Content

Content - Volume 97, Issue 10

Editor's choice in this issue

REVIEW
Henoch-Schönlein Purpura: A Literature Review
Liv Eline Hetland, Kjærsti Sørensen Susrud , Kim Hein Lindahl, Anette Bygum
Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought to arise from IgA depositions in blood vessel walls in the affected organs, mostly skin, gastrointe ...
Pages: 1160-1166
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INVESTIGATIVE REPORT
Increased Interleukin-19 Expression in Cutaneous T-cell Lymphoma and Atopic Dermatitis
Tomonori Oka, Makoto Sugaya, Naomi Takahashi, Rina Nakajima, Sayaka Otobe, Miyoko Kabasawa, Hiraku Suga, Tomomitsu Miyagaki, Yoshihide Asano, Shinichi Sato
Interleukin-19 (IL-19), a pro-inflammatory cytokine known to stimulate the production of T helper type 2 (Th2) cytokines, is induced by IL-17A and highly expressed in the lesional skin of psoriasis and atopic dermatitis (AD). This aim of this study was to investigate whether IL-19 is involved in cutaneous T-cell lym­phoma (CTCL) and AD. IL-19 levels were significantly higher in the sera of patien ...
Pages: 1172-1177
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All articles

REVIEW
Henoch-Schönlein Purpura: A Literature Review
Liv Eline Hetland, Kjærsti Sørensen Susrud , Kim Hein Lindahl, Anette Bygum
Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought to arise from IgA depositions in blood vessel walls in the affected organs, mostly skin, gastrointe ...
Pages: 1160-1166
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SPECIAL REPORT
The Role of Topical Timolol in the Treatment of Infantile Hemangiomas: A Systematic Review and Meta-analysis
Maham Khan, Aaron Boyce, David Prieto-Merino, Åke Svensson, Emma Wedgeworth, Carsten Flohr
To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not been reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement f ...
Pages: 1167-1171
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INVESTIGATIVE REPORT
Increased Interleukin-19 Expression in Cutaneous T-cell Lymphoma and Atopic Dermatitis
Tomonori Oka, Makoto Sugaya, Naomi Takahashi, Rina Nakajima, Sayaka Otobe, Miyoko Kabasawa, Hiraku Suga, Tomomitsu Miyagaki, Yoshihide Asano, Shinichi Sato
Interleukin-19 (IL-19), a pro-inflammatory cytokine known to stimulate the production of T helper type 2 (Th2) cytokines, is induced by IL-17A and highly expressed in the lesional skin of psoriasis and atopic dermatitis (AD). This aim of this study was to investigate whether IL-19 is involved in cutaneous T-cell lym­phoma (CTCL) and AD. IL-19 levels were significantly higher in the sera of patien ...
Pages: 1172-1177
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INVESTIGATIVE REPORT
Mineral Depositions of Calcifying Skin Disorders are Predominantly Composed of Carbonate Apatite
Michael Franzen, Elena Moré, Janne Cadamuro, Josef Koller, Wolfgang Salmhofer, Iris Wohlmuth-Wieser, Cornelia Kronberger, Hermann Salmhofer
Subcutaneous calcifications can lead to complications, including pain, inflammation, ulceration and immobilization. Studies on the pathophysiology of mineral compositions and effective treatment modalities are limited. We therefore studied 14 patients with subcutaneous calcifications. Mineral material was collected and analysed by Fourier transform infrared spectrometry. Blood analyses were run to ...
Pages: 1178-1181
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INVESTIGATIVE REPORT
Determinants of Psychosocial Health in Psoriatic Patients: A Multi­national Study
Karolina Lesner, Adam Reich, Jacek C. Szepietowski, Florence J. Dalgard, Uwe Gieler, Lucía Tomas-Aragones, Lars Lien, Françoise Poot, Gregor B. Jemec, Laurent Misery, Csanád Szabó, Dennis Linder, Francesca Sampogna, Andrea W.M. Evers, Jon Anders Halvorsen, Flora Balieva, Andrey Lvov, Servando E. Marron, Ilknur K. Altunay, Andrew Y. Finlay, Sam S. Salek, Jörg Kupfer
There are limited data on the differences in the impact of psoriasis between various countries with respect to quality of life (QoL). The aim of this study was to explore the psychosocial health of patients with psoriasis in different European countries. A total of 682 patients were recruited in 13 European countries. All patients completed a questionnaire regarding socio-demographic information, ...
Pages: 1182-1188
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INVESTIGATIVE REPORT
Suicidal Ideation in Adult Patients with Atopic Dermatitis: A German Cross-sectional Study
Jan Dieris-Hirche, Uwe Gieler, Frank Petrak, Wolfgang Milch, Bert te Wildt, Barbara Dieris, Stephan Herpertz
A cross-sectional study was performed to assess symptoms of suicidality, depression and anxiety in adult patients with atopic dermatitis. The study describes the relationships between these psychiatric symptoms and skin-specific factors, such as atopic dermatitis severity and skin satisfaction. A sample of 181 German patients with atopic dermatitis was compared with a control group of 64 persons w ...
Pages: 1189-1195
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INVESTIGATIVE REPORT
Efficacy of a Daily Protective Moisturizer with High UVB and UVA Photoprotection in Decreasing Ultraviolet Damage: Evaluation by Reflectance Confocal Microscopy
Antonio Gomes-Neto, Paula Aguilera, Leonor Prieto, Sophie Seité, Dominique Moyal, Cristina Carrera, Josep Malvehy, Susana Puig
Patients with photodermatoses or actinic keratosis benefit from very high ultraviolet B-ultraviolet A (UVB-UVA) photoprotection. However, poor compliance is an issue that jeopardizes adequate protection, leading to disease recurrence. This study evaluated the efficacy of a daily protective moisturizer with high UVB and UVA photoprotection applied 8 h before irradiation. A monocentric, open-label, ...
Pages: 1196-1201
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INVESTIGATIVE REPORT
Long-term Trend in Sunscreen Use among Beachgoers in Denmark
Ida M. Heerfordt, Peter A. Philipsen, Bettina Ø. Larsen, Hans Christian Wulf
This observational study examined the trend from the 1990s to 2016 of sunscreen use, sun protection factor (SPF) and quantity of sunscreen applied amongst beachgoers in Denmark. In 1997, 1998, 1999 and 2016, a total of 1,306 beachgoers were asked if they had used sunscreen on that day and, if so, which SPF. In 1992 and 2016 another 143 beachgoers had their sunscreen bottles weighed before and afte ...
Pages: 1202-1205
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CLINICAL REPORT
Lethal Melanomas: A Population-based Registry Study in Western Sweden from 1990 to 2014
Magdalena Claeson, Martin Gillstedt, David C. Whiteman, John Paoli
The incidence rates of thin melanomas (≤1 mm Breslow thickness) have increased in many fair-skinned populations, prompting a need to better identify patients with thin melanomas who will eventually die from the disease. This study aimed to describe the clinicopathological characteristics of lethal melanomas in Western Sweden, with a focus on thin lesions. Population-based data on invasive me ...
Pages: 1206-1211
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CLINICAL REPORT
Circulating Tumour DNA for Monitoring Treatment Response to Anti-PD-1 Immunotherapy in Melanoma Patients
Atsuko Ashida, Kaori Sakaizawa, Hisashi Uhara, Ryuhei Okuyama
Anti-programmed cell death-1 (anti-PD-1) antibody shows high therapeutic efficacy in patients with advanced melanoma. However, assessment of its therapeutic activity can be challenging because of tumour enlargement associated with intratumoural inflammation. Because circulating tumour DNA (ctDNA) correlates with tumour burden, we assessed the value of ctDNA levels as an indicator of tumour changes ...
Pages: 1212-1218
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CLINICAL REPORT
Seven Non-melanoma Features to Rule Out Facial Melanoma
Philipp Tschandl, Alessio Gambardella, Amélie Boespflug, Teresa Deinlein , Vincenzo de Giorgi, Harald Kittler, Aimilios Lallas, Josep Malvehy, Elvira Moscarella, Susana Puig, Massimiliano Scalvenzi, Luc Thomas, Iris Zalaudek, Roberto Alfano, Giuseppe Argenziano
Facial melanoma is difficult to diagnose and dermatoscopic features are often subtle. Dermatoscopic non-melanoma patterns may have a comparable diagnostic value. In this pilot study, facial lesions were collected retrospectively, resulting in a case set of 339 melanomas and 308 non-melanomas. Lesions were evaluated for the prevalence (> 50% of lesional surface) of 7 dermatoscopic non-melanom ...
Pages: 1219-1224
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CLINICAL REPORT
Autoimmune Disease in Children and Adolescents with Psoriasis: A Cross-sectional Study in Denmark
Christoffer Blegvad, Alexander Egeberg, Tilde E. Tind Nielsen, Gunnar H. Gislason, Claus Zachariae, Anne-Marie Nybo Andersen, Lone Skov
Psoriasis is an immune-mediated inflammatory disease, which, in studies among adults, have been shown to cluster with autoimmune disease. The aim of this cross-sectional register study was to examine possible associations between 9 pre-selected autoimmune diseases and psoriasis in children and adolescents. The study population consisted of all individuals living in Denmark, age under 18 years on 3 ...
Pages: 1225-1229
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CLINICAL REPORT
Risk of Non-melanoma Skin Cancer in Patients with Chronic Kidney Disease and its Relationship to Uraemic Pruritus
Chia-Chen Wang, Chao-Hsiun Tang, Siao-Yuan Huang, Kuan-Chih Huang, Yuh-Mou Sue
This study investigated the risk of non-melanoma skin cancer (NMSC) in pre-dialysis patients with chronic kidney disease (CKD) and explored associated risk factors. A population-based cohort of 1,515,858 Taiwanese CKD patients was included. The standardized incidence ratio (SIR) for incident NMSC was determined. Compared with the general population, a 1.14-fold risk of NMSC was found in the CKD co ...
Pages: 1230-1234
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CLINICAL REPORT
Mycoplasma genitalium and Macrolide Resistance-associated Mutations in the Skåne Region of Southern Sweden 2015
Ola Forslund, Max Hjelm, Raghd El-Ali, Annika Johnsson, Carina Bjartling
Mycoplasma genitalium is a sexually transmitted infection ordinarily treated with azithromycin. Emerging resistance to macrolide is linked to mutations in the 23S rRNA gene. We analysed the frequency of such mutations of M. genitalium isolates from patients that were symptomatic, and from sexual partners of symptomatic individuals, from October to December of 2015, in the Skåne Region of Sweden. ...
Pages: 1235-1238
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SHORT COMMUNICATION
Photodynamic Therapy with Red Light and 5-Aminolaevulinic Acid for Herpes Simplex Recurrence: Preliminary Results
Beata J. Osiecka, Piotr Nockowski, Stanisław Kwiatkowski, Jacek C. Szepietowski
Abstract is missing (Short communication)
Pages: 1239-1240
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SHORT COMMUNICATION
Use of Molecular Biology Techniques in Sarcoidal Granulomatous Dermatitis: A Clinicopathological and Molecular Approach with Diagnostic Implications
Tiago C. Esteves, Teresa Tórtola, Berta Ferrer, Gloria Aparicio, Elena Sulleiro, Juanjo González-López, Zaira Moure, Dani Romero, Vicente Garcia-Patos
Abstract is missing (Short communication)
Pages: 1241-1242
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SHORT COMMUNICATION
Agreement Between Self-reported Inflammatory Skin Disorders and Dermatologists’ Diagnosis: A Cross-sectional Diagnostic Study
Céline Phan, Khaled Ezzedine, Cindy Lai, Laurence Le Cleach, Oliver Cogrel, Laurence Fardet, Pierre Wolkenstein, Olivier Chosidow, Marie Beylot Barry, Emilie Sbidian
Abstract is missing (Short communication)
Pages: 1243-1244
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SHORT COMMUNICATION
Cutis Verticis Gyrata Fluctuation with Atopic Dermatitis Disease Activity
Hideyuki Kosumi, Kentaro Izumi, Ken Natsuga, Yasuyuki Yamaguchi, Akira Itami, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 1245-1246
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SHORT COMMUNICATION
Consumer Behaviour Among Nickel-allergic Patients
Malin G. Ahlström, Jacob P. Thyssen, Torkil Menné, Jeanne D. Johansen
Abstract is missing (Short communication)
Pages: 1247-1248
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SHORT COMMUNICATION
Lipoid Proteinosis: A Previously Unrecognized Mutation and Therapeutic Response to Acitretin
Claudia Carnevale, Daniele Castiglia, Andrea Diociaiuti, Vittoria Proto, Simona Giancristoforo, Renata Boldrini, Giovanna Zambruno, Maya El Hachem
Abstract is missing (Short communication)
Pages: 1249-1251
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SHORT COMMUNICATION
Coincident Metastatic Melanoma and Merkel Cell Carcinoma with Complete Remission on Treatment with Pembrolizumab
Alexander Thiem, Hermann Kneitz, Patrick Schummer, Stefan Herz, David Schrama, Roland Houben, Matthias Goebeler, Bastian Schilling, Anja Gesierich
Abstract is missing (Short communication)
Pages: 1252-1254
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SHORT COMMUNICATION
An HIV-negative Same-sex Male Couple Both Infected with Hepatitis C Virus
Roeland C.A. Achterbergh, Sylvia M. Bruisten, Thijs J.W. v.d. Laar, Charlie P. van der Weijden, Maarten Scholing, Marion Cornelissen, Henry J.C. de Vries
Abstract is missing (Short communication)
Pages: 1255-1257
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SHORT COMMUNICATION
Trichomonas vaginalis is Rare Among Women in Iceland
Ingibjorg Hilmarsdottir, Erna Sigmundsdottir, Audur Eiriksdottir, Daniel Golparian, Magnus Unemo
Abstract is missing (Short communication)
Pages: 1258-1260
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QUIZ
A Pinkish-Blue Exophytic Nodule on the Arm of an Elderly Man: A Quiz
Calogero Pagliarello, Ignazio Stanganelli, Roberto Ricci, Claudio Feliciani, Sergio Di Nuzzo
Abstract is missing (Quiz)
Pages: 1261-1262
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QUIZ
Bone Formation in Cutaneous Nodules on the Leg: A Quiz
Ferdinand Toberer, Alexander H. Enk, Wolfgang Hartschuh, Jessica Hassel
Abstract is missing (Quiz)
Pages: 1263-1264
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QUIZ
A Large Skin-colored Nodule on the Plantar Foot: A Quiz
Nathan W. Rojek, Veselina Korcheva, Sancy A. Leachman
Abstract is missing (Quiz)
Pages: 1265-1266
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CORRESPONDENCE
Cutaneous Side Effects of Single Versus Combined BRAF Inhibitors: A Comment to Erfan et al.
Rachel Anforth, Pablo Fernandez-Penas
Abstract is missing (Correspondence)
Pages: 1267-1268
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CORRESPONDENCE
Microdialysis in Profiling Cytokines and Other Macromolecules in the Skin in Health and Disease: A Comment to Falcone et al.
Bijar Ghafouri, Chris D. Anderson
Abstract is missing (Correspondence)
Pages: 1269-1270
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