in children’s skin and to determine possible age-related differences in the expression level. The mRNA expression level of IL10, IL19, IL20, IL22, IL24, IL26, IL28B, IL29 and their receptors IL10RA, IL10RB, IL20RA, ...
Pages: 386-392
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Small Bowel Transglutaminase 2-specific IgA Deposits in Dermatitis Herpetiformis
Teea T. Salmi, Kaisa Hervonen, Kaija Laurila, Pekka Collin, Markku Mäki, Outi Koskinen, Heini Huhtala, Katri Kaukinen, Timo Reunala
Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease. Untreated coeliac disease patients are known to have transglutaminase 2 (TG2)-targeted IgA deposits in the small bowel mucosa. To evaluate whether similar intestinal IgA deposits are also present in DH and whether the deposits disappear with gluten-free diet, 47 untreated and 27 treated DH patients were studied. ...
Pages: 393-397
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Usage Tests of Oak Moss Absolutes Containing High and Low Levels of Atranol and Chloroatranol
Martin Mowitz, Cecilia Svedman, Erik Zimerson, Magnus Bruze
Atranol and chloroatranol are strong contact allergens in oak moss absolute, a lichen extract used in perfumery. Fifteen subjects with contact allergy to oak moss absolute underwent a repeated open application test (ROAT) using solutions of an untreated oak moss absolute (sample A) and an oak moss absolute with reduced content of atranol and chloroatranol (sample B). All subjects were in addition ...
Pages: 398-402
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Significant Differences in Nurses’ Knowledge of Basic Wound Management – Implications for Treatment
Kian Zarchi, Seemab Latif, Vibeke B. Haugaard, Ida R.C. Hjalager, Gregor B.E. Jemec
Wounds represent a growing healthcare problem due to an aging population. Nurses play a key role in wound management and their theoretical understanding of basic wound management may be expected to influence the quality of wound therapy fundamentally. In this study, we evaluated the level of knowledge of wound management in 136 Danish nurses working in 3 different settings: advanced wound care cli ...
Pages: 403-407
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Patch Testing with Formaldehyde 2.0% in Parallel with 1.0% by the Swedish Contact Dermatitis Research Group
Marléne Isaksson, Johanna Bråred-Christensson, Malin Engfeldt, Magnus Lindberg, Mihaly Matura, Halvor Möller, Kristina Ryberg, Berndt Stenberg, Cecilia Svedman, Magnus Bruze
In a multicentre study consecutively patch-tested dermatitis patients were tested simultaneously with 1.0% and 2.0% (w/v) formaldehyde in aqua applied with a micropipette (15 µl) to the filter paper disc in Finn Chambers (0.30 mg/cm2 and 0.60 mg/cm2, respectively). A total of 2,122 dermatitis patients were patch-tested. In all, 77 (3.6%) patients reacted positively to formaldehyde; 37 reacted onl ...
Pages: 408-410
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Quality of Life Assessment of Patients with Scalp Dermatitis Using the Italian Version of the Scalpdex
Francesca Sampogna, Dennis Linder, Stefano Piaserico, Gianfranco Altomare, Marco Bortune, Piergiacomo Calzavara-Pinton, Camilla Dalle Vedove, Giampiero Girolomoni, Andrea Peserico, Raffaella Sala, Damiano Abeni
The aim of this study was to assess quality of life in patients with scalp dermatitis using the Italian version of the Scalpdex, and to validate the instrument in Italian. The survey was conducted in outpatients with psoriasis, seborrhoeic dermatitis, alopecia, or follicular lichen. Data were completed on 194 patients, 78% of whom had psoriasis. Scalpdex scores were always higher in women than in ...
Pages: 411-414
Abstract  HTML  PDF
CLINICAL REPORT
Three Randomised Phase I/IIa Trials of 5% Cis-urocanic Acid Emulsion Cream in Healthy Adult Subjects and in Patients with Atopic Dermatitis
Juha M. Peltonen, Liisa Pylkkänen, Christer T. Jansén, Iina Volanen, Terhi Lehtinen, Jarmo K. Laihia, Lasse Leino
New treatment modalities are needed in atopic dermatitis. We evaluated the pharmacokinetics, safety, tolerability, and efficacy of topical cis-urocanic acid (cis-UCA) cream in randomised vehicle-controlled double-blinded clinical trials. The subjects received 5% cis-UCA emulsion cream and control vehicle on volar forearms after right–left randomisation. Study 1: 16 healthy subjects received one ...
Pages: 415-420
Abstract  HTML  PDF
CLINICAL REPORT
The Prevalence of Skin Disorders in Norwegian Paediatric Renal Transplant Recipients
Jan Cezary Sitek, Trine Tangeraas, Anna Bjerre, Per Helsing
A few key publications report on the frequency of skin disorders in paediatric organ transplant recipients in Southern and Central Europe presenting cumulative incidences. We aimed to estimate frequencies of skin disorders both as cumulative incidences and prevalence data, and describe skin problems in paediatric renal transplant recipients in a Norwegian renal transplant population. Clinical exam ...
Pages: 421-424
Abstract  HTML  PDF
CLINICAL REPORT
The Risk of Skin Cancer in Psoriasis Patients Treated with UVB Therapy
Amra Osmancevic, Martin Gillstedt, Ann-Marie Wennberg, Olle Larkö
Phototherapy is an effective and widely used treatment for generalised plaque psoriasis. Despite the mutagenic effects of UVB this type of therapy is still assumed to be a safe treatment option. We have performed a cross sectional study to assess the risk of skin cancer in the cohort of psoriasis patients treated with UVB. A total of 162 white patients (116 men and 46 women, mean ± st ...
Pages: 425-430
Abstract  HTML  PDF
CLINICAL REPORT
Bowen’s Disease: A Six-year Retrospective Study of Treatment with Emphasis on Resection Margins
Annet Westers-Attema, Fleur van den Heijkant, Bjorn G.P.M. Lohman, Patty J. Nelemans, Veronique Winnepenninckx, Nicole W.J. Kelleners-Smeets, Klara Mosterd
Bowen’s disease is an in situ squamous cell carcinoma of the skin with various treatment modalities available. A major advantage of surgical excision is the opportunity to histologically examine the resection margins. There is no consensus about the most appropriate margin. This retrospective study evaluates the clearance rates achieved by excision with a 5 mm margin and estimates how that might ...
Pages: 431-435
Abstract  HTML  PDF
CLINICAL REPORT
Hereditary Angioedema – Consequences of a New Treatment Paradigm in Denmark
Anette Bygum
Experiences from a Danish patient cohort with hereditary angioedema are reported with focus on home therapy and burden of illness. Eighty patients have been prospectively followed over 11 years, having experienced a total of 7,809 attacks over 469 patient years. More than half of the patients stopped long-term prophylaxis with danazol or tranexamic acid and changed treatment regimen to on-demand ...
Pages: 436-441
Abstract  HTML  PDF
CLINICAL REPORT
Health-related Quality of Life in Epidermolysis Bullosa: Validation of the Dutch QOLEB Questionnaire and Assessment in the Dutch Population
Wing Yan Yuen, John W. Frew, Kelly Veerman, Edwin R. van den Heuvel, Dedee F. Murrell, Marcel F. Jonkman
Defining the health-related quality of life (HRQoL) in patients suffering from the heritable blistering disease epidermolysis bullosa (EB) is important in assessing the efficacy of new treatments. The quality of life in EB questionnaire (QOLEB) is an English 17-item EB-specific HRQoL measurement tool. The aim of this study was to develop a validated and reliable QOLEB in Dutch and assess the HRQoL ...
Pages: 442-447
Abstract  HTML  PDF
CLINICAL REPORT
Cutaneous Deliberate Self-harm in Polish School Teenagers – An Inter­disciplinary Challenge
Agnieszka Gmitrowicz, Adrian Kostulski, Pawel Kropiwnicki, Anna Zalewska-Janowska
Self-harm of the skin is a complex problem encountered mainly in adolescents and young adults. The aim of the study was to assess the prevalence of deliberate cutaneous self-harm without suicidal intent among secondary school teenagers of the Lodz region. A self-administered specially designed anonymous questionnaire was delivered to 1,448 secondary school teenagers, aged 12–19 years. The lifeti ...
Pages: 448-453
Abstract  HTML  PDF
CLINICAL REPORT
Cutaneous Location of Atypical Teratoid/Rhabdoid Tumour
Nathalia Bellon, Sylvie Fraitag, Catherine Miquel, Laurent J. Salomon, Franck Bourdeaut, Christine Bodemer, Thomas Roujeau, Michel Zerah, Smail Hadj-Rabia
Atypical teratoid/rhabdoid tumour is a rare and highly malignant tumour of the posterior fossae nervous system that occurs in children especially in the first few years of life. Cutaneous location is not previously reported. A newborn boy was referred for both aqueductal stenosis detected antenatally and skin tags mimicking hamartoma. The cerebral tumour increased in size during a few months leadi ...
Pages: 454-456
Abstract  HTML  PDF
SHORT COMMUNICATION
Sun-induced Pustular Dermatosis of the Scalp – A New Variant of Erosive Pustular Dermatosis of the Scalp?
Birgit Aigner, Franz J. Legat, Christian Schuster, Laila El Shabrawi-Caelen
Abstract is missing (Short)
Pages: 457-458
Abstract  HTML  PDF
SHORT COMMUNICATION
Iatrogenic Vitamin D Deficiency in a Patient with Gorlin Syndrome: The Conundrum of Photoprotection
Sabrina Gentzsch, Johannes S. Kern, Stefan Loeckermann, Eva Geissler, Jochen Seufert , Carsten Bernard, Juergen Kohlhase, Leena Bruckner-Tuderman, Frank Meiss
Abstract is missing (Short)
Pages: 459-460
Abstract  HTML  PDF
SHORT COMMUNICATION
Scalp Angiosarcoma Presented as Skin-coloured Papules
Ji Yeon Byun, Eun Ah Suhng, Seung Hyun Cheong, You Won Choi, Hae Young Choi
Abstract is missing (Short)
Pages: 461-462
Abstract  HTML  PDF
SHORT COMMUNICATION
Two Cases of Imported Tungiasis with Severe Staphylococcus aureus Superinfection
Stefano Veraldi, Federica Dassoni, Ermira Çuka, Gianluca Nazzaro
Abstract is missing (Short)
Pages: 463-464
Abstract  HTML  PDF
SHORT COMMUNICATION
Symmetrical Giant Facial Plaque-type Juvenile Xanthogranuloma Persisting Beyond 10 years of Age
Kazumitsu Sugiura, Yoshie Hasegawa, Yoshie Shimoyama, Hideo Hashizume, Masashi Akiyama
Abstract is missing (Short)
Pages: 465-466
Abstract  HTML  PDF
SHORT COMMUNICATION
Phacomatosis Pigmentokeratotica: A Follow-up Report with Fatal Outcome
Gong-Yau Chu, Ching-Ying Wu
Abstract is missing (Short)
Pages: 467-468
Abstract  HTML  PDF
SHORT COMMUNICATION
Imiquimod 5%: A Successful Treatment for Pseudolymphoma
Jane Baumgartner-Nielsen, Henrik Lorentzen
Abstract is missing (Short)
Pages: 469-469
Abstract  HTML  PDF
SHORT COMMUNICATION
Annular Erythema Associated with Sjögren’s Syndrome Preceding Overlap Syndrome of Rheumatoid Arthritis and Polymyositis with Anti-PL-12 Autoantibodies
Kazumitsu Sugiura, Yoshinao Muro, Masashi Akiyama
Abstract is missing (Short)
Pages: 470-471
Abstract  HTML  PDF
SHORT COMMUNICATION
First-line Combination Therapy with Rituximab and Corticosteroids is Effective and Safe for Pemphigus
Yung-Tsu Cho, Fang-Yu Lee, Chia-Yu Chu, Li-Fang Wang
Abstract is missing (Short)
Pages: 472-473
Abstract  HTML  PDF
SHORT COMMUNICATION
Lymphomatoid Papulosis Type D or an Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma?
Rosa Marie Andersen, Mathilde Skaarup Larsen, Tim Svenstrup Poulsen, Anne Falensteen Lauritzen, Lone Skov
Abstract is missing (Short)
Pages: 474-475
Abstract  HTML  PDF
SHORT COMMUNICATION
Risk of Kaposi Sarcoma Among Immigrants to Sweden
Seyed Mohsen Mousavi, Jan Sundquist, Kari Hemminki
Abstract is missing (Short)
Pages: 476-477
Abstract  HTML  PDF
SHORT COMMUNICATION
Pemphigus Foliaceus Associated with Anti-NXP2 Autoantibody-positive Dermatomyositis
Noriki Fujimoto, Satoru Takayama, Yasuhito Hamaguchi, Manabu Fujimoto, Toshihiro Tanaka
Abstract is missing (Short)
Pages: 478-479
Abstract  HTML  PDF
SHORT COMMUNICATION
Is Adult Atopic Eczema More Common Than We Think? – A Population-based Study in Danish Adults
Gabrielle R. Vinding, Kian Zarchi, Kristina S. Ibler, Iben M. Miller, Christina Ellervik, Gregor B.E. Jemec
Abstract is missing (Short)
Pages: 480-482
Abstract  HTML  PDF
SHORT COMMUNICATION
Detection of Human Papillomavirus Type 56 in Giant Condyloma Acuminatum
Takahiro Ishibuchi, Akira Shimizu, Madoka Kato, Yuko Takeuchi, Kumi Aoyama, Masahito Yasuda, Ayumi Takahashi, Etsuko Okada, Sei-ichiro Motegi, Hiroo Amano, Osamu Ishikawa
Abstract is missing (Short)
Pages: 482-483
Abstract  HTML  PDF
SHORT COMMUNICATION
Downregulation of c-Kit/MITF-M in Graying Hair of Juvenile Poliosis
Hua Feng, Yina Sun, Qi Wang
Abstract is missing (Short)
Pages: 484-485
Abstract  HTML  PDF
SHORT COMMUNICATION
Generalised Acanthosis Nigricans in Childhood with Short Stature Associated with Poor Response to Growth Hormone Provocation
Maiko Iwade, Eisaku Ogawa, Hiroshi Koga, Fumi Mizuno, Kenichi Koike, Kazuhiko Matsumoto, Ryuhei Okuyama
Abstract is missing (Short)
Pages: 486-487
Abstract  HTML  PDF
SHORT COMMUNICATION
Induction of Skin Lesions by Ultraviolet B Irradiation in a Case of Pemphigus Erythematosus
Teruhiko Makino, Yuri Seki, Hiroshi Hara, Megumi Mizawa, Kotaro Matsui , Kyoko Shimizu, Tadamichi Shimizu
Abstract is missing (Short)
Pages: 487-488
Abstract  HTML  PDF
SHORT COMMUNICATION
Peristomal Epidermolysis Bullosa Acquisita in a Patient with Crohn’s Disease
Nerea Ormaechea-Pérez, Anna Tuneu-Valls, Hernan Andres Borja-Consigliere, Elena Del Alcazar-Viladomiu, Ane Jaka-Moreno
Abstract is missing (Short)
Pages: 489-490
Abstract  HTML  PDF
QUIZ
A Perianal Erythematous Plaque: A Quiz
Hirohisa Ishibuchi, Akira Shimizu, Izumi Negishi, Osamu Ishikawa
Abstract is missing (Quiz)
Pages: 492-496
Abstract  HTML  PDF
QUIZ
Purulent Discharge from the Nipples: A Quiz
Elena del Alcázar Viladomiu, Anna Tuneu Valls, Maria Asunción Arregui Murua, Ane Jaka Moreno, Nerea Ormaechea-Pérez
Abstract is missing (Quiz)
Pages: 492-496
Abstract  HTML  PDF
QUIZ
Follicular Erythematous Papules with Keratotic Spicules: A Quiz
Miriam Linke, Cyrill Géraud, Christian Sauer, Alexander Marx, Sergij Goerdt, Wiebke K. Peitsch
Abstract is missing (Quiz)
Pages: 492-496
Abstract  HTML  PDF