Content

Content - Volume 98, Issue 5

Editor's choice in this issue

CLINICAL REPORT
Propionibacterium acnes Abundance Correlates Inversely with Staphylococcus aureus: Data from Atopic Dermatitis Skin Microbiome
Wojciech Francuzik, Kristin Franke, Ralf R. Schumann, Guido Heine, Margitta Worm
Skin microbiota are important for skin homeostasis and are dysregulated in atopic dermatitis. In this paper, the abundance of P. acnes correlated negatively with that of S. aureus in lesional skin from atopic dermatitis patients. P. acnes may have a protective effect against S. aureus colonization. That finding suggests that a selective modification of the skin microbiome could potentially be used as a therapeutic strategy in atopic dermatitis.
Pages: 490-495
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CLINICAL REPORT
Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor
Gil Yosipovitch, Linda F. Stein Gold, Mark G. Lebwohl, Jonathan I. Silverberg, Anna M. Tallman, Lee T. Zane
Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatiti ...
Pages: 484-489
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All articles

EDITORIAL
ActaDV Soon Celebrates 100-year Anniversary
Artur Schmidtchen
Abstract is missing (Editorial)
Pages: 480-480
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REVIEW
Light and Laser Modalities in the Treatment of Cutaneous Sarcoidosis: A Systematic Review
Ana Luiza Lima, Steven Goetze, Tanja Illing, Peter Elsner
Sarcoidosis is a systemic non-caseating granulomatous disease of unknown aetiology. Cutaneous manifestations are present in approximately 10–30% of the patients with the systemic form. Therapy is indicated in case of disabling symptoms, organ dysfunction or cosmetically distressing manifestation. Despite different therapeutic possibilities, cutaneous sarcoidosis remains exceptionally difficult t ...
Pages: 481-483
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CLINICAL REPORT
Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor
Gil Yosipovitch, Linda F. Stein Gold, Mark G. Lebwohl, Jonathan I. Silverberg, Anna M. Tallman, Lee T. Zane
Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatiti ...
Pages: 484-489
Abstract  HTML  PDF
CLINICAL REPORT
Propionibacterium acnes Abundance Correlates Inversely with Staphylococcus aureus: Data from Atopic Dermatitis Skin Microbiome
Wojciech Francuzik, Kristin Franke, Ralf R. Schumann, Guido Heine, Margitta Worm
The microbiome may influence disease severity in atopic dermatitis. The skin of atopic dermatitis patients and healthy individuals was sampled in a standardized manner and the microbial composition analysed using next-generation sequencing. Optical density measurements were used to investigate bacterial growth under defined conditions in vitro. Lesional skin from patients with atopic dermatitis ha ...
Pages: 490-495
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CLINICAL REPORT
Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics
Edyta Lelonek, Łukasz Matusiak, Tomasz Wróbel, Jacek C. Szepietowski
Aquagenic pruritus is one of the main clinical features of polycythemia vera. The aim of this study was to analyse the clinical characteristics of aquagenic pruritus. The study group comprised 102 patients with molecularly confirmed polycythemia vera. Demographic data, data on disease history, polycythemia vera status and treatment modalities were collected. Moreover, various clinical features of ...
Pages: 496-500
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CLINICAL REPORT
Methotrexate Treatment for Pityriasis Rubra Pilaris: A Case Series and Literature Review
Lukas Koch, Clemens Schöffl, Werner Aberer, Cesare Massone
Treatment recommendations for pityriasis rubra pilaris (PRP) are based solely on case reports and small case series, as to-date no randomized controlled trials are available. We present here a case series of 3 patients and a literature review of 28 studies treating a total of 116 patients, with the aim of providing data regarding efficacy and safety of methotrexate in the treatment of PRP. Methotr ...
Pages: 501-505
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CLINICAL REPORT
Evaluation of IgG4+ Plasma Cell Infiltration in Patients with Systemic Plasmacytosis and Other Plasma Cell-infiltrating Skin Diseases
Shintaro Takeoka, Masahiro Kamata, Carren Sy Hau, Mihoko Tateishi, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yuko Sasajima, Shinichi Watanabe, Yayoi Tada
Systemic plasmacytosis is a rare skin disorder characterized by marked infiltration of plasma cells in the dermis. IgG4-related disease is pathologically characterized by lymphoplasmacytic infiltration rich in IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis, accompanied by elevated levels of serum IgG4. Reports of cases of systemic plasmacytosis with abundant infiltration of IgG ...
Pages: 506-511
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CLINICAL REPORT
Characteristics of Familial Melanoma in Valencia, Spain, Based on the Presence of CDKN2A Mutations and MC1R Variants
Claudia Huerta, Zaida Garcia-Casado, José Bañuls, Manuel Moragon, Vicente Oliver, Blanca Unamuno, Celia Requena, Rajiv Kumar, Eduardo Nagore
Melanoma results from a complex interplay between environmental factors and individual genetic susceptibility. Familial melanoma is attributable to predisposition genes with variable penetrance. The aim of this study was to identify differences between familial melanoma and sporadic cases in our population, based on the presence of CDKN2A mutations and MC1R variants. Comparing 107 patients with fa ...
Pages: 512-516
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CLINICAL REPORT
Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study
Irena Angelova-Fischer, Frank Rippke, Daniel Richter, Alexander Filbry, Craig Arrowitz, Teresa Weber, Tobias W. Fischer, Detlef Zillikens
Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had bee ...
Pages: 517-523
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SHORT COMMUNICATION
Two Severe Cases of Adult-onset Still's Disease with Persistent Pruritic Eruptions
Yang Liu, Tetsuya Ikawa, Yayoi Tada, Takamitsu Tanaka, Takamitsu Ohnishi, Shinichi Watanabe, Daisuke Tsukui, Kurumi Asako, Hajime Kono
Abstract is missing (Short communication)
Pages: 524-525
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SHORT COMMUNICATION
Generalized Chronic Itch as a First Sign of Malignancy Resembling Paraneoplastic Sensomotoric Neuropathy
Minaya Beigi, Michael Häberle, Andreas Gschwendtner, Ulrich Baum, Elke Weisshaar
Abstract is missing (Short communication)
Pages: 526-527
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SHORT COMMUNICATION
Testicular Cancer in Monozygotic Twin Brothers with Urticaria Pigmentosa
Tatiana Péčová, Karolína Vorčáková, Markéta Žaliová, Tatiana Burjanivová, Bibiana Malicherová, Lukáš Plank, Jan Trka, Klaudia Péčová, Katarína Adamicová, Martin Péč, Juraj Pec
Abstract is missing (Short communication)
Pages: 528-529
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SHORT COMMUNICATION
Pyoderma Gangrenosum Under Dabrafenib and Trametinib for Metastatic Melanoma
Mélanie Saint-Jean, Marie Le Moigne, Justine Daguze, Céline Bossard, Lucie Peuvrel, Gaëlle Quéreux, Brigitte Dréno
Abstract is missing (Short communication)
Pages: 530-531
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SHORT COMMUNICATION
Toe Gangrene Associated with Macroangiopathy in Systemic Sclerosis: A Case Series on the Unreliability of the Ankle-brachial Pressure Index
Takashi Hashimoto, Takahiro Satoh, Hiroo Yokozeki
Abstract is missing (Short communication)
Pages: 532-533
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SHORT COMMUNICATION
A Postzygotic SMO Mutation Caused the Original Case of Happle–Tinschert Syndrome
Martin Zenker, Sigrid Tinschert, Ilse Wieland, Denny Schanze, Rudolf Happle
Abstract is missing (Short communication)
Pages: 534-535
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SHORT COMMUNICATION
Folate Supplementation During Methotrexate Therapy: A Population-based Retrospective Cohort Study
Canelle Mazaud, Laurence Fardet
Abstract is missing (Short communication)
Pages: 536-538
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CORRESPONDENCE
RASA1 Variants in Capillary Malformations of Children: A Comment to Maruani A et al.
Rudolf Happle
Abstract is missing (Correspondence)
Pages: 539-539
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QUIZ
Brownish Plaque with Progressive Growth on the Breast: A Quiz
Javier Arellano, Maria Jose Mesa, Yamile Corredoira
Abstract is missing (Quiz)
Pages: 540-541
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QUIZ
Painful Papules on the Hand: A Quiz
Elizabeth Lee, Tejesh Patel, Gillian Hale, Sherif Zaki, Kristopher Fisher
Abstract is missing (Quiz)
Pages: 542-543
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