Content

Content - Volume 100, December

Editor's choice in this issue

INVESTIGATIVE REPORT
The Amygdala Network for Processing Itch in Human Brains
Hideki Mochizuki, Loren Hernandez, Gil Yosipovitch, Norihiro Sadato, Ryusuke Kakigi
Negative emotions due to itch is a significant factor to diminish mental health in chronic itch patients. The amygdala was identified to be a key hub of network to regulate the negative emotions. However, the exact network remains unknown. This paper aimed to address this gap. We found that the amygdala network for processing itch involves the serotonergic system responsible for negative emotions and memory system to consolidate emotional experiences. We feel this finding is very important, because these systems may be­come therapeutic targets for preventing or reducing diminished mental health commonly seen in chronic itch patients.
Pages: 1-5
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All articles

SPECIAL REPORT
NEWSLETTER (December 2020)
Pages: 1-2
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EDITORIAL
The Editorial Office of ActaDV Appears in a New Costume
Anders Vahlquist, Olle Larkö
Abstract is missing (Editorial)
Page: 1
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QUIZ
Multiple Nasal Papules in a 12-year-old Boy: A Quiz
Dania Abu Assab, Alexander Maly, Abraham Zlotogorski, Vered Molho-Pessach
Abstract is missing (Quiz)
Pages: 1-2
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CLINICAL REPORT
Ixekizumab Survival in Heavily Pretreated Patients with Psoriasis: A Two-year Single-centre Retrospective Study
Shany Sherman, Ory Zloczower, Yehonatan Noyman, Iris Amitay-Laish, Emmilia Hodak, Lev Pavlovsky
The long-term effect of intra-anti-interleukin-17-class switch on drug survival is unclear. The aim of this study was to evaluate the efficacy and long-term survival of ixekizumab in bio-experienced psoriatic patients with and without previous exposure to anti-interleukin-17 treatment. Retrospective search of a tertiary medical centre database for 2017 to 2019 yielded 73 patients treated with ixek ...
Pages: 1-5
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SHORT COMMUNICATION
Generalized Argyria Successfully Treated with Q-switched Alexandrite Laser: A Case Report
Maiko Fukayama, Yoshihide Asano, Jun Omatsu, Haruka Kawashima, Akira Shirai, Shinichi Sato
Abstract is missing (Short communication)
Pages: 1-2
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SHORT COMMUNICATION
Prevalence of Atrophic and Hypertrophic Skin Ageing Phenotypes: A UK-based Observational Study
Abigail K. Langton, Zara Ali, Mark Hann, Jean Ayer, Rachel E.B. Watson, Christopher E.M. Griffiths
Abstract is missing (Short communication)
Pages: 1-3
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CLINICAL REPORT
Melanoma Risk is Increased in Patients with Mycosis Fungoides Compared with Patients with Psoriasis and the General Population*
Shany Sherman, Noa Kremer, Adam Dalal, Efrat Solomon-Cohen, Einav Berkovich, Yehonatan Noyman, Maya Ben-Lassan, Assi Levi, Lev Pavlovsky, Hadas Prag Naveh, Emmilia Hodak, Iris Amitay-Laish
Patients with mycosis fungoides (MF) are thought to be at increased risk of melanoma. However, studies addressing surveillance-bias and treatments as a possible confounder are lacking. This retrospective study compared the prevalence and risk of melanoma between 982 patients with MF, and 3,165 patients with psoriasis attending tertiary cutaneous-lymphoma/psoriasis clinics during 2009 to 2018. Mela ...
Pages: 1-7
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INVESTIGATIVE REPORT
The Amygdala Network for Processing Itch in Human Brains
Hideki Mochizuki, Loren Hernandez, Gil Yosipovitch, Norihiro Sadato, Ryusuke Kakigi
Itch is an unpleasant and aversive somatosensory experience. These negative emotions significantly affect mental health in patients with chronic itch; it is therefore important to understand the brain mechanism of negative emotions due to itch. The amygdala is a key hub of networks regulating negative emotions due to itch. However, the exact network involved in this process is unknown. This study ...
Pages: 1-5
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CLINICAL REPORT
An Analysis of Patient-reported Outcomes in IXORA-S: Comparing Ixekizumab and Ustekinumab over 52 Weeks in Moderate-to-severe Psoriasis
Lluís Puig, Mark Lomaga, Kristin Hollister, Yves Dutronc, Lovisa Berggren, Peter C.M. van de Kerkhof
Patient-reported outcomes are valuable for assessing new psoriasis therapies. This study investigated patient-reported outcomes in patients with moderate-to-severe plaque psoriasis treated with ixekizumab or ustekinumab, dosed according to their respective labels, for 52 weeks (IXORA-S-NCT02561806). Patient-reported outcomes investigated included patient global assessment, pruritus, skin pain, hea ...
Pages: 1-7
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INVESTIGATIVE REPORT
Cumulative Sum Analysis for the Learning Curve of Optical Coherence Tomography Assisted Diagnosis of Basal Cell Carcinoma
Eva van Loo, Kelly A.E. Sinx, Julia Welzel, Sandra Schuh, Nicole W.J. Kelleners-Smeets, Klara Mosterd, Patty J. Nelemans
The amount of training needed to correctly interpret optical coherence tomography scans of the skin is undefined. The aim of this study was to illustrate how cumulative sum charts can be used to determine how many optical coherence tomography scans novice assessors should evaluate in order to obtain competence in diagnosing basal cell carcinoma. Four hundred lesions suspected for non-melanoma skin ...
Pages: 1-5
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INVESTIGATIVE REPORT
Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis
Kristine Rossbach, Katharina Wahle, Gustav Bruer, Ralph Brehm, Marion Langeheine, Kristina Rode, Katrin Schaper-Gerhardt, Ralf Gutzmer, Thomas Werfel, Manfred Kietzmann, Wolfgang Bäumer
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch. Histamine, acting via histamine 1–4 receptors, is known to modulate immune responses in the skin and to induce itch. The aim of this study was to test the role of histamine 2 receptors and histamine 4 receptors in the imiquimod ...
Pages: 1-8
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CLINICAL REPORT
Management of Congenital Melanocytic Naevi in Children: A French National Survey Using Clinical Vignettes
Hélène Aubert, Morgane Pere, Frédérique Bellier Waast, Pierre Perrot, Sébastien Barbarot, on behalf of the Groupe de Recherche en Dermatologie Pédiatrique
Management of congenital melanocytic naevi in childhood may vary depending on the habits and experience of the treating clinician. The aim of this study was to assess current practice and determinants of surgical excision decision-making among French physicians. A national survey was conducted among dermatologists, paediatricians and surgeons, using clinical vignettes illustrating 29 scenarios. Th ...
Pages: 1-6
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INVESTIGATIVE REPORT
Health Economic Consequences of a Tightly Controlled Dose Reduction Strategy for Adalimumab, Etanercept and Ustekinumab Compared with Standard Psoriasis Care: A Cost-utility Analysis of the CONDOR Study
Selma Atalay, Juul M.P.A. van den Reek, Marisol E. Otero, Marcellus D. Njoo, Johannes M. Mommers, Paul M. Ossenkoppele , Marjolein I. Koetsier, Maartje M. Berends, Peter C.M. van de Kerkhof, Hans M.M. Groenewoud, Alfons A. den Broeder, Elke M.G.J. de Jong, Wietske Kievit
A dose reduction strategy for adalimumab, etanercept and ustekinumab in patients with psoriasis who have stable and low disease activity has recently been compared with usual care in the CONDOR study (CONtrolled DOse Reduction) of biologics in patients with psoriasis with low disease activity. The aim of the current study was to perform a cost-utility analysis with a 12-month time horizon alongsid ...
Pages: 1-7
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SHORT COMMUNICATION
Vaccination Granuloma Itch Treated with Capsaicin 8% Patches
Stine Hoffmann, Jesper Elberling
Abstract is missing (Short communication)
Pages: 1-2
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SHORT COMMUNICATION
Pyoderma Gangrenosum Revealing Myeloid Activation of Fanconi Anaemia: Two Case Reports
Alexandra Mokrzycki, Coralie Lheure, Nathalie Franck, Gérard Socié, Clémence Mauppin, Flore Sicre de Fontbrune, Régis Peffault De Latour, Clémence Lepelletier, Adèle de Masson, Maxime Battistella, Guy Leverger, Pierre Sohier, Jean-David Bouaziz, Nicolas Dupin
Abstract is missing (Short Communication)
Pages: 1-2
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CLINICAL REPORT
Towards More Shared Decision Making in Dermatology: Develop­ment of Evidence-based Decision Cards for Psoriasis and Atopic Eczema Treatments
Francisca M. Vermeulen, Gayle E. van der Kraaij, Ronald A. Tupker, Anne Bijlsma, Hans Blaauwbroek, Francine Das, Tessa Geltink, Josine S. van der Kraan, Renske Kranenburg, Dirk J. van der Veen, Kristie Venhorst, Phyllis I. Spuls
In shared decision making (SDM) patients and physi­cians make treatment decisions together based on the best available evidence and the values and preferences of patients. SDM is very suitable for use in dermatological practice, but is infrequently applied by dermatologists. To support the application of SDM in dermatology we developed Decision Cards: 1-page overviews of possible treatment option ...
Pages: 1-8
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