Content

Content - Volume 98, Issue 6

Editor's choice in this issue

CLINICAL REPORT
The Role of Therapy in Impairing Quality of Life in Dermatological Patients: A Multinational Study
Flora N. Balieva, Andrew Y. Finlay, Jörg Kupfer, Lucía Tomas Aragones, Lars Lien, Uwe Gieler, Françoise Poot, Gregor B. E. Jemec, Laurent Misery, Lajos Kemeny, Francesca Sampogna, Henriët van Middendorp, Jon Anders Halvorsen, Thomas Ternowitz, Jacek C. Szepietowski, Nikolay Potekaev, Servando E. Marron, Ilknur K. Altunay, Sam S. Salek, Florence J. Dalgard
Skin disease and its therapy affect health-related quality of life (HRQoL). The aim of this study was to measure the burden caused by dermatological therapy in 3,846 patients from 13 European countries. Adult outpatients completed questionnaires, including the Dermatology Life Quality Index (DLQI), which has a therapy impact question. Therapy issues were reported by a majority of patients with ato ...
Pages: 563-569
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INVESTIGATIVE REPORT
Inflammasome Activation Characterizes Lesional Skin of Folliculitis Decalvans
Alexia Eyraud, Brigitte Milpied, Denis Thiolat, Anne-Sophie Darrigade, Katia Boniface, Alain Taïeb, Julien Seneschal
Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and ...
Pages: 570-575
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All articles

CLINICAL REPORT
Duration of Psoriatic Skin Disease as Risk Factor for Subsequent Onset of Psoriatic Arthritis
Alexander Egeberg, Lone Skov, Claus Zachariae, Gunnar H. Gislason, Jacob P. Thyssen, Lotus Mallbris
It is unclear whether psoriasis is a progressive disease that requires early aggressive intervention. This population-based study identified patients with psoriasis and psoriatic arthritis (PsA). Survival analysis and Kaplan–Meier life table techniques were used. The study comprised 10,011 psoriasis patients (severe n = 4,618), and 1,269 patients also had PsA. Incidence of PsA increased with ...
Pages: 546-550
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CLINICAL REPORT
Metastasis Risk of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients and Immunocompetent Patients
Roel E. Genders, Joris A.J. Osinga, Elise E. Tromp, Peter O'Rourke, Jan N. Bouwes Bavinck, Elsemieke I. Plasmeijer
Organ transplant recipients (OTRs) have a high incidence of cutaneous squamous cell carcinoma (cSCC), and immunosuppression has been reported to be an important risk factor for metastasis. The aim of this study was to identify the metastasis risk over a 10-year period for 593 patients with cSCC, of whom 134 were OTR and 459 were immunocompetent. Metastasis incidence rate was 1,046 (95% confidence ...
Pages: 551-555
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CLINICAL REPORT
Dysplastic vs. Common Naevus-associated vs. De novo Melanomas: An Observational Retrospective Study of 1,021 Patients
Alejandro Martin-Gorgojo, Celia Requena, Zaida Garcia-Casado, Victor Traves, Rajiv Kumar, Eduardo Nagore
The aim of this case-case study was to determine the differences between dysplastic and common naevus-associated melanomas (NAM) and de novo melanomas. A total of 1,021 prospectively collected patients with invasive cutaneous melanoma from an oncology referral centre were included in the study. Of these, 75.51% had de novo melanomas, 12.93% dysplastic NAM, and 11.56% common NAM. Dysplastic NAM, co ...
Pages: 556-562
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CLINICAL REPORT
The Role of Therapy in Impairing Quality of Life in Dermatological Patients: A Multinational Study
Flora N. Balieva, Andrew Y. Finlay, Jörg Kupfer, Lucía Tomas Aragones, Lars Lien, Uwe Gieler, Françoise Poot, Gregor B. E. Jemec, Laurent Misery, Lajos Kemeny, Francesca Sampogna, Henriët van Middendorp, Jon Anders Halvorsen, Thomas Ternowitz, Jacek C. Szepietowski, Nikolay Potekaev, Servando E. Marron, Ilknur K. Altunay, Sam S. Salek, Florence J. Dalgard
Skin disease and its therapy affect health-related quality of life (HRQoL). The aim of this study was to measure the burden caused by dermatological therapy in 3,846 patients from 13 European countries. Adult outpatients completed questionnaires, including the Dermatology Life Quality Index (DLQI), which has a therapy impact question. Therapy issues were reported by a majority of patients with ato ...
Pages: 563-569
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Inflammasome Activation Characterizes Lesional Skin of Folliculitis Decalvans
Alexia Eyraud, Brigitte Milpied, Denis Thiolat, Anne-Sophie Darrigade, Katia Boniface, Alain Taïeb, Julien Seneschal
Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and ...
Pages: 570-575
Abstract  HTML  PDF
INVESTIGATIVE REPORT
8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model
Nitesh Shirsath, Karin Wagner, Simone Tangermann, Michaela Schlederer, Christian Ringel, Lukas Kenner, Bernhard Brüne, Peter Wolf
The effects of 8-Methoxypsoralen plus ultraviolet A (PUVA) or ultraviolet B (UVB) alone on imiquimod-induced psoriasis were examined in a mouse model. Mouse skin was treated with repetitive sub-phototoxic doses of PUVA or UVB before or during the induction of toll-like receptor 7/8 activation and psoriasis through the application of imiquimod. PUVA, to a greater degree than UVB, suppressed the est ...
Pages: 576-584
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INVESTIGATIVE REPORT
Ten-eleven Translocation-2 Regulates DNA Hydroxymethylation Status and Psoriasiform Dermatitis Progression in Mice
Xin Wang, Xinxin Liu, Xiaoru Duan, Ke Zhu, Song Zhang, Lu Gan, Nian Liu, Himanshu Jaypaul, Johanna T. Makamure, Zhangyin Ming, Hongxiang Chen
Epigenetics plays an important role in the development and progression of many diseases. There is increasing evidence for the importance of epigenetic modifications in the progression of psoriasis. The aim of this study was to examine the role and potential mechanism of action of 5-hydroxymethylcytosine (5-hmC) and ten-eleven translocation-2 (TET2) in psoriasiform dermatitis in mice. Immunohistoch ...
Pages: 585-593
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INVESTIGATIVE REPORT
Overexpression of Amyloid Precursor Protein Promotes the Onset of Seborrhoeic Keratosis and is Related to Skin Ageing
Yuanying Li, Yu Wang, Wei Zhang, Leiwei Jiang, Wenming Zhou, Zhi Liu, Shijun Li, Hongguang Lu
Seborrhoeic keratosis (SK) is an age-related skin disease. Amyloid precursor protein (APP) plays an important role in the pathogenesis of age-related Alzheimer’s disease. The aim of this study was to elucidate the expression characteristics of APP in SK tissues (n = 50), and explore whether the production of APP is related to the onset of SK and skin ageing, including ultraviolet (UV)-induce ...
Pages: 594-600
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SHORT COMMUNICATION
Successful Treatment with Dupilumab in a Patient with Severe, Difficult to Treat Atopic Dermatitis: Beware of Symptomatic Adrenal Insufficiency due to Abrupt Discontinuation of Potent Topical Corticosteroids
Lieneke F.M. Ariëns, Jorien van der Schaft, Aline M.E. Stades, Anthonie A. van de Woestijne , Marjolein S. De Bruin-Weller
Abstract is missing (Short Communication)
Pages: 601-602
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SHORT COMMUNICATION
Localized Scleroderma of the Head and Face Area: A Retrospective Cross-sectional Study of 96 Patients from 5 German Tertiary Referral Centres
Alexander Kreuter, Georg Mitrakos, Silke C. Hofmann, Percy Lehmann, Michael Sticherling, Thomas Krieg, Nina Lahner, Christian Tigges, Nicolas Hunzelmann, Pia Moinzadeh
Abstract is missing (Short communication)
Pages: 603-605
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SHORT COMMUNICATION
Extensive Nasal Plaque: An Unusual Presentation of IgG4-related Disease
Camila Cortés, Silvia Bielsa, Josep Manel Fernandez, Felip Vilardell, Blanca Gonzalez-Farré, Josep Manel Casanova
Abstract is missing (Short communication)
Pages: 606-607
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SHORT COMMUNICATION
Spontaneous Regression of Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type
Ferdinand Toberer, Gunhild Mechtersheimer, Hannah Jaschinski, Alexander Enk, Lara Hakim-Meibodi, Holger A. Haenssle
Abstract is missing (Short communication)
Pages: 608-609
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SHORT COMMUNICATION
A Case of Refractory Subcutaneous Panniculitis-like T-cell Lymphoma with Bone Marrow and Lung Involvement Treated Successfully with Oral Etoposide
Akimasa Saito, Naoko Okiyama, Ryota Tanaka, Hiroshi Maruyama, Manabu Fujimoto
Abstract is missing (Short communication)
Pages: 610-611
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SHORT COMMUNICATION
Up-regulation of Human Herpesvirus 6B-derived microRNAs in the Serum of Patients with Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms
Kazuya Miyashita, Fumi Miyagawa, Yuki Nakamura, Rie Ommori, Hiroaki Azukizawa, Hideo Asada
Abstract is missing (Short communication)
Pages: 612-613
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SHORT COMMUNICATION
Calcinosis Cutis Caused by Subcutaneous Injection of Calcium-containing Heparin in a Patient with Systemic Lupus Erythematosus
Mai Hattori , Akira Shimizu, Osamu Ishikawa
Abstract is missing (Short communication)
Pages: 614-615
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SHORT COMMUNICATION
Simultaneous Induction of Benign Condyloma and High-grade Anal Dysplasia Induced by Low-risk Human Papillomavirus Type 42
Alexander Kreuter, Martin Hufbauer, Steffi Silling, Frank Oellig, Baki Akgül, Ulrike Wieland
Abstract is missing (Short communication)
Pages: 616-617
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QUIZ
Scalp Hair Hypopigmentation in a Five-month-old Infant: A Quiz
Sophie Leducq, Emmanuelle Blanchard, Thierry Perez, Annabel Maruani
Abstract is missing (Quiz)
Pages: 618-619
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QUIZ
Yellow-brown Papules on the Cheeks and Limbs of a Male Infant: A Quiz
Julia K. Winkler, Susanne Hanner, Arno Rütten, Alexander H. Enk, Holger Haenssle, Ferdinand Toberer
Abstract is missing (Quiz)
Pages: 620-621
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