Content

Content - Volume 97, Issue 9

Editor's choice in this issue

INVESTIGATIVE REPORT
Folliculotropic Mycosis Fungoides with Skewed T-cell Receptor CDR3 Motif: Suggestive of Lipid-antigen Selection?
Panagiota Mantaka, Agnieszka Malecka, Gunhild Trøen, Per Helsing, Petter Gjersvik, Klaus Beiske, Jan Delabie
Folliculotropic mycosis fungoides (FMF), a variant of mycosis fungoides (MF) with distinct clinical features, is characterized by infiltration of malignant T cells in hair follicles. This raises the hypothesis that antigens in the hair follicle may contribute to the pathogenesis of FMF. T-cell receptor β gene (TRB) sequences as well as dendritic cell subsets in patients with FMF (n =&# ...
Pages: 1081-1086
Abstract  HTML  PDF
CLINICAL REPORT
A Novel Actinic Keratosis Field Assessment Scale for Grading Actinic Keratosis Disease Severity
Brigitte Dréno, Rino Cerio, Thomas Dirschka, Ignasi Figueras Nart, John T. Lear, Ketty Peris, Andrés Ruiz de Casas, Shaniko Kaleci, Giovanni Pellacani; Progressing Evidence in AK (PEAK) Working Group
Actinic keratosis (AK) lesions are surrounded by field cancerization (areas of subclinical, non-visible sun damage). Existing AK grading tools rely on AK counts, which are not reproducible. An Actinic Keratosis Field Assessment Scale (AK-FAS) for grading the severity of AK/field was developed. Standardized photographs of patients representing the full range of AK severity were collected. Six inves ...
Pages: 1108-1113
Abstract  HTML  PDF

All articles

EDITORIAL
“The Times They Are A-changin’ …”
Anders Vahlquist
Abstract is missing (Editorial)
Page: 1063
Abstract  PDF
COMMENTARY
The Brain Network of Itch Distraction
Clemens Forster
Abstract is missing (Commentary)
Pages: 1064-1065
Abstract  PDF
SPECIAL REPORT
Minimally-invasive Sampling of Interleukin-1α and Interleukin-1 Receptor Antagonist from the Skin: A Systematic Review of In vivo Studies in Humans
Denise Falcone, Pieter Spee, Peter C.M. van de Kerkhof, Piet E.J. van Erp
Interleukin-1α (IL-1α) and its receptor antagonist IL-1RA play a pivotal role in skin homeostasis and disease. Although the use of biopsies to sample these cytokines from human skin is widely employed in dermatological practice, knowledge about less invasive, in vivo sampling methods is scarce. The aim of this study was to provide an overview of such methods by systematically reviewing studies i ...
Pages: 1066-1073
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Distraction From Itch Shows Brainstem Activation Without Reduction in Experimental Itch Sensation
Astrid Stumpf, Bettina Pfleiderer, Gudrun Schneider, Gereon Heuft, Martin Schmelz, Ngoc Quan Phan, Sonja Ständer, Markus Burgmer
The central processing of itch is not completely understood. This is the first study to use functional magnetic resonance imaging (fMRI) to examine the central modulation by distraction of experimentally induced itch. A total of 33 healthy volunteers were examined with fMRI. Periods of itch induction without distraction and itch with distraction by a Stroop task (psychological test, where the part ...
Pages: 1074-1080
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Folliculotropic Mycosis Fungoides with Skewed T-cell Receptor CDR3 Motif: Suggestive of Lipid-antigen Selection?
Panagiota Mantaka, Agnieszka Malecka, Gunhild Trøen, Per Helsing, Petter Gjersvik, Klaus Beiske, Jan Delabie
Folliculotropic mycosis fungoides (FMF), a variant of mycosis fungoides (MF) with distinct clinical features, is characterized by infiltration of malignant T cells in hair follicles. This raises the hypothesis that antigens in the hair follicle may contribute to the pathogenesis of FMF. T-cell receptor β gene (TRB) sequences as well as dendritic cell subsets in patients with FMF (n =&# ...
Pages: 1081-1086
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice
Claudia Bürger, Nitesh Shirsath, Victoria Lang, Sandra Diehl, Roland Kaufmann, Andreas Weigert, Ying-ying Han, Christian Ringel, Peter Wolf
The mTOR (mechanistic target of rapamycin) inhibitor rapamycin has long been known for its immune suppressive properties, but it has shown limited therapeutic success when given systemically to patients with psoriasis. Recent data have shown that the mTOR pathway is hyperactivated in lesional psoriatic skin, which probably contributes to the disease by interfering with maturation of keratinocytes. ...
Pages: 1087-1094
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Pemphigus Vulgaris and Pemphigus Foliaceus: Differences in Epidemiology and Mortality
Khalaf Kridin, Shira Zelber-Sagi, Reuven Bergman
Little is known about differences in epidemiological features and prognosis between pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The objective of this study was to compare PV and PF patients regarding ethnic variations and mortality rates. Mortality of PV and PF patients was compared with age- and sex-matched control subjects in the general population. The study cohort comprised 207 patie ...
Pages: 1095-1099
Abstract  HTML  PDF
CLINICAL REPORT
Diagnostic Efficacy of Digital Dermoscopy and Clinical Findings in Thin Melanoma of the Lower Limbs
Emi Dika, Marco Adriano Chessa, Simone Ribero, Pier A. Fanti, Carlotta Gurioli, Martina Lambertini, Carlotta Baraldi, Annalisa Patrizi
The introduction of dermoscopy has improved the accuracy of diagnosis of melanoma. However, early stage melanoma can be difficult to diagnose. Eighty-nine cases of thin melanoma with a Breslow thickness ≤1 mm located on the lower limb and diagnosed between 2008 and 2016 were assessed using 4 dermoscopic algorithms: (i) modified pattern analysis; (ii) ABCD rule of dermoscopy; (iii) 7-point ch ...
Pages: 1100-1107
Abstract  HTML  PDF
CLINICAL REPORT
A Novel Actinic Keratosis Field Assessment Scale for Grading Actinic Keratosis Disease Severity
Brigitte Dréno, Rino Cerio, Thomas Dirschka, Ignasi Figueras Nart, John T. Lear, Ketty Peris, Andrés Ruiz de Casas, Shaniko Kaleci, Giovanni Pellacani; Progressing Evidence in AK (PEAK) Working Group
Actinic keratosis (AK) lesions are surrounded by field cancerization (areas of subclinical, non-visible sun damage). Existing AK grading tools rely on AK counts, which are not reproducible. An Actinic Keratosis Field Assessment Scale (AK-FAS) for grading the severity of AK/field was developed. Standardized photographs of patients representing the full range of AK severity were collected. Six inves ...
Pages: 1108-1113
Abstract  HTML  PDF
CLINICAL REPORT
A Review of 52 Pedigrees with Epidermolysis Bullosa Simplex Identifying Ten Novel Mutations in KRT5 and KRT14 in Australia
Emma N. Kim, Adam G. Harris, Linda J. Bingham, Wenfei Yan, John C. Su, Dedee F. Murrell
Epidermolysis bullosa simplex (EBS) is a rare heritable skin fragility disorder, most commonly caused by dominant mutations in KRT5 and KRT14. EBS shows clinical heterogeneity with localised, intermediate and generalised severe forms, which tend to correlate with the location and nature of the disease causing mutations. We therefore aimed to identify the KRT5 and KRT14 mutations in patients diagno ...
Pages: 1114-1119
Abstract  HTML  PDF
CLINICAL REPORT
Topical Oxybutynin 10% Gel for the Treatment of Primary Focal Hyperhidrosis: A Randomized Double-blind Placebo-controlled Split Area Study
Ofir Artzi, Christophoros Loizides, Eyal Zur, Eli Sprecher
Limited efficacy, costs, side-effects and complications are issues of concern for most current therapeutic modalities for focal hyperhidrosis. This study evaluated the efficacy of topical oxybutynin 10% gel in treating 61 patients with primary focal hyperhidrosis. The gel was applied to the right or left axilla, palms or soles vs. a placebo compound to the contralateral side for 30 days. A blinded ...
Pages: 1120-1124
Abstract  HTML  PDF
SHORT COMMUNICATION
No Viral Transcripts Associated with Folliculotropic Mycosis Fungoides Using a High Throughput Sequencing Approach
Aurélie Du-Thanh, Olivier Dereure, Justine Cheval, Marine Dumarest, Liza Al-Shikhley, Céline Girard, Bernard Guillot, Marc Eloit
Abstract is missing (Short communication)
Pages: 1125-1126
Abstract  HTML  PDF
SHORT COMMUNICATION
Prevalence of Cancer in Adult Patients with Atopic Dermatitis: A Nationwide Study
Samine Ruff, Alexander Egeberg, Yuki M.F. Andersen, Gunnar Gislason, Lone Skov, Jacob P. Thyssen
Abstract is missing (Short communication)
Pages: 1127-1129
Abstract  HTML  PDF
SHORT COMMUNICATION
Prurigo Pigmentosa in a 21-year-old Caucasian Man: A Clinicopathological Correlation
Ferdinand Toberer, Alexander Enk, Christine Fink, Holger A. Haenssle
Abstract is missing (Short communication)
Pages: 1130-1131
Abstract  HTML  PDF
SHORT COMMUNICATION
Methotrexate-associated Sexual Dysfunction: Two Case Reports
Grigorios Theodosiou, Åke Svensson
Abstract is missing (Short communication)
Pages: 1132-1133
Abstract  HTML  PDF
SHORT COMMUNICATION
Rare Ingestive Food Allergy to Mushroom Boletus badius
Tatjana Fischer, Bernadette Eberlein, Knut Brockow, Markus Ollert, Johannes Ring, Ulf Darsow
Abstract is missing (Short communication)
Pages: 1134-1135
Abstract  HTML  PDF
SHORT COMMUNICATION
Pemphigus Vulgaris Persistently Localized to the Nose with Local and Systemic Response to Topical Steroids
Connie Zhang, Ilana Goldscheider, Thomas Ruzicka, Miklós Sárdy
Abstract is missing (Short communication)
Pages: 1136-1137
Abstract  HTML  PDF
SHORT COMMUNICATION
Bortezomib Does Not Prevent the Occurrence of Kaposi’s Sarcoma in Patients with Haematological Malignancies: Two Case Reports
Nathalie Chavarot, Celeste Lebbe, Eric Thervet, Didier Bouscary, Alexandre Karras
Abstract is missing (Short communication)
Pages: 1138-1139
Abstract  HTML  PDF
SHORT COMMUNICATION
Abscopal Effect of Local Irradiation Treatment for Diffuse Large B-cell Lymphoma
Yuri Hidaka , Takuya Takeichi, Yuichi Ishikawa, Mariko Kawamura, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 1140-1141
Abstract  HTML  PDF
SHORT COMMUNICATION
Concurrent Double Fungal Infections of the Skin Caused by Phialemoniopsis endophytica and Exophiala jeanselmei in a Patient with Microscopic Polyangiitis
Ayako Ito, Nanako Yamada, Ryoko Kimura, Natsumi Tanaka, Jun Kurai, Kazushi Anzawa, Takashi Mochizuki, Osamu Yamamoto
Abstract is missing (Short communication)
Pages: 1142-1144
Abstract  HTML  PDF
SHORT COMMUNICATION
Quality of Life in Greek Patients with Autoimmune Bullous Diseases Assessed with ABQOL and TABQOL Indexes
Aikaterini Patsatsi, Miltiadis Kokolios, Aikaterini Kyriakou, Fotini Lamprou, Despoina Stylianidou, Apostolos Tsapas, Dimitrios G. Goulis, Dedee F. Murrell, Dimitrios Sotiriadis
Abstract is missing (Short communication)
Pages: 1145-1147
Abstract  HTML  PDF
QUIZ
Livedo Reticularis on the Lower Limbs in a Patient with Lupus Erythematosus: A Quiz
Elodie Miquelestorena-Standley, Alia Saleh, Anne Lataste, Christophe Monegier du Sorbier, Laurent Machet
Abstract is missing (Quiz)
Pages: 1148-1149
Abstract  HTML  PDF
QUIZ
Subcutaneous Nodule on the Right Palm of a Young Boy: A Quiz
Takuya Maeda, Yasuyuki Fujita, Keisuke Imafuku, Shinichi Nakazato, Hiroo Hata, Toshifumi Nomura, Tomoko Mitsuhashi, Takashi Anan, Tadashi Hasegawa, Shuji Hamaoka, Hiroshi Shimizu
Abstract is missing (Quiz)
Pages: 1150-1151
Abstract  HTML  PDF
CORRESPONDENCE
Human Herpesvirus-7 Papular Rash: A Comment to Brazzelli et al.
Francesco Drago, Giulia Ciccarese, Aurora Parodi
Abstract is missing (Correspondence)
Pages: 1152-1154
Abstract  HTML  PDF